160 Matching Annotations
  1. Aug 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting the CHD3 chromatin remodeler exploits a synthetic lethal vulnerability in dual SMARCA4/SMARCA2-deficient cancers via derepression of PARD3B
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    pmc.ncbi.nlm.nih.gov/articles/PMC13469703/
  3. www.nature.com www.nature.com
    HERC4 synergizes with USP16 to promote lung adenocarcinoma growth by augmenting protein translation via stabilizing RPS15
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    nature.com/articles/s41388-026-03902-w
  4. www.sciencedirect.com www.sciencedirect.com
    m6A-dependent regulation of DGUOK-AS1 by RBM15 and HNRNPH1 in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2589004226024569
  5. www.sciencedirect.com www.sciencedirect.com
    Mycoplasma infection drives EGFR-TKI resistance through convergent transcriptomic reprogramming in non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S2589004226023771
  6. Jul 2026
  7. www.sciencedirect.com www.sciencedirect.com
    Extracellular vesicles derived from cancer-associated fibroblasts facilitate NSCLC progression and metastasis via miR-664b-5p-mediated activation of the CXCL12/CXCR4 chemokine pathway
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    sciencedirect.com/science/article/pii/S0925443926002231
  8. 54.241.53.176 54.241.53.176
    MTFR2 promotes VDAC1 oligomerization to reprogram BCAA metabolism in tumor cells to polarize TAMs in LUAD
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    54.241.53.176/05086ace4c7a9d30ef1a5082d0bfcf0e99f62e65/s41419-026-08871-2_reference-html.html
  9. Jun 2026
  10. www.cancerbiomed.org www.cancerbiomed.org
    Single-cell and spatial transcriptome analyses reveal tumor immunometabolism in lymph node metastasis of lung cancer
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    cancerbiomed.org/content/early/2026/02/19/j.issn.2095-3941.2025.0587
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ABTB1 modulates EGFR signaling and confers icotinib sensitivity in lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13289116/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting IRF1-TRIM21 axis enhances anti-tumor immunity by promoting ubiquitin-mediated degradation of FGL1 in non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13287663/
  13. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Two New Citrinin Derivatives From the Marine Sponge-Derived Fungus Aspergillus sp. S4I4-4
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    onlinelibrary.wiley.com/doi/10.1002/cbdv.71442
  14. www.sciencedirect.com www.sciencedirect.com
    Targeting TROP2 in drug-tolerant persister cells delays EGFR tyrosine kinase inhibitor resistance in non-small-cell lung cancer
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    sciencedirect.com/science/article/pii/S1535610826002655
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VANGL1 links angiogenesis–stemness programs and tumor microenvironment remodeling: a pan-cancer, multi-omics study with translational validation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13259748/
  16. www.sciencedirect.com www.sciencedirect.com
    Effect of isoginkgetin on targeting methylenetetrahydrofolate dehydrogenase 2 to induce ROS-mediated apoptosis in non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S0944711326006562
  17. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Variant-Specific Landscape of Mutual Exclusivity Among BRAF, EGFR, and KRAS Oncogenes Reveals Overlap With Functionally Antagonistic Mutant Pairs
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    onlinelibrary.wiley.com/doi/10.1002/ijc.70558
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    JAK inhibitors alleviate EGFR-inhibitor-induced diarrhea by protecting intestinal stem cells from adaptive-immune-exacerbated injury
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    pmc.ncbi.nlm.nih.gov/articles/PMC13249821/
  19. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose-driven glioblastoma
    1
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70274
  20. May 2026
  21. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70264
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DNA hypomethylation-activated PRAME drives early-stage lung adenocarcinoma recurrence via ZNF740 and PI3K/AKT/mTOR signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC13186639/
  23. www.sciencedirect.com www.sciencedirect.com
    ARID1A loss drives osimertinib resistance by epigenetically suppressing PTEN and activating the Akt pathway in lung cancer
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    sciencedirect.com/science/article/pii/S0006291X26006728
  24. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Bioprinted Tumor Microenvironment Models Reveal Immune Evasion and Guide CAR-NK Therapeutic Strategies
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202521188
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    JIN-A02, a Mutant-Selective Fourth-Generation EGFR inhibitor, Overcomes C797S-Mediated Resistance and Demonstrates Intracranial Activity in NSCLC
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    pmc.ncbi.nlm.nih.gov/articles/PMC13133602/
  26. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R-Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202521238
  27. Apr 2026
  28. www.sciencedirect.com www.sciencedirect.com
    Oxidative stress-driven m5C methylation by NSUN5 confers cisplatin resistance in lung adenocarcinoma through promoting glycolysis
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    sciencedirect.com/science/article/pii/S2213231726001916
  29. www.sciencedirect.com www.sciencedirect.com
    Long noncoding RNA AFAP1-AS1 aggravates immunotherapy resistance in NSCLC by enhancing JAK2 and TYK2 translation
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    sciencedirect.com/science/article/pii/S2090123226003589
  30. www.sciencedirect.com www.sciencedirect.com
