Hypothesis

10 Matching Annotations

Last 7 days
www.sciencedirect.com www.sciencedirect.com

Targeting PGAM5-driven mitochondrial integrated stress response slows ALS progression across subtypes

1
1. scibot 13 Mar 2026
  
  in Public
  
  RRID:IMSR_JAX:010700
  
  DOI: 10.1016/j.neuron.2026.02.003
  
  Resource: (IMSR Cat# JAX_010700,RRID:IMSR_JAX:010700)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:010700
  
  What is this?
  
  RRID:IMSR_JAX:010700
Visit annotations in context

Tags

RRID:IMSR_JAX:010700

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0896627326000863
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Highly sensitive chemiluminescence imaging of misfolded proteins in neurodegenerative models

1
1. scibot 11 Mar 2026
  
  in Public
  
  RRID:IMSR_JAX:010700
  
  DOI: 10.1073/pnas.2513311123
  
  Resource: (IMSR Cat# JAX_010700,RRID:IMSR_JAX:010700)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:010700
  
  What is this?
  
  RRID:IMSR_JAX:010700
Visit annotations in context

Tags

RRID:IMSR_JAX:010700

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12799164/
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The CCL2-CCR2 axis drives neuromuscular denervation in amyotrophic lateral sclerosis

1
1. scibot 05 Aug 2025
  
  in Public
  
  RRID:IMSR_JAX:010700
  
  DOI: 10.1038/s41467-025-62351-3
  
  Resource: (IMSR Cat# JAX_010700,RRID:IMSR_JAX:010700)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:010700
  
  What is this?
  
  RRID:IMSR_JAX:010700
Visit annotations in context

Tags

RRID:IMSR_JAX:010700

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12316999/
Apr 2025
www.biorxiv.org www.biorxiv.org

Detection of misfolded proteins in neurodegenerative disease models with a highly sensitive chemiluminescence probe

1
1. scibot 19 Apr 2025
  
  in Public
  
  RRID:IMSR_JAX:010700
  
  DOI: 10.1101/2025.04.12.648090
  
  Resource: (IMSR Cat# JAX_010700,RRID:IMSR_JAX:010700)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:010700
  
  What is this?
  
  RRID:IMSR_JAX:010700
Visit annotations in context

Tags

RRID:IMSR_JAX:010700

Annotators

scibot

URL

biorxiv.org/content/10.1101/2025.04.12.648090v1
Jun 2022
www.sciencedirect.com www.sciencedirect.com

Blocking Immune Cell infiltration of the Central Nervous System to Tame Neuroinflammation in Amyotrophic Lateral Sclerosis

1
1. scibot 15 Jun 2022
  
  in Public
  
  RRID:IMSR_JAX:010700
  
  DOI: 10.1016/j.bbi.2022.06.004
  
  Resource: (IMSR Cat# JAX_010700,RRID:IMSR_JAX:010700)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:010700
  
  What is this?
  
  RRID:IMSR_JAX:010700
Visit annotations in context

Tags

RRID:IMSR_JAX:010700

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0889159122001568
Mar 2022
www.sciencedirect.com www.sciencedirect.com

Excessive release of inorganic phosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons

1
1. scibot 18 Mar 2022
  
  in Public
  
  RRID:IMSR_JAX:010700
  
  DOI: 10.1016/j.neuron.2022.02.010
  
  Resource: (IMSR Cat# JAX_010700,RRID:IMSR_JAX:010700)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:010700
  
  What is this?
  
  RRID:IMSR_JAX:010700
Visit annotations in context

Tags

RRID:IMSR_JAX:010700

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0896627322001489
Jan 2022
www.nature.com www.nature.com

Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons

1
1. scibot 10 Jan 2022
  
  in Public
  
  010700
  
  DOI: 10.1038/s41434-021-00303-4
  
  Resource: (IMSR Cat# JAX_010700,RRID:IMSR_JAX:010700)
  
  Curator: @bandrow
  
  SciCrunch record: RRID:IMSR_JAX:010700
  
  What is this?
  
  RRID:IMSR_JAX:010700
Visit annotations in context

Tags

RRID:IMSR_JAX:010700

Annotators

scibot

URL

nature.com/articles/s41434-021-00303-4
Oct 2021
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

1
1. scibot 20 Oct 2021
  
  in Public
  
  RRID:IMSR_JAX:010700
  
  DOI: 10.1111/bph.15665
  
  Resource: (IMSR Cat# JAX_010700,RRID:IMSR_JAX:010700)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:010700
  
  What is this?
  
  RRID:IMSR_JAX:010700
Visit annotations in context

Tags

RRID:IMSR_JAX:010700

Annotators

scibot

URL

bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15665
Oct 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

1
1. scibot 10 Oct 2020
  
  in Public
  
  B6.Cg-Tg(Prnp-TARDBP∗A315T)95Balo/J (Prp-TDP-43Tg/+)
  
  DOI: 10.1016/j.cell.2020.09.020
  
  Resource: (IMSR Cat# JAX_010700,RRID:IMSR_JAX:010700)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:010700
  
  Curator comments: B6.Cg-Tg(Prnp-TARDBP*A315T)95Balo/J Mus musculus IMSR Cat# JAX:010700
  
  What is this?
  
  RRID:IMSR_JAX:010700 RRIDCUR:Missing
Visit annotations in context

Tags

RRID:IMSR_JAX:010700

RRIDCUR:Missing

Annotators

scibot

URL

pubmed.ncbi.nlm.nih.gov/33031745/
Sep 2020
www.nature.com www.nature.com

Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

1
1. scibot 03 Sep 2020
  
  in Public
  
  RRID:IMSR_JAX:010700
  
  DOI: 10.1038/s41467-020-15644-8
  
  Resource: (IMSR Cat# JAX_010700,RRID:IMSR_JAX:010700)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:010700
  
  What is this?
  
  RRID:IMSR_JAX:010700 RRIDCUR:Validated
Visit annotations in context

Tags

RRID:IMSR_JAX:010700

RRIDCUR:Validated

Annotators

scibot

URL

nature.com/articles/s41467-020-15644-8