Hypothesis

34 Matching Annotations

Mar 2026
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Aberrant multicellular interferon signaling underlies Adar1 mutation–driven Aicardi-Goutières syndrome-like encephalopathy

1
1. scibot 20 Mar 2026
  
  in Public
  
  RRID:IMSR_JAX:004600
  
  DOI: 10.1016/j.celrep.2026.117113
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @scibot
  
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  RRID:IMSR_JAX:004600
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scibot

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sciencedirect.com/science/article/pii/S2211124726001919
Feb 2026
www.sciencedirect.com www.sciencedirect.com

Male-biased Yap1-Cd276/B7-H3 axis for immune evasion in medulloblastoma

1
1. scibot 06 Feb 2026
  
  in Public
  
  RRID:IMSR_JAX:004600
  
  DOI: 10.1016/j.ccell.2026.01.005
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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scibot

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sciencedirect.com/science/article/pii/S1535610826000449
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Microglia and myeloid cell populations of the developing mouse retina

1
1. scibot 04 Feb 2026
  
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  RRID:IMSR_JAX:004600
  
  DOI: 10.1002/glia.70115
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC12857260/
Aug 2025
www.sciencedirect.com www.sciencedirect.com

Protocol for recording and analyzing neuronal network activity ex vivo with multi-electrode arrays in mouse brain tissue

1
1. scibot 14 Aug 2025
  
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  RRID:IMSR_JAX:004600
  
  DOI: 10.1016/j.xpro.2025.104019
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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scibot

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sciencedirect.com/science/article/pii/S2666166725004253
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Radial glia integrin avb8 regulates cell autonomous microglial TGFβ1 signaling that is necessary for microglial identity

1
1. scibot 27 Mar 2025
  
  in Public
  
  RRID:IMSR_JAX:004600
  
  DOI: 10.1038/s41467-025-57684-y
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC11929771/
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

1
1. scibot 23 Nov 2024
  
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  004600
  
  DOI: 10.1038/nn.2467
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @AleksanderDrozdz
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC2840225/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Conditional Gene Expression in the Mouse Inner Ear Using Cre-loxP

1
1. scibot 22 Nov 2024
  
  in Public
  
  4600
  
  DOI: 10.1007/s10162-012-0324-5
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @AleksanderDrozdz
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC3346893/
Jun 2024
www.sciencedirect.com www.sciencedirect.com

Imaging brain glucose metabolism in vivo reveals propionate as a major anaplerotic substrate in pyruvate dehydrogenase deficiency

1
1. scibot 05 Jun 2024
  
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  RRID:IMSR_JAX:004600
  
  DOI: 10.1016/j.cmet.2024.05.002
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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scibot

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sciencedirect.com/science/article/pii/S1550413124001785
May 2024
www.sciencedirect.com www.sciencedirect.com

Astroglial gap junctions strengthen hippocampal network activity by sustaining afterhyperpolarization via KCNQ channels

1
1. scibot 09 May 2024
  
  in Public
  
  RRID:IMSR_JAX:004600
  
  DOI: 10.1016/j.celrep.2024.114158
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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scibot

URL

sciencedirect.com/science/article/pii/S2211124724004868
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

FGF9 is required for Purkinje cell development and function in the cerebellum

1
1. scibot 15 Feb 2024
  
  in Public
  
  JAX:004600
  
  DOI: 10.1016/j.isci.2024.109039
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10863307/
Dec 2023
www.sciencedirect.com www.sciencedirect.com

BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development

1
1. scibot 16 Dec 2023
  
  in Public
  
  Jackson LaboratoryStock No: 004600
  
  DOI: 10.1016/j.devcel.2023.11.018
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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scibot

URL

sciencedirect.com/science/article/pii/S1534580723006160
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Chronic AMPK inactivation slows SHH medulloblastoma progression by inhibiting mTORC1 signaling and depleting tumor stem cell populations

1
1. scibot 15 Dec 2023
  
  in Public
  
  RRID:IMSR_JAX:004600
  
  DOI: 10.1016/j.isci.2023.108443
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10716552/
Oct 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Radial glia promote microglial development through integrin αVβ8 -TGFβ1 signaling

