111 Matching Annotations
  1. Jan 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C–MHC I Complex Demonstrate the Antitumor Efficacy of Hapten-Based Strategies
    1
    1. scibot 25 Jan 2025
      RRID:RIMSR_JAX:002019

      DOI: 10.1158/0008-5472.CAN-24-2450

      Resource: None

      Curator: @evieth

      SciCrunch record: RRID:IMSR_JAX:002019

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      RRID:IMSR_JAX:002019 RRIDCUR:Unresolved
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    pmc.ncbi.nlm.nih.gov/articles/PMC11733532/
  3. Dec 2024
  4. www.cell.com www.cell.com
    The histone H3.3 K27M mutation suppresses Ser31phosphorylation and mitotic fidelity, which can directly drive gliomagenesis
    1
    1. scibot 29 Dec 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.cub.2024.11.035

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

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    cell.com/current-biology/abstract/S0960-9822(24)01575-6
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
    1
    1. scibot 21 Dec 2024
      JAX:002019

      DOI: 10.1101/2024.02.20.581056

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

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    pmc.ncbi.nlm.nih.gov/articles/PMC11601497/
  6. 52.53.155.43 52.53.155.43
    can-24-2450-html.html
    1
    1. scibot 19 Dec 2024
      RRID:RIMSR_JAX:002019

      DOI: 10.1158/0008-5472.can-24-2450

      Resource: None

      Curator: @mzhang007

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      RRID:IMSR_JAX:002019 RRIDCUR:Unresolved
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    52.53.155.43/eda542f05a259fcd2586bec9365306e8eda4954b/can-24-2450-html.html
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Capicua C1 Domain Is Required for Full Activity of the CIC::DUX4 Fusion Oncoprotein
    1
    1. scibot 11 Dec 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1158/2767-9764.CRC-24-0348

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

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    pmc.ncbi.nlm.nih.gov/articles/PMC11626509/
  8. www.sciencedirect.com www.sciencedirect.com
    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
    1
    1. scibot 05 Dec 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.celrep.2024.115026

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

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    sciencedirect.com/science/article/pii/S2211124724013779
  9. Oct 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer
    1
    1. scibot 09 Oct 2024
      Strain# 002019

      DOI: 10.1016/j.chembiol.2024.09.004

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @vtello

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    sciencedirect.com/science/article/pii/S2451945624003969
  11. www.sciencedirect.com www.sciencedirect.com
    PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451
    1
    1. scibot 04 Oct 2024
      Cat# 002019

      DOI: 10.1016/j.biomaterials.2024.122874

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @vtello

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    sciencedirect.com/science/article/pii/S0142961224004083
  12. Sep 2024
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimized in vivo multispectral bioluminescent imaging of tumor biology using engineered BRET reporters
    1
    1. scibot 12 Sep 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.isci.2024.110655

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

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    ncbi.nlm.nih.gov/pmc/articles/PMC11381837/
  14. www.sciencedirect.com www.sciencedirect.com
    Protocol for establishing and evaluating a cancer cachexia mouse model
    1
    1. scibot 04 Sep 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.xpro.2024.103281

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

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    sciencedirect.com/science/article/pii/S2666166724004465
  15. Aug 2024
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma
    1
    1. scibot 22 Aug 2024
      JAX:002019

      DOI: 10.1038/s41467-024-50861-5

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

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    ncbi.nlm.nih.gov/pmc/articles/PMC11310337/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SEMA3F-NRP1/NRP2 axis is a key factor in the acquisition of invasive traits in in situ breast ductal carcinoma
    1
    1. scibot 22 Aug 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1186/s13058-024-01871-0

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

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    ncbi.nlm.nih.gov/pmc/articles/PMC11320849/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TKI type switching overcomes ROS1 L2086F in ROS1 fusion-positive cancers
    1
    1. scibot 21 Aug 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1038/s41698-024-00663-1

