Hypothesis

36 Matching Annotations

May 2026
aacrjournals.org aacrjournals.org

IL-1R2 Deficiency Unleashes Neutrophil-Mediated Antitumor Potential in Sarcoma

1
1. scibot 05 May 2026
  
  in Public
  
  RRID:IMSR_JAX:003245
  
  DOI: 10.1158/2326-6066.CIR-25-0651
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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aacrjournals.org/cancerimmunolres/article/14/5/751/784456/IL1R2-Deficiency-Unleashes-Neutrophil-Mediated
Jan 2026
www.sciencedirect.com www.sciencedirect.com

Commensal-myeloid crosstalk in neonatal skin regulates interleukin-1 signaling and cutaneous type 17 inflammation

1
1. scibot 30 Jan 2026
  
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  JAX:003245
  
  DOI: 10.1016/j.immuni.2026.01.005
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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sciencedirect.com/science/article/pii/S1074761326000051
www.sciencedirect.com www.sciencedirect.com

MyD88 signaling in myeloid cells induces gastrointestinal tract injury and systemic inflammation after West Nile virus infection

1
1. scibot 22 Jan 2026
  
  in Public
  
  RRID:IMSR_JAX:003245
  
  DOI: 10.1016/j.celrep.2025.116852
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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scibot

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sciencedirect.com/science/article/pii/S2211124725016249
Sep 2025
www.biorxiv.org www.biorxiv.org

Chemotherapy Induces an IL1β-dependent Neutrophil Recruitment that Promotes Chemoresistance in Metastatic Ovarian Cancer

1
1. scibot 27 Sep 2025
  
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  RRID:IMSR_JAX:003245
  
  DOI: 10.1101/2025.09.21.677600
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
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  RRID:IMSR_JAX:003245
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biorxiv.org/content/10.1101/2025.09.21.677600v1
Jan 2025
www.sciencedirect.com www.sciencedirect.com

Nuclear adenine activates hnRNPA2B1 to enhance antibacterial innate immunity

1
1. scibot 16 Jan 2025
  
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  The Jackson LaboratoryJAX 003245
  
  DOI: 10.1016/j.cmet.2024.11.014
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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sciencedirect.com/science/article/pii/S1550413124004820
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Vaccine-elicited IL-1R signaling results in Th17 TRM-mediated immunity

1
1. scibot 21 May 2024
  
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  003245
  
  DOI: 10.1038/s42003-024-06138-0
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @bandrow
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245 DOI:10.1038/s42003-024-06138-0
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DOI:10.1038/s42003-024-06138-0

RRID:IMSR_JAX:003245

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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC11003962/
www.biorxiv.org www.biorxiv.org

GM-CSF-mediated epithelial-immune cell crosstalk orchestrates pulmonary immunity to Aspergillus fumigatus

1
1. scibot 02 May 2024
  
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  003245
  
  DOI: 10.1101/2024.01.03.574062
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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biorxiv.org/content/10.1101/2024.01.03.574062v1
Mar 2024
www.sciencedirect.com www.sciencedirect.com

Maternal inflammation regulates fetal emergency myelopoiesis

2
1. scibot 01 Mar 2024
  
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  RRID:IMSR_JAX:003245
  
  DOI: 10.1016/j.cell.2024.02.002
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
2. scibot 01 Mar 2024
  
  in Public
  
  RRID:IMSR_JAX:003245
  
  DOI: 10.1016/j.cell.2024.02.002
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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sciencedirect.com/science/article/pii/S0092867424001235
Oct 2023
www.sciencedirect.com www.sciencedirect.com

Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection

1
1. scibot 13 Oct 2023
  
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  JAX:003245
  
  DOI: 10.1016/j.cmet.2023.09.001
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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RRID:IMSR_JAX:003245

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scibot

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sciencedirect.com/science/article/pii/S1550413123003327
Apr 2023
aacrjournals.org aacrjournals.org

IL-18 receptor signaling regulates tumor-reactive CD8+ T-cell exhaustion via activation of the IL-2/STAT5/mTOR pathway in a pancreatic cancer model

1
1. scibot 21 Apr 2023
  
  in Public
  
  RRID:IMSR_JAX:003245
  
  DOI: 10.1158/2326-6066.CIR-22-0398
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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RRID:IMSR_JAX:003245

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aacrjournals.org/cancerimmunolres/article/11/4/421/718978/IL18-Receptor-Signaling-Regulates-Tumor-Reactive
Jan 2023
www.sciencedirect.com www.sciencedirect.com

Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles

1
1. scibot 19 Jan 2023
  
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  RRID:IMSR_JAX:003245
  
  DOI: 10.1016/j.xcrm.2022.100899
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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RRID:IMSR_JAX:003245

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scibot

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sciencedirect.com/science/article/pii/S2666379122004785
Dec 2022
www.sciencedirect.com www.sciencedirect.com

Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells

1
1. scibot 08 Dec 2022
  
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  JAX:003245
  
  DOI: 10.1016/j.cmet.2022.11.003
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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RRID:IMSR_JAX:003245

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scibot

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sciencedirect.com/science/article/pii/S1550413122004946
Nov 2022
www.sciencedirect.com www.sciencedirect.com

BlpC-mediated selfish program leads to rapid loss of Streptococcus pneumoniae clonal diversity during infection

1
1. scibot 17 Nov 2022
  
  in Public
  
  RRID:IMSR_JAX:003245
  
  DOI: 10.1016/j.chom.2022.10.015
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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RRID:IMSR_JAX:003245

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scibot

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sciencedirect.com/science/article/pii/S1931312822005285
Oct 2022
www.sciencedirect.com www.sciencedirect.com

Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output

1
1. scibot 05 Oct 2022
  
  in Public
  
  RRID:IMSR_JAX:003245
  
  DOI: 10.1016/j.celrep.2022.111447
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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RRID:IMSR_JAX:003245

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scibot

URL

sciencedirect.com/science/article/pii/S2211124722012888
Aug 2022
www.sciencedirect.com www.sciencedirect.com

Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment

1
1. scibot 02 Aug 2022
  
  in Public
  
  JAX:003245
  
  DOI: 10.1016/j.immuni.2022.07.001
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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RRID:IMSR_JAX:003245

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scibot

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sciencedirect.com/science/article/pii/S107476132200334X
Jun 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cytotoxic CD4+ T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate Trypanosoma cruzi-infected hearts

1
1. scibot 30 Jun 2022
  
  in Public
  
  RRID:IMSR_JAX:003245
  
  DOI: 10.7554/eLife.74636
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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RRID:IMSR_JAX:003245

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9236613/
Mar 2022
www.sciencedirect.com www.sciencedirect.com

P2X7-dependent constitutive Interleukin-1β release from pyramidal neurons of the normal mouse hippocampus: Evidence for a role in maintenance of the innate seizure threshold

1
1. scibot 13 Mar 2022
  
  in Public
  
  The Jackson Laboratory (Stock #003245
  
  DOI: 10.1016/j.nbd.2022.105689
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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RRID:IMSR_JAX:003245

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scibot

URL

sciencedirect.com/science/article/pii/S0969996122000808
Feb 2022
www.sciencedirect.com www.sciencedirect.com

Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer

1
1. scibot 04 Feb 2022
  
  in Public
  
  JAX:003245
  
  DOI: 10.1016/j.ccell.2022.01.004
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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RRID:IMSR_JAX:003245

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scibot

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sciencedirect.com/science/article/pii/S153561082200006X
www.sciencedirect.com www.sciencedirect.com

Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-A

1
1. scibot 02 Feb 2022
  
  in Public
  
  RRID:IMSR_JAX:003245
  
  DOI: 10.1016/j.celrep.2022.110309
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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RRID:IMSR_JAX:003245

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scibot

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sciencedirect.com/science/article/pii/S2211124722000213
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes

1
1. scibot 25 Aug 2021
  
  in Public
  
  JAX:003245
  
  DOI: 10.1016/j.celrep.2021.109608
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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RRID:IMSR_JAX:003245

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scibot

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sciencedirect.com/science/article/pii/S2211124721010469
www.sciencedirect.com www.sciencedirect.com

The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation

1
1. scibot 08 Aug 2021
  
  in Public
  
  RRID:IMSR_JAX:003245
  
  DOI: 10.1016/j.neuron.2018.06.035
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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RRID:IMSR_JAX:003245

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scibot

URL

sciencedirect.com/science/article/pii/S0896627318305312
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin

1
1. scibot 05 Aug 2021
  
  in Public
  
  RRID:IMSR_JAX:003245
  
  DOI: 10.1016/j.immuni.2019.03.003
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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RRID:IMSR_JAX:003245

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6476404/
www.sciencedirect.com www.sciencedirect.com

