143 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DNA hypomethylation-activated PRAME drives early-stage lung adenocarcinoma recurrence via ZNF740 and PI3K/AKT/mTOR signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC13186639/
  3. www.sciencedirect.com www.sciencedirect.com
    ARID1A loss drives osimertinib resistance by epigenetically suppressing PTEN and activating the Akt pathway in lung cancer
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    sciencedirect.com/science/article/pii/S0006291X26006728
  4. May 2026
  5. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Bioprinted Tumor Microenvironment Models Reveal Immune Evasion and Guide CAR-NK Therapeutic Strategies
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202521188
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    JIN-A02, a Mutant-Selective Fourth-Generation EGFR inhibitor, Overcomes C797S-Mediated Resistance and Demonstrates Intracranial Activity in NSCLC
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    pmc.ncbi.nlm.nih.gov/articles/PMC13133602/
  7. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R-Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202521238
  8. Apr 2026
  9. www.sciencedirect.com www.sciencedirect.com
    Oxidative stress-driven m5C methylation by NSUN5 confers cisplatin resistance in lung adenocarcinoma through promoting glycolysis
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    sciencedirect.com/science/article/pii/S2213231726001916
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    Long noncoding RNA AFAP1-AS1 aggravates immunotherapy resistance in NSCLC by enhancing JAK2 and TYK2 translation
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    sciencedirect.com/science/article/pii/S2090123226003589
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    Extracellular Matrix Stiffness Orchestrates NETs Formation and mTOR-Driven Metabolic Reprogramming in Lung Cancer
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    sciencedirect.com/science/article/pii/S0304383526003009
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oligodendrocyte-secreted ERBB3 Mediates the Competitive Uptake of Copper Ions by Tumor Cells to Promote Brain Metastasis in Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13086005/
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    Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome
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    sciencedirect.com/science/article/pii/S1074761326000750
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitofusin-2 suppresses tumor immune escape through EGFR/STAT3-mediated PD-L1 transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC13039860/
  15. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Lactate Facilitates the Survival and Invasion of Pancreatic Cancer Cells Under Glucose Deprivation
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202503162RR
  16. Mar 2026
  17. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Design, Synthesis, and Characterization of Novel 1,3,4-Thiadiazole-Benzo[b]Oxepine Derivatives: Study of Their Antiproliferative Activity, Docking, DFT, and ADME–T Properties
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    onlinelibrary.wiley.com/doi/10.1002/cbdv.202503136
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NN-01-195, a novel conjugate of HSP90 and AURKA inhibitors, effectively targets solid tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12977774/
  19. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    SATB2 Mediates H3K9 Delactylation by Recruiting HDAC3 to Repress LCN2 and Inhibit Lung Tumor Growth and Metastasis
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202522996
  20. Feb 2026
  21. www.sciencedirect.com www.sciencedirect.com
    Dual PD-1/IL-2Rα targeting restores CD8+ T cell fitness via STAT5/CD47 axis in SMARCA4-deficient NSCLC
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    sciencedirect.com/science/article/pii/S2666379126000509
  22. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.73843
  23. Jan 2026
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrative clinico-molecular analysis reveals actionable subtypes and biomarkers in lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12852120/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SERPINB3 enhances NPM1 sumoylation via inhibiting SENP3’s activity and promotes lung tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847774/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A combined strategy of EGFR-MET bispecific antibody and HER3 ADC to overcome osimertinib resistance in NSCLC
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847129/
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    Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202511408
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    ANP32A-mediated Histone 3 K27 Acetylation is Essential for Sotorasib Activity in KRAS-mutant Non-Small Cell Lung Cancer
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    sciencedirect.com/science/article/pii/S002192582502962X
  29. www.nature.com www.nature.com
    PDZRN4 suppresses lung adenocarcinoma progression via inhibiting ubiquitin-mediated HIF-1A degradation
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    nature.com/articles/s41388-025-03670-z
  30. Dec 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel β-carboline alkaloid derivative targeting MDM2-p53 pathway suppresses colorectal cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12698734/
  32. Nov 2025
  33. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Lysine methylation-mediated SMYD2 degradation by casticin sensitizes non-small-cell lung cancer cells to osimertinib therapy
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    sciencedirect.com:5037/science/article/pii/S0006295225008275
  34. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Multimodal cell death induced by indirubin-3′-oxime through inhibition of Akt/mTOR axis in lung cancer cells