1
1. scibot 12 Oct 2023
  
  in Public
  
  RRID:IMSR_JAX:004600
  
  DOI: 10.1101/2023.07.13.548459
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10542141/
Aug 2023
www.sciencedirect.com www.sciencedirect.com

hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation

1
1. scibot 10 Aug 2023
  
  in Public
  
  RRID:IMSR_JAX
  
  DOI: 10.1016/j.isci.2023.107501
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @olekpark
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRIDCUR:Unresolved RRID:IMSR_JAX:004600
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RRIDCUR:Unresolved

RRID:IMSR_JAX:004600

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scibot

URL

sciencedirect.com/science/article/pii/S258900422301578X
Jan 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cancer stem cells, not bulk tumor cells, determine mechanisms of resistance to SMO inhibitors

1
1. scibot 25 Jan 2023
  
  in Public
  
  RRID:IMSR_JAX:004600
  
  DOI: 10.1158/2767-9764.crc-22-0124
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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RRID:IMSR_JAX:004600

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9853917/
Oct 2022
www.nature.com www.nature.com

Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2

1
1. scibot 25 Oct 2022
  
  in Public
  
  RRID:IRSR_JAX:004600
  
  DOI: 10.1038/s41467-022-33819-3
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRIDCUR:Unresolved RRID:IMSR_JAX:004600
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RRIDCUR:Unresolved

RRID:IMSR_JAX:004600

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scibot

URL

nature.com/articles/s41467-022-33819-3
Aug 2022
www.sciencedirect.com www.sciencedirect.com

GFAP-directed Inactivation of Men1 Exploits Glial Cell Plasticity in Favor of Neuroendocrine Reprogramming

1
1. scibot 17 Aug 2022
  
  in Public
  
  JAX:004600
  
  DOI: 10.1016/j.jcmgh.2022.06.009
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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RRID:IMSR_JAX:004600

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scibot

URL

sciencedirect.com/science/article/pii/S2352345X22001552
www.sciencedirect.com www.sciencedirect.com

Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions

1
1. scibot 13 Aug 2022
  
  in Public
  
  JAX:004600
  
  DOI: 10.1016/j.neuron.2022.07.010
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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RRID:IMSR_JAX:004600

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scibot

URL

sciencedirect.com/science/article/pii/S0896627322006559
Jul 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Single-Nucleus RNA-seq of Normal-Appearing Brain Regions in Relapsing-Remitting vs. Secondary Progressive Multiple Sclerosis: Implications for the Efficacy of Fingolimod

1
1. scibot 04 Jul 2022
  
  in Public
  
  RRID:IMSR_JAX:004600
  
  DOI: 10.3389/fncel.2022.918041
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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RRID:IMSR_JAX:004600

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9247150/
Jun 2022
aacrjournals.org aacrjournals.org

Cancer Stem Cells, not Bulk Tumor Cells, Determine Mechanisms of Resistance to SMO Inhibitors

1
1. scibot 15 Jun 2022
  
  in Public
  
  RRID:IMSR_JAX:004600
  
  DOI: 10.1158/2767-9764.CRC-22-0124
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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RRID:IMSR_JAX:004600

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scibot

URL

aacrjournals.org/cancerrescommun/article/2/6/402/699311/Cancer-Stem-Cells-not-Bulk-Tumor-Cells-Determine
Sep 2021
www.sciencedirect.com www.sciencedirect.com

Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells

1
1. scibot 01 Sep 2021
  
  in Public
  
  JAX:004600
  
  DOI: 10.1016/j.celrep.2021.109639
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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RRID:IMSR_JAX:004600

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scibot

URL

sciencedirect.com/science/article/pii/S2211124721010822
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Exploring the longitudinal glioma microenvironment landscape uncovers reprogrammed pro-tumorigenic neutrophils in the bone marrow

1
1. scibot 04 Aug 2021
  
  in Public
  
  RRID:IMSR_JAX:004600
  
  DOI: 10.1016/j.celrep.2021.109480
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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RRID:IMSR_JAX:004600

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scibot

URL

sciencedirect.com/science/article/pii/S2211124721009074
Jul 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Large-scale death of retinal astrocytes during normal development is non-apoptotic and implemented by microglia

1
1. scibot 31 Jul 2021
  
  in Public
  
  Jackson Labs004600
  
  DOI: 10.1371/journal.pbio.3000492
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @bandrow
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600 RRIDCUR:Missing
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RRID:IMSR_JAX:004600

RRIDCUR:Missing

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6821132/
www.sciencedirect.com www.sciencedirect.com

