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www.sciencedirect.com:5037 www.sciencedirect.com:5037

circATF6 triggers calcium overload to synergize with EGFR-TKI in non-small cell lung cancer via modulation of proteostasis

1
1. scibot 09 Dec 2025
  
  in Public
  
  RRID:IMSR_GPT:D000521
  
  DOI: 10.1016/j.celrep.2025.116659
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @scibot
  
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  RRID:IMSR_GPT:D000521
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sciencedirect.com:5037/science/article/pii/S2211124725014317
Nov 2025
www.sciencedirect.com www.sciencedirect.com

UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression

1
1. scibot 22 Nov 2025
  
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  Gempharmatech, Inc (China)Cat#D000521
  
  DOI: 10.1016/j.molcel.2025.10.030
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @areedewitt04
  
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  RRID:IMSR_GPT:D000521
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sciencedirect.com/science/article/pii/S1097276525008913
www.sciencedirect.com www.sciencedirect.com

Paneth-like transition drives resistance to dual targeting of KRAS and EGFR in colorectal cancer

1
1. scibot 16 Nov 2025
  
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  Gempharmatech-GDCat# D000521
  
  DOI: 10.1016/j.ccell.2025.10.010
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @areedewitt04
  
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  RRID:IMSR_GPT:D000521
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sciencedirect.com/science/article/pii/S1535610825004519
Oct 2025
54.241.53.176 54.241.53.176

1-s2.0-S2589004225021376-main-html.html

1
1. scibot 29 Oct 2025
  
  in Public
  
  Gempharmatech D000521
  
  DOI: 10.1016/j.isci.2025.113876
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @areedewitt04
  
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54.241.53.176/1317e59fd2d0f056081cc0eecb18d40452c42a91/1-s2.0-S2589004225021376-main-html.html
www.sciencedirect.com www.sciencedirect.com

Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy

1
1. scibot 28 Oct 2025
  
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  GempharmatechStrain NO.D000521
  
  DOI: 10.1016/j.cmet.2025.09.010
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @areedewitt04
  
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  RRID:IMSR_GPT:D000521
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sciencedirect.com/science/article/pii/S155041312500395X
www.sciencedirect.com www.sciencedirect.com

Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity

1
1. scibot 18 Oct 2025
  
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  GemPharmatechStrain NO. D000521
  
  DOI: 10.1016/j.celrep.2025.116433
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @areedewitt04
  
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  RRID:IMSR_GPT:D000521
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sciencedirect.com/science/article/pii/S2211124725012045
Sep 2025
www.sciencedirect.com www.sciencedirect.com

Pp1-87B/PPP1CC-JNK axis integrates apoptosis and ferroptosis-like cell death to regulate cell competition and tumorigenesis

1
1. scibot 04 Sep 2025
  
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  GemPharmatech Co., Ltd.D000521
  
  DOI: 10.1016/j.celrep.2025.116240
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @areedewitt04
  
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  RRID:IMSR_GPT:D000521
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sciencedirect.com/science/article/pii/S2211124725010113
Jul 2025
www.sciencedirect.com www.sciencedirect.com

CircYAP1 inhibits osteosarcoma progression through the miR-135b-5p/FRK axis

1
1. scibot 01 Jul 2025
  
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  GempharmatechCat# NO. D000521
  
  DOI: 10.1016/j.isci.2025.112858
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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sciencedirect.com/science/article/pii/S2589004225011198
May 2025
www.sciencedirect.com www.sciencedirect.com

DDX5 super-enhancer promotes vasculogenic mimicry formation and metastasis in nasopharyngeal carcinoma by enhancing ADAM10 transcription

1
1. scibot 29 May 2025
  
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  GemPharmatech Co.Cat#D000521
  
  DOI: 10.1016/j.xcrm.2025.102146
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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sciencedirect.com/science/article/pii/S2666379125002198
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312

