395 Matching Annotations
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    Nuclear localization of the glutaminyl-tRNA synthetase QARS reveals its role in DNA damage response in ovarian cancer
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    Cellular self-organization orchestrates ferroptosis propagation
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    Pharmacologically targeting CDK12 induces BRCAness and synergizes with merestinib to exacerbate DNA damage in high-risk neuroblastoma
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  5. Oct 2026
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    Contractile perinuclear actomyosin network promotes peripheral and polar chromosome interaction with the mitotic spindle
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    An epigenetic program dictates MYC amplification dynamics that promote transient, extrachromosomal, and inherited genomic events
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  8. Sep 2026
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    Molecular mechanism of HUWE1-HAPSTR1-USP7-mediated ubiquitin chain amplification on nuclear proteins
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    Integrative proteomics defines FANCA as a multifunctional hub linking DNA repair to translation
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    MicroNucML enables machine learning-based micronuclei segmentation and micronuclei-nuclei association
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    Combined inhibition of PLK4 and PPM1D promotes cell death in cancer cells with 17q amplification
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  13. Aug 2026
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    CDC7 and APC/CCdh1 gate distinct routes to initiate DNA replication
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    CDT1 acts with the replisome to remodel replication forks
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    The regulation of protein phosphatase 4 by FBXO42 is required for cancer cell survival
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    MDM2 binds and suppresses RNA polymerase III to restrain the innate immune response to cytosolic DNA
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  18. Jul 2026
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    CIP2A recruits SLX4-MUS81-XPF in mitosis and protects against replication stress
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    Progerin-induced nuclear envelope remodeling is shaped by cell division and NUP153
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    Cryo-EM structure of soluble VPS13C suggests its regulation by a conformational switch and by calmodulin
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    SMAD4 MH2 Mutations Disrupt CREBBP/EP300 Recruitment and TGF-β-Induced Transcription in Colorectal Cancer
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    A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions
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    Cell-cycle-dependent regulation of DNA end resection by PLK1 and PLK3 without CtIP level modulation
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  25. Jun 2026
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    A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces cell cycle arrest and senescence
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    Progerin-Induced Nuclear Envelope Remodeling is Shaped by Cell Division and NUP153
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    Centrosome linker protein CEP68 modulates cellular stress responses via nuclear condensate formation and HSP27 interaction
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    FANCA-dependent FEN1 recruitment suppresses transcription-replication conflicts and PARPi sensitivity
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    hSpindly dynamics modulate spindle assembly checkpoint signaling, promoting resistance to mitotic inhibitors
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    GPC6 facilitates progression of SHH-subgroup medulloblastoma by enhancing Hedgehog secretion and signaling responses
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    Single kinetochores execute an ordered series of molecular events as the spindle assembly checkpoint is silenced
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  33. May 2026
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    The Host Cell Factor Phosphatase-2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type-1
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    Diamond-Blackfan anemia gene product RPS19 counteracts SET to maintain p53 transcriptional activity and tumor suppressor function
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    Identification of Small-Molecule Autophagy Activators via GFP-LC3 High-Throughput Screening and a Cargo-Based Autophagy Flux and Processing Assay
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  39. Apr 2026
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    The cytotoxic effect of prexasertib is a consequence of dual inhibition on both CHK1 and AMPK
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    RB loss modulates chromatin organization by regulating cohesin-dependent loops and enhancer-promoter interactions
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    Proximity-based activation of AURORA A by MPS1 potentiates error correction
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    Proteomic Profiling Reveals How Physiological Media Reshape Cancer Cell Proteomes and Signaling Networks
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    Pharmacologic and Oncohistone Inhibition of SETD2 Converge on Genomic Instability
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    CDK11 inhibition induces cytoplasmic p21 WAF1 splice variant by p53 stabilisation and SF3B1 inactivation
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  49. Mar 2026
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    Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses
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  54. Feb 2026
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    Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability
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  58. Jan 2026
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    Lysine demethylase 4A is a centrosome‐associated protein required for centrosome integrity and genomic stability
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    1-deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway
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    Distinct Regulation of the ARF and TAp73 Tumor Suppressor Genes by the Transcription Factor E2F1 Enables Discrimination of Cancer Cells from Normal Growing Cells
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  67. Dec 2025
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    D3-GPC2-directed CAR T cells are safe and efficacious in preclinical models of neuroblastoma and small cell lung cancer
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    Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex
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  74. Nov 2025
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    Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope
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    KIF18A promotes chromosome congression in cooperation with CENP-E downstream of CENP-C
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    BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM
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    Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
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  80. Oct 2025
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    Impact of somatic XIST deletions on ongoing XIST expression and inactive X silencing and heterochromatin
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    A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function
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    Protocol for identifying DNA damage responders through proximity biotinylation of proliferating cell nuclear antigen interactors
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  85. Sep 2025
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    Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response
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    IFT88-KAP interaction defines a conserved mechanism for kinesin-2-IFT coupling
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    PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region
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  92. Aug 2025
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    YTHDF proteins and m6A-RNA clients undergo autophagic turnover during contact inhibition
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    Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress
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    53BP1 regulates p53-E2F7-dependent transcriptional gene repression and participates in the Fanconi anemia pathway
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    Accurate Identification of Cell Cycle Stages in RPE1 Cells Using the ImmunoCellCycle-ID Method
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    Harnessing Lactiplantibacillus plantarum EP21 and its membrane vesicles to inhibit myopia development
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