49 Matching Annotations
  1. Aug 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An emergent disease-associated motor neuron state precedes cell death in ALS
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    pmc.ncbi.nlm.nih.gov/articles/PMC13446465/
  3. Jun 2026
  4. www.sciencedirect.com www.sciencedirect.com
    Administration of Pgk1 missense mutation leads to more effective mitigation of neurodegenerative effects observed in ALS mice and transgenic zebrafish
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    sciencedirect.com/science/article/pii/S0753332226007109
  5. May 2026
  6. insight.jci.org insight.jci.org
    Reduced osteogenic factors and early osteoblast senescence in SOD1(G93A) ALS mouse model
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    insight.jci.org/articles/view/197475
  7. Apr 2026
  8. www.sciencedirect.com www.sciencedirect.com
    BDNF insufficiency exacerbates ALS progression
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    sciencedirect.com/science/article/pii/S2666379126001758
  9. Mar 2026
  10. www.sciencedirect.com www.sciencedirect.com
    Targeting PGAM5-driven mitochondrial integrated stress response slows ALS progression across subtypes
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    sciencedirect.com/science/article/pii/S0896627326000863
  11. Jan 2026
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Apolipoprotein A1 reduces blood–spinal cord barrier leakage, improves astrocytic coverage, and enhances motor neuron survival to restore the neurovascular unit in ALS mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12832854/
  13. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202514128
  14. Nov 2025
  15. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    A 16-amino acid peptide delays the progression of motor neuron degeneration and pathogenic symptoms in ALS models
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    sciencedirect.com:5037/science/article/pii/S1878747925002843
  16. Oct 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TSPO Expression and [18F]DPA‐714 PET/CT Imaging as Pathogenetic and Diagnostic Biomarkers in Symptomatic Stages of Skeletal Muscle Fiber Degeneration in SOD1‐G93A ALS Mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12519919/
  18. Jul 2025
  19. www.biorxiv.org www.biorxiv.org
    Targeting Neuromuscular Junction Regeneration is a Therapeutic Strategy in ALS
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    biorxiv.org/content/10.1101/2025.07.13.664600v1
  20. www.sciencedirect.com www.sciencedirect.com
    A mechanistic basis of fast myofiber vulnerability to neuromuscular diseases
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    sciencedirect.com/science/article/pii/S2211124725007302
  21. May 2025
  22. 52.53.155.43 52.53.155.43
    1-s2.0-S1525001625003806-main-html.html
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    52.53.155.43/1f8027de8a77cdc6b8dd6c2280a8a83083808fa3/1-s2.0-S1525001625003806-main-html.html
  23. Mar 2025
  24. www.sciencedirect.com www.sciencedirect.com
    Secreted neurofilament light chain after neuronal damage induces myeloid cell activation and neuroinflammation
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    sciencedirect.com/science/article/pii/S2211124725001536
  25. Feb 2025
  26. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17448
  27. 52.53.155.43 52.53.155.43
    Acute Viral Infection Accelerates Neurodegeneration in a Mouse Model of ALS
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    52.53.155.43/092e20e743f7aa0c65579e6270e39a6921c10b64/2024.09.17.613525.full-html.html
  28. Jan 2025
  29. www.nature.com www.nature.com
    Altered mitochondria-associated ER membrane (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS)
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    nature.com/articles/s41467-024-51578-1
  30. www.sciencedirect.com www.sciencedirect.com
    Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS
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    sciencedirect.com/science/article/pii/S2211124724014748
  31. Dec 2024
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength
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    pmc.ncbi.nlm.nih.gov/articles/PMC5919779/
  33. www.sciencedirect.com www.sciencedirect.com
    Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration
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    sciencedirect.com/science/article/pii/S2211124724013974
  34. www.sciencedirect.com www.sciencedirect.com
    Protocol for handling and using SOD1 mice for amyotrophic lateral sclerosis pre-clinical studies
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    sciencedirect.com/science/article/pii/S2666166724006245
  35. Sep 2024
  36. www.sciencedirect.com www.sciencedirect.com
    Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response
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    sciencedirect.com/science/article/pii/S2211124724010702
  37. Aug 2024
  38. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Identification of B6SJL mSOD1G93A mouse subgroups with different disease progression rates
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    onlinelibrary.wiley.com/doi/10.1002/cne.23814/full
  39. May 2024
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    OSMR is a potential driver of inflammation in amyotrophic lateral sclerosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11090450/
  41. Sep 2023
  42. analyticalsciencejournals.onlinelibrary.wiley.com analyticalsciencejournals.onlinelibrary.wiley.com
    Identifying potential imaging markers for diffusion property changes in a mouse model of amyotrophic lateral sclerosis: Application of the continuous time random walk model to ultrahigh b-value diffusion-weighted MR images of spinal cord tissue
