Hypothesis

111 Matching Annotations

Oct 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Extrachromosomal DNA–Driven Oncogene Spatial Heterogeneity and Evolution in Glioblastoma

1
1. scibot 17 Oct 2025
  
  in Public
  
  strain: 008462
  
  DOI: 10.1158/2159-8290.CD-24-1555
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12498097/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Deciphering Precursor Cell Dynamics in Esophageal Preneoplasia via Genetic Barcoding and Single-Cell Transcriptomics

1
1. scibot 17 Oct 2025
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1101/2025.02.26.637920
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11888434/
www.sciencedirect.com www.sciencedirect.com

Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas

1
1. scibot 08 Oct 2025
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.ccell.2025.09.005
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

sciencedirect.com/science/article/pii/S1535610825003976
Sep 2025
www.sciencedirect.com www.sciencedirect.com

Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state

1
1. scibot 25 Sep 2025
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.celrep.2025.116185
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

sciencedirect.com/science/article/pii/S2211124725009568
Aug 2025
www.sciencedirect.com www.sciencedirect.com

Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy

1
1. scibot 30 Aug 2025
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.xcrm.2025.102317
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

sciencedirect.com/science/article/pii/S2666379125003908
www.biorxiv.org www.biorxiv.org

L1CAM signaling through planar cell polarity generates SOX2+ metastatic progenitors in lung adenocarcinoma

1
1. scibot 27 Aug 2025
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1101/2025.08.22.671773
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

biorxiv.org/content/10.1101/2025.08.22.671773v1
pathsocjournals.onlinelibrary.wiley.com pathsocjournals.onlinelibrary.wiley.com

Activation of PI3K and deletion of p53 in keratin 15-expressing mouse mammary cells induces tumor heterogeneity and plasticity modeling metaplastic breast cancer

1
1. scibot 19 Aug 2025
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1002/path.6463
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6463
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A RAS(ON) Multi-Selective Inhibitor Combination Therapy Triggers Long-term Tumor Control through Senescence-Associated Tumor-Immune Equilibrium in Pancreatic Ductal Adenocarcinoma

1
1. scibot 06 Aug 2025
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1158/2159-8290.CD-24-1425
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12319406/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RIT1 Drives Oncogenic Transformation and is an Actionable Target in Lung Adenocarcinoma

1
1. scibot 25 Jul 2025
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1158/0008-5472.CAN-24-3819
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12281470/
Jun 2025
www.sciencedirect.com www.sciencedirect.com

MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma

1
1. scibot 11 Jun 2025
  
  in Public
  
  Jackson Laboratory Stock_008462
  
  DOI: 10.1016/j.cell.2025.05.019
  
  Resource: None
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRIDCUR:Unresolved RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

RRIDCUR:Unresolved

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scibot

URL

sciencedirect.com/science/article/pii/S0092867425005690
May 2025
www.sciencedirect.com www.sciencedirect.com

KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy

1
1. scibot 16 May 2025
  
  in Public
  
  Jackson LaboratoryStock # 008462
  
  DOI: 10.1016/j.ccell.2025.04.002
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

sciencedirect.com/science/article/pii/S1535610825001394
Apr 2025
www.sciencedirect.com www.sciencedirect.com

Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation

1
1. scibot 19 Apr 2025
  
  in Public
  
  JAX:008462
  
  DOI: 10.1016/j.ccell.2025.03.027
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

sciencedirect.com/science/article/pii/S153561082500128X
www.sciencedirect.com www.sciencedirect.com

Histamine 1 Receptor (HRH1): A potential therapeutic target for Pancreatic Ductal Adenocarcinoma

2
1. scibot 08 Apr 2025
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.jpet.2025.103573
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
  What is this?
  
  RRID:IMSR_JAX:008462
2. scibot 08 Apr 2025
  
  in Public
  
  JAX:008462
  
  DOI: 10.1016/j.jpet.2025.103573
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

sciencedirect.com/science/article/pii/S0022356525397867
Feb 2025
www.sciencedirect.com www.sciencedirect.com

KRAS4B oncogenic mutants promote non-small cell lung cancer progression via the interaction of deubiquitinase USP25 with RNF31

1
1. scibot 14 Feb 2025
  
  in Public
  
  The Jackson LaboratoryStrain# 008462
  
  DOI: 10.1016/j.devcel.2025.01.015
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

sciencedirect.com/science/article/pii/S1534580725000358
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer

1
1. scibot 13 Feb 2025
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1126/scitranslmed.adj9366
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11811823/
www.sciencedirect.com www.sciencedirect.com

Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy

1
1. scibot 07 Feb 2025
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.xcrm.2024.101927
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

sciencedirect.com/science/article/pii/S2666379124006980
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography

1
1. scibot 21 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1038/s41467-024-54852-4
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @sjvitug
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
  What is this?
  
