77 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13238595/
  3. Jun 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EGFR- and HER3-targeted bispecific antibody-drug conjugate demonstrates antitumor activity in metastatic castration-resistant prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13221231/
  5. Apr 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    hsa-circKLK3-25 promotes epithelial-mesenchymal transition and malignant progression of prostate cancer through the JNK/ERK signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC13090479/
  7. www.sciencedirect.com www.sciencedirect.com
    Betulinic acid induces lysosome-dependent death in prostate cancer by targeting DDX5
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    sciencedirect.com/science/article/pii/S0944711326003776
  8. Mar 2026
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Synergistic Efficacy of Gedatolisib and Darolutamide in Prostate Cancer to Overcome Resistance to Androgen-Targeted Therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12958000/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases
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    pmc.ncbi.nlm.nih.gov/articles/PMC12955874/
  11. Feb 2026
  12. www.nature.com www.nature.com
    The FOSB-IGFBP5-IGF-1 axis: a novel regulatory pathway that suppresses prostate cancer growth
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    nature.com/articles/s41417-026-01012-z
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VAV2 drives EGFR-mediated Rac1 responses in prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12324970/
  14. Jan 2026
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lactate derived from cancer-associated fibroblasts promotes alternative splicing and castration resistance in prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12810638/
  16. www.sciencedirect.com www.sciencedirect.com
    Cooperative interaction between YAP1 and EphA3 receptor tyrosine kinase regulates cellular plasticity and treatment response in prostate cancer
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    sciencedirect.com/science/article/pii/S0898656826000173
  17. Dec 2025
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual inhibition of ATR and DNA-PKcs radiosensitizes ATM-mutant prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12127007/
  19. Nov 2025
  20. www.nature.com www.nature.com
    KBTBD11 loss promotes AKT hyperactivation and therapeutic vulnerability in prostate cancer
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    nature.com/articles/s41388-025-03576-w
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical activity of the DLL3-targeted T cell engager MK-6070 in neuroendocrine prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12554248/
  22. Oct 2025
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated Omics and Multi-Cohort Analyses Identify an Enhancer Variant Linking Ferroptosis to Precision Therapy in Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12485374/
  24. Sep 2025
  25. www.nature.com www.nature.com
    KBTBD11 loss promotes AKT hyperactivation and therapeutic vulnerability in prostate cancer
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    nature.com/articles/s41388-025-03576-w
  26. 52.53.155.43 52.53.155.43
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  27. Aug 2025
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A PSMA-targeted Tri-specific Killer Engager enhances NK cell cytotoxicity against prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11790377/
  29. Jun 2025
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ADT increases prostate cancer cell invasion via altering AR/SALL4/SOX2-OCT4 stem cell signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12176959/
  31. www.cell.com www.cell.com
    BCL2 drives castration resistance in castration-sensitive prostate cancer by orchestrating reciprocal crosstalk between oncogenic pathways
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    cell.com/cell-reports/fulltext/S2211-1247(25)00550-9
  32. May 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Heterogeneous Responses to High-Dose Testosterone in Castration-Resistant Prostate Cancer Tumors with Mixed Rb-Proficient and Rb-Deficient Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046331/
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    DHA suppresses hormone-sensitive and castration-resistant prostate cancer growth by decreasing de novo lipogenesis
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    sciencedirect.com/science/article/pii/S1388198125000423
  35. Apr 2025
  36. 52.53.155.43 52.53.155.43
    rational-design-and-development-of-selective-brd7-bromodomain-inhibitors-and-their-activity-in-prostate-cancer-html.html
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    Development and validation of a kinase-related gene signature as a novel diagnostic and prognostic model for prostate cancer
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    sciencedirect.com/science/article/pii/S0925443925000675
  39. www.sciencedirect.com www.sciencedirect.com
    FMNL2/SRC-mediated androgen receptor translocation into the nucleus promotes enzalutamide resistance of prostate cancer
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    sciencedirect.com/science/article/pii/S2589004225004663
  40. Feb 2025
  41. aacrjournals.org aacrjournals.org
