58 Matching Annotations
  1. Last 7 days
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    Nose-to-brain delivery of a SOD1-stabilizing small molecule ameliorates pathology in an ALS mouse model
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    sciencedirect.com/science/article/pii/S1878747926000747
  3. Feb 2026
  4. www.biorxiv.org www.biorxiv.org
    Divergent mitochondrial and metabolic adaptations shape selective vulnerability in ALS
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    biorxiv.org/content/10.64898/2026.01.30.702552v1
  5. Sep 2025
  6. www.biorxiv.org www.biorxiv.org
    miR-146a is a Pleiotropic Regulator of Motor Neuron Degeneration
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    biorxiv.org/content/10.1101/2025.09.04.674013v1
  7. Apr 2025
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    A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis
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    sciencedirect.com/science/article/pii/S2352396425001367
  9. Mar 2025
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    Single-cell transcriptomic and functional studies identify glial state changes and a role for inflammatory RIPK1 signaling in ALS pathogenesis
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    sciencedirect.com/science/article/pii/S1074761325000913
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Parthenolide regulates microglial and astrocyte function in primary cultures from ALS mice and has neuroprotective effects on primary motor neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC11918366/
  12. Jan 2025
  13. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Genetic Ablation of Sarm1 Mitigates Disease Acceleration after Traumatic Brain Injury in the SOD1G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
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    onlinelibrary.wiley.com/doi/10.1002/ana.27174
  14. Dec 2024
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    GDF15-GFRAL signaling drives weight loss and lipid metabolism in mouse model of amyotrophic lateral sclerosis
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    sciencedirect.com/science/article/pii/S0889159124007396
  16. www.sciencedirect.com www.sciencedirect.com
    Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration
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    sciencedirect.com/science/article/pii/S2211124724013974
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    Protocol for handling and using SOD1 mice for amyotrophic lateral sclerosis pre-clinical studies
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    sciencedirect.com/science/article/pii/S2666166724006245
  18. Aug 2024
  19. www.mdpi.com www.mdpi.com
    An Intercellular Flow of Glutathione Regulated by Interleukin 6 Links Astrocytes and the Liver in the Pathophysiology of Amyotrophic Lateral Sclerosis
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    mdpi.com/2076-3921/10/12/2007/htm
  20. Jun 2024
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement
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    ncbi.nlm.nih.gov/pmc/articles/PMC11130262/
  22. May 2024
  23. www.sciencedirect.com www.sciencedirect.com
    Targeting low levels of MIF expression as a potential therapeutic strategy for ALS
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    sciencedirect.com/science/article/pii/S2666379124002386
  24. Mar 2024
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TwinF interface inhibitor FP802 stops loss of motor neurons and mitigates disease progression in a mouse model of ALS
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    ncbi.nlm.nih.gov/pmc/articles/PMC10897598/
  26. Feb 2024
  27. www.sciencedirect.com www.sciencedirect.com
    Communication defects with astroglia contribute to early impairments in the motor cortex plasticity of SOD1G93A mice
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    sciencedirect.com/science/article/pii/S0969996124000342
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10839647/
  29. Jan 2024
  30. www.sciencedirect.com www.sciencedirect.com
    Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis
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    sciencedirect.com/science/article/pii/S0969996123000451
  31. Sep 2023
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1G93A model of ALS
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    ncbi.nlm.nih.gov/pmc/articles/PMC10498603/
  33. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Intranasal neuropeptide Y1 receptor antagonism improves motor deficits in symptomatic SOD1 ALS mice
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    onlinelibrary.wiley.com/doi/10.1002/acn3.51885
  34. Jul 2023
  35. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15906
  36. Jun 2023
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    5-Hydroxytryptamine: a potential therapeutic target in amyotrophic lateral sclerosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10233787/
  38. May 2023
  39. www.mdpi.com www.mdpi.com
    Differential NPY-Y1 Receptor Density in the Motor Cortex of ALS Patients and Familial Model of ALS
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    mdpi.com/2076-3425/11/8/969/htm
  40. Jan 2023
  41. journals.lww.com journals.lww.com
    A candidate protective factor in amyotrophic lateral... : Neural Regeneration Research
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    journals.lww.com/nrronline/Fulltext/2023/07000/A_candidate_protective_factor_in_amyotrophic.26.aspx
  42. Jun 2022
  43. www.sciencedirect.com www.sciencedirect.com
    Blocking Immune Cell infiltration of the Central Nervous System to Tame Neuroinflammation in Amyotrophic Lateral Sclerosis
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    sciencedirect.com/science/article/pii/S0889159122001568
  44. Apr 2022
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AMPA receptor and RNA processing gene dysregulation are early determinants of selective motor neuron vulnerability in a mouse model of amyotrophic lateral sclerosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC9016138/