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    analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/nbm.5037
  43. Jun 2023
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Altered Sensory Neuron Development in CMT2D Mice Is Site-Specific and Linked to Increased GlyRS Levels
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    ncbi.nlm.nih.gov/pmc/articles/PMC7431706/
  45. Jan 2023
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer’s Disease Brains and Mouse Neurodegeneration Models
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    ncbi.nlm.nih.gov/pmc/articles/PMC9836029/
  47. Dec 2022
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutant SOD1 aggregates formed in vitro and in cultured cells are polymorphic and differ from those arising in the CNS
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    pmc.ncbi.nlm.nih.gov/articles/PMC10099669/
  49. Aug 2022
  50. www.embopress.org www.embopress.org
    Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons
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    embopress.org/doi/10.15252/embj.2021110486
  51. Mar 2022
  52. www.sciencedirect.com www.sciencedirect.com
    Excessive release of inorganic phosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons
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    sciencedirect.com/science/article/pii/S0896627322001489
  53. Jan 2022
  54. www.nature.com www.nature.com
    Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons
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    nature.com/articles/s41434-021-00303-4
  55. Sep 2021
  56. www.sciencedirect.com www.sciencedirect.com
    Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
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    sciencedirect.com/science/article/pii/S1097276521006924
  57. Aug 2021
  58. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Untitled document
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    onlinelibrary.wiley.com/doi/full/10.1002/cne.23814
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC5308886/
  60. Jul 2021
  61. onlinelibrary.wiley.com onlinelibrary.wiley.com
    ROCK inhibition improves axonal regeneration in a preclinical model of amyotrophic lateral sclerosis
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    onlinelibrary.wiley.com/doi/full/10.1002/cne.24679
  62. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Untitled document
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    onlinelibrary.wiley.com/doi/abs/10.1002/cne.24679
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC5919779/
  64. May 2021
  65. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Nuclear lipidome is altered in amyotrophic lateral sclerosis: a pilot study
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15373
  66. Sep 2020
  67. elifesciences.org elifesciences.org
    Relaxation of synaptic inhibitory events as a compensatory mechanism in fetal SOD spinal motor networks
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    elifesciences.org/articles/51402
  68. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Wild‐type and Mutant SOD1 Localizes to RNA‐Rich Structures in Cells and Mice But Does Not Bind RNA
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15126
  69. Jan 2020
  70. elifesciences.org elifesciences.org
    Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66/NgR-independent targeting of NogoA
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    elifesciences.org/articles/49175
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of a resilient mouse facial motoneuron population following target disconnection by injury or disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC6373730/
  72. www.sciencedirect.com www.sciencedirect.com
    Mir-17∼92 Confers Motor Neuron Subtype Differential Resistance to ALS-Associated Degeneration
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    sciencedirect.com/science/article/pii/S1934590919301651
  73. onlinelibrary.wiley.com onlinelibrary.wiley.com
    ROCK inhibition improves axonal regeneration in a preclinical model of amyotrophic lateral sclerosis
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    onlinelibrary.wiley.com/doi/full/10.1002/cne.24679
  74. Nov 2018
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stage-dependent remodeling of projections to motor cortex in ALS mouse model revealed by a new variant retrograde-AAV9
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    ncbi.nlm.nih.gov/pmc/articles/PMC6125125/
  76. elifesciences.org elifesciences.org
    Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS
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    elifesciences.org/articles/30955
  77. www.sciencedirect.com www.sciencedirect.com
    Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength
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    sciencedirect.com/science/article/pii/S0896627318301879
  78. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Screening the expression characteristics of several miRNAs in G93A‐SOD1 transgenic mouse: altered expression of miRNA‐124 is associated with astrocyte differentiation by targeting Sox2 and Sox9
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14229/full
  79. Nov 2017
  80. www.sciencedirect.com www.sciencedirect.com
    Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes
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    sciencedirect.com/science/article/pii/S0896627316310078
  81. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Identification of B6SJL mSOD1G93A mouse subgroups with different disease progression rates
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    onlinelibrary.wiley.com/doi/10.1002/cne.23814/full