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    sciencedirect.com:5037/science/article/pii/S0009279725004818
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    UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression
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    sciencedirect.com/science/article/pii/S1097276525008913
  36. www.sciencedirect.com www.sciencedirect.com
    PROTAC-mediated structure–function disruption of CD26: a therapeutic strategy for driver-negative non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S2352396425004700
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic Engineering of TROP2-Targeted CAR T-Cell Therapy Overcomes Resistance Pathways in Solid Tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12580781/
  38. Oct 2025
  39. www.sciencedirect.com www.sciencedirect.com
    Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer
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    sciencedirect.com/science/article/pii/S1550413125004358
  40. www.biorxiv.org www.biorxiv.org
    Co-targeting MERTK and EGFR with a Bispecific Antibody Overcomes Drug Resistance Across Mutations in Exons 19, 20, and 21
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    biorxiv.org/content/10.1101/2025.10.16.681972v1
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    tRF3a-MetCAT Promotes EGFR-Targeted Therapeutic Resistance through the TRIM21–STAT1–C5a Axis in Lung Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12501432/
  42. www.biorxiv.org www.biorxiv.org
    Associative memory in human cancer cells
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    biorxiv.org/content/10.1101/2025.09.29.679179v1
  43. Sep 2025
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In situ RAS:RAF binding correlates with response to KRASG12C inhibitors in KRASG12C-mutant non–small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11924342/
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    A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2
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    nature.com/articles/s41587-025-02793-8
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Eradicating Drug Tolerant Persister Cells in EGFR-Mutated Non-Small Cell Lung Cancer by Targeting TROP2 with CAR-T cellular therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12374242/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PKN2 is a dependency of the mesenchymal-like cancer cell state
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875962/
  48. Aug 2025
  49. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70238
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    Synthesis, Characterization and Antitumor Assessments of Sulfonamide-1,2,4-Triazole Compounds with EGRF inhibitory Potential: DFT Calculation, Molecular Docking, Molecular Dynamics, and MM/PBSA Approaches
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    sciencedirect.com/science/article/pii/S0022286025023968
  51. bmccancer.biomedcentral.com bmccancer.biomedcentral.com
    HACD3 promotes malignant progression of NSCLC by suppressing the MKK7/MAPK10 signaling axis
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    bmccancer.biomedcentral.com/articles/10.1186/s12885-025-14621-y
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    Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis
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    sciencedirect.com/science/article/pii/S153458072500471X
  53. www.sciencedirect.com www.sciencedirect.com
    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    sciencedirect.com/science/article/pii/S1535610825003101
  54. onlinelibrary.wiley.com onlinelibrary.wiley.com
    FBXW5 Promotes Epithelial-Mesenchymal Transition in Lung Adenocarcinoma Through the KLF13/TROAP Signaling Pathway
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    onlinelibrary.wiley.com/doi/full/10.1002/mc.70018
  55. Jul 2025
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70096
  57. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Prediction of Lung Cancer Metastasis Risk Based on Single-Cell Metabolic Profiling of Circulating Tumor Cells
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202508878
  58. Jun 2025
  59. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202503322
  60. 52.53.155.43 52.53.155.43
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  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cathepsin C correlates with M2 macrophage infiltration and regulates the tumor growth and metastasis in non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12139067/
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    Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation
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    sciencedirect.com/science/article/pii/S2451945625001667
  63. May 2025
  64. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    FAT1 Enhances the Sensitivity of Non-Small Cell Lung Cancer to VCP Inhibitors by Regulating the Activation of the Endoplasmic Reticulum Stress Pathway
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202500097RR
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    hnRNPA2B1 potentiates the immune escape of non-small cell lung cancer by accelerating tumor microenvironment acidification
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    sciencedirect.com/science/article/pii/S0891584925006781
  66. Apr 2025
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-s2.0-S2589004225006480-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC12063144/
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EFTUD2 is a promising diagnostic and prognostic indicator involved in the tumor immune microenvironment and glycolysis of lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11996642/
  69. www.sciencedirect.com www.sciencedirect.com
    Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity
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    sciencedirect.com/science/article/pii/S0092867425002909
  70. Mar 2025
