214 Matching Annotations
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    Functional reprogramming of neutrophils within the brain tumor microenvironment by hypoxia-driven histone lactylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12133432/
  3. Nov 2025
  4. www.biorxiv.org www.biorxiv.org
    The electrophilic metabolite of kynurenine, kynurenine-CKA, targets C151 in Keap1 to derepress Nrf2
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    biorxiv.org/content/10.1101/2025.11.18.689077v1
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    Synaptic-like coupling of macrophages to myofibers regulates muscle repair
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    sciencedirect.com/science/article/pii/S0960982225014587
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    1-s2.0-S2589004225023211-main-html.html
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  7. Oct 2025
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    A non-canonical immunometabolic function of BRD3 during sepsis
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    sciencedirect.com/science/article/pii/S153458072500601X
  9. Sep 2025
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    Control of Inflammatory Response by Tissue Microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC11118380/
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    Redefined Strategies to generate Conditional miR-141/200c miRNA cluster Knockout mice to eliminate confounding neo cassettes
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    biorxiv.org/content/10.1101/2025.09.02.673774v1
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    Targeting lysozyme 2 in endocardium promotes rapid recovery by modulating remote injury signals
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    sciencedirect.com/science/article/pii/S1934590925003303
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    2025.09.04.674092v1.full-html.html
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    Dietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1β–mediated inflammation in mice and humans
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    science.org/doi/10.1126/scitranslmed.adp5653
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    Tolerance to non-inherited maternal antigen is sustained by LysM+ CD11c+ maternal microchimeric cells
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    sciencedirect.com/science/article/pii/S1074761325003681
  16. Aug 2025
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    Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ
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  18. Jul 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TREM2‐Mediated Myeloid Cells Protect Against Pathological Choroidal Neovascularization
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    Estrogens protect bone mass by inhibiting NAD+ metabolism in osteoclasts
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    biorxiv.org/content/10.1101/2025.07.11.664289v1
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    The aryl hydrocarbon receptor interacting protein suppresses RNA virus-induced type I IFN and IL-6 in mouse macrophages
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    RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
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    Lysozyme 1 Inflamed CCR2+ Macrophages Promote Obesity-Induced Cardiac Dysfunction | Circulation Research
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    ahajournals.org/doi/full/10.1161/CIRCRESAHA.124.324106
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    Role of Macrophage PARP1 in the Regulation of Crosstalk between Adipose Immune Cells and Adipocytes during Diet-induced Obesity
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  25. Jun 2025
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    Methylglyoxal is an antibacterial effector produced by macrophages during infection
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    Piezo1 senses hyphae and initiates host defense against pathogenic fungi
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    EGR2 O-GlcNAcylation orchestrates the development of protumoral macrophages to limit CD8+ T cell antitumor responses
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    Distinct TAM subset with cross-dressing capability determines the bifurcation of tumor immunity
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    Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis
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    PGK1 phosphorylates NLRP3 and mediates inflammasome activation independent of its glycolytic activity
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  32. May 2025
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    Myeloid-specific HNRNPA2B1 deficiency disrupts macrophage function and in vivo responses
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    12-Lipoxygenase inhibition improves glycemia and obesity-associated inflammation in male human gene replacement mice
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    Endothelial Nrf2 deficiency promotes atherosclerotic lesion formation by shaping a proinflammatory niche
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    Activation of the endoplasmic reticulum stress regulator IRE1α compromises pulmonary host defenses
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  38. Apr 2025
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    cGAS and STING in Host Myeloid Cells Are Essential for Effective Cyclophosphamide Treatment of Advanced Breast Cancer
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    Potentiation of macrophage Piezo1 by atherogenic 7-ketocholesterol
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    Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway
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  43. Mar 2025
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    Enterobactin inhibits microbiota-dependent activation of AhR to promote bacterial sepsis in mice
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    Phosphatase PHLPP1 is an alveolar-macrophage-intrinsic transcriptional checkpoint controlling pulmonary fibrosis
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    A heart-brain-spleen axis controls cardiac remodeling to hypertensive stress
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  47. Feb 2025
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    MerTK Induces Dysfunctional Dendritic Cells by Metabolic Reprogramming
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    ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation
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    Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity
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  51. Jan 2025
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    Nuclear adenine activates hnRNPA2B1 to enhance antibacterial innate immunity
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    Metabolic reprogramming of macrophages by PKM2 promotes IL-10 production via adenosine
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  55. Dec 2024
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Long non-coding RNA Malat1 fine-tunes bone homeostasis and repair by orchestrating cellular crosstalk and β-catenin-OPG/Jagged1 pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11666238/
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    A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control
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  58. Nov 2024
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cytoplasmic RNA quality control failure engages mTORC1-mediated autoinflammatory disease
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    NRG4-ErbB4 signaling represses proinflammatory macrophage activity
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    Stored RBC Transfusions Leads to the Systemic Inflammatory Response Syndrome in Anemic Murine Neonates
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    Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance
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    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) deletion in myeloid cells augments cholestatic liver injury
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    Ablation of PC1/3 in POMC-expressing Tissues but not in Immune Cells Induces Sepsis Hypersensitivity
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  65. Sep 2024
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    Notch signaling regulates macrophage-mediated inflammation in metabolic dysfunction-associated steatotic liver disease
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    PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders
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  69. Aug 2024
  70. www.biorxiv.org www.biorxiv.org
    Myeloid-Specific Thrombospondin-1 Deficiency Exacerbates Aortic Rupture via Broad Suppression of Extracellular Matrix Proteins
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    Krüppel-like Factor (KLF) family members control expression of genes required for serous cavity and alveolar macrophage identities
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    Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice
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    The involvement of neuroimmune cells in adipose innervation
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    The choroid plexus synergizes with immune cells during neuroinflammation
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  75. Jul 2024
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    Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner
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  79. May 2024
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    Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma
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    PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages
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  82. Apr 2024
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    Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury
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    Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration
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    Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages
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    Peripheral HMGB1 is linked to O3 pathology of disease-associated astrocytes and amyloid
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  89. Mar 2024
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    A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages
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    MAFB in macrophages regulates cold-induced neuronal density in brown adipose tissue
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    Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy
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    RBP-J regulates homeostasis and function of circulating Ly6Clo monocytes
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    Neutrophil-inflicted vasculature damage suppresses immune-mediated optic nerve regeneration
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    PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages
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  96. Feb 2024
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    Downregulation of IRF8 in alveolar macrophages by G-CSF promotes metastatic tumor progression
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    IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline
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    Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis
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  100. Jan 2024
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    Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging
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    Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration
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    Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
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    Age-associated features of norovirus infection analysed in mice
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    Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis
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    Myeloid cell-specific deletion of epidermal growth factor receptor aggravates acute cardiac injury
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  107. Dec 2023
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    Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growth
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    Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18
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