Hypothesis

11 Matching Annotations

May 2026
www.nature.com www.nature.com

Systematic design of combination therapy by targeting master regulators of coexisting diffuse midline glioma cell states

1
1. scibot 01 May 2026
  
  in Public
  
  RRID:CVCL_IT39
  
  DOI: 10.1038/s41588-026-02550-w
  
  Resource: (RRID:CVCL_IT39)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_IT39
  
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  RRID:CVCL_IT39
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RRID:CVCL_IT39

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scibot

URL

nature.com/articles/s41588-026-02550-w
Nov 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

2
1. scibot 03 Nov 2023
  
  in Public
  
  RRID:CVCL_IT39
  
  DOI: 10.1158/2159-8290.CD-23-0131
  
  Resource: (RRID:CVCL_IT39)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_IT39
  
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  RRID:CVCL_IT39
2. scibot 03 Nov 2023
  
  in Public
  
  RRID:CVCL_IT39
  
  DOI: 10.1158/2159-8290.CD-23-0131
  
  Resource: (RRID:CVCL_IT39)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_IT39
  
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  RRID:CVCL_IT39
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RRID:CVCL_IT39

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10618742/
Dec 2022
aacrjournals.org aacrjournals.org

BAF complex maintains glioma stem cells in pediatric H3K27M-glioma

1
1. scibot 03 Dec 2022
  
  in Public
  
  RRID:CVCL_IT39
  
  DOI: 10.1158/2159-8290.CD-21-1491
  
  Resource: (RRID:CVCL_IT39)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_IT39
  
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  RRID:CVCL_IT39
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RRID:CVCL_IT39

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scibot

URL

aacrjournals.org/cancerdiscovery/article/12/12/2880/711164/BAF-Complex-Maintains-Glioma-Stem-Cells-in
Nov 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

FOXR2 is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits

1
1. scibot 02 Nov 2022
  
  in Public
  
  RRID:CVCL_IT39
  
  DOI: 10.1158/0008-5472.CAN-22-0671
  
  Resource: (RRID:CVCL_IT39)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_IT39
  
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  RRID:CVCL_IT39
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RRID:CVCL_IT39

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9437574/
May 2022
www.sciencedirect.com www.sciencedirect.com

AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma

1
1. scibot 26 May 2022
  
  in Public
  
  CVCL_IT39
  
  DOI: 10.1016/j.isci.2022.104398
  
  Resource: (RRID:CVCL_IT39)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_IT39
  
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  RRID:CVCL_IT39
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RRID:CVCL_IT39

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scibot

URL

sciencedirect.com/science/article/pii/S2589004222006691
Feb 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Splicing is an alternate oncogenic pathway activation mechanism in glioma

2
1. scibot 11 Feb 2022
  
  in Public
  
  RRID:CVCL_IT39
  
  DOI: 10.1038/s41467-022-28253-4
  
  Resource: (RRID:CVCL_IT39)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_IT39
  
  What is this?
  
  RRID:CVCL_IT39
2. scibot 10 Feb 2022
  
  in Public
  
  RRID:CVCL_IT39
  
  DOI: 10.1038/s41467-022-28253-4
  
  Resource: (RRID:CVCL_IT39)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_IT39
  
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  RRID:CVCL_IT39
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RRID:CVCL_IT39

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URL

ncbi.nlm.nih.gov/pmc/articles/PMC8803922/
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG

1
1. scibot 01 Aug 2021
  
  in Public
  
  RRID:CVCL_IT39
  
  DOI: 10.1016/j.ccell.2019.09.005
  
  Resource: (RRID:CVCL_IT39)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_IT39
  
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  RRIDCUR:Validated RRID:CVCL_IT39
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RRIDCUR:Validated

RRID:CVCL_IT39

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scibot

URL

sciencedirect.com/science/article/pii/S1535610819304258
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

1
1. scibot 20 Apr 2021
  
  in Public
  
  RRID:CVCL_IT39
  
  DOI: 10.1016/j.ccell.2020.07.008
  
  Resource: (RRID:CVCL_IT39)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_IT39
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_IT39
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RRIDCUR:Validated

RRID:CVCL_IT39

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scibot

URL

sciencedirect.com/science/article/pii/S153561082030369X
Sep 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas

1
1. scibot 05 Sep 2020
  
  in Public
  
  RRID:CVCL_IT39
  
  DOI: 10.1016/j.ccell.2020.02.002
  
  Resource: (RRID:CVCL_IT39)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_IT39
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_IT39
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RRIDCUR:Validated

RRID:CVCL_IT39

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scibot

URL

pubmed.ncbi.nlm.nih.gov/32142668/