  71. www.sciencedirect.com www.sciencedirect.com
    Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S1097276525001947
  72. Feb 2025
  73. aacrjournals.org aacrjournals.org
    TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma
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    aacrjournals.org/cancerres/article/83/13/2262/727433/TGF-Antagonizes-IFN-Mediated-Adaptive-Immune
  74. Jan 2025
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NRP1 overexpression potentially enhances osimertinib resistance in NSCLC via activation of the PI3K/AKT signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11711526/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intratumor heterogeneity of EGFR expression mediates targeted therapy resistance and formation of drug tolerant microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695629/
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    Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation
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    sciencedirect.com/science/article/pii/S1074761324005685
  78. Dec 2024
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pericytes Modulate Third‐Generation Tyrosine Kinase Inhibitor Sensitivity in EGFR‐Mutated Lung Cancer Cells Through IL32‐β5‐Integrin Paracrine Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11633494/
  80. www.sciencedirect.com www.sciencedirect.com
    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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    sciencedirect.com/science/article/pii/S235239642400495X
  81. Sep 2024
  82. www.nature.com www.nature.com
    Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer
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    nature.com/articles/s41467-024-51831-7
  83. www.sciencedirect.com www.sciencedirect.com
    A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
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    sciencedirect.com/science/article/pii/S2666379124004245
  84. Aug 2024
  85. www.pnas.org www.pnas.org
    Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer
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    pnas.org/doi/10.1073/pnas.2319429121
  86. aacrjournals.org aacrjournals.org
    MTX-13, a novel PTK7-directed antibody-drug conjugate with widened therapeutic index shows sustained tumor regressions for a broader spectrum of PTK7-positive tumors
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    aacrjournals.org/mct/article/22/10/1128/729312/MTX-13-a-Novel-PTK7-Directed-Antibody-Drug
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Blockade of STAT3/IL-4 overcomes EGFR T790M-cis-L792F-induced resistance to osimertinib via suppressing M2 macrophages polarization
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    ncbi.nlm.nih.gov/pmc/articles/PMC9358434/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Myeloid cell differentiation-related gene signature for predicting clinical outcome, immune microenvironment, and treatment response in lung adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11286868/
  89. Jul 2024
  90. www.sciencedirect.com www.sciencedirect.com
    Incense-burning smoke ingredient Auramine enhances lincRNA-p21 expression for chemosensitization in p53-mutated non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S0304389424016844
  91. Jun 2024
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Morphological basis of the lung adenocarcinoma subtypes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11066476/
  93. www.sciencedirect.com www.sciencedirect.com
    Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform
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    sciencedirect.com/science/article/pii/S2211124724006417
  94. May 2024
  95. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Discovery of a novel potent EGFR inhibitor against EGFR activating mutations and on-target resistance in NSCLC
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    pubmed.ncbi.nlm.nih.gov/38330145/
  96. aacrjournals.org aacrjournals.org
    TNFRSF19 within the 13q12.12 risk locus functions as a lung cancer suppressor by binding Wnt3a to inhibit Wnt/β-catenin signaling.
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    aacrjournals.org/mcr/article/22/3/227/734703/TNFRSF19-within-the-13q12-12-Risk-Locus-Functions
  97. Apr 2024
  98. aacrjournals.org aacrjournals.org
    EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth
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    aacrjournals.org/cancerdiscovery/article/14/3/524/734906/EGFR-Driven-Lung-Adenocarcinomas-Co-opt-Alveolar
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Omics Analysis Identifies CCR6 as a Therapeutic Target to Overcome Cancer Resistance to EGFR Inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10972824/
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IL-17 induces NSCLC cell migration and invasion by elevating MMP19 gene transcription and expression through the interaction of p300-dependent STAT3-K631 acetylation and its Y705-phosphorylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10972722/
  101. Mar 2024
  102. www.sciencedirect.com www.sciencedirect.com
    A single-cell characterised signature integrating heterogeneity and microenvironment of lung adenocarcinoma for prognostic stratification
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    sciencedirect.com/science/article/pii/S2352396424001270
  103. www.sciencedirect.com www.sciencedirect.com
    Silibinin is a suppressor of the metastasis-promoting transcription factor ID3
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    sciencedirect.com/science/article/pii/S0944711324001570
  104. Feb 2024
  105. 52.53.155.43 52.53.155.43
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  106. www.sciencedirect.com www.sciencedirect.com
    Sialyltransferase ST3GAL4 confers osimertinib resistance and offers strategies to overcome resistance in non-small cell lung cancer
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