    Preclinical efficacy of a PSMA-targeted actinium-225 conjugate (225Ac-macropa-pelgifatamab) - a targeted alpha therapy for prostate cancer
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    aacrjournals.org/clincancerres/article/30/11/2531/745373/Preclinical-Efficacy-of-a-PSMA-Targeted-Actinium
  42. Jan 2025
  43. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial uncouplers inhibit oncogenic E2F1 activity and prostate cancer growth
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    sciencedirect.com/science/article/pii/S266637912400661X
  44. Dec 2024
  45. www.cell.com www.cell.com
    MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity
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    cell.com/cell-reports/abstract/S2211-1247(24)01471-2
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Characterization of ARX517, a Site-Specific Stable PSMA-Targeted Antibody–Drug Conjugate for the Treatment of Metastatic Castration-Resistant Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11612621/
  47. Nov 2024
  48. www.sciencedirect.com www.sciencedirect.com
    Spatial transcriptomics identifies RBM39 as a gene associated with Gleason score progression in prostate cancer
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    sciencedirect.com/science/article/pii/S2589004224025768
  49. Sep 2024
  50. aacrjournals.org aacrjournals.org
    Squalene epoxidase metabolic dependency is a targetable vulnerability in castration-resistant prostate cancer
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    aacrjournals.org/cancerres/article/82/17/3032/708286/Squalene-Epoxidase-Metabolic-Dependency-Is-a
  51. Aug 2024
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rational Design and Development of Selective BRD7 Bromodomain Inhibitors and Their Activity in Prostate Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10641717/
  53. www.biorxiv.org www.biorxiv.org
    Dual inhibition of ATR and DNA-PKcs radiosensitizes ATM-mutant prostate cancer
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    biorxiv.org/content/10.1101/2024.07.10.602941v2
  54. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Assessments of prostate cancer cell functions highlight differences between a pan-PI3K/mTOR inhibitor, gedatolisib, and single-node inhibitors of the PI3K/AKT/mTOR pathway
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13703
  55. www.cell.com www.cell.com
    Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis
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    cell.com/cell-reports/fulltext/S2211-1247(24)00760-5
  56. Apr 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer-associated fibroblasts promote enzalutamide resistance and PD-L1 expression in prostate cancer through CCL5-CCR5 paracrine axis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11031830/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response
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    ncbi.nlm.nih.gov/pmc/articles/PMC11052917/
  59. aacrjournals.org aacrjournals.org
    Adipose triglyceride lipase is a therapeutic target in advanced prostate cancer that promotes metabolic plasticity
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    aacrjournals.org/cancerres/article/84/5/703/734936/Adipose-Triglyceride-Lipase-Is-a-Therapeutic
  60. Feb 2024
  61. 52.53.155.43 52.53.155.43
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  62. Jan 2024
  63. www.sciencedirect.com www.sciencedirect.com
    UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas
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    sciencedirect.com/science/article/pii/S2666379123006109
  64. Dec 2023
  65. www.sciencedirect.com www.sciencedirect.com
    AID-induced CXCL12 upregulation enhances castration-resistant prostate cancer cell metastasis by stabilizing β-catenin expression
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    sciencedirect.com/science/article/pii/S2589004223026007
  66. Nov 2023
  67. www.sciencedirect.com www.sciencedirect.com
    PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer
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    sciencedirect.com/science/article/pii/S2451945623003847
  68. Sep 2023
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mechanistic target of rapamycin (mTOR) regulates self-sustained quiescence, tumor indolence, and late clinical metastasis in a Beclin-1-dependent manner
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    ncbi.nlm.nih.gov/pmc/articles/PMC9928463/
  70. Aug 2023
  71. 52.53.155.43 52.53.155.43
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    52.53.155.43/908848ce9212d2a4c8be94b24c71e399d1f50f03/Molecular Oncology - 2023 - Ito-html.html
  72. Jul 2023
  73. 52.53.155.43 52.53.155.43
    rational-design-and-development-of-selective-brd7-bromodomain-inhibitors-and-their-activity-in-prostate-cancer-html.html
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  74. Jun 2023
  75. www.sciencedirect.com www.sciencedirect.com
    Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer
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    sciencedirect.com/science/article/pii/S1535610823001836
  76. www.sciencedirect.com www.sciencedirect.com
    Minor intron splicing is critical for survival of lethal prostate cancer
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    sciencedirect.com/science/article/pii/S1097276523003738
  77. May 2023
