103 Matching Annotations
  1. Last 7 days
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    Genetic suppression features ABHD18 as a Barth syndrome therapeutic target
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    nature.com/articles/s41586-025-09373-5
  3. Aug 2025
  4. www.science.org www.science.org
    Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
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    science.org/doi/10.1126/sciadv.adt1798
  5. 52.53.155.43 52.53.155.43
    A lipid transfer-dependent feedback loop activates ATG9A compartments in autophagy initiation
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    52.53.155.43/d4ad68e14ea5acb61caf80d1a118f583c2293300/2025.08.16.670665v1.full-html.html
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12363560/
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    RNA-mediated inhibition of mitochondrial SHMT2 impairs cancer cell proliferation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12328718/
  8. Jul 2025
  9. 52.53.155.43 52.53.155.43
    41556_2025_1712_MOESM4_ESM-html.html
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    A new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomics
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    pmc.ncbi.nlm.nih.gov/articles/PMC12280027/
  11. www.biorxiv.org www.biorxiv.org
    Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screens
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    biorxiv.org/content/10.1101/2025.06.30.662330v1
  12. Jun 2025
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    Phenotypic screens for SIRPA expression reveal RAB21 as a general regulator of macrophage surface identity
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    sciencedirect.com/science/article/pii/S2211124725006928
  14. May 2025
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    SLC7A11 is an unconventional H+ transporter in lysosomes
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    sciencedirect.com/science/article/pii/S0092867425004064
  16. Apr 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A guide to selecting high-performing antibodies for TAF15 (UniProt ID: Q92804) for use in western blot, immunoprecipitation, and immunofluorescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC11966097/
  18. Mar 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition
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    pmc.ncbi.nlm.nih.gov/articles/PMC11925450/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A guide to selecting high-performing antibodies for Rab1A and Rab1B for use in Western Blot, immunoprecipitation and immunofluorescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC10979127/
  21. Feb 2025
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A guide to selecting high-performing antibodies for Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) for use in Western Blot, immunoprecipitation and immunofluorescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC11811605/
  23. aacrjournals.org aacrjournals.org
    A novel human SDHA‑knockout cell line model for the functional analysis of clinically‑relevant SDHA variants
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    aacrjournals.org/clincancerres/article/30/23/5399/750191/A-Novel-Human-SDHA-Knockout-Cell-Line-Model-for
  24. Jan 2025
  25. link.springer.com link.springer.com
    Comparative Pharmacological Analysis of Mitotic Inhibitors Using Isogenic Ploidy Series of HAP1 Cells
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    link.springer.com/protocol/10.1007/978-1-0716-4224-5_14
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    The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
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    sciencedirect.com/science/article/pii/S2451945624004896
  27. Dec 2024
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mapping protein–DNA interactions with DiMeLo-seq
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    pmc.ncbi.nlm.nih.gov/articles/PMC11674881/
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    Circular RNAs trigger nonsense-mediated mRNA decay
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    sciencedirect.com/science/article/pii/S109727652400947X
  30. Nov 2024
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    Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes
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    sciencedirect.com/science/article/pii/S0092867424012091
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A guide to selecting high-performing antibodies for CSNK2A1 (UniProt ID: P68400) for use in western blot, immunoprecipitation and immunofluorescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC11472280/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    4’-Ethynyl-2’-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC11286238/
  34. Oct 2024
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A guide to selecting high-performing antibodies for amyloid-beta precursor protein for use in Western Blot, immunoprecipitation and immunofluorescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC11445640/
  36. Sep 2024
  37. www.sciencedirect.com www.sciencedirect.com
    Saturation mutagenesis-reinforced functional assays for disease-related genes
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  38. Aug 2024
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A guide to selecting high-performing antibodies for human Midkine for use in Western blot and immunoprecipitation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11292187/
  40. www.cell.com www.cell.com
    Genome-scale exon perturbation screens uncover exons critical for cell fitness
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    cell.com/molecular-cell/abstract/S1097-2765(24)00447-7
  41. Jul 2024
  42. www.biorxiv.org www.biorxiv.org
    Click-chemistry-aided quantitation and sequencing of oxidized guanines and apurinic sites uncovers their transcription-linked strand bias in human cells
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    biorxiv.org/content/10.1101/2024.07.21.604463v1
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites
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    ncbi.nlm.nih.gov/pmc/articles/PMC11271486/
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    Efficient, specific, and combinatorial control of endogenous exon splicing with dCasRx-RBM25
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    Lack of mismatch repair enhances resistance to methylating agents for cells deficient in oxidative demethylation
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    The TSC22D, WNK, and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation
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    sciencedirect.com/science/article/pii/S2211124724007460
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    Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1
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  48. Jun 2024