1
1. scibot 21 May 2025
  
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  RRID:IMSR_GPT:D000521
  
  DOI: 10.1158/2767-9764.CRC-25-0001
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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pmc.ncbi.nlm.nih.gov/articles/PMC12076188/
Apr 2025
www.sciencedirect.com www.sciencedirect.com

CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers

1
1. scibot 19 Apr 2025
  
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  GemPharmatech Co, LtdStrain NO.D000521
  
  DOI: 10.1016/j.chembiol.2025.03.006
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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sciencedirect.com/science/article/pii/S2451945625000960
www.sciencedirect.com www.sciencedirect.com

Hypoxia-induced phase separation of ZHX2 alters chromatin looping to drive cancer metastasis

1
1. scibot 05 Apr 2025
  
  in Public
  
  GempharmatechCat# D000521
  
  DOI: 10.1016/j.molcel.2025.03.009
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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sciencedirect.com/science/article/pii/S1097276525002023
www.cell.com www.cell.com

PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms

1
1. scibot 02 Apr 2025
  
  in Public
  
  Strain NO. D000521
  
  DOI: 10.1016/j.celrep.2025.115484
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @sjvitug
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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scibot

URL

cell.com/cell-reports/fulltext/S2211-1247(25)00255-4
Mar 2025
www.sciencedirect.com www.sciencedirect.com

PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth

1
1. scibot 29 Mar 2025
  
  in Public
  
  GemPharmatechCat#D000521
  
  DOI: 10.1016/j.molcel.2025.02.024
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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sciencedirect.com/science/article/pii/S1097276525001868
www.sciencedirect.com www.sciencedirect.com

Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism

1
1. scibot 20 Mar 2025
  
  in Public
  
  GemPharmatechCat# D000521
  
  DOI: 10.1016/j.cmet.2025.02.008
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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sciencedirect.com/science/article/pii/S155041312500066X
Feb 2025
www.sciencedirect.com www.sciencedirect.com

Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation

1
1. scibot 25 Feb 2025
  
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  GemPharmatechCat#D000521
  
  DOI: 10.1016/j.stem.2025.01.013
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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sciencedirect.com/science/article/pii/S193459092500013X
www.sciencedirect.com www.sciencedirect.com

Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma

1
1. scibot 21 Feb 2025
  
  in Public
  
  RRID:IMSR_GPT
  
  DOI: 10.1016/j.xcrm.2025.101977
  
  Resource: None
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRIDCUR:Unresolved RRID:IMSR_GPT:D000521
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RRID:IMSR_GPT:D000521

RRIDCUR:Unresolved

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scibot

URL

sciencedirect.com/science/article/pii/S2666379125000503
Nov 2024
www.sciencedirect.com www.sciencedirect.com

ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma

1
1. scibot 11 Nov 2024
  
  in Public
  
  NO. D000521
  
  DOI: 10.1016/j.celrep.2024.114962
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @vtello
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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scibot

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sciencedirect.com/science/article/pii/S2211124724013135
Aug 2024
www.cell.com www.cell.com

Anti-tumor efficacy of HRS-4642 and its potential combination with proteasome inhibition in KRAS G12D-mutant cancer

1
1. scibot 13 Aug 2024
  
  in Public
  
  D000521
  
  DOI: 10.1016/j.ccell.2024.06.001
  
  Resource: RRID:IMSR_GPT:D000521
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521 DOI:10.1016/j.ccell.2024.06.001
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DOI:10.1016/j.ccell.2024.06.001

RRID:IMSR_GPT:D000521

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scibot

URL

cell.com/cancer-cell/abstract/S1535-6108(24)00226-5
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Decoding sunitinib resistance in ccRCC: Metabolic-reprogramming-induced ABAT and GABAergic system shifts

1
1. scibot 19 Jul 2024
  
  in Public
  
  RRID:IMSR_GPT:D000521
  
  DOI: 10.1016/j.isci.2024.110415
  
  Resource: (IMSR Cat# GPT_D000521,RRID:IMSR_GPT:D000521)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC11295714/
www.sciencedirect.com www.sciencedirect.com

Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE2 production

1
1. scibot 12 Jul 2024
  
  in Public
  
  RRID:IMSR_GPT:D000521
  
  DOI: 10.1016/j.celrep.2024.114469
  
  Resource: (IMSR Cat# GPT_D000521,RRID:IMSR_GPT:D000521)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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RRID:IMSR_GPT:D000521

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scibot

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sciencedirect.com/science/article/pii/S2211124724007988
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Onvansertib in Combination with FOLFIRI and Bevacizumab in Second-line Treatment of KRAS-mutant Metastatic Colorectal Cancer: A Phase 1b Clinical Study

1
1. scibot 17 May 2024
  
  in Public
  
  RRID:IMSR_GPT:D000521
  
  DOI: 10.1158/1078-0432.CCR-23-3053
  
  Resource: (IMSR Cat# GPT_D000521,RRID:IMSR_GPT:D000521)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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RRID:IMSR_GPT:D000521

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC11094418/
Apr 2024
www.sciencedirect.com www.sciencedirect.com

Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome

1
1. scibot 16 Apr 2024
  
  in Public
  
  Cat#D000521
  
  DOI: 10.1016/j.celrep.2024.114111
  
  Resource: (IMSR Cat# GPT_D000521,RRID:IMSR_GPT:D000521)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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RRID:IMSR_GPT:D000521

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scibot

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sciencedirect.com/science/article/pii/S221112472400439X
Feb 2024
www.sciencedirect.com www.sciencedirect.com

Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma

1
1. scibot 14 Feb 2024
  
  in Public
  
  GempharmatechD000521
  
  DOI: 10.1016/j.celrep.2024.113771
  
  Resource: (IMSR Cat# GPT_D000521,RRID:IMSR_GPT:D000521)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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scibot

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sciencedirect.com/science/article/pii/S2211124724000998
Jan 2024
52.53.155.43 52.53.155.43

Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors

1
1. scibot 10 Jan 2024
  
  in Public
  
  Cat# D000521
  
  DOI: 10.1126/sciimmunol.abq2424
  
  Resource: (IMSR Cat# GPT_D000521,RRID:IMSR_GPT:D000521)
  
  Curator: @anisehay
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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RRID:IMSR_GPT:D000521

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scibot

URL

52.53.155.43/93ebbe5a83b6a28b0d01edad42fa81f437079176/sciimmunol.abq2424_sm-html.html
Feb 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Extracellular Vesicle-Mediated Transfer of LncRNA IGFL2-AS1 Confers Sunitinib Resistance in Renal Cell Carcinoma

1
1. scibot 10 Feb 2023
  
  in Public
  
  RRID:IMSR_GPT:D000521
  
  DOI: 10.1158/0008-5472.CAN-21-3432
  
  Resource: (IMSR Cat# GPT_D000521,RRID:IMSR_GPT:D000521)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9811158/
Mar 2022
www.sciencedirect.com www.sciencedirect.com

Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression

1
1. scibot 02 Mar 2022
  
  in Public
  
  GemPharmatechStock No D000521
  
  DOI: 10.1016/j.cmet.2022.02.006
  
  Resource: (IMSR Cat# GPT_D000521,RRID:IMSR_GPT:D000521)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521
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RRID:IMSR_GPT:D000521

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scibot

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sciencedirect.com/science/article/pii/S155041312200050X
Jul 2021
www.sciencedirect.com www.sciencedirect.com

TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma

1
1. scibot 31 Jul 2021
  
  in Public
  
  Mouse: BALB/c nude: BALB/cJGpt-Foxn1nu/Gpt
  
  DOI: 10.1016/j.celrep.2019.12.017
  
  Resource: (IMSR Cat# GPT_D000521,RRID:IMSR_GPT:D000521)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_GPT:D000521
  
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  RRID:IMSR_GPT:D000521 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:IMSR_GPT:D000521

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scibot

URL

sciencedirect.com/science/article/pii/S2211124719316675