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34 Matching Annotations

Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumors

1
1. scibot 03 Dec 2025
  
  in Public
  
  RRID:JAX:007799
  
  DOI: 10.1158/1535-7163.MCT-24-1053
  
  Resource: None
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799 RRIDCUR:Unresolved
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pmc.ncbi.nlm.nih.gov/articles/PMC12668261/
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer

1
1. scibot 23 Nov 2025
  
  in Public
  
  RRID:IMSR_JAX:007799
  
  DOI: 10.1261/rna.080637.125
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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pmc.ncbi.nlm.nih.gov/articles/PMC12530129/
Oct 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Carbonic Anhydrase Inhibition Sensitizes Group 3 Medulloblastoma to Radiation Therapy

1
1. scibot 03 Oct 2025
  
  in Public
  
  RRID:IMSR_JAX:007799
  
  DOI: 10.1158/0008-5472.CAN-24-3894
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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pmc.ncbi.nlm.nih.gov/articles/PMC12442109/
Sep 2025
www.sciencedirect.com www.sciencedirect.com

Drug screening in 3D microtumors reveals DDR1/2-MAPK12-GLI1 as a vulnerability in cancer-associated fibroblasts

1
1. scibot 23 Sep 2025
  
  in Public
  
  JAX:007799
  
  DOI: 10.1016/j.xcrm.2025.102357
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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sciencedirect.com/science/article/pii/S2666379125004306
www.biorxiv.org www.biorxiv.org

ACTL6A regulates the Warburg effect through coordinated activation of AP-1 signaling in head and neck squamous cell carcinoma

1
1. scibot 10 Sep 2025
  
  in Public
  
  RRID:IMSR_JAX:007799
  
  DOI: 10.1101/2025.09.02.671886
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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biorxiv.org/content/10.1101/2025.09.02.671886v1
Jul 2025
52.53.155.43 52.53.155.43

2025.07.14.664742v1.full-html.html

1
1. scibot 25 Jul 2025
  
  in Public
  
  007799
  
  DOI: 10.1101/2025.07.14.664742
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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52.53.155.43/0ddeb0d5c1e9d78409db30015477d90afb34bbce/2025.07.14.664742v1.full-html.html
Jun 2025
www.sciencedirect.com www.sciencedirect.com

An integrated proteomic portrait of prostate cancer progression

1
1. scibot 17 Jun 2025
  
  in Public
  
  The Jackson LaboratoryStrain #007799
  
  DOI: 10.1016/j.celrep.2025.115828
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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sciencedirect.com/science/article/pii/S2211124725005996
www.sciencedirect.com www.sciencedirect.com

Combined inhibition of KAT6A/B and Menin reverses estrogen receptor-driven gene expression programs in breast cancer

1
1. scibot 14 Jun 2025
  
  in Public
  
  Jackson Laboratory007799
  
  DOI: 10.1016/j.xcrm.2025.102192
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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sciencedirect.com/science/article/pii/S2666379125002654
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Human CSPG4-targeting CAR-macrophages inhibit melanoma growth

1
1. scibot 11 Jun 2025
  
  in Public
  
  RRID:IMSR_JAX:007799
  
  DOI: 10.1038/s41388-025-03332-0
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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pmc.ncbi.nlm.nih.gov/articles/PMC12122381/
Apr 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225006972-main-html.html

1
1. scibot 17 Apr 2025
  
  in Public
  
  RRID:IMSR_JAX:007799
  
  DOI: 10.1016/j.isci.2025.112436
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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RRID:IMSR_JAX:007799

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scibot

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52.53.155.43/be11899c572d4eef940b4fb0c7f6692cd5cc7cb8/1-s2.0-S2589004225006972-main-html.html
Mar 2025
www.cell.com www.cell.com

Small-molecule RNA therapeutics to target prostate cancer

1
1. scibot 23 Mar 2025
  
  in Public
  
  RRID:IMSR_JAX:007799
  
  DOI: 10.1016/j.ccell.2025.02.027
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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cell.com/cancer-cell/abstract/S1535-6108(25)00079-0
Feb 2025
www.sciencedirect.com www.sciencedirect.com

FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

1
1. scibot 28 Feb 2025
  
  in Public
  
  Jackson Laboratorystock 7799
  
  DOI: 10.1016/j.ccell.2025.02.001
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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RRID:IMSR_JAX:007799

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sciencedirect.com/science/article/pii/S1535610825000534
Nov 2024
www.sciencedirect.com www.sciencedirect.com

