359 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture
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    pmc.ncbi.nlm.nih.gov/articles/PMC13040219/
  3. Mar 2026
  4. www.sciencedirect.com www.sciencedirect.com
    Cancer cell-derived sialylated IgG interacting with Siglec-7/9/10 is a potential immunotherapeutic target in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126000777
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ORMDL Proteins Turnover via Proteasome and Autophagy Is Cell‐Type Dependent and Tied to Ceramide Homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12974560/
  6. www.biorxiv.org www.biorxiv.org
    The Alternative Polyadenylation Factor CFIm25 Orchestrates Macrophage Antibacterial Immunity by Amplifying TAB2-Mediated MAPK and NF-κB Signaling During Salmonella Infection
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    biorxiv.org/content/10.64898/2026.02.26.707986v1
  7. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Matrix Metalloproteinase‐13 Is an Unfavorable Prognostic Factor in Chordoma by Digesting Growth Inhibitory Collagens
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    onlinelibrary.wiley.com/doi/10.1002/cam4.71662
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    Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12936425/
  9. Feb 2026
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MIG-6 Regulates HDAC1-Mediated Angiogenesis and Tumorigenesis in PTEN-Deficient Endometrioid Endometrial Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12935093/
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    GCAD: A Computational Framework for Mammalian Genetic Program Computer-Aided Design
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    sciencedirect.com/org/science/article/pii/S2161506326000549
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    Matrix Metalloproteinase‐13 Is an Unfavorable Prognostic Factor in Chordoma by Digesting Growth Inhibitory Collagens
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    onlinelibrary.wiley.com/doi/10.1002/cam4.71662
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    Syndecan-1-targeted therapeutic antibody impairs macropinocytosis and elicits antitumor immunity in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126000303
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Therapeutic targeting of YOD1 disrupts the PAX-FOXO1-N-Myc feedback loop in rhabdomyosarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12892920/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12900515/
  16. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004226002245-main-html.html
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    54.241.53.176/13360403228ba0d0ecbe95f3c3444604c2a213b8/1-s2.0-S2589004226002245-main-html.html
  17. Jan 2026
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    Axes of biological variation in diffuse large B cell lymphoma
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    sciencedirect.com/science/article/pii/S1535610825005495
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    Afatinib exerts an inhibitory effect on T cell-mediated cytotoxicity
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    link.springer.com/article/10.1007/s00262-025-04279-7
  20. elifesciences.org elifesciences.org
    Nonlinear transcriptional responses to gradual modulation of transcription factor dosage
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    elifesciences.org/articles/100555
  21. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Crosstalk between the ribosome quality control-associated E3 ubiquitin ligases LTN1 and RNF10
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.70230
  22. Dec 2025
  23. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology
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    sciencedirect.com:5037/science/article/pii/S2666379125005932
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DNMT3A R882H Is Not Required for Disease Maintenance in Primary Human AML, but Is Associated With Increased Leukemia Stem Cell Frequency
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    pmc.ncbi.nlm.nih.gov/articles/PMC12717831/
  25. www.nature.com www.nature.com
    MDC1 counteracts replication fork reversal and mediates chemosensitivity in BRCA1/2-deficient tumors
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    nature.com/articles/s41388-025-03659-8
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
  27. www.biorxiv.org www.biorxiv.org
    DYRK1A regulates cancer cell and cancer-associated fibroblast secretomes to foster an immunosuppressive microenvironment in pancreatic cancer
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    biorxiv.org/content/10.1101/2025.11.26.690756v1
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NAT10 promotes cancer metastasis by modulating p300/CBP activity through chromatin-associated tRNA
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  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Multipotent PROX1+ Tumor Stem/Progenitor Cell Population Emerges during Intestinal Tumorigenesis and Mediates Radioresistance in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12666315/
  30. Nov 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DUSP11 is an intracellular innate immune checkpoint in lung adenocarcinoma
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  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhanced cleavage of genomic CCR5 using CASX2Max
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  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Claudin-4 as a dual regulator of genome stability and immune evasion in high grade serous ovarian cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12603150/
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    Inhibiting cholesterol synthesis halts rhabdomyosarcoma growth via ER stress and cell cycle arrest
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    embopress.org/doi/10.1038/s44321-025-00336-x
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs
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    Radiation-induced glioblastoma stem cell-mediated T cell exhaustion via EGR1-Gal3-LAG3 axis in glioblastoma
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    sciencedirect.com/science/article/pii/S0304383525006974
  38. Oct 2025
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    Proximity interactome mapping furthers a role for spinophilin in protein homeostasis
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    Identification of molecular markers and exploration of the oncogenic role of exomeres in hepatocellular carcinoma
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    GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer
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    biorxiv.org/content/10.1101/2025.10.17.682994v1
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    Inhibition of GSK3 and TSC2 Mediates the Oncogenic Activity of AKT in Hepatocellular Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12500318/
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    Lipid-regulated phosphorylation hierarchy of the T cell receptor tyrosine motifs
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  44. Sep 2025
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    CA-125 as a Biomarker in Renal Medullary Carcinoma: Integrated Molecular Profiling, Functional Characterization, and Prospective Clinical Validation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11913570/
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    Structural insights into DdCBE in action enable high-precision mitochondrial DNA editing
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    The tumor suppressor CYLD acts as a deubiquitinase for mTOR to constrain its activity
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    biorxiv.org/content/10.1101/2025.09.01.673523v1