  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11652680/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence

1
1. scibot 11 Dec 2024
  
  in Public
  
  Jackson Laboratory Stock_008462
  
  DOI: 10.1016/j.isci.2024.111311
  
  Resource: None
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
  What is this?
  
  RRIDCUR:Unresolved RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

RRIDCUR:Unresolved

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11617384/
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

IL‐36γ and IL‐36Ra Reciprocally Regulate Colon Inflammation and Tumorigenesis by Modulating the Cell–Matrix Adhesion Network and Wnt Signaling

1
1. scibot 14 Nov 2024
  
  in Public
  
  008462
  
  DOI: 10.1002/advs.202103035
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @AleksanderDrozdz
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC8981487/
www.sciencedirect.com www.sciencedirect.com

A subset of neutrophils activates anti-tumor immunity and inhibits non-small-cell lung cancer progression

1
1. scibot 11 Nov 2024
  
  in Public
  
  Strain# 008462
  
  DOI: 10.1016/j.devcel.2024.10.010
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @vtello
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

sciencedirect.com/science/article/pii/S1534580724006294
Sep 2024
www.biorxiv.org www.biorxiv.org

Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes

1
1. scibot 13 Sep 2024
  
  in Public
  
  RRID:IMSR_JAX008462
  
  DOI: 10.1101/2024.08.19.607671
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
  What is this?
  
  RRIDCUR:Unresolved RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

RRIDCUR:Unresolved

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scibot

URL

biorxiv.org/content/10.1101/2024.08.19.607671v1
Jul 2024
www.science.org www.science.org

Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer

1
1. scibot 25 Jul 2024
  
  in Public
  
  JAX:008462
  
  DOI: 10.1126/science.adh4567
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

science.org/doi/10.1126/science.adh4567
Jun 2024
www.sciencedirect.com www.sciencedirect.com

CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma

1
1. scibot 06 Jun 2024
  
  in Public
  
  RRID:IMSR_JAX:008462Info
  
  DOI: 10.1016/j.celrep.2024.114286
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
  What is this?
  
  RRIDCUR:Unresolved RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

RRIDCUR:Unresolved

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scibot

URL

sciencedirect.com/science/article/pii/S2211124724006144
www.biorxiv.org www.biorxiv.org

Aging represses lung tumorigenesis and alters tumor suppression

1
1. scibot 04 Jun 2024
  
  in Public
  
  RRID:IMSR_JAX008462
  
  DOI: 10.1101/2024.05.28.596319
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @mzhang007
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  DOI:10.1101/2024.05.28.596319 RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

DOI:10.1101/2024.05.28.596319

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scibot

URL

biorxiv.org/content/10.1101/2024.05.28.596319v1
May 2024
www.sciencedirect.com www.sciencedirect.com

CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma

1
1. scibot 30 May 2024
  
  in Public
  
  JAX:008462
  
  DOI: 10.1016/j.celrep.2024.114286
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

sciencedirect.com/science/article/pii/S2211124724006144
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma

2
1. scibot 23 May 2024
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1101/2024.04.23.590638
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
  What is this?
  
  RRID:IMSR_JAX:008462
2. scibot 23 May 2024
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1101/2024.04.23.590638
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC11071395/
www.sciencedirect.com www.sciencedirect.com

Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor

1
1. scibot 07 May 2024
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.stem.2024.04.011
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

sciencedirect.com/science/article/pii/S1934590924001383
www.sciencedirect.com www.sciencedirect.com

Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size

1
1. scibot 02 May 2024
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.neuron.2024.04.006
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

sciencedirect.com/science/article/pii/S0896627324002447
Apr 2024
www.sciencedirect.com www.sciencedirect.com

