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    1. The acidic fraction 21_33 induced Lxr activity in an Lxr-responsive element (LXRE)-luciferase reporter system in mouse substantia nigra dopaminergic cells (SN4741), an effect similar to that resulting from induction with total ventral midbrain extracts or a known Lxr ligand, 22-HC (Fig. 1a). CA (upper panel in Fig. 1b), a bile acid found in the adult brain28, was identified by LC/MS as the putative Lxr ligand in fraction 21_33 (Supplementary Fig. 1b and Online Methods).

      DOI: 10.1038/nchembio.1156

      Resource: (RRID:CVCL_S466)

      Curator: @gabimpine

      SciCrunch record: RRID:CVCL_S466


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    1. The acidic fraction 21_33 induced Lxr activity in an Lxr-responsive element (LXRE)-luciferase reporter system in mouse substantia nigra dopaminergic cells (SN4741), an effect similar to that resulting from induction with total ventral midbrain extracts or a known Lxr ligand, 22-HC (Fig. 1a). CA (upper panel in Fig. 1b), a bile acid found in the adult brain28, was identified by LC/MS as the putative Lxr ligand in fraction 21_33 (Supplementary Fig. 1b and Online Methods).

      Curator: @gabimpine

      Resource used:

      RRID:CVCL_S466

      SciCrunch record: RRID:CVCL_S466

      Alternate resolvers: SciCrunch xml N2T identifiers.org


      What is this?