Hypothesis

21 Matching Annotations

Nov 2025
www.biorxiv.org www.biorxiv.org

The electrophilic metabolite of kynurenine, kynurenine-CKA, targets C151 in Keap1 to derepress Nrf2

1
1. scibot 25 Nov 2025
  
  in Public
  
  RRID:IMSR_JAX:017009
  
  DOI: 10.1101/2025.11.18.689077
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

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scibot

URL

biorxiv.org/content/10.1101/2025.11.18.689077v1
Aug 2025
www.cell.com www.cell.com

A mechano-resistance mechanism in skin adapts to terrestrial locomotion

1
1. scibot 08 Aug 2025
  
  in Public
  
  Stock No: 017009
  
  DOI: 10.1016/j.cell.2025.07.012
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

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scibot

URL

cell.com/cell/fulltext/S0092-8674(25)00801-3
Jul 2025
www.sciencedirect.com www.sciencedirect.com

Phenotypic screening in influenza-infected zebrafish identifies Nrf2-mediated compound protective against ischemia-reperfusion injury

1
1. scibot 22 Jul 2025
  
  in Public
  
  RRID:IMSR_JAX:017009
  
  DOI: 10.1016/j.isci.2025.113065
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

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scibot

URL

sciencedirect.com/science/article/pii/S2589004225013264
www.cell.com www.cell.com

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

1
1. scibot 15 Jul 2025
  
  in Public
  
  Stock No: 017009
  
  DOI: 10.1016/j.cell.2025.06.018
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

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scibot

URL

cell.com/cell/fulltext/S0092-8674(25)00684-1
Jun 2025
www.sciencedirect.com www.sciencedirect.com

Itaconate promotes inflammatory responses in tissue-resident alveolar macrophages and exacerbates acute lung injury

1
1. scibot 17 Jun 2025
  
  in Public
  
  Jackson Laboratory Stock_017009
  
  DOI: 10.1016/j.cmet.2025.05.012
  
  Resource: None
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009 RRIDCUR:Unresolved
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RRID:IMSR_JAX:017009

RRIDCUR:Unresolved

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scibot

URL

sciencedirect.com/science/article/pii/S1550413125002682
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription

1
1. scibot 15 Nov 2024
  
  in Public
  
  017009
  
  DOI: 10.1016/j.redox.2018.04.001
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @AleksanderDrozdz
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC5953240/
Sep 2024
www.nature.com www.nature.com

Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium

1
1. scibot 27 Sep 2024
  
  in Public
  
  RRID:IMSR_JAX:017009
  
  DOI: 10.1038/s41588-024-01875-8
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
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  RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

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scibot

URL

nature.com/articles/s41588-024-01875-8
Jul 2024
www.biorxiv.org www.biorxiv.org

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors

1
1. scibot 03 Jul 2024
  
  in Public
  
  RRID:IMSR_JAX:017009
  
  DOI: 10.1101/2024.06.24.600383
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

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scibot

URL

biorxiv.org/content/10.1101/2024.06.24.600383v1
Mar 2024
www.sciencedirect.com www.sciencedirect.com

Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway

1
1. scibot 27 Mar 2024
  
  in Public
  
  RRID:IMSR_JAX
  
  DOI: 10.1016/j.devcel.2024.03.002
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRIDCUR:Unresolved RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

RRIDCUR:Unresolved

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1534580724001424
Jan 2024
www.sciencedirect.com www.sciencedirect.com

Under peroxisome proliferation acyl-CoA oxidase coordinates with catalase to enhance ethanol metabolism

1
1. scibot 03 Jan 2024
  
  in Public
  
  017009
  
  DOI: 10.1016/j.freeradbiomed.2023.08.016
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @bandrow
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

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scibot

URL

sciencedirect.com/science/article/pii/S0891584923005889
Oct 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SIRT2 inhibition protects against cardiac hypertrophy and ischemic injury

1
1. scibot 12 Oct 2023
  
  in Public
  
  RRID:IMSR_JAX:017009
  
  DOI: 10.7554/eLife.85571
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10558204/
Sep 2023
www.sciencedirect.com www.sciencedirect.com

Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease

1
1. scibot 01 Sep 2023
  
  in Public
  
  RRID:IMSR_JAX:017009
  
  DOI: 10.1016/j.ebiom.2023.104778
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

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scibot

URL

sciencedirect.com/science/article/pii/S2352396423003444
Mar 2023
www.biorxiv.org www.biorxiv.org

Epithelioids: Self-sustaining 3D epithelial cultures to study long-term processes

1
1. scibot 02 Mar 2023
  
  in Public
  
  RRID:IMSR_JAX:017009
  
  DOI: 10.1101/2023.01.03.522589
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

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scibot

URL

biorxiv.org/content/10.1101/2023.01.03.522589v1
May 2022
www.sciencedirect.com www.sciencedirect.com

Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs

1
1. scibot 19 May 2022
  
  in Public
  
  JAX:017009
  
  DOI: 10.1016/j.immuni.2022.04.015
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

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scibot

URL

sciencedirect.com/science/article/pii/S1074761322001868
www.mdpi.com www.mdpi.com

Activation of Nrf2 in Mice Causes Early Microvascular Cyclooxygenase-Dependent Oxidative Stress and Enhanced Contractility

1
1. scibot 10 May 2022
  
  in Public
  
  RRID:IMSR_JAX:017009
  
  DOI: 10.3390/antiox11050845
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

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scibot

URL

mdpi.com/2076-3921/11/5/845
May 2021
www.sciencedirect.com www.sciencedirect.com

Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection

1
1. scibot 19 May 2021
  
  in Public
  
  https://www.jax.org/strain/017009
  
  DOI: 10.1016/j.xcrm.2021.100277
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009 RRIDCUR:Missing
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RRID:IMSR_JAX:017009

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2666379121001051
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome

1
1. scibot 29 Apr 2021
  
  in Public
  
  RRID:IMSR_JAX:017009
  
  DOI: 10.1016/j.cmet.2020.05.003
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1550413120302424
www.sciencedirect.com www.sciencedirect.com

Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis

1
1. scibot 23 Apr 2021
  
  in Public
  
  Strain: 017009
  
  DOI: 10.1016/j.ccell.2021.02.016
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRIDCUR:Missing RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1535610821001185
Mar 2021
www.sciencedirect.com www.sciencedirect.com

Itaconate confers tolerance to late NLRP3 inflammasome activation

1
1. scibot 11 Mar 2021
  
  in Public
  
  Stock# 017009
  
  DOI: 10.1016/j.celrep.2021.108756
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009 RRIDCUR:Missing
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RRID:IMSR_JAX:017009

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124721000693
Sep 2020
www.sciencedirect.com www.sciencedirect.com

The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

1
1. scibot 03 Sep 2020
  
  in Public
  
  Jackson LaboratoryCat# 017009
  
  DOI: 10.1016/j.immuni.2020.03.004
  
  Resource: (IMSR Cat# JAX_017009,RRID:IMSR_JAX:017009)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  What is this?
  
  RRID:IMSR_JAX:017009
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RRID:IMSR_JAX:017009

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scibot

URL

sciencedirect.com/science/article/pii/S1074761320301175
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

1
1. scibot 05 Nov 2018
  
  in Public
  
  017009
  
  Curator: @Jmenke
  
  Resource used:
  
  RRID:IMSR_JAX:017009
  
  SciCrunch record: RRID:IMSR_JAX:017009
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:017009 RRIDCUR:Missing
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RRID:IMSR_JAX:017009

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1550413118303966