  49. www.nature.com www.nature.com
    Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD
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    nature.com/articles/s41594-024-01338-y
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    Electro-elution-based purification of covalent DNA–protein cross-links
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    Integrating genome-wide CRISPR screens and in silico drug profiling for targeted antidote development
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    nature.com/articles/s41596-024-00995-z
  52. May 2024
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry
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    ncbi.nlm.nih.gov/pmc/articles/PMC11102361/
  54. Apr 2024
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A guide to selecting high-performing antibodies for RNA-binding protein TIA1 for use in Western Blot, immunoprecipitation and immunofluorescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC11024596/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Type I interferon regulation by USP18 is a key vulnerability in cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11022047/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Early recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2
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    ncbi.nlm.nih.gov/pmc/articles/PMC11018354/
  58. www.biorxiv.org www.biorxiv.org
    Fragility of ER homeostatic regulation underlies haploid instability in human somatic cells
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    biorxiv.org/content/10.1101/2024.04.05.588249v1
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A guide to selecting high-performing antibodies for Rab1A and Rab1B for use in Western Blot, immunoprecipitation and immunofluorescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC10979127/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator
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    ncbi.nlm.nih.gov/pmc/articles/PMC10983002/
  61. Mar 2024
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of high-performing antibodies for Vacuolar protein sorting-associated protein 35 (hVPS35) for use in Western Blot, immunoprecipitation and immunofluorescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC10905012/
  63. Feb 2024
  64. www.sciencedirect.com www.sciencedirect.com
    Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting
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  65. www.biorxiv.org www.biorxiv.org
    qTAG: An adaptable CRISPR-based endogenous tagging protocol using optimized repair cassettes.
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    biorxiv.org/content/10.1101/2023.11.01.565029v2
  66. dx.doi.org dx.doi.org
    Functional assay for assessment of pathogenicity of BAP1 variants
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    dx.doi.org/10.1093/hmg/ddad193
  67. Jan 2024
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of high-performing antibodies for Apolipoprotein E for use in Western Blot and immunoprecipitation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10755264/
  69. Dec 2023
  70. www.nature.com www.nature.com
    Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype
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    nature.com/articles/s41467-023-43657-6
  71. Nov 2023
  72. www.sciencedirect.com www.sciencedirect.com
    RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks
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    sciencedirect.com/science/article/pii/S1097276523008493
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12
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    ncbi.nlm.nih.gov/pmc/articles/PMC10639087/
  74. Oct 2023
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity
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    Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method
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    sciencedirect.com/science/article/pii/S1534580723004951
  77. Sep 2023
  78. www.biorxiv.org www.biorxiv.org
    Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD
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    biorxiv.org/content/10.1101/2023.09.25.559255v1
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The identification of high-performing antibodies for Coiled-coil-helix-coiled-coil-helix domain containing protein 10 (CHCHD10) for use in Western Blot, immunoprecipitation and immunofluorescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC10521100/
  80. Aug 2023
  81. www.science.org www.science.org
    Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12
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    science.org/doi/10.1126/scisignal.adg0485
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The identification of high-performing antibodies for Profilin-1 for use in Western blot, immunoprecipitation and immunofluorescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC10415725/
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The identification of high-performing antibodies for transmembrane protein 106B (TMEM106B) for use in Western blot, immunoprecipitation, and immunofluorescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC10403746/
  84. Jul 2023
  85. www.sciencedirect.com www.sciencedirect.com
    Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery
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    sciencedirect.com/science/article/pii/S2211124723008185
  86. Jun 2023
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The identification of high-preforming antibodies for Ubiquilin-2 for use in Western Blot, immunoprecipitation, and immunofluorescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC10285353/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The identification of high-performing antibodies for TDP-43 for use in Western Blot, immunoprecipitation and immunofluorescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC10285334/
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    The identification of high-performing antibodies for Vacuolar protein sorting-associated protein 35 (hVPS35) for use in Western Blot, immunoprecipitation and immunofluorescence
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    52.53.155.43/3699d5f980e0b6171344a18f720674e249948766/7d387731-c0ad-4a85-8ff4-5af49adcc5bc_133696_-_kathleen_southern-html.html
  90. 52.53.155.43 52.53.155.43
    The identification of high-performing antibodies for Coiled-coil-helix-coiled-coil-helix domain containing protein 10 (CHCHD10) for use in Western Blot, immunoprecipitation and immunofluorescence
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    The identification of high-performing antibodies for Midkine for use in Western blot and immunoprecipitation
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    52.53.155.43/5a59890f8b795ae07e053fb5e51e3758d1bced38/988b674f-b8fd-4046-8eb4-41f742fe2791_130587_-_kathleen_southern-html.html