    Extracellular Matrix Stiffness Orchestrates NETs Formation and mTOR-Driven Metabolic Reprogramming in Lung Cancer
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    sciencedirect.com/science/article/pii/S0304383526003009
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oligodendrocyte-secreted ERBB3 Mediates the Competitive Uptake of Copper Ions by Tumor Cells to Promote Brain Metastasis in Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13086005/
  32. www.sciencedirect.com www.sciencedirect.com
    Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome
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    sciencedirect.com/science/article/pii/S1074761326000750
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitofusin-2 suppresses tumor immune escape through EGFR/STAT3-mediated PD-L1 transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC13039860/
  34. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Lactate Facilitates the Survival and Invasion of Pancreatic Cancer Cells Under Glucose Deprivation
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202503162RR
  35. Mar 2026
  36. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Design, Synthesis, and Characterization of Novel 1,3,4-Thiadiazole-Benzo[b]Oxepine Derivatives: Study of Their Antiproliferative Activity, Docking, DFT, and ADME–T Properties
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    onlinelibrary.wiley.com/doi/10.1002/cbdv.202503136
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NN-01-195, a novel conjugate of HSP90 and AURKA inhibitors, effectively targets solid tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12977774/
  38. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    SATB2 Mediates H3K9 Delactylation by Recruiting HDAC3 to Repress LCN2 and Inhibit Lung Tumor Growth and Metastasis
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202522996
  39. Feb 2026
  40. www.sciencedirect.com www.sciencedirect.com
    Dual PD-1/IL-2Rα targeting restores CD8+ T cell fitness via STAT5/CD47 axis in SMARCA4-deficient NSCLC
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    sciencedirect.com/science/article/pii/S2666379126000509
  41. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.73843
  42. Jan 2026
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrative clinico-molecular analysis reveals actionable subtypes and biomarkers in lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12852120/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SERPINB3 enhances NPM1 sumoylation via inhibiting SENP3’s activity and promotes lung tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847774/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A combined strategy of EGFR-MET bispecific antibody and HER3 ADC to overcome osimertinib resistance in NSCLC
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847129/
  46. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202511408
  47. www.sciencedirect.com www.sciencedirect.com
    ANP32A-mediated Histone 3 K27 Acetylation is Essential for Sotorasib Activity in KRAS-mutant Non-Small Cell Lung Cancer
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    sciencedirect.com/science/article/pii/S002192582502962X
  48. www.nature.com www.nature.com
    PDZRN4 suppresses lung adenocarcinoma progression via inhibiting ubiquitin-mediated HIF-1A degradation
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    nature.com/articles/s41388-025-03670-z
  49. Dec 2025
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel β-carboline alkaloid derivative targeting MDM2-p53 pathway suppresses colorectal cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12698734/
  51. Nov 2025
  52. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Lysine methylation-mediated SMYD2 degradation by casticin sensitizes non-small-cell lung cancer cells to osimertinib therapy
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    sciencedirect.com:5037/science/article/pii/S0006295225008275
  53. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Multimodal cell death induced by indirubin-3′-oxime through inhibition of Akt/mTOR axis in lung cancer cells
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    sciencedirect.com:5037/science/article/pii/S0009279725004818
  54. www.sciencedirect.com www.sciencedirect.com
    UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression
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    sciencedirect.com/science/article/pii/S1097276525008913
  55. www.sciencedirect.com www.sciencedirect.com
    PROTAC-mediated structure–function disruption of CD26: a therapeutic strategy for driver-negative non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S2352396425004700
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic Engineering of TROP2-Targeted CAR T-Cell Therapy Overcomes Resistance Pathways in Solid Tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12580781/
  57. Oct 2025
  58. www.sciencedirect.com www.sciencedirect.com
    Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer
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    sciencedirect.com/science/article/pii/S1550413125004358
  59. www.biorxiv.org www.biorxiv.org
    Co-targeting MERTK and EGFR with a Bispecific Antibody Overcomes Drug Resistance Across Mutations in Exons 19, 20, and 21
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    biorxiv.org/content/10.1101/2025.10.16.681972v1
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    tRF3a-MetCAT Promotes EGFR-Targeted Therapeutic Resistance through the TRIM21–STAT1–C5a Axis in Lung Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12501432/
  61. www.biorxiv.org www.biorxiv.org
    Associative memory in human cancer cells
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    biorxiv.org/content/10.1101/2025.09.29.679179v1
  62. Sep 2025
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In situ RAS:RAF binding correlates with response to KRASG12C inhibitors in KRASG12C-mutant non–small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11924342/
