125 Matching Annotations
  1. Oct 2025
  2. www.biorxiv.org www.biorxiv.org
    Genotoxic antibody-drug conjugates combined with Bcl-xL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer
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    biorxiv.org/content/10.1101/2025.09.05.674562v1
  3. Sep 2025
  4. www.biorxiv.org www.biorxiv.org
    Genotoxic antibody-drug conjugates combined with Bcl-xL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer
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    biorxiv.org/content/10.1101/2025.09.05.674562v1
  5. www.biorxiv.org www.biorxiv.org
    A Wnt-induced conformational phospho-switch in DVL3 controls interaction with Frizzled receptors and Wnt/β-catenin signaling
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    biorxiv.org/content/10.1101/2025.09.10.675378v1
  6. www.sciencedirect.com www.sciencedirect.com
    Development of a cyst-targeted therapy for polycystic kidney disease using an antagonistic dimeric IgA monoclonal antibody against cMET
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    sciencedirect.com/science/article/pii/S2666379125004082
  7. Aug 2025
  8. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progression
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70236
  9. www.sciencedirect.com www.sciencedirect.com
    Engineering affinity-matured variants of an anti-polysialic acid monoclonal antibody with superior cytotoxicity-mediating potency
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    sciencedirect.com/science/article/pii/S2451945625002302
  10. Jul 2025
  11. www.sciencedirect.com www.sciencedirect.com
    CD4 T cell counts are inversely correlated with anti-gp120 cluster A antibodies in antiretroviral therapy-treated PLWH
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    sciencedirect.com/science/article/pii/S2352396425003007
  12. www.sciencedirect.com www.sciencedirect.com
    Spike-specific IgG4 generated post BNT162b2 mRNA vaccination is inhibitory when directly competing with functional IgG subclasses
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    sciencedirect.com/science/article/pii/S2211124725007715
  13. www.sciencedirect.com www.sciencedirect.com
    Structural and functional insights into the evolution of SARS-CoV-2 KP.3.1.1 spike protein
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    sciencedirect.com/science/article/pii/S2211124725007120
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor integrin-targeted glucose oxidase enzyme promotes ROS-mediated cell death that combines with interferon alpha therapy for tumor control
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695183/
  15. Jun 2025
  16. www.science.org www.science.org
    Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates
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    science.org/doi/10.1126/scitranslmed.adn5651
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structural Insights into the High Basal Activity and Inverse Agonism of the Orphan GPR6 Receptor Implicated in Parkinson’s Disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11850111/
  18. Mar 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor-localized interleukin-2 and interleukin-12 combine with radiation therapy to safely potentiate regression of advanced malignant melanoma in pet dogs
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    pmc.ncbi.nlm.nih.gov/articles/PMC11398984/
  20. Feb 2025
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glu592 of the axon guidance receptor ROBO3 mediates a pH‐dependent interaction with NELL2 ligand
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11848016/
  22. Jan 2025
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Broadening a SARS-CoV-1–neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11771511/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695057/
  25. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Cryo-EM structures of the full-length human contactin-2
    1
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.17364
  26. Dec 2024
  27. www.science.org www.science.org
    Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease
    1
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    science.org/doi/10.1126/scisignal.ado8741
  28. Nov 2024
  29. www.sciencedirect.com www.sciencedirect.com
    Sialylated IgG induces the transcription factor REST in alveolar macrophages to protect against lung inflammation and severe influenza disease
    1
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    sciencedirect.com/science/article/pii/S1074761324004825
  30. elifesciences.org elifesciences.org
    TRPML1 gating modulation by allosteric mutations and lipids
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    elifesciences.org/articles/100987
  31. Oct 2024
  32. www.sciencedirect.com www.sciencedirect.com
    Context-restricted PD-(L)1 checkpoint agonism by CTLA4-Ig therapies inhibits T cell activity
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    sciencedirect.com/science/article/pii/S2211124724011859
  33. Sep 2024
  34. www.sciencedirect.com www.sciencedirect.com
    Discovery and characterization of a pan-betacoronavirus S2-binding antibody
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    sciencedirect.com/science/article/pii/S0969212624003691
  35. Aug 2024
  36. www.sciencedirect.com www.sciencedirect.com
    Affinity-independent memory B cell origin of the early antibody-secreting cell response in naive individuals upon SARS-CoV-2 vaccination
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    sciencedirect.com/science/article/pii/S1074761324003728
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Vaccine priming of rare HIV broadly neutralizing antibody precursors in non-human primates
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    pmc.ncbi.nlm.nih.gov/articles/PMC11309785/
  38. Jul 2024
  39. www.sciencedirect.com www.sciencedirect.com
    SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition
    1
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    sciencedirect.com/science/article/pii/S1097276524005355
  40. www.sciencedirect.com www.sciencedirect.com
    Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5
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    sciencedirect.com/science/article/pii/S0092867424007116
  41. www.sciencedirect.com www.sciencedirect.com
    Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2
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    sciencedirect.com/science/article/pii/S2589004224015797
  42. May 2024
  43. www.sciencedirect.com www.sciencedirect.com
    Structural elucidation of the mesothelin-mucin-16/CA125 interaction
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    sciencedirect.com/science/article/pii/S0969212624001370
  44. Apr 2024
  45. www.sciencedirect.com www.sciencedirect.com
    Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses
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    sciencedirect.com/science/article/pii/S1074761324001432
  46. www.sciencedirect.com www.sciencedirect.com
    Human V-ATPase function is positively and negatively regulated by TLDc proteins
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    sciencedirect.com/science/article/pii/S0969212624000911
  47. www.sciencedirect.com www.sciencedirect.com
    The essential malaria protein PfCyRPA targets glycans to invade erythrocytes
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    sciencedirect.com/science/article/pii/S2211124724003401
  48. Jan 2024
  49. www.sciencedirect.com www.sciencedirect.com
    Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques
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    sciencedirect.com/science/article/pii/S009286742301334X
  50. Dec 2023
  51. www.sciencedirect.com www.sciencedirect.com
    Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts
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    sciencedirect.com/science/article/pii/S096098222301655X
  52. Nov 2023
  53. link.springer.com link.springer.com
    A nanobody-based strategy for rapid and scalable purification of human protein complexes
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    link.springer.com/article/10.1038/s41596-023-00904-w
  54. Oct 2023
  55. www.science.org www.science.org
    Broadening a SARS-CoV-1–neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution
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    science.org/doi/10.1126/scisignal.abk3516
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of Antibodies Selectively Recognizing Epitopes in a Formaldehyde-Fixed Cell-Surface Antigen Using Virus-like Particle Display and Hybridoma Technology
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    ncbi.nlm.nih.gov/pmc/articles/PMC10525569/
  57. Jul 2023
  58. www.sciencedirect.com www.sciencedirect.com
    Humoral immune responses associated with control of SARS-CoV-2 breakthrough infections in a vaccinated US military population
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    sciencedirect.com/science/article/pii/S2352396423002487
  59. Jun 2023
  60. dx.doi.org dx.doi.org
    Collagen-anchored interleukin-2 and interleukin-12 safely reprogram the tumor microenvironment in canine soft tissue sarcomas
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    dx.doi.org/10.1158/1078-0432.CCR-23-0006
  61. May 2023
  62. www.sciencedirect.com www.sciencedirect.com
    Unconventional initiation of PINK1/Parkin mitophagy by Optineurin
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    sciencedirect.com/science/article/pii/S1097276523002927
  63. www.sciencedirect.com www.sciencedirect.com
    Reconstruction of a polyclonal ADCC antibody repertoire from an HIV-1 non-transmitting mother
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    sciencedirect.com/science/article/pii/S2589004223008398
  64. www.sciencedirect.com www.sciencedirect.com
    BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses
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    sciencedirect.com/science/article/pii/S0960982223004694
  65. Mar 2023
  66. www.sciencedirect.com www.sciencedirect.com
    Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120
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    sciencedirect.com/science/article/pii/S2451945623000624
  67. www.sciencedirect.com www.sciencedirect.com
    A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans
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    sciencedirect.com/science/article/pii/S1074761323000948
  68. Jan 2023
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 Omicron subvariants Spike recognition and neutralization elicited after the third dose of mRNA vaccine
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    ncbi.nlm.nih.gov/pmc/articles/PMC9826988/
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An extended SARS-CoV-2 mRNA vaccine prime-boost interval enhances B cell immunity with limited impact on T cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9797215/
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape
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    ncbi.nlm.nih.gov/pmc/articles/PMC9721160/
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD
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    ncbi.nlm.nih.gov/pmc/articles/PMC9733284/
  73. Dec 2022
  74. www.sciencedirect.com www.sciencedirect.com
    Antibody effector functions are associated with protection from respiratory syncytial virus
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    sciencedirect.com/science/article/pii/S0092867422014246
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    T follicular helper cells and the germinal centre are required for memory B cell formation and humoral immunity after ChAdOx1 nCoV-19 vaccination.