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

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    ncbi.nlm.nih.gov/pmc/articles/PMC11310217/
  19. www.sciencedirect.com www.sciencedirect.com
    Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD
    1
    1. scibot 21 Aug 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.ccell.2024.07.007

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

      SciCrunch record: RRID:IMSR_JAX:002019

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    sciencedirect.com/science/article/pii/S1535610824002721
  20. www.sciencedirect.com www.sciencedirect.com
    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
    1
    1. scibot 21 Aug 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.ccell.2024.07.005

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

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    sciencedirect.com/science/article/pii/S1535610824002708
  21. www.sciencedirect.com www.sciencedirect.com
    The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes
    1
    1. scibot 13 Aug 2024
      # 002019

      DOI: 10.1016/j.isci.2024.110499

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @vtello

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    sciencedirect.com/science/article/pii/S2589004224017243
  22. Jul 2024
  23. www.cell.com www.cell.com
    Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK
    1
    1. scibot 30 Jul 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.chom.2024.07.001

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

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    cell.com/cell-host-microbe/abstract/S1931-3128(24)00254-3
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Growth Hormone Receptor Antagonist Markedly Improves Gemcitabine Response in a Mouse Xenograft Model of Human Pancreatic Cancer
    1
    1. scibot 17 Jul 2024
      RRID:IMSR_JAX:002019

      DOI: 10.3390/ijms25137438

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

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    ncbi.nlm.nih.gov/pmc/articles/PMC11242728/
  25. www.tandfonline.com www.tandfonline.com
    SIGLEC15, negatively correlated with PD-L1 in HCC, could induce CD8+ T cell apoptosis to promote immune evasion
    1
    1. scibot 12 Jul 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1080/2162402X.2024.2376264

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

      SciCrunch record: RRID:IMSR_JAX:002019

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      RRID:IMSR_JAX:002019
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    tandfonline.com/doi/full/10.1080/2162402X.2024.2376264
  26. Jun 2024
  27. www.biorxiv.org www.biorxiv.org
    The Capicua C1 Domain is Required for Full Activity of the CIC::DUX4 Fusion Oncoprotein
    1
    1. scibot 22 Jun 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1101/2024.06.06.597815

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

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    biorxiv.org/content/10.1101/2024.06.06.597815v1
  28. www.sciencedirect.com www.sciencedirect.com
    Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
    1
    1. scibot 04 Jun 2024
      002019

      DOI: 10.1016/j.devcel.2024.05.010

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @abever99

      SciCrunch record: RRID:IMSR_JAX:002019

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      DOI:10.1016/j.devcel.2024.05.010 RRID:IMSR_JAX:002019
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    sciencedirect.com/science/article/pii/S1534580724003277
  29. www.sciencedirect.com www.sciencedirect.com
    De novo and salvage purine synthesis pathways across tissues and tumors
    1
    1. scibot 04 Jun 2024
      002019

      DOI: 10.1016/j.cell.2024.05.011

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @abever99

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      RRID:IMSR_JAX:002019 DOI:10.1016/j.cell.2024.05.011
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    sciencedirect.com/science/article/pii/S0092867424005208
  30. May 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors
    1
    1. scibot 24 May 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.isci.2024.109860

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

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    ncbi.nlm.nih.gov/pmc/articles/PMC11108982/
  32. aacrjournals.org aacrjournals.org
    NRAS mutant dictates AHCYL1-governed ER calcium homeostasis for melanoma tumor growth
    1
    1. scibot 23 May 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1158/1541-7786.MCR-23-0445

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

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    aacrjournals.org/mcr/article/22/4/386/741848/NRAS-Mutant-Dictates-AHCYL1-Governed-ER-Calcium
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Resf1 is a compound G4 quadruplex-associated tumor suppressor for triple negative breast cancer
    1
    1. scibot 11 May 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1371/journal.pgen.1011236