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    APOE expression and secretion are modulated by mitochondrial dysfunction
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    ncbi.nlm.nih.gov/pmc/articles/PMC10231934/
  93. May 2023
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    FEBS Press
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    52.53.155.43/55175f335d9d63eca4c96b1d663be208d4b843b1/Molecular Oncology - 2023 - Koob - MND1 enables homologous recombination in somatic cells primarily outside the context of-html.html
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    MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
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    sciencedirect.com/science/article/pii/S2211124723004953
  96. Apr 2023
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    Salmonella invasion of a cell is self-limiting due to effector-driven activation of N-WASP
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    sciencedirect.com/science/article/pii/S2589004223007204
  98. Mar 2023
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    Phosphoantigen sensing combines TCR-dependent recognition of the BTN3A IgV domain and germline interaction with BTN2A1
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    sciencedirect.com/science/article/pii/S2211124723003327
  100. Feb 2023
  101. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13379
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chikungunya virus entry and infectivity is primarily facilitated through cell line dependent attachment factors in mammalian and mosquito cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9895848/
  103. Jan 2023
  104. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    ANALYSIS OF A PANEL OF TMEM16A CHLORIDE CHANNEL INHIBITORS REVEALS INDIRECT MECHANISMS INVOLVING ALTERATION OF CALCIUM SIGNALING
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15995
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    Rabies virus P protein binds to TBK1 and interferes with the formation of innate immunity-related liquid condensates
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    sciencedirect.com/science/article/pii/S2211124722018502
  106. Nov 2022
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Mitochondrial RNA Granule Modulates Manganese-Dependent Cell Toxicity
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    ncbi.nlm.nih.gov/pmc/articles/PMC9635304/
  108. Jul 2022
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    Context-dependent regulation of ferroptosis sensitivity
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    sciencedirect.com/science/article/pii/S2451945622002367
  110. Jun 2022
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    Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
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    sciencedirect.com/science/article/pii/S0092867422006523
  112. Apr 2022
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    Sulfur- and phosphorus-standardized metal quantification of biological specimens using inductively coupled plasma mass spectrometry
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    sciencedirect.com/science/article/pii/S2666166722002143
  114. Dec 2021
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    PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective
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    sciencedirect.com/science/article/pii/S2589004221015418
  116. Nov 2021
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    Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs
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    sciencedirect.com/science/article/pii/S1097276521009102
  118. Aug 2021
  119. elifesciences.org elifesciences.org
    Quantitative live-cell imaging and computational modeling shed new light on endogenous WNT/CTNNB1 signaling dynamics
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    elifesciences.org/articles/66440
  120. www.biorxiv.org www.biorxiv.org
    Scalable, FACS-Free Genome-Wide Phenotypic Screening
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    biorxiv.org/content/10.1101/612887v1
  121. Jul 2021
  122. www.sciencedirect.com www.sciencedirect.com
    Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies
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  123. Jun 2021
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    Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin
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  125. May 2021
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    A method for benchmarking genetic screens reveals a predominant mitochondrial bias
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  127. Apr 2021
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    NDUFS3 depletion permits complex I maturation and reveals TMEM126A/OPA7 as an assembly factor binding the ND4-module intermediate
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  129. Feb 2021
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    Targeted degradation of the enhancer lysine acetyltransferases CBP and p300
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  131. www.cell.com www.cell.com
    TMEM41B IS A PAN-FLAVIVIRUS HOST FACTOR
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    cell.com/cell/abstract/S0092-8674(20)31627-5
  132. Dec 2020
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    Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
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  134. Oct 2020
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    POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan
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  136. Sep 2020
  137. www.nature.com www.nature.com
    Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform
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  138. elifesciences.org elifesciences.org
    p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways
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  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations
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  140. Jan 2020
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    High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting
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  142. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies
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  144. Nov 2018
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    Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation
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    Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread
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    MLKL Requires the Inositol Phosphate Code to Execute Necroptosis
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  149. Nov 2017
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    Structure of protein O-mannose kinase reveals a unique active site architecture
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