  64. www.nature.com www.nature.com
    A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2
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    nature.com/articles/s41587-025-02793-8
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Eradicating Drug Tolerant Persister Cells in EGFR-Mutated Non-Small Cell Lung Cancer by Targeting TROP2 with CAR-T cellular therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12374242/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PKN2 is a dependency of the mesenchymal-like cancer cell state
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875962/
  67. Aug 2025
  68. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70238
  69. www.sciencedirect.com www.sciencedirect.com
    Synthesis, Characterization and Antitumor Assessments of Sulfonamide-1,2,4-Triazole Compounds with EGRF inhibitory Potential: DFT Calculation, Molecular Docking, Molecular Dynamics, and MM/PBSA Approaches
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    sciencedirect.com/science/article/pii/S0022286025023968
  70. bmccancer.biomedcentral.com bmccancer.biomedcentral.com
    HACD3 promotes malignant progression of NSCLC by suppressing the MKK7/MAPK10 signaling axis
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    bmccancer.biomedcentral.com/articles/10.1186/s12885-025-14621-y
  71. www.sciencedirect.com www.sciencedirect.com
    Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis
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    sciencedirect.com/science/article/pii/S153458072500471X
  72. www.sciencedirect.com www.sciencedirect.com
    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    sciencedirect.com/science/article/pii/S1535610825003101
  73. onlinelibrary.wiley.com onlinelibrary.wiley.com
    FBXW5 Promotes Epithelial-Mesenchymal Transition in Lung Adenocarcinoma Through the KLF13/TROAP Signaling Pathway
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    onlinelibrary.wiley.com/doi/full/10.1002/mc.70018
  74. Jul 2025
  75. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70096
  76. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Prediction of Lung Cancer Metastasis Risk Based on Single-Cell Metabolic Profiling of Circulating Tumor Cells
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202508878
  77. Jun 2025
  78. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202503322
  79. 52.53.155.43 52.53.155.43
    1-s2.0-S155608642500766X-main-html.html
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    52.53.155.43/948e09910b1ed27c4203114717163170d10423c7/1-s2.0-S155608642500766X-main-html.html
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cathepsin C correlates with M2 macrophage infiltration and regulates the tumor growth and metastasis in non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12139067/
  81. www.sciencedirect.com www.sciencedirect.com
    Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation
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    sciencedirect.com/science/article/pii/S2451945625001667
  82. May 2025
  83. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    FAT1 Enhances the Sensitivity of Non-Small Cell Lung Cancer to VCP Inhibitors by Regulating the Activation of the Endoplasmic Reticulum Stress Pathway
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202500097RR
  84. www.sciencedirect.com www.sciencedirect.com
    hnRNPA2B1 potentiates the immune escape of non-small cell lung cancer by accelerating tumor microenvironment acidification
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    sciencedirect.com/science/article/pii/S0891584925006781
  85. Apr 2025
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-s2.0-S2589004225006480-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC12063144/
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EFTUD2 is a promising diagnostic and prognostic indicator involved in the tumor immune microenvironment and glycolysis of lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11996642/
  88. www.sciencedirect.com www.sciencedirect.com
    Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity
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    sciencedirect.com/science/article/pii/S0092867425002909
  89. Mar 2025
  90. www.sciencedirect.com www.sciencedirect.com
    Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S1097276525001947
  91. Feb 2025
  92. aacrjournals.org aacrjournals.org
    TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma
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    aacrjournals.org/cancerres/article/83/13/2262/727433/TGF-Antagonizes-IFN-Mediated-Adaptive-Immune
  93. Jan 2025
  94. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NRP1 overexpression potentially enhances osimertinib resistance in NSCLC via activation of the PI3K/AKT signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11711526/
  95. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intratumor heterogeneity of EGFR expression mediates targeted therapy resistance and formation of drug tolerant microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695629/
  96. www.sciencedirect.com www.sciencedirect.com
    Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation
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    sciencedirect.com/science/article/pii/S1074761324005685
  97. Dec 2024
  98. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pericytes Modulate Third‐Generation Tyrosine Kinase Inhibitor Sensitivity in EGFR‐Mutated Lung Cancer Cells Through IL32‐β5‐Integrin Paracrine Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11633494/
  99. www.sciencedirect.com www.sciencedirect.com
    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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    sciencedirect.com/science/article/pii/S235239642400495X
  100. Sep 2024
  101. www.nature.com www.nature.com
    Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer
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