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

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    pmc.ncbi.nlm.nih.gov/articles/PMC11081379/
  34. 52.53.155.43 52.53.155.43
    TERC promotes non-small cell lung cancer progression by facilitating the nuclear localization of TERT
    1
    1. scibot 09 May 2024
      JAX:002019

      DOI: 10.1016/j.isci.2024.109869

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

      Curator: @scibot

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    52.53.155.43/761c70660e3a03a822484173742c13c4c44cc6bf/PIIS2589004224010915-html.html
  35. www.biorxiv.org www.biorxiv.org
    TKI Type Switching Overcomes ROS1 L2086F in ROS1 Fusion-Positive Cancers
    1
    1. scibot 03 May 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1101/2024.01.16.575901

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

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    biorxiv.org/content/10.1101/2024.01.16.575901v1
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Use of Payload Binding Selectivity Enhancers to Improve Therapeutic Index of Maytansinoid-Antibody-Drug Conjugates
    1
    1. scibot 02 May 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1158/1535-7163.MCT-22-0804

      Resource: (IMSR Cat# JAX_002019,RRID:IMSR_JAX:002019)

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    ncbi.nlm.nih.gov/pmc/articles/PMC10811745/
  37. Apr 2024
  38. www.sciencedirect.com www.sciencedirect.com
    The MYCN 5′ UTR as a therapeutic target in neuroblastoma
    1
    1. scibot 25 Apr 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.celrep.2024.114134

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    sciencedirect.com/science/article/pii/S2211124724004625
  39. Mar 2024
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance
    1
    1. scibot 19 Mar 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.celrep.2024.113897

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    ncbi.nlm.nih.gov/pmc/articles/PMC11209755/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification and characterization of a small molecule Bcl-2 Functional Converter
    1
    1. scibot 06 Mar 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1158/2767-9764.CRC-22-0526

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    ncbi.nlm.nih.gov/pmc/articles/PMC10911799/
  42. Feb 2024
  43. aacrjournals.org aacrjournals.org
    Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
    1
    1. scibot 23 Feb 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1158/1078-0432.CCR-22-3952

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    aacrjournals.org/clincancerres/article/30/2/283/733204/Magnetic-Resonance-Imaging-of-Iron-Metabolism-with
  44. Jan 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants
    1
    1. scibot 18 Jan 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1158/0008-5472.CAN-22-3464

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    ncbi.nlm.nih.gov/pmc/articles/PMC10524763/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    miRNA-194-3p represses NF-κB in gliomas to attenuate iPSC genes and proneural to mesenchymal transition.
    1
    1. scibot 18 Jan 2024
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.isci.2023.108650

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    ncbi.nlm.nih.gov/pmc/articles/PMC10788216/
  47. Dec 2023
  48. 52.53.155.43 52.53.155.43
    ccr-22-3952-html.html
    1
    1. scibot 01 Dec 2023
      RRID:IMSR_JAX:002019

      DOI: 10.1158/1078-0432.ccr-22-3952

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    52.53.155.43/1e3797f7cbc427b9cbbf2f04bead8cea21f4b910/ccr-22-3952-html.html
  49. Nov 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Enniatin A inhibits the chaperone Hsp90 and unleashes the immune system against triple-negative breast cancer
    1
    1. scibot 18 Nov 2023
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.isci.2023.108308

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    sciencedirect.com/science/article/pii/S2589004223023854
  51. www.sciencedirect.com www.sciencedirect.com
    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
    1
    1. scibot 17 Nov 2023
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.celrep.2023.113352

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  52. Oct 2023
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    WIP1 is a novel specific target for growth hormone action
    1
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      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.isci.2023.108117

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  54. Sep 2023
  55. www.nature.com www.nature.com
    MC1R signaling through the cAMP-CREB/ATF-1 and ERK-NFκB pathways accelerates G1/S transition promoting breast cancer progression
    1
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      RRID:IMSR_JAX:002019