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    UBE2T promotes epithelial-mesenchymal transition and motility in oral cancer cells via induction of IL-6 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12365892/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PKN2 is a dependency of the mesenchymal-like cancer cell state
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  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1 Mutant Melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12221223/pdf/can-24-3904.pdf
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875992/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GCAD: a Computational Framework for Mammalian Genetic Program Computer-Aided Design
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    pmc.ncbi.nlm.nih.gov/articles/PMC12393561/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Conversion of natural cytokine receptors into orthogonal synthetic biosensors
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  54. www.nature.com www.nature.com
    Evaluating CAR-T cells from neurofibromatosis type 1 (NF1) patients for targeting AXL in malignant peripheral nerve sheath tumors associated with NF1
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    nature.com/articles/s41416-025-03151-w
  55. 52.53.155.43 52.53.155.43
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    Distinct interaction modes orchestrate the polymerization of ASC PYD and CARD domains into filamentous structures
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70242
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    K29-Linked Ubiquitination of Transcription Regulators Controls Cell Proliferation in the Unfolded Protein Response
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202509817
  58. Aug 2025
  59. www.sciencedirect.com www.sciencedirect.com
    Fibroblast bioelectric signaling drives hair growth
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  60. www.biorxiv.org www.biorxiv.org
    Exploration of oncogenic cooperation between germline variation and somatic mutation in prostate cancer progression
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    biorxiv.org/content/10.1101/2025.08.05.668679v1
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ENHANCED CLEAVAGE OF GENOMIC CCR5 USING CASX2Max
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265720/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated real-time imaging of executioner caspase dynamics, apoptosis-induced proliferation, and immunogenic cell death using a stable fluorescent reporter platform
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    pmc.ncbi.nlm.nih.gov/articles/PMC12328661/
  63. www.cell.com www.cell.com
    Systematic screening for functional exon-skipping isoforms using the CRISPR-RfxCas13d system
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    cell.com/cell-systems/fulltext/S2405-4712(25)00184-X
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    Enhanced bioluminescence imaging of tumor cells surviving chemotherapy in a murine model of triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12311029/
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    Structure and mechanism of the RalGAP tumor suppressor complex
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    pmc.ncbi.nlm.nih.gov/articles/PMC12311180/
  66. Jul 2025
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Triglycerides are an important fuel reserve for synapse function in the brain
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    Loss of Predicted Cell Adhesion Molecule MPZL3 Promotes EMT in Ovarian Cancer
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    Massively parallel in vivo Perturb-seq screening
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    Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer
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  71. Jun 2025
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    A bedside-to-bench translational analysis of NF1 alterations and CDK4/6 inhibitor resistance in hormone receptor-positive metastatic breast cancer
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    Phase separation of TTBK2 and CEP164 is necessary for ciliogenesis
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    cell.com/cell-reports/fulltext/S2211-1247(25)00581-9
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    RalGAP complexes control secretion and primary cilia in pancreatic disease
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  76. 52.53.155.43 52.53.155.43
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    Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
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  79. May 2025
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    Therapeutic targeting of circTNK2 with nanoparticles restores tamoxifen sensitivity and enhances NK cell-mediated immunity in ER-positive breast cancer
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    CKAP5 promotes progression and cisplatin resistance in esophageal squamous cell carcinoma via microtubule-mediated YAP activation
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    sciencedirect.com/science/article/pii/S0024320525003595
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-resolution transcriptional impact of AIRE: effects of pathogenic variants p.Arg257Ter, p.Cys311Tyr, and polygenic risk variant p.Arg471Cys
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    pmc.ncbi.nlm.nih.gov/articles/PMC12053179/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Heat shock factor 2 regulates oncogenic gamma-herpesvirus gene expression by remodeling the chromatin at the ORF50 and BZLF1 promoter
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    Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression
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    Secreted spermidine synthase reveals a paracrine role for PGC1α-induced growth suppression in prostate cancer
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    The E3 Ligase NEDD4L Prevents Colorectal Cancer Liver Metastasis via Degradation of PRMT5 to Inhibit the AKT/mTOR Signaling Pathway
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  88. Apr 2025
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human long noncoding RNA VILMIR is induced by major respiratory viral infections and modulates the host interferon response
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    pmc.ncbi.nlm.nih.gov/articles/PMC11998520/
  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Vertical inhibition of p110α/AKT and N‐cadherin enhances treatment efficacy in PIK3CA‐aberrated ovarian cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11977650/
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    MicroRNA mechanisms instructing Purkinje cell specification
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  93. Mar 2025
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    Amyloidogenesis promotes HSF1 activity enhancing cell survival during breast cancer metastatic colonization
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    Peptide Tags and Domains for Expression and Detection of Mammalian Membrane Proteins at the Cell Surface
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    The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma
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    Both carvedilol and cimetidine alleviate cisplatin-induced nephrotoxicity via downregulating OCT2
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  198. Dec 2023
  199. www.cell.com www.cell.com
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  200. Nov 2023
  201. www.embopress.org www.embopress.org
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  215. Sep 2023
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  223. Jul 2023
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