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9663747/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure of human phagocyte NADPH oxidase in the resting state
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    ncbi.nlm.nih.gov/pmc/articles/PMC9711523/
  77. academic.oup.com academic.oup.com
    Human histone pre-mRNA assembles histone or canonical mRNA-processing complexes by overlapping 3′-end sequence elements
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac878/6814441
  78. Nov 2022
  79. www.sciencedirect.com www.sciencedirect.com
    HIV-1 Vpu restricts Fc-mediated effector functions in vivo
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    sciencedirect.com/science/article/pii/S2211124722014954
  80. www.sciencedirect.com www.sciencedirect.com
    An epitope-enriched immunogen expands responses to a conserved viral site
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    sciencedirect.com/science/article/pii/S2211124722014991
  81. www.sciencedirect.com www.sciencedirect.com
    Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses
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    sciencedirect.com/science/article/pii/S1931312822005236
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification and differential usage of a host metalloproteinase entry pathway by SARS-CoV-2 Delta and Omicron
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    ncbi.nlm.nih.gov/pmc/articles/PMC9549715/
  83. Oct 2022
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A boost with SARS-CoV-2 BNT162b2 mRNA vaccine elicits strong humoral responses independently of the interval between the first two doses
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9533674/
  85. elifesciences.org elifesciences.org
    A specific role for importin-5 and NASP in the import and nuclear hand-off of monomeric H3
    1
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    elifesciences.org/articles/81755
  86. Sep 2022
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Recent infection with HCoV-OC43 may be associated with protection against SARS-CoV-2 infection
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9458542/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Humoral immune responses against SARS-CoV-2 Spike variants after mRNA vaccination in solid organ transplant recipients
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    ncbi.nlm.nih.gov/pmc/articles/PMC9395219/
  89. Aug 2022
  90. www.sciencedirect.com www.sciencedirect.com
    TITLE: Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways
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    sciencedirect.com/science/article/pii/S2589004222011865
  91. www.sciencedirect.com www.sciencedirect.com
    Antibody response against SARS-CoV-2 variants of concern in children infected with pre-Omicron variants: An observational cohort study
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    sciencedirect.com/science/article/pii/S2352396422004121
  92. www.sciencedirect.com www.sciencedirect.com
    Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus
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    sciencedirect.com/science/article/pii/S1074761322003399
  93. Jun 2022
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VE607 Stabilizes SARS-CoV-2 Spike In the “RBD-up” Conformation and Inhibits Viral Entry
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    ncbi.nlm.nih.gov/pmc/articles/PMC9164512/
  95. May 2022
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural mapping of antibody landscapes to human betacoronavirus spike proteins
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    ncbi.nlm.nih.gov/pmc/articles/PMC9067923/
  97. Mar 2022
  98. www.sciencedirect.com www.sciencedirect.com
    TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile
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    sciencedirect.com/science/article/pii/S0092867422001817
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting
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    ncbi.nlm.nih.gov/pmc/articles/PMC8898741/
  100. www.sciencedirect.com www.sciencedirect.com
    Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer
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    sciencedirect.com/science/article/pii/S2211124722002182
  101. www.sciencedirect.com www.sciencedirect.com
    Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies
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    sciencedirect.com/science/article/pii/S2211124722001632
  102. Feb 2022
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC8786652/
  104. www.sciencedirect.com www.sciencedirect.com
    Components of a HIV-1 vaccine mediate virus-like particle (VLP)-formation and display of envelope proteins exposing broadly neutralizing epitopes
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    sciencedirect.com/science/article/pii/S0042682222000150
  105. Jan 2022
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern
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    ncbi.nlm.nih.gov/pmc/articles/PMC8673750/
  107. Dec 2021
  108. www.sciencedirect.com www.sciencedirect.com
    Strong humoral immune responses against SARS-CoV-2 Spike after BNT162b2 mRNA vaccination with a 16-week interval between doses
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    sciencedirect.com/science/article/pii/S1931312821005692
  109. mct.aacrjournals.org mct.aacrjournals.org
    Antibody-drug conjugate efficacy in neuroblastoma - role of payload, resistance mechanisms, target density, and antibody internalization
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    mct.aacrjournals.org/content/20/11/2228
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Relative Ratios of Human Seasonal Coronavirus Antibodies Predict the Efficiency of Cross-Neutralization of SARS-CoV-2 Spike Binding to ACE2
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    ncbi.nlm.nih.gov/pmc/articles/PMC8629681/
  111. elifesciences.org elifesciences.org
    Cross-reactive antibodies after SARS-CoV-2 infection and vaccination
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    elifesciences.org/articles/70330
  112. Oct 2021
  113. www.sciencedirect.com www.sciencedirect.com
    Pan-ebolavirus protective therapy by two multifunctional human antibodies
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    sciencedirect.com/science/article/pii/S009286742101165X
  114. www.sciencedirect.com www.sciencedirect.com
    Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel
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    sciencedirect.com/science/article/pii/S0896627321007741
  115. elifesciences.org elifesciences.org
    Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics
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    elifesciences.org/articles/70658
  116. Sep 2021
  117. www.sciencedirect.com www.sciencedirect.com
    Live Imaging of SARS-CoV-2 Infection in Mice Reveals that Neutralizing Antibodies Require Fc Function for Optimal Efficacy
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    sciencedirect.com/science/article/pii/S1074761321003472
  118. Aug 2021
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase
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    ncbi.nlm.nih.gov/pmc/articles/PMC8376247/
  120. elifesciences.org elifesciences.org
    Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection
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    elifesciences.org/articles/68110
  121. www.sciencedirect.com www.sciencedirect.com
    Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals
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    sciencedirect.com/science/article/pii/S2211124721010421
  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6235560/
  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An MPER antibody neutralizes HIV-1 using germline features shared among donors
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    ncbi.nlm.nih.gov/pmc/articles/PMC6879610/
  124. elifesciences.org elifesciences.org
    Structural and functional characterization of an otopetrin family proton channel
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  172. Nov 2017
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