Hypothesis

12 Matching Annotations

Aug 2025
www.sciencedirect.com www.sciencedirect.com

Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells

1
1. scibot 01 Aug 2025
  
  in Public
  
  RRID:IMSR_JAX:016977
  
  DOI: 10.1016/j.immuni.2025.07.008
  
  Resource: (IMSR Cat# JAX_016977,RRID:IMSR_JAX:016977)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:016977
  
  What is this?
  
  RRID:IMSR_JAX:016977
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RRID:IMSR_JAX:016977

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1074761325003176
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Embryological cellular origins and hypoxia-mediated mechanisms in PIK3CA-driven refractory vascular malformations

2
1. scibot 17 Jun 2025
  
  in Public
  
  RRID:IMSR_JAX:016977
  
  DOI: 10.1038/s44321-025-00235-1
  
  Resource: (IMSR Cat# JAX_016977,RRID:IMSR_JAX:016977)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:016977
  
  What is this?
  
  RRID:IMSR_JAX:016977
2. scibot 17 Jun 2025
  
  in Public
  
  RRID:IMSR_JAX
  
  DOI: 10.1038/s44321-025-00235-1
  
  Resource: None
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:016977
  
  What is this?
  
  RRID:IMSR_JAX:016977 RRIDCUR:Unresolved
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RRID:IMSR_JAX:016977

RRIDCUR:Unresolved

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12162881/
May 2025
www.sciencedirect.com www.sciencedirect.com

Epidermal growth factor receptor specific immunotherapy for SHH medulloblastoma tested in an in vitro blood-brain-barrier model

1
1. scibot 29 May 2025
  
  in Public
  
  JAX #016977
  
  DOI: 10.1016/j.ctarc.2025.100950
  
  Resource: (IMSR Cat# JAX_016977,RRID:IMSR_JAX:016977)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:016977
  
  What is this?
  
  RRID:IMSR_JAX:016977
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RRID:IMSR_JAX:016977

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2468294225000863
Feb 2025
www.biorxiv.org www.biorxiv.org

Embryological cellular origins and hypoxia-mediated mechanisms in PIK3CA-Driven refractory vascular malformations

1
1. scibot 07 Feb 2025
  
  in Public
  
  RRID:IMSR_JAX: 016977
  
  DOI: 10.1101/2024.10.16.618777
  
  Resource: (IMSR Cat# JAX_016977,RRID:IMSR_JAX:016977)
  
  Curator: @inessasarian
  
  SciCrunch record: RRID:IMSR_JAX:016977
  
  What is this?
  
  RRID:IMSR_JAX:016977
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RRID:IMSR_JAX:016977

Annotators

scibot

URL

biorxiv.org/lookup/doi/10.1101/2024.10.16.618777
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling

1
1. scibot 16 Apr 2024
  
  in Public
  
  RRID:IMSR_JAX:016977
  
  DOI: 10.1016/j.xcrm.2024.101510
  
  Resource: (IMSR Cat# JAX_016977,RRID:IMSR_JAX:016977)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:016977
  
  What is this?
  
  RRID:IMSR_JAX:016977
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RRID:IMSR_JAX:016977

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC11148513/
Jun 2023
aacrjournals.org aacrjournals.org

Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer

1
1. scibot 03 Jun 2023
  
  in Public
  
  RRID:IMSR_JAX:016977
  
  DOI: 10.1158/0008-5472.CAN-22-2525
  
  Resource: (IMSR Cat# JAX_016977,RRID:IMSR_JAX:016977)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:016977
  
  What is this?
  
  RRID:IMSR_JAX:016977
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RRID:IMSR_JAX:016977

Annotators

scibot

URL

aacrjournals.org/cancerres/article/83/8/1280/725099/Dysregulation-of-Mitochondrial-Translation-Caused
Nov 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Multiple congenital malformations arise from somatic mosaicism for constitutively active Pik3ca signaling

1
1. scibot 10 Nov 2022
  
  in Public
  
  RRID:IMSR_JAX:016
  
  DOI: 10.3389/fcell.2022.1013001
  
  Resource: (IMSR Cat# JAX_016977,RRID:IMSR_JAX:016977)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:016977
  
  What is this?
  
  RRID:IMSR_JAX:016977 RRIDCUR:Unresolved
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Tags

RRID:IMSR_JAX:016977

RRIDCUR:Unresolved

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9637999/
Aug 2022
www.sciencedirect.com www.sciencedirect.com

De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

1
1. scibot 22 Aug 2022
  
  in Public
  
  Jackson LaboratoriesCat# 016977
  
  DOI: 10.1016/j.ccell.2022.07.011
  
  Resource: (IMSR Cat# JAX_016977,RRID:IMSR_JAX:016977)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:016977
  
  What is this?
  
  RRID:IMSR_JAX:016977
Visit annotations in context

Tags

RRID:IMSR_JAX:016977

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1535610822003245
Jul 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Somatic mutations activating the mTOR pathway in dorsal telencephalic progenitors cause a continuum of cortical dysplasias

1
1. scibot 27 Jul 2021
  
  in Public
  
  RRID:MGI_5000472
  
  DOI: 10.1016/j.celrep.2017.11.106
  
  Resource: (IMSR Cat# JAX_016977,RRID:IMSR_JAX:016977)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:016977
  
  Curator comments: IMSR Cat# JAX:016977, FVB.129S6-Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/J Mus musculus
  
  What is this?
  
  RRID:IMSR_JAX:016977 RRIDCUR:Unresolved RRIDCUR:Incorrect
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Tags

RRID:IMSR_JAX:016977

RRIDCUR:Incorrect

RRIDCUR:Unresolved

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC5752134/
Nov 2020
www.sciencedirect.com www.sciencedirect.com

ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation

1
1. scibot 14 Nov 2020
  
  in Public
  
  (Gt)Rosa26Pik3ca∗H1047R
  
  DOI: 10.1016/j.celrep.2020.108366
  
  Resource: (IMSR Cat# JAX_016977,RRID:IMSR_JAX:016977)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:016977
  
  Curator comments: FVB.129S6-Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/J Mus musculus IMSR Cat# JAX:016977
  
  What is this?
  
  RRID:IMSR_JAX:016977 RRIDCUR:Missing
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Tags

RRIDCUR:Missing

RRID:IMSR_JAX:016977

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124720313553
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas

1
1. scibot 09 Sep 2020
  
  in Public
  
  RRID:IMSR_JAX:016977
  
  DOI: 10.1016/j.ccell.2020.02.002
  
  Resource: (IMSR Cat# JAX_016977,RRID:IMSR_JAX:016977)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:016977
  
  What is this?
  
  RRID:IMSR_JAX:016977 RRIDCUR:Validated
Visit annotations in context

Tags

RRID:IMSR_JAX:016977

RRIDCUR:Validated

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S153561082030091X