Telomere dysfunction alters intestinal stem cell dynamics to promote cancer

1
1. scibot 04 Apr 2024
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.devcel.2024.03.020
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

sciencedirect.com/science/article/pii/S1534580724001886
Mar 2024
www.sciencedirect.com www.sciencedirect.com

FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis

1
1. scibot 22 Mar 2024
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.molcel.2024.02.037
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
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  RRID:IMSR_JAX:008462
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RRID:IMSR_JAX:008462

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scibot

URL

sciencedirect.com/science/article/pii/S1097276524001801
www.sciencedirect.com www.sciencedirect.com

PRMT1 promotes pancreatic cancer development and resistance to chemotherapy

2
1. scibot 12 Mar 2024
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.xcrm.2024.101461
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:008462
  
  What is this?
  
  RRID:IMSR_JAX:008462
2. scibot 12 Mar 2024
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.xcrm.2024.101461
  
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sciencedirect.com/science/article/pii/S2666379124001058
Feb 2024
aacrjournals.org aacrjournals.org

Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models

1
1. scibot 27 Feb 2024
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1158/2767-9764.CRC-23-0308
  
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aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants

1
1. scibot 18 Jan 2024
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1158/0008-5472.CAN-22-3464
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10524763/
aacrjournals.org aacrjournals.org

Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models

1
1. scibot 10 Jan 2024
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1158/2767-9764.CRC-23-0308
  
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aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
www.sciencedirect.com www.sciencedirect.com

Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells

2
1. scibot 04 Jan 2024
  
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  JAX:008462
  
  DOI: 10.1016/j.devcel.2023.07.025
  
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2. scibot 04 Jan 2024
  
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  JAX:008462
  
  DOI: 10.1016/j.devcel.2023.07.025
  
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Dec 2023
onlinelibrary.wiley.com onlinelibrary.wiley.com

TGF-β signaling promotes desmoid tumor formation via CSRP2 upregulation

1
1. scibot 15 Dec 2023
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1111/cas.16037
  
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onlinelibrary.wiley.com/doi/10.1111/cas.16037
Oct 2023
www.nature.com www.nature.com

Decreased liver B vitamin-related enzymes as a metabolic hallmark of cancer cachexia

1
1. scibot 07 Oct 2023
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1038/s41467-023-41952-w
  
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nature.com/articles/s41467-023-41952-w
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development

1
1. scibot 12 Aug 2023
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.isci.2023.107368
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10407955/
Jun 2023
52.53.155.43 52.53.155.43

can-22-3464-html.html

1
1. scibot 30 Jun 2023
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1158/0008-5472.CAN-22-3464
  
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52.53.155.43/8f4ba7cf674bbb2f5b6878f674808aab8499538e/can-22-3464-html.html
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression

1
1. scibot 17 Jun 2023
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1158/0008-5472.CAN-22-3848
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10267679/
May 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors

1
1. scibot 04 May 2023
  
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  JAX:008462
  
  DOI: 10.1158/0008-5472.CAN-22-3000
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10152234/
Apr 2023
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Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development

1
1. scibot 13 Apr 2023
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.devcel.2023.03.016
  
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Mar 2023
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Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease

1
1. scibot 04 Mar 2023
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.celrep.2023.112198
  
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sciencedirect.com/science/article/pii/S2211124723002097
Jan 2023
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The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer

1
1. scibot 28 Jan 2023
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.celrep.2022.111878
  
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sciencedirect.com/science/article/pii/S2211124722017740
Dec 2022
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KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition

1
1. scibot 17 Dec 2022
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.ccell.2022.11.015
  
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sciencedirect.com/science/article/pii/S1535610822005621
Nov 2022
aacrjournals.org aacrjournals.org

The cAMP/PKA/CREB and TGF-β/SMAD4 pathways regulate stemness and metastatic potential in colorectal cancer cells

1
1. scibot 22 Nov 2022
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1158/0008-5472.CAN-22-1369
  
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aacrjournals.org/cancerres/article/82/22/4179/710134/The-cAMP-PKA-CREB-and-TGF-SMAD4-Pathways-Regulate
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NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma

1
1. scibot 09 Nov 2022
  
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  008462
  
  DOI: 10.1016/j.celrep.2022.111623
  
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sciencedirect.com/science/article/pii/S2211124722014942
Oct 2022
52.53.155.43 52.53.155.43

can-22-1369-html.html

1
1. scibot 27 Oct 2022
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.1158/0008-5472.CAN-22-1369
  