Bioluminescence assay of lysine deacylase sirtuin activity

1
1. scibot 17 Nov 2024
  
  in Public
  
  RRID:IMSR_JAX:007799
  
  DOI: 10.1016/j.chembiol.2024.10.006
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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sciencedirect.com/science/article/pii/S2451945624004410
Oct 2024
aacrjournals.org aacrjournals.org

H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone

1
1. scibot 02 Oct 2024
  
  in Public
  
  RRID:IMSR_JAX:007799
  
  DOI: 10.1158/2159-8290.CD-20-0461
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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RRID:IMSR_JAX:007799

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scibot

URL

aacrjournals.org/cancerdiscovery/article/10/12/1968/2414/H3-3-G34W-Promotes-Growth-and-Impedes
Apr 2024
www.sciencedirect.com www.sciencedirect.com

Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses

1
1. scibot 23 Apr 2024
  
  in Public
  
  RRID:IMSR_JAX:007799
  
  DOI: 10.1016/j.cell.2024.03.026
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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RRID:IMSR_JAX:007799

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URL

sciencedirect.com/science/article/pii/S0092867424003179
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Galectin-1 mediates chronic STING activation in tumors to promote metastasis through MDSC recruitment

1
1. scibot 03 Apr 2024
  
  in Public
  
  RRID:IMSR_JAX:007799
  
  DOI: 10.1158/0008-5472.CAN-23-0046
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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RRID:IMSR_JAX:007799

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10592379/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma

1
1. scibot 21 Feb 2024
  
  in Public
  
  RRID:IMSR_JAX:007799
  
  DOI: 10.1038/s41467-024-45760-8
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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RRID:IMSR_JAX:007799

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ncbi.nlm.nih.gov/pmc/articles/PMC10873513/
www.sciencedirect.com www.sciencedirect.com

Intestinal microbiota programming of alveolar macrophages influences severity of respiratory viral infection

1
1. scibot 02 Feb 2024
  
  in Public
  
  JAX:007799
  
  DOI: 10.1016/j.chom.2024.01.002
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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RRID:IMSR_JAX:007799

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scibot

URL

sciencedirect.com/science/article/pii/S1931312824000064
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Therapy-induced normal tissue damage promotes breast cancer metastasis

1
1. scibot 05 Jan 2024
  
  in Public
  
  JAX:007799
  
  DOI: 10.1016/j.isci.2023.108503
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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RRID:IMSR_JAX:007799

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URL

ncbi.nlm.nih.gov/pmc/articles/PMC10755366/
Dec 2023
www.sciencedirect.com www.sciencedirect.com

Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability

1
1. scibot 02 Dec 2023
  
  in Public
  
  RRID:IMSR_JAX:007799
  
  DOI: 10.1016/j.celrep.2023.113503
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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URL

sciencedirect.com/science/article/pii/S2211124723015152
Jun 2023
elifesciences.org elifesciences.org

The CD73 immune checkpoint promotes tumor cell metabolic fitness

1
1. scibot 14 Jun 2023
  
  in Public
  
  JAX:007799
  
  DOI: 10.7554/eLife.84508
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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RRID:IMSR_JAX:007799

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URL

elifesciences.org/articles/84508
Apr 2023
www.sciencedirect.com www.sciencedirect.com

Polycomb Ezh1 maintains murine muscle stem cell quiescence through non-canonical regulation of Notch signaling

1
1. scibot 27 Apr 2023
  
  in Public
  
  JAX:007799
  
  DOI: 10.1016/j.devcel.2023.04.005
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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RRID:IMSR_JAX:007799

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scibot

URL

sciencedirect.com/science/article/pii/S1534580723001582
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors

1
1. scibot 21 Apr 2023
  
  in Public
  
  RRID:IMSR_JAX:007799
  
  DOI: 10.1158/1078-0432.CCR-22-3722
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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RRID:IMSR_JAX:007799

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10102849/
Jul 2022
www.sciencedirect.com www.sciencedirect.com

Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy

1
1. scibot 27 Jul 2022
  
  in Public
  
  Jackson LaboratoryCAT#007799
  
  DOI: 10.1016/j.celrep.2022.111128
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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RRID:IMSR_JAX:007799

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scibot

URL

sciencedirect.com/science/article/pii/S2211124722009342
Feb 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma

1
1. scibot 16 Feb 2022
  
  in Public
  
  RRID:IMSR_JAX:007799
  
  DOI: 10.1158/0008-5472.CAN-21-1677
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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URL

ncbi.nlm.nih.gov/pmc/articles/PMC7611539/
Sep 2021
www.sciencedirect.com www.sciencedirect.com

A hydride transfer complex reprograms NAD metabolism and bypasses senescence

1
1. scibot 23 Sep 2021
  
  in Public
  
  RRID:IMSR_JAX:007799
  
  DOI: 10.1016/j.molcel.2021.08.028
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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sciencedirect.com/science/article/pii/S109727652100695X
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope

1
1. scibot 28 Jul 2021
  
  in Public
  
  NOD-Rag1null IL2rgnull (NRG)
  
  DOI: 10.1016/j.immuni.2019.04.014
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799
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URL

sciencedirect.com/science/article/pii/S1074761319301943
www.sciencedirect.com www.sciencedirect.com

Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility

1
1. scibot 27 Jul 2021
  
  in Public
  
  RRID:IMSR_JAX
  
  DOI: 10.1016/j.stem.2019.02.005
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @bandrow
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRID:IMSR_JAX:007799 RRIDCUR:Unresolved
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RRIDCUR:Unresolved

RRID:IMSR_JAX:007799

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scibot

URL

sciencedirect.com/science/article/pii/S1934590919300475
Apr 2021
www.sciencedirect.com www.sciencedirect.com

The bone microenvironment invigorates metastatic seeds for further dissemination

1
1. scibot 20 Apr 2021
  
  in Public
  
  RRID:IMSR_JAX:007799
  
  DOI: 10.1016/j.cell.2021.03.011
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRIDCUR:Validated RRID:IMSR_JAX:007799
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RRIDCUR:Validated

RRID:IMSR_JAX:007799

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scibot

URL

sciencedirect.com/science/article/pii/S0092867421002968
www.cell.com www.cell.com

Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment

1
1. scibot 14 Apr 2021
  
  in Public
  
  JAX:007799
  
  DOI: 10.1016/j.cmet.2021.03.023
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
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  RRIDCUR:Validated RRID:IMSR_JAX:007799
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RRIDCUR:Validated

RRID:IMSR_JAX:007799

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scibot

URL

cell.com/cell-metabolism/fulltext/S1550-4131(21)00130-3
Dec 2020
www.sciencedirect.com www.sciencedirect.com

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

1
1. scibot 17 Dec 2020
  
  in Public
  
  NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ
  
  DOI: 10.1016/j.celrep.2020.108493
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
  Curator comments: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ Mus musculus IMSR Cat# JAX:007799
  
  What is this?
  
  RRIDCUR:Missing RRID:IMSR_JAX:007799
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RRIDCUR:Missing

RRID:IMSR_JAX:007799

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720314820
Sep 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction

1
1. scibot 26 Sep 2020
  
  in Public
  
  NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ (NRG) mice
  
  DOI: 10.1016/j.xcrm.2020.100097
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
  Curator comments: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ Mus musculus IMSR Cat# JAX:007799
  
  What is this?
  
  RRIDCUR:Missing RRID:IMSR_JAX:007799
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Tags

RRIDCUR:Missing

RRID:IMSR_JAX:007799

Annotators

scibot

URL

pubmed.ncbi.nlm.nih.gov/33205073/
www.sciencedirect.com www.sciencedirect.com

Senescence, Necrosis, and Apoptosis Govern Circulating Cell-free DNA Release Kinetics

1
1. scibot 04 Sep 2020
  
  in Public
  
  Nod Rag Gamma
  
  DOI: 10.1016/j.celrep.2020.107830
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
  Curator comments: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ Mus musculus IMSR Cat# JAX:007799
  
  What is this?
  
  RRID:IMSR_JAX:007799 RRIDCUR:Missing
Visit annotations in context

Tags

RRIDCUR:Missing

RRID:IMSR_JAX:007799

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124720308111
www.cell.com www.cell.com

Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody

1
1. scibot 03 Sep 2020
  
  in Public
  
  The Jackson LaboratoryCat#007799
  
  DOI: 10.1016/j.cell.2020.01.010
  
  Resource: (IMSR Cat# JAX_007799,RRID:IMSR_JAX:007799)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:007799
  
  What is this?
  
  RRID:IMSR_JAX:007799
Visit annotations in context

Tags

RRID:IMSR_JAX:007799

Annotators

scibot

URL

cell.com/cell/abstract/S0092-8674(20)30057-X