Hypothesis

29 Matching Annotations

Jun 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Development of CAR T cells Targeting a Surface RNA Binding Protein for the Treatment of Acute Leukemias

1
1. scibot 18 Jun 2026
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1158/2159-8290.CD-25-0920
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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pmc.ncbi.nlm.nih.gov/articles/PMC13271017/
May 2026
dx.doi.org dx.doi.org

Preclinical efficacy of tasquinimod-based combinations in advanced myeloproliferative neoplasms (MPN) in blastic phase

1
1. scibot 14 May 2026
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1182/bloodadvances.2025016898
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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dx.doi.org/10.1182/bloodadvances.2025016898
Mar 2026
www.sciencedirect.com www.sciencedirect.com

Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia

1
1. scibot 20 Mar 2026
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1016/j.xcrm.2026.102687
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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sciencedirect.com/science/article/pii/S2666379126001047
Nov 2025
www.sciencedirect.com www.sciencedirect.com

Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia

1
1. scibot 22 Nov 2025
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1016/j.cell.2025.10.028
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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sciencedirect.com/science/article/pii/S0092867425012334
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia

1
1. scibot 20 Nov 2025
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1158/2767-9764.CRC-25-0283
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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pmc.ncbi.nlm.nih.gov/articles/PMC12620962/
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Systematic evaluation of GAPs and GEFs identifies a targetable dependency for hematopoietic malignancies

1
1. scibot 16 Sep 2025
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1158/2159-8290.CD-25-0299
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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pmc.ncbi.nlm.nih.gov/articles/PMC12427560/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis

1
1. scibot 11 Jun 2025
  
  in Public
  
  CVCL_2187
  
  DOI: 10.1158/2159-8290.CD-24-0093
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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pmc.ncbi.nlm.nih.gov/articles/PMC11611684/
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Augmenting CAR T Cell Functions with LIGHT

1
1. scibot 02 Apr 2025
  
  in Public
  
  SET-2
  
  DOI: 10.1158/2326-6066.CIR-24-0246
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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pmc.ncbi.nlm.nih.gov/articles/PMC11444887/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Pre-clinical efficacy of CDK7 inhibitor-based combinations against myeloproliferative neoplasms (MPN) transformed to AML

1
1. scibot 20 Feb 2025
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1182/blood.2024026388
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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RRID:CVCL_2187

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pmc.ncbi.nlm.nih.gov/articles/PMC11811934/
Jun 2024
www.sciencedirect.com www.sciencedirect.com

A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML

1
1. scibot 06 Jun 2024
  
  in Public
  
  ACC 608
  
  DOI: 10.1016/j.xcrm.2024.101592
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @abever99
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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RRID:CVCL_2187

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sciencedirect.com/science/article/pii/S2666379124002842
Mar 2024
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

1
1. scibot 27 Mar 2024
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1002/1878-0261.13638
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13638
Dec 2023
www.sciencedirect.com www.sciencedirect.com

Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms

1
1. scibot 22 Dec 2023
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1016/j.celrep.2023.113608
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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sciencedirect.com/science/article/pii/S2211124723016200
Nov 2023
www.embopress.org www.embopress.org

An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions

1
1. scibot 25 Nov 2023
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.15252/embj.2023114221
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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embopress.org/doi/10.15252/embj.2023114221
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms

1
1. scibot 07 Sep 2023
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1158/1078-0432.CCR-22-1763
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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RRID:CVCL_2187

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ncbi.nlm.nih.gov/pmc/articles/PMC9992133/
Jun 2023
www.sciencedirect.com www.sciencedirect.com

New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

1
1. scibot 08 Jun 2023
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1016/j.chembiol.2023.05.007
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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sciencedirect.com/science/article/pii/S2451945623001502
aacrjournals.org aacrjournals.org

Targeting CHAF1B enhances Interferon activity against Myeloproliferative Neoplasm cells

1
1. scibot 02 Jun 2023
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1158/2767-9764.CRC-23-0010
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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RRID:CVCL_2187

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URL

aacrjournals.org/cancerrescommun/article/3/5/943/727012/Targeting-CHAF1B-Enhances-IFN-Activity-against
Mar 2023
52.53.155.43 52.53.155.43