      DOI: 10.1038/s41698-023-00437-1

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    nature.com/articles/s41698-023-00437-1
  56. www.sciencedirect.com www.sciencedirect.com
    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
    1
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      DOI: 10.1016/j.celrep.2023.113070

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  57. www.sciencedirect.com www.sciencedirect.com
    AXL-initiated paracrine activation of pSTAT3 enhances mesenchymal and vasculogenic supportive features of tumor-associated macrophages
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      DOI: 10.1016/j.celrep.2023.113067

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  58. Aug 2023
  59. www.embopress.org www.embopress.org
    Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors
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      RRID:IMSR_JAX:002019

      DOI: 10.15252/emmm.202217367

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  60. 52.53.155.43 52.53.155.43
    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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      JAX:002019

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  61. Jul 2023
  62. www.sciencedirect.com www.sciencedirect.com
    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
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      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.celrep.2023.112764

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  63. Jun 2023
  64. 52.53.155.43 52.53.155.43
    can-22-3464-html.html
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      RRID:IMSR_JAX:002019

      DOI: 10.1158/0008-5472.can-22-3464

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  65. www.mdpi.com www.mdpi.com
    Calcitonin Related Polypeptide Alpha Mediates Oral Cancer Pain
    1
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      RRID:IMSR_JAX:002019

      DOI: 10.3390/cells12131675

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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chi3l1 is a modulator of glioma stem cell states and a therapeutic target in glioblastoma
    1
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      RRID:IMSR_JAX:002019

      DOI: 10.1158/0008-5472.CAN-21-3629

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  67. aacrjournals.org aacrjournals.org
    USP10 regulates ZEB1 ubiquitination and protein stability to inhibit ZEB1-mediated colorectal cancer metastasis
    1
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      DOI: 10.1158/1541-7786.MCR-22-0552

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    aacrjournals.org/mcr/article/21/6/578/726510/USP10-Regulates-ZEB1-Ubiquitination-and-Protein
  68. www.sciencedirect.com www.sciencedirect.com
    5-Azacytidine- and retinoic-acid-induced reprogramming of DCCs into dormancy suppresses metastasis via restored TGF-β-SMAD4 signaling
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      DOI: 10.1016/j.celrep.2023.112560

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  69. 52.53.155.43 52.53.155.43
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  70. Apr 2023
  71. aacrjournals.org aacrjournals.org
    Payload-binding Fab fragments increase the therapeutic index of MMAE antibody-drug conjugates
    1
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      DOI: 10.1158/1535-7163.MCT-22-0440

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    aacrjournals.org/mct/article/22/4/459/719018/Payload-Binding-Fab-Fragments-Increase-the
  72. www.biorxiv.org www.biorxiv.org
    Engineering GliaTrap: a biodegradable non-swelling hydrogel with tuned release of CXCL12 to attract migrating glioblastoma cells
    2
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      RRID:IMSR_JAX:002019

      DOI: 10.1101/2023.04.12.536581

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      DOI: 10.1101/2023.04.12.536581

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  73. www.sciencedirect.com www.sciencedirect.com
    A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer
    1
    1. scibot 19 Apr 2023
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.xcrm.2023.101015

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    sciencedirect.com/science/article/pii/S2666379123001258
  74. Mar 2023
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sustained oncogenic signaling in the cytostatic state enables targeting of non-proliferating persistent cancer cells
    1
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      RRID:IMSR_JAX:002019

      DOI: 10.1158/0008-5472.CAN-21-2908

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    ncbi.nlm.nih.gov/pmc/articles/PMC9444958/
  76. Jan 2023
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Genome-wide screen identifies PDPK1 as a target to enhance the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma
    1
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      RRID:IMSR_JAX:002019