CUL3 Deficiency Causes Social Deficits and Anxiety-like Behaviors by Impairing Excitation-Inhibition Balance through the Promotion of Cap-Dependent Translation

1
1. scibot 29 Jul 2021
  
  in Public
  
  RRID: IMSR_JAX:004600
  
  DOI: 10.1016/j.neuron.2019.10.035
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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RRID:IMSR_JAX:004600

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scibot

URL

sciencedirect.com/science/article/pii/S0896627319309304
www.sciencedirect.com www.sciencedirect.com

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

1
1. scibot 29 Jul 2021
  
  in Public
  
  Jackson laboratoryCat#4600
  
  DOI: 10.1016/j.cell.2019.06.024
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @bandrow
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600 RRIDCUR:Unrecognized
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RRIDCUR:Unrecognized

RRID:IMSR_JAX:004600

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scibot

URL

sciencedirect.com/science/article/pii/S0092867419306877
elifesciences.org elifesciences.org

Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice

1
1. scibot 29 Jul 2021
  
  in Public
  
  004600
  
  DOI: 10.7554/eLife.45303
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @bandrow
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600 RRIDCUR:Unrecognized
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RRIDCUR:Unrecognized

RRID:IMSR_JAX:004600

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scibot

URL

elifesciences.org/articles/45303
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells

1
1. scibot 27 Jul 2021
  
  in Public
  
  MGI:2179048
  
  DOI: 10.7554/eLife.42918
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
  Curator comments: IMSR Cat# JAX:004600, FVB-Tg(GFAP-cre)25Mes/J Mus musculus
  
  What is this?
  
  RRIDCUR:Unresolved RRID:IMSR_JAX:004600 RRIDCUR:Incorrect
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RRIDCUR:Unresolved

RRIDCUR:Incorrect

RRID:IMSR_JAX:004600

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6459675/
Jun 2021
www.sciencedirect.com www.sciencedirect.com

Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

1
1. scibot 04 Jun 2021
  
  in Public
  
  Cat#4600
  
  DOI: 10.1016/j.ccell.2021.05.002
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600 RRIDCUR:Missing
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RRID:IMSR_JAX:004600

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1535610821002683
May 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Environmental oxygen regulates astrocyte proliferation to guide angiogenesis during retinal development

1
1. scibot 21 May 2021
  
  in Public
  
  Jax stock 004600
  
  DOI: 10.1242/dev.199418
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
  What is this?
  
  RRIDCUR:Missing RRID:IMSR_JAX:004600
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RRID:IMSR_JAX:004600

RRIDCUR:Missing

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8126409/
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors

1
1. scibot 05 Sep 2020
  
  in Public
  
  JAX:004600
  
  DOI: 10.1016/j.neuron.2020.01.008
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
  What is this?
  
  RRIDCUR:Validated RRID:IMSR_JAX:004600
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RRID:IMSR_JAX:004600

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S0896627320300088
www.sciencedirect.com www.sciencedirect.com

Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog

1
1. scibot 03 Sep 2020
  
  in Public
  
  The Jackson LaboratoryStock No. 004600
  
  DOI: 10.1016/j.celrep.2020.03.027
  
  Resource: (IMSR Cat# JAX_004600,RRID:IMSR_JAX:004600)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
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RRID:IMSR_JAX:004600

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720303417
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma

1
1. scibot 05 Nov 2018
  
  in Public
  
  004600
  
  Curator: @Jmenke
  
  Resource used:
  
  RRID:IMSR_JAX:004600
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:004600 RRIDCUR:Missing
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RRID:IMSR_JAX:004600

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sciencedirect.com/science/article/pii/S1534580718301072
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Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration

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1. scibot 05 Nov 2018
  
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  RRID:IMSR_JAX:004600
  
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  RRID:IMSR_JAX:004600
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:IMSR_JAX:004600
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RRID:IMSR_JAX:004600

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sciencedirect.com/science/article/pii/S0197018618302432
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mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma

1
1. scibot 05 Nov 2018
  
  in Public
  
  004600
  
  Curator: @Jmenke
  
  Resource used:
  
  RRID:IMSR_JAX:004600
  
  SciCrunch record: RRID:IMSR_JAX:004600
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:004600 RRIDCUR:Missing
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RRID:IMSR_JAX:004600

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1534580717308249