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52.53.155.43/73ac479c11a5b7254565d9c8982a4bd5bdf3415d/can-22-1369-html.html
www.sciencedirect.com www.sciencedirect.com

The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes

1
1. scibot 09 Oct 2022
  
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  008462
  
  DOI: 10.1016/j.cell.2022.09.020
  
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sciencedirect.com/science/article/pii/S0092867422011928
Aug 2022
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Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma

1
1. scibot 31 Aug 2022
  
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  JAX:008462
  
  DOI: 10.1016/j.celrep.2022.111253
  
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sciencedirect.com/science/article/pii/S2211124722010713
Jul 2022
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Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling

1
1. scibot 13 Jul 2022
  
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  THE JACKSON LABORATORYCat # 008462
  
  DOI: 10.1016/j.celrep.2022.111072
  
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sciencedirect.com/science/article/pii/S2211124722008701
Jun 2022
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Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma

1
1. scibot 22 Jun 2022
  
  in Public
  
  Jackson LaboratoryStock# 008462
  
  DOI: 10.1016/j.celrep.2022.110991
  
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sciencedirect.com/science/article/pii/S221112472200777X
May 2022
www.sciencedirect.com www.sciencedirect.com

Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling

1
1. scibot 18 May 2022
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.cmet.2022.04.012
  
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sciencedirect.com/science/article/pii/S1550413122001826
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer

1
1. scibot 04 May 2022
  
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  JAX 008462
  
  DOI: 10.1158/0008-5472.CAN-20-4028
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8563406/
Apr 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis

1
1. scibot 15 Apr 2022
  
  in Public
  
  RRID:IMSR_JAX:008462
  
  DOI: 10.7554/eLife.74595
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9007587/
Feb 2022
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Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer

1
1. scibot 04 Feb 2022
  
  in Public
  
  JAX:008462
  
  DOI: 10.1016/j.ccell.2022.01.003
  
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sciencedirect.com/science/article/pii/S1535610822000058
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Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer

1
1. scibot 04 Feb 2022
  
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  JAX:008462
  
  DOI: 10.1016/j.ccell.2022.01.004
  
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sciencedirect.com/science/article/pii/S153561082200006X
Dec 2021
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Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity

1
1. scibot 21 Dec 2021
  
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  Jax stock 008462
  
  DOI: 10.1016/j.devcel.2021.11.020
  
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sciencedirect.com/science/article/pii/S1534580721009448
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A new murine esophageal organoid culture method and organoid-based model of esophageal squamous cell neoplasia

1
1. scibot 11 Dec 2021
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.isci.2021.103440
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8633967/
Nov 2021
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Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities

1
1. scibot 24 Nov 2021
  
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  Stock# 008462
  
  DOI: 10.1016/j.celrep.2021.110054
  
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Glut1 expression in tumor-associated neutrophils promotes lung cancer growth and resistance to radiotherapy

2
1. scibot 05 Nov 2021
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1158/0008-5472.CAN-20-2870
  
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2. scibot 05 Nov 2021
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1158/0008-5472.CAN-20-2870
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8137580/
Sep 2021
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Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors

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  DOI: 10.1016/j.cell.2021.08.020
  
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NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis

1
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Conventional type I dendric cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes

1
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UV-induced reduction in Polycomb repression promotes epidermal pigmentation

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Untitled document

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  DOI: 10.1016/j.celrep.2018.12.030
  
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Untitled document

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  DOI: 10.1016/j.ccell.2018.11.015
  
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The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number

1
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  DOI: 10.1016/j.devcel.2018.09.021
  
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Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma

1
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  The Jackson Laboratory008462
  
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Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer

1
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  B6.129P2-Trp53tm1Brn/J (Trp53L)
  
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Multi-organ Mapping of Cancer Risk

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  IMSR_JAX:008462
  
  DOI: 10.1016/j.cell.2016.07.045
  
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2. scibot 27 Jul 2021
  
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  IMSR_JAX:008462
  
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Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype

1
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Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness

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Signaling levels mold the RAS mutation tropism of urethane

1
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  DOI: 10.7554/eLife.67172
  
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Jun 2021
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Protocol to establish a lung adenocarcinoma immunotherapy allograft mouse model with FACS and immunofluorescence-based analysis of tumor response