      DOI: 10.1158/0008-5472.CAN-21-3217

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    ncbi.nlm.nih.gov/pmc/articles/PMC9298960/
  78. aacrjournals.org aacrjournals.org
    Spatial transcriptomic analysis of ovarian cancer precursors reveals reactivation of IGFBP2 during pathogenesis
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      RRID:IMSR_JAX:002019

      DOI: 10.1158/0008-5472.CAN-22-1620

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    aacrjournals.org/cancerres/article/82/24/4528/711522/Spatial-Transcriptomic-Analysis-of-Ovarian-Cancer
  79. Dec 2022
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1
    1
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      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.isci.2022.105626

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    ncbi.nlm.nih.gov/pmc/articles/PMC9719099/
  81. Oct 2022
  82. www.sciencedirect.com www.sciencedirect.com
    Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer
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    1. scibot 05 Oct 2022
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.celrep.2022.111443

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    sciencedirect.com/science/article/pii/S2211124722012840
  83. Aug 2022
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ARID1A-deficient bladder cancer is dependent on PI3K signaling and sensitive to EZH2 and PI3K inhibitors
    1
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      RRID:IMSR_JAX:002019

      DOI: 10.1172/jci.insight.155899

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    ncbi.nlm.nih.gov/pmc/articles/PMC9462490/
  85. 52.53.155.43 52.53.155.43
    can-21-2908-html.html
    1
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      RRID:IMSR_JAX:002019

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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting ribonucleotide reductase induces synthetic lethality in PP2A-deficient uterine serous carcinoma
    1
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      DOI: 10.1158/0008-5472.CAN-21-1987

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  87. www.sciencedirect.com www.sciencedirect.com
    Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer
    1
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    sciencedirect.com/science/article/pii/S221112472201035X
  88. www.sciencedirect.com www.sciencedirect.com
    EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression
    1
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      Jackson LaboratoryCat #002019

      DOI: 10.1016/j.isci.2022.104827

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  89. www.sciencedirect.com www.sciencedirect.com
    Co-targeting of specific epigenetic regulators in combination with CDC7 potently inhibit melanoma growth
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      Jackson LaboratoryStock No. 002019

      DOI: 10.1016/j.isci.2022.104752

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  90. Jul 2022
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Differentiated glioma cell-derived fibromodulin activates integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth
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      DOI: 10.7554/eLife.78972

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  92. Jun 2022
  93. www.sciencedirect.com www.sciencedirect.com
    G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment
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      RRID:IMSR_JAX:002019

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  94. www.sciencedirect.com www.sciencedirect.com
    Endogenous spacing enables co-processing of microRNAs and efficient combinatorial RNAi
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      DOI: 10.1016/j.crmeth.2022.100239

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  95. aacrjournals.org aacrjournals.org
    Liver Endothelium Promotes HER3-mediated Cell Survival in Colorectal Cancer with Wild-type and Mutant KRAS
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    aacrjournals.org/mcr/article/20/6/996/699064/Liver-Endothelium-Promotes-HER3-Mediated-Cell
  96. www.sciencedirect.com www.sciencedirect.com
    Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer
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      JAX:002019

      DOI: 10.1016/j.ccell.2022.05.006

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  97. May 2022
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cellular microRNA-127-3p suppresses oncogenic herpesvirus-induced transformation and tumorigenesis via down-regulation of SKP2
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      DOI: 10.1073/pnas.2105428118

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  99. Apr 2022
  100. aacrjournals.org aacrjournals.org
    Hotspot ESR1 mutations are multimodal and contextual modulators of breast cancer metastasis
    1
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      RRID:IMSR_JAX:002019

      DOI: 10.1158/0008-5472.CAN-21-2576

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  101. Feb 2022
  102. www.sciencedirect.com www.sciencedirect.com
    Development of human alveolar epithelial cell models to study distal lung biology and disease
    1
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      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.isci.2022.103780

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  103. Jan 2022
  104. www.sciencedirect.com www.sciencedirect.com
    Stride-level analysis of mouse open field behavior using deep-learning-based pose estimation
    1
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      JAX:002019