  78. www.biorxiv.org www.biorxiv.org
    The androgen receptor does not directly regulate the transcription of DNA damage response genes
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    biorxiv.org/content/10.1101/2023.05.13.540653v1
  79. Mar 2023
  80. www.nature.com www.nature.com
    HOXB3 drives WNT-activation associated progression in castration-resistant prostate cancer
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    nature.com/articles/s41419-023-05742-y
  81. Feb 2023
  82. aacrjournals.org aacrjournals.org
    Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
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    aacrjournals.org/cancerres/article/83/2/219/715076/Plk1-Inhibitors-and-Abiraterone-Synergistically
  83. www.science.org www.science.org
    PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition
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    science.org/doi/10.1126/sciadv.ade8641
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimization and characterization of a bone culture model to study prostate cancer bone metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC9357208/
  85. Aug 2022
  86. 52.53.155.43 52.53.155.43
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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9398446/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Assessment of Androgen Receptor splice variant-7 as a biomarker of clinical response in castration-sensitive prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9378683/
  90. www.sciencedirect.com www.sciencedirect.com
    Air-liquid organotypic assays to investigate cellular crosstalk in the tumor microenvironment of cancer cells
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    sciencedirect.com/science/article/pii/S2666166722005159
  91. Jul 2022
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9251882/
  93. May 2022
  94. www.sciencedirect.com www.sciencedirect.com
    The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62
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    sciencedirect.com/science/article/pii/S2211124722005599
  95. www.cell.com www.cell.com
    Systematic discovery of mutation-directed neo-protein-protein interactions in cancer
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    cell.com/cell/fulltext/S0092-8674(22)00461-5
  96. Apr 2022
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MIRO2 regulates prostate cancer cell growth via GCN1-dependent stress signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC8983529/
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PIP5K1α is Required for Promoting Tumor Progression in Castration-Resistant Prostate Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8979106/
  99. Mar 2022
  100. www.sciencedirect.com www.sciencedirect.com
    Inhibiting 3βHSD1 to eliminate the oncogenic effects of progesterone in prostate cancer
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    sciencedirect.com/science/article/pii/S2666379122000684
  101. Nov 2021
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AXL cooperates with EGFR to mediate neutrophil elastase-induced migration of prostate cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8567381/
  103. Aug 2021
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRD9 is a critical regulator of androgen receptor signaling and prostate cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC8026650/
  105. www.sciencedirect.com www.sciencedirect.com
    CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer
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    sciencedirect.com/science/article/pii/S2211124719313828
  106. Apr 2021
  107. www.sciencedirect.com www.sciencedirect.com
    SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways
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    sciencedirect.com/science/article/pii/S1535610820302725
  108. Feb 2021
  109. www.sciencedirect.com www.sciencedirect.com
    An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors
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    sciencedirect.com/science/article/pii/S2211124721000577
  110. Jan 2021
  111. www.nature.com www.nature.com
    CD117/c-kit defines a prostate CSC-like subpopulation driving progression and TKI resistance
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    nature.com/articles/s41598-021-81126-6
  112. Sep 2020
  113. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.12706
  114. Aug 2020
  115. elifesciences.org elifesciences.org
    AR phosphorylation and CHK2 kinase activity regulates IR-stabilized AR–CHK2 interaction and prostate cancer survival
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    elifesciences.org/articles/51378
  116. Jan 2020
  117. www.sciencedirect.com www.sciencedirect.com
    VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells
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    sciencedirect.com/science/article/pii/S2405471219301905
  118. www.sciencedirect.com www.sciencedirect.com
    ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest
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    sciencedirect.com/science/article/pii/S240547121930033X
  119. www.sciencedirect.com www.sciencedirect.com
    Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progression
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    sciencedirect.com/science/article/pii/S2352396418306273