  46. Mar 2022
  47. www.sciencedirect.com www.sciencedirect.com
    Unique molecular features and cellular responses differentiate two populations of motor cortical layer 5b neurons in a preclinical model of ALS
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    sciencedirect.com/science/article/pii/S221112472200300X
  48. www.nature.com www.nature.com
    Argonaute 2 is lost from neuromuscular junctions affected with amyotrophic lateral sclerosis in SOD1G93A mice
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    nature.com/articles/s41598-022-08455-y
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Murine glial progenitor cells transplantation and synthetic PreImplantation Factor (sPIF) reduces inflammation and early motor impairment in ALS mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC8901633/
  50. Feb 2022
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphoinositide-3-kinase regulatory subunit 4 participates in the occurrence and development of amyotrophic lateral sclerosis by regulating autophagy
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    ncbi.nlm.nih.gov/pmc/articles/PMC8771104/
  52. Dec 2021
  53. www.sciencedirect.com www.sciencedirect.com
    KLF15 overexpression in myocytes fails to ameliorate ALS-related pathology or extend the lifespan of SOD1G93A mice
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    sciencedirect.com/science/article/pii/S0969996121003326
  54. Oct 2021
  55. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15665
  56. Aug 2021
  57. www.jneurosci.org www.jneurosci.org
    Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis
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    jneurosci.org/content/37/6/1413
  58. Jul 2021
  59. www.nature.com www.nature.com
    Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity
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    nature.com/articles/s41593-019-0479-z
  60. www.mdpi.com www.mdpi.com
    Assessment of Immunological Potential of Glial Restricted Progenitor Graft In Vivo—Is Immunosuppression Mandatory?
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    mdpi.com/2073-4409/10/7/1804/htm
  61. Sep 2020
  62. www.nature.com www.nature.com
    Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis
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    nature.com/articles/s41467-020-15644-8
  63. www.sciencedirect.com www.sciencedirect.com
    The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice
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    sciencedirect.com/science/article/pii/S0896627320301914
  64. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15119
  65. www.sciencedirect.com www.sciencedirect.com
    Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis
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    sciencedirect.com/science/article/pii/S235239642030356X
  66. www.sciencedirect.com www.sciencedirect.com
    6-Deoxyjacareubin, a natural compound preventing hypoxia-induced cell death, ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis
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    sciencedirect.com/science/article/pii/S0168010219306522
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Androgen receptor antagonism accelerates disease onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC6555856/
  68. www.sciencedirect.com www.sciencedirect.com
    Spinal Motoneuron TMEM16F Acts at C-boutons to Modulate Motor Resistance and Contributes to ALS Pathogenesis
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    sciencedirect.com/science/article/pii/S2211124720301558
  69. Jan 2020
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC6594754/
  71. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Untitled document
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14657
  72. Nov 2018
  73. www.sciencedirect.com www.sciencedirect.com
    Ca2+-activated K+ channels modulate microglia affecting motor neuron survival in hSOD1G93A mice
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    sciencedirect.com/science/article/pii/S0889159118302885
  74. elifesciences.org elifesciences.org
    Untitled document
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    elifesciences.org/articles/34375
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC5837562/
  76. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1‐linked amyotrophic lateral sclerosis mice
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14285/full
  77. www.sciencedirect.com www.sciencedirect.com
    Impact of peripheral immune status on central molecular responses to facial nerve axotomy
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    sciencedirect.com/science/article/pii/S0889159117304580
  78. Nov 2017
  79. www.jneurosci.org www.jneurosci.org
    SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions
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    jneurosci.org/content/37/17/4493
  80. www.sciencedirect.com www.sciencedirect.com
    Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions
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    sciencedirect.com/science/article/pii/S0896627317302970
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC4227046/
  82. www.jneurosci.org www.jneurosci.org
    Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses during Aging and Progression of ALS
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    jneurosci.org/content/37/1/70.long
  83. www.nature.com www.nature.com
    Calretinin and Neuropeptide Y interneurons are differentially altered in the motor cortex of the SOD1G93A mouse model of ALS
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    nature.com/articles/srep44461
  84. www.jneurosci.org www.jneurosci.org
    Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis
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    jneurosci.org/content/37/6/1413
  85. www.sciencedirect.com www.sciencedirect.com
    The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes
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    sciencedirect.com/science/article/pii/S0969996114001727