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  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AP-2α Regulates S-phase and is a Marker for Sensitivity to PI3K-inhibitor Buparlisib in Colon Cancer
    1
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      RRID:IMSR_JAX:002019

      DOI: 10.1158/1541-7786.MCR-20-0867

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  106. Dec 2021
  107. www.sciencedirect.com www.sciencedirect.com
    Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis
    1
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      Cat#002019

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  108. Oct 2021
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation
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      RRID:IMSR_JAX:002019

      DOI: 10.7554/eLife.68394

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  110. Sep 2021
  111. www.sciencedirect.com www.sciencedirect.com
    REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
    1
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      RRID:IMSR_JAX:002019

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  112. Aug 2021
  113. www.sciencedirect.com www.sciencedirect.com
    METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation
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    1. scibot 05 Aug 2021
      Cat# #002019

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  114. Jul 2021
  115. www.sciencedirect.com www.sciencedirect.com
    Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses
    1
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      The Jackson LaboratoryStock#002019

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  116. www.nature.com www.nature.com
    Urothelial organoids originating from Cd49f high mouse stem cells display Notch-dependent differentiation capacity
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      Jackson Laboratories, 002019

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  117. www.sciencedirect.com www.sciencedirect.com
    p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
    1
    1. scibot 29 Jul 2021
      Mouse strain: NU/J; FOXN1nu

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  118. www.sciencedirect.com www.sciencedirect.com
    Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling
    1
    1. scibot 28 Jul 2021
      002019

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  119. Jun 2021
  120. www.nature.com www.nature.com
    Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer
    1
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      RRID:IMSR_JAX:002019

      DOI: 10.1038/s41467-021-23780-y

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  121. May 2021
  122. onlinelibrary.wiley.com onlinelibrary.wiley.com
    In vivo CRISPR screening for novel noncoding RNA functional targets in glioblastoma models
    1
    1. scibot 18 May 2021
      RRID:IMSR_JAX:002019

      DOI: 10.1002/jnr.24850

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    onlinelibrary.wiley.com/doi/10.1002/jnr.24850
  123. cancerres.aacrjournals.org cancerres.aacrjournals.org
    Serine-threonine kinase TAO3-mediated trafficking of endosomes containing the invadopodia scaffold TKS5α promotes cancer invasion and tumor growth
    1
    1. scibot 10 May 2021
      RRID:IMSR_JAX:002019

      DOI: 10.1158/0008-5472.CAN-20-2383

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  124. www.sciencedirect.com www.sciencedirect.com
    Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells
    1
    1. scibot 09 May 2021
      RRID:IMSR_JAX:002019

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    sciencedirect.com/science/article/pii/S1934590921001636
  125. Apr 2021
  126. www.sciencedirect.com www.sciencedirect.com
    Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers
    1
    1. scibot 24 Apr 2021
      002019

      DOI: 10.1016/j.cell.2020.07.009

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    sciencedirect.com/science/article/pii/S0092867420308746
  127. www.sciencedirect.com www.sciencedirect.com
    CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling
    1
    1. scibot 24 Apr 2021
      002019

      DOI: 10.1016/j.cell.2020.06.021

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    sciencedirect.com/science/article/pii/S0092867420307534
  128. www.sciencedirect.com www.sciencedirect.com
    Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas
    1
    1. scibot 20 Apr 2021
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.ccell.2020.07.008

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    sciencedirect.com/science/article/pii/S153561082030369X
  129. www.sciencedirect.com www.sciencedirect.com
    Dual blockade of EGFR and CDK4/6 delays head and neck squamous cell carcinoma progression by inducing metabolic rewiring
    1
    1. scibot 20 Apr 2021
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.canlet.2021.04.004

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    sciencedirect.com/science/article/pii/S0304383521001580
  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage
    1
    1. scibot 15 Apr 2021
      RRID:IMSR_JAX:002019