Differential Roles of the mTOR-STAT3 Signaling in Dermal γδ T Cell Effector Function in Skin Inflammation

1
1. scibot 01 Aug 2021
  
  in Public
  
  RRID:IMSR_JAX:003245
  
  DOI: 10.1016/j.celrep.2019.05.019
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:IMSR_JAX:003245

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scibot

URL

sciencedirect.com/science/article/pii/S2211124719306308
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Impaired Tumor-Necrosis-Factor-α-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in Infants

1
1. scibot 28 Jul 2021
  
  in Public
  
  003245
  
  DOI: 10.1016/j.immuni.2018.11.012
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @Jmenke
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRIDCUR:Missing RRID:IMSR_JAX:003245
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RRIDCUR:Missing

RRID:IMSR_JAX:003245

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URL

sciencedirect.com/science/article/pii/S1074761318304941
www.sciencedirect.com www.sciencedirect.com

Untitled document

1
1. scibot 28 Jul 2021
  
  in Public
  
  RRID:IMSR_JAX:003245
  
  DOI: 10.1016/j.immuni.2019.03.003
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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sciencedirect.com/science/article/pii/S1074761319300937
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Microbiota regulate innate immune signaling and protective immunity against cancer

1
1. scibot 24 Apr 2021
  
  in Public
  
  RRID:IMSR_JAX:003245
  
  DOI: 10.1016/j.chom.2021.03.016
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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sciencedirect.com/science/article/pii/S193131282100144X
www.sciencedirect.com www.sciencedirect.com

The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis

1
1. scibot 23 Apr 2021
  
  in Public
  
  JAX 003245
  
  DOI: 10.1016/j.cell.2020.05.048
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:IMSR_JAX:003245

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sciencedirect.com/science/article/pii/S0092867420306814
Feb 2021
www.cell.com www.cell.com

Legionella-Infected Macrophages Engage the Alveolar Epithelium to Metabolically Reprogram Myeloid Cells and Promote Antibacterial Inflammation

1
1. scibot 24 Feb 2021
  
  in Public
  
  RRID:IMSR_JAX:003245
  
  DOI: 10.1016/j.chom.2020.07.019
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:IMSR_JAX:003245

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scibot

URL

cell.com/cell-host-microbe/fulltext/S1931-3128(20)30422-4
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Platelets Fuel the Inflammasome Activation of Innate Immune Cells

1
1. scibot 03 Sep 2020
  
  in Public
  
  The Jackson LaboratoryStock 003245
  
  DOI: 10.1016/j.celrep.2020.107615
  
  Resource: (IMSR Cat# JAX_003245,RRID:IMSR_JAX:003245)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
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  RRID:IMSR_JAX:003245
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RRID:IMSR_JAX:003245

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scibot

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sciencedirect.com/science/article/pii/S2211124720305647
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:IMSR_JAX:003245
  
  Resource used:
  
  RRID:IMSR_JAX:003245
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:IMSR_JAX:003245
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RRID:IMSR_JAX:003245

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scibot

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sciencedirect.com/science/article/pii/S1074761318303261
www.sciencedirect.com www.sciencedirect.com

Alveolar Macrophages Provide an Early Mycobacterium tuberculosis Niche and Initiate Dissemination

1
1. scibot 05 Nov 2018
  
  in Public
  
  003245
  
  Curator: @Jmenke
  
  Resource used:
  
  RRID:IMSR_JAX:003245
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:IMSR_JAX:003245 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:IMSR_JAX:003245

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scibot

URL

sciencedirect.com/science/article/pii/S1931312818304104
www.sciencedirect.com www.sciencedirect.com

An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication

1
1. scibot 05 Nov 2018
  
  in Public
  
  003245
  
  Curator: @Jmenke
  
  Resource used:
  
  RRID:IMSR_JAX:003245
  
  SciCrunch record: RRID:IMSR_JAX:003245
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:IMSR_JAX:003245 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:IMSR_JAX:003245

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scibot

URL

sciencedirect.com/science/article/pii/S1097276518305562
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Staphylococcus aureus Virulent PSMα Peptides Induce Keratinocyte Alarmin Release to Orchestrate IL-17-Dependent Skin Inflammation

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1. scibot 05 Nov 2018
  
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Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection.

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1. scibot 05 Nov 2018
  
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  Curator: @evieth
  
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europepmc.org/articles/PMC5629024/
Nov 2017
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The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression

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1. scibot 08 Nov 2017
  
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