943-html.html

1
1. scibot 16 Mar 2023
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1158/1078-0432.ccr-22-1763
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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RRID:CVCL_2187

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52.53.155.43/c8f103b982e67ed0e9f7f2acbda462e2c6f6fa27/943-html.html
May 2022
www.sciencedirect.com www.sciencedirect.com

Antigen presentation safeguards the integrity of the hematopoietic stem cell pool

1
1. scibot 06 May 2022
  
  in Public
  
  DSMZACC 608
  
  DOI: 10.1016/j.stem.2022.04.007
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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RRID:CVCL_2187

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URL

sciencedirect.com/science/article/pii/S1934590922001606
Mar 2022
www.sciencedirect.com www.sciencedirect.com

The proteogenomic subtypes of acute myeloid leukemia

1
1. scibot 04 Mar 2022
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1016/j.ccell.2022.02.006
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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RRID:CVCL_2187

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URL

sciencedirect.com/science/article/pii/S1535610822000587
Jan 2022
www.sciencedirect.com www.sciencedirect.com

SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia

1
1. scibot 12 Jan 2022
  
  in Public
  
  ACC 608
  
  DOI: 10.1016/j.celrep.2021.110233
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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RRID:CVCL_2187

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sciencedirect.com/science/article/pii/S2211124721017423
Aug 2021
www.sciencedirect.com www.sciencedirect.com

ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency

1
1. scibot 07 Aug 2021
  
  in Public
  
  ACC-608
  
  DOI: 10.1016/j.molcel.2021.07.018
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187 RRIDCUR:Missing
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RRID:CVCL_2187

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1097276521005876
Jul 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells

1
1. scibot 28 Jul 2021
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1038/s41408-018-0165-5
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_2187
  
  What is this?
  
  RRIDCUR:Unrecognized RRID:CVCL_2187
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RRIDCUR:Unrecognized

RRID:CVCL_2187

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6333829/
www.sciencedirect.com www.sciencedirect.com

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

1
1. scibot 27 Jul 2021
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1016/j.ccell.2018.05.007
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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RRID:CVCL_2187

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sciencedirect.com/science/article/pii/S1535610818302216
Apr 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mechanistic basis and efficacy of targeting the β-catenin–TCF7L2–JMJD6–c-Myc axis to overcome resistance to BET inhibitors

1
1. scibot 10 Apr 2021
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1182/blood.2019002922
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_2187
  
  What is this?
  
  RRID:CVCL_2187 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_2187

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7146021/
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets

1
1. scibot 13 Sep 2020
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1016/j.molcel.2020.04.008
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_2187
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_2187
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RRIDCUR:Validated

RRID:CVCL_2187

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scibot

URL

sciencedirect.com/science/article/pii/S1097276520302343
clincancerres.aacrjournals.org clincancerres.aacrjournals.org

5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-mediated Apoptosis.

1
1. scibot 04 Sep 2020
  
  in Public
  
  CVCL_2187
  
  DOI: 10.1158/1078-0432.CCR-19-1900
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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RRID:CVCL_2187

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clincancerres.aacrjournals.org/content/26/13/3371
www.sciencedirect.com www.sciencedirect.com

Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2

1
1. scibot 04 Sep 2020
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1016/j.cell.2020.03.051
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_2187
  
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  RRID:CVCL_2187
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RRID:CVCL_2187

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URL

sciencedirect.com/science/article/pii/S0092867420303445
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:CVCL_2187
  
  DOI: 10.1016/j.molcel.2019.01.009
  
  Resource: (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_2187
  
  What is this?
  
  RRID:CVCL_2187 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_2187

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scibot

URL

sciencedirect.com/science/article/pii/S1097276519300097
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:CVCL_2187
  
  Resource used:
  
  (DSMZ Cat# ACC-608, RRID:CVCL_2187)
  
  SciCrunch record: RRID:CVCL_2187
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:CVCL_2187
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RRID:CVCL_2187

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scibot

URL

sciencedirect.com/science/article/pii/S1535610817305123