333 Matching Annotations
  1. Nov 2025
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    Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope
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    sciencedirect.com/science/article/pii/S1097276525008688
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    A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology
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    sciencedirect.com/science/article/pii/S1534580725006665
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    KIF18A promotes chromosome congression in cooperation with CENP-E downstream of CENP-C
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    sciencedirect.com/science/article/pii/S2211124725012860
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM
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    pmc.ncbi.nlm.nih.gov/articles/PMC12583604/
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    Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
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    sciencedirect.com/science/article/pii/S009286742501178X
  7. Oct 2025
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    Impact of somatic XIST deletions on ongoing XIST expression and inactive X silencing and heterochromatin
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    academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddaf160/8300178
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    Chromatin remodeling activity of EP400 safeguards chromosomal stability by preventing CENP-A mislocalization
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    sciencedirect.com/science/article/pii/S2211124725011945
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    A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function
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    Protocol for identifying DNA damage responders through proximity biotinylation of proliferating cell nuclear antigen interactors
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  12. Sep 2025
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response
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    Intrinsic heterogeneity of primary cilia revealed through spatial proteomics
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    IFT88-KAP interaction defines a conserved mechanism for kinesin-2-IFT coupling
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    PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region
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    Pharmacologic interrogation of USP28 cellular function in p53 signaling
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  19. Aug 2025
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    YTHDF proteins and m6A-RNA clients undergo autophagic turnover during contact inhibition
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    Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress
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    53BP1 regulates p53-E2F7-dependent transcriptional gene repression and participates in the Fanconi anemia pathway
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    Accurate Identification of Cell Cycle Stages in RPE1 Cells Using the ImmunoCellCycle-ID Method
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  27. Jul 2025
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    Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling
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    14-3-3É› inhibits premature centriole disengagement by inhibiting the activity of Plk1 and Separase
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    Mitotic slippage causes nuclear instability in polyploid cells
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    The mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregation
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    Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ
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    Proteasome-dependent Orc6 removal from chromatin upon S-phase entry safeguards against minichromosome maintenance complex reloading and tetraploidy
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    Protocol for immunostaining of non-adherent cells and cellular structures using centrifugal filter devices
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  35. Jun 2025
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    The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells
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    Transcriptional enhancers in human neuronal differentiation provide clues to neuronal disorders
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    Phase separation of TTBK2 and CEP164 is necessary for ciliogenesis
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    Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
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    Germline pathogenic variants in HIC1 DNA binding domains are associated with familial serrated polyposis syndrome
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  43. May 2025
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion
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    Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells
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    Multigenerational cell tracking of DNA replication and heritable DNA damage
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    Direct Arp2/3-vinculin binding is required for pseudopod extension, but only on compliant substrates and in 3D
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    CDK4/6 activity is required during G2 arrest to prevent stress induced endoreplication
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  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Therapy-induced senescence of glioblastoma cells is determined by the p21CIP1-CDK1/2 axis and does not require activation of DREAM
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    OSMOTIC STRESS INFLUENCES MICROTUBULE DRUG RESPONSE VIA WNK1 KINASE SIGNALING
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  51. Apr 2025
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway–Deficient Acute Myeloid Leukemia
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    NF-κB signaling directs a program of transient amplifications at innate immune response genes
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    The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage
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    Supra-second tracking and live-cell karyotyping reveal principles of mitotic chromosome dynamics
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  57. Mar 2025
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    Targeting WEE1 kinase as a therapeutic strategy in ATIP3-deficient breast cancers
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    Transcriptional enhancers in human neuronal differentiation provide clues to neuronal disorders
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    The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis
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    Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape
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  63. Feb 2025
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  66. elifesciences.org elifesciences.org
    Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis
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    Targeting GPC2 on intraocular and CNS metastatic retinoblastomas with local and systemic delivery of CAR T-cells
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    The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability
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  69. Jan 2025
  70. elifesciences.org elifesciences.org
    PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response
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    elifesciences.org/articles/102852
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement
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  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination
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  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome and epigenome
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  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint
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    mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase
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    Phosphorylation of Ephexin4 at Ser-41 contributes to chromosome alignment via RhoG activation in cell division
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    Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation
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  78. Dec 2024
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    The histone H3.3 K27M mutation suppresses Ser31phosphorylation and mitotic fidelity, which can directly drive gliomagenesis
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    cell.com/current-biology/abstract/S0960-9822(24)01575-6
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    PEBP1 amplifies mitochondrial dysfunction induced integrated stress response
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    elifesciences.org/reviewed-preprints/102852
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell Lines
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    Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation
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  84. Nov 2024
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2
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    Inter-chromosomal contacts demarcate genome topology along a spatial gradient
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    Acute multi-level response to defective de novo chromatin assembly in S-phase
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    Rab11-Rab8 cascade dynamics in primary cilia and membrane tubules
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    Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells
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  90. Oct 2024
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CALHM2 is a mitochondrial protein import channel that regulates fatty acid metabolism
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    Pervasive mislocalization of pathogenic coding variants underlying human disorders
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  93. Sep 2024
  94. www.biorxiv.org www.biorxiv.org
    PEBP1 amplifies mitochondrial dysfunction induced integrated stress response
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    biorxiv.org/content/10.1101/2024.09.20.614039v1
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    In vivo DNA replication dynamics unveil aging-dependent replication stress
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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage
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    ncbi.nlm.nih.gov/pmc/articles/PMC11385192/
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    TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival
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  98. Aug 2024
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor Vessel Normalization via PFKFB3 Inhibition Alleviates Hypoxia and Increases Tumor Necrosis in Rectal Cancer upon Radiotherapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC11310748/
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    The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress
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    A High-Throughput Screening Identifies MCM Chromatin loading Inhibitors Targeting Cells with increased Replication Origins
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  217. May 2022
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  220. Apr 2022
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  230. Mar 2022
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