Hypothesis

32 Matching Annotations

Mar 2026
dx.doi.org dx.doi.org

Perturbation of azurophilic granule integrity drives NLRP3-independent IL-1β processing and release in neutrophils

1
1. scibot 31 Mar 2026
  
  in Public
  
  RRID: IMSR_JAX: 021302
  
  DOI: 10.1093/jimmun/vkag033
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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scibot

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dx.doi.org/10.1093/jimmun/vkag033
Feb 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cry2 deficiency leads to cognitive impairment through the microbiota-gut-brain axis mediated S1P/NLRP3/IL-1β pathway in mice

1
1. scibot 21 Feb 2026
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.1186/s12974-026-03706-5
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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pmc.ncbi.nlm.nih.gov/articles/PMC12918613/
Sep 2025
www.science.org www.science.org

Dietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1β–mediated inflammation in mice and humans

1
1. scibot 04 Sep 2025
  
  in Public
  
  JAX, no. 021302
  
  DOI: 10.1126/scitranslmed.adp5653
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

science.org/doi/10.1126/scitranslmed.adp5653
Jul 2025
www.embopress.org www.embopress.org

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal

1
1. scibot 22 Jul 2025
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.1038/s44318-025-00507-z
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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scibot

URL

embopress.org/doi/full/10.1038/s44318-025-00507-z
www.embopress.org www.embopress.org

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11

1
1. scibot 22 Jul 2025
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.1038/s44318-025-00507-z
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

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embopress.org/doi/10.1038/s44318-025-00507-z
Jun 2025
www.sciencedirect.com www.sciencedirect.com

1-s2.0-S2589004225009149-main-html.html

1
1. scibot 13 Jun 2025
  
  in Public
  
  Jackson Laboratory#021302
  
  DOI: 10.1016/j.isci.2025.112653
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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sciencedirect.com/science/article/pii/S2589004225009149
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection

1
1. scibot 19 May 2025
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.1038/s44318-025-00412-5
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12048508/
Mar 2025
www.sciencedirect.com www.sciencedirect.com

The actin and microtubule network regulator WHAMM is identified as a key kidney disease risk gene

1
1. scibot 29 Mar 2025
  
  in Public
  
  Jackson LaboratoryStock#21302
  
  DOI: 10.1016/j.celrep.2025.115462
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

sciencedirect.com/science/article/pii/S2211124725002335
Feb 2025
www.sciencedirect.com www.sciencedirect.com

Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP

1
1. scibot 25 Feb 2025
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.1016/j.celrep.2025.115340
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

sciencedirect.com/science/article/pii/S2211124725001111
Jan 2025
www.sciencedirect.com www.sciencedirect.com

Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells

1
1. scibot 03 Jan 2025
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.1016/j.cell.2024.11.018
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

sciencedirect.com/science/article/pii/S0092867424013345
Dec 2024
www.sciencedirect.com www.sciencedirect.com

A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control

1
1. scibot 02 Dec 2024
  
  in Public
  
  JAX# 021302
  
  DOI: 10.1016/j.immuni.2024.10.010
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @vtello
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

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sciencedirect.com/science/article/pii/S1074761324004904
Oct 2024
aacrjournals.org aacrjournals.org

Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation

1
1. scibot 02 Oct 2024
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.1158/2326-6066.CIR-20-1043
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

aacrjournals.org/cancerimmunolres/article/9/9/1008/666146/Overproduction-of-Gastrointestinal-5-HT-Promotes
Sep 2024
onlinelibrary.wiley.com onlinelibrary.wiley.com

Enteric glial NLRP3 inflammasome contributes to gut mucosal barrier alterations in a mouse model of diet-induced obesity

1
1. scibot 27 Sep 2024
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.1111/apha.14232
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

onlinelibrary.wiley.com/doi/10.1111/apha.14232
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

NLRP3 promotes allergic responses to birch pollen extract in a model of intranasal sensitization

1
1. scibot 03 Jul 2024
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.3389/fimmu.2024.1393819
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC11199694/
Dec 2023
www.sciencedirect.com www.sciencedirect.com

Emulsion and liposome