      DOI: 10.1073/pnas.2008772118

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    ncbi.nlm.nih.gov/pmc/articles/PMC8020668/
  131. www.sciencedirect.com www.sciencedirect.com
    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
    1
    1. scibot 07 Apr 2021
      002019

      DOI: 10.1016/j.molcel.2021.03.009

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    sciencedirect.com/science/article/pii/S1097276521001775
  132. Jan 2021
  133. www.sciencedirect.com www.sciencedirect.com
    Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma
    1
    1. scibot 28 Jan 2021
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.celrep.2020.108678

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    sciencedirect.com/science/article/pii/S2211124720316673
  134. Sep 2020
  135. www.sciencedirect.com www.sciencedirect.com
    Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases
    1
    1. scibot 26 Sep 2020
      nu/nu mice

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    sciencedirect.com/science/article/pii/S2211124720311700
  136. www.sciencedirect.com www.sciencedirect.com
    Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer
    1
    1. scibot 11 Sep 2020
      RRID:IMSR_JAX:002019

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    sciencedirect.com/science/article/pii/S1534580720300666
  137. www.sciencedirect.com www.sciencedirect.com
    Tissue-Resident PDGFRα+ Progenitor Cells Contribute to Fibrosis versus Healing in a Context- and Spatiotemporally Dependent Manner
    1
    1. scibot 05 Sep 2020
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.celrep.2019.12.045

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    sciencedirect.com/science/article/pii/S2211124719317024
  138. www.sciencedirect.com www.sciencedirect.com
    Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy
    1
    1. scibot 04 Sep 2020
      Mouse nu/nu

      DOI: 10.1016/j.ccell.2017.11.002

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    sciencedirect.com/science/article/pii/S1535610817304725
  139. www.cell.com www.cell.com
    Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer
    1
    1. scibot 03 Sep 2020
      The Jackson Laboratory002019

      DOI: 10.1016/j.ccell.2019.12.012

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    cell.com/cancer-cell/abstract/S1535-6108(19)30582-3
  140. www.sciencedirect.com www.sciencedirect.com
    Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis
    1
    1. scibot 03 Sep 2020
      Jackson LaboratoryNU/J 002019

      DOI: 10.1016/j.cmet.2020.04.006

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    sciencedirect.com/science/article/pii/S1550413120301881
  141. www.sciencedirect.com www.sciencedirect.com
    Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment
    1
    1. scibot 03 Sep 2020
      Nude, Strain NU/J

      DOI: 10.1016/j.celrep.2020.107884

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    sciencedirect.com/science/article/pii/S2211124720308652
  142. Jan 2020
  143. www.sciencedirect.com www.sciencedirect.com
    Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma
    1
    1. scibot 13 Jan 2020
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.celrep.2019.11.046

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  144. www.sciencedirect.com www.sciencedirect.com
    A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity
    1
    1. scibot 13 Jan 2020
      RRID:IMSR_JAX:002019

      DOI: 10.1016/j.cell.2019.11.036

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    sciencedirect.com/science/article/pii/S0092867419313212
  145. www.nature.com www.nature.com
    MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma
    1
    1. scibot 13 Jan 2020
      RRID:IMSR_JAX:002019

      DOI: 10.1038/s41388-019-0869-4

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    nature.com/articles/s41388-019-0869-4
  146. Nov 2018
  147. www.sciencedirect.com www.sciencedirect.com
    Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks
    1
    1. scibot 05 Nov 2018
      002019

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  148. www.sciencedirect.com www.sciencedirect.com
    Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction
    1
    1. scibot 05 Nov 2018
      RRID:IMSR_JAX:002019

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  149. Nov 2017
  150. www.sciencedirect.com www.sciencedirect.com
    Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer
    1
    1. scibot 08 Nov 2017
      Mouse: NU/J (athymic nude, nu/nu)The Jackson LaboratoryStock#002019

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