1
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  DOI: 10.1016/j.xpro.2021.100595
  
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Protocol for single-cell ATAC sequencing using combinatorial indexing in mouse lung adenocarcinoma

1
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  DOI: 10.1016/j.xpro.2021.100583
  
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cancerdiscovery.aacrjournals.org cancerdiscovery.aacrjournals.org

Cell of Origin Influences Pancreatic Cancer Subtype

1
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1158/2159-8290.CD-20-0633
  
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Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

1
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Apr 2021
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High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer

1
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Emergence of a High-Plasticity Cell State during Lung Cancer Evolution

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Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma

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SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy

1
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PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis

1
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  DOI: 10.1016/j.molcel.2021.02.001
  
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Skeletal Muscle Subpopulation Rearrangements upon Rhabdomyosarcoma Development through Single-Cell Mass Cytometry

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Feb 2021
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Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

1
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  RRID:IMSR_JAX:008462
  
  DOI: 10.7554/eLife.53618
  
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An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming

1
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  DOI: 10.7554/eLife.63665
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7758072/
Dec 2020
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Lgr5 Marks Adult Progenitor Cells Contributing to Skeletal Muscle Regeneration and Sarcoma Formation

1
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  JAX:008462
  
  DOI: 10.1016/j.celrep.2020.108535
  
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Sep 2020
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Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

1
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.cell.2020.03.062
  
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Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

1
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  DOI: 10.1016/j.cell.2020.03.008
  
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High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down

1
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  JAX Stock No. 008462
  
  DOI: 10.1016/j.molcel.2020.05.009
  
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Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation

1
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  The Jackson Laboratory008462
  
  DOI: 10.1016/j.celrep.2020.02.080
  
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The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer

1
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  JaxLab, Stock number 008462
  
  DOI: 10.1038/s41388-020-1196-5
  
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nature.com/articles/s41388-020-1196-5
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Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth

1
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  JAX#008462
  
  DOI: 10.1016/j.cell.2019.12.024
  
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sciencedirect.com/science/article/pii/S0092867419313868
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Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in Lung Squamous Cell Carcinoma

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1. scibot 02 Sep 2020
  
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  The Jackson Laboratory008462
  
  DOI: 10.1016/j.celrep.2019.12.071
  
  Resource: (IMSR Cat# JAX_008462,RRID:IMSR_JAX:008462)
  
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sciencedirect.com/science/article/pii/S2211124719317280
Jan 2020
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IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development

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1. scibot 13 Jan 2020
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.celrep.2019.10.120
  
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Rare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch

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1. scibot 13 Jan 2020
  
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  RRID:IMSR_JAX:008462
  
  DOI: 10.1016/j.cell.2019.09.010
  
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sciencedirect.com/science/article/pii/S0092867419310165
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Untitled document

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1. scibot 13 Jan 2020
  
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  JAX:008462
  
  DOI: 10.1016/j.celrep.2018.12.030
  
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  Curator: @evieth
  
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sciencedirect.com/science/article/pii/S2211124718319600
Nov 2018
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The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment

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1. scibot 05 Nov 2018
  
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  RRID:IMSR_JAX:008462
  
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sciencedirect.com/science/article/pii/S1074761318304357
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Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells

1
1. scibot 05 Nov 2018
  
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  RRID:IMSR_JAX:008462
  
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Twist1 Activation in Muscle Progenitor Cells Causes Muscle Loss Akin to Cancer Cachexia

1
1. scibot 05 Nov 2018
  
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  008462
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1534580718304192
elifesciences.org elifesciences.org

Untitled document

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1. scibot 05 Nov 2018
  
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  RRID:IMSR_JAX:008462
  
  Curator: @evieth
  
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elifesciences.org/articles/36389
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Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation

1
1. scibot 05 Nov 2018
  
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  RRID:IMSR_JAX:008462
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5720590/
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Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

1
1. scibot 05 Nov 2018
  
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  JAX:008462
  
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sciencedirect.com/science/article/pii/S1074761317305721
Nov 2017
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A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer

1
1. scibot 08 Nov 2017
  
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  008462
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1535610817304117
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Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

1
1. scibot 08 Nov 2017
  
  in Public
  
  008462
  
  Curator: @Jmenke
  
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