15 Matching Annotations
  1. Aug 2025
  2. 52.53.155.43 52.53.155.43
    ssrn-5392056-html.html
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    52.53.155.43/969cb0acb0f42ae5b2af48a318fee51aab354b08/ssrn-5392056-html.html
  3. Jul 2025
  4. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225013914-main-html.html
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    52.53.155.43/90007a778f462697c048df1da24432bb37ed810f/1-s2.0-S2589004225013914-main-html.html
  5. May 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose
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    pmc.ncbi.nlm.nih.gov/articles/PMC12058456/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS‐AD‐linked degenerative phenotypes in the Dp16 mouse model of Down syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC12058459/
  8. May 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Integrative multi-omic analysis reveals conserved cell-projection deficits in human Down syndrome brains
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    sciencedirect.com/science/article/pii/S0896627324003295
  10. Apr 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    “Heterogeneous subpopulations of GABAAR-responding neurons coexist across neuronal networks scales and developmental stages in health and disease”
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    ncbi.nlm.nih.gov/pmc/articles/PMC10966311/
  12. Aug 2023
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Down Syndrome is Associated with Altered Frequency and Functioning of Tracheal Multiciliated Cells, and Response to Influenza Virus Infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC10405068/
  14. Jun 2023
  15. 52.53.155.43 52.53.155.43
    Interferon hyperactivity impairs cardiogenesis in Down syndrome via downregulation of canonical Wnt signaling
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    52.53.155.43/bed7a9208c54adf86acc18c446f54a38acbd010c/1-s2.0-S2589004223010891-main-html.html
  16. Feb 2021
  17. www.sciencedirect.com www.sciencedirect.com
    JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome
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    sciencedirect.com/science/article/pii/S2211124720313966
  18. Nov 2020
  19. www.sciencedirect.com www.sciencedirect.com
    JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome
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    sciencedirect.com/science/article/pii/S2211124720313966
  20. Oct 2020
  21. www.sciencedirect.com www.sciencedirect.com
    Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome
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    sciencedirect.com/science/article/pii/S0896627320307108
  22. Nov 2017
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Trisomy 21 consistently activates the interferon response
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    ncbi.nlm.nih.gov/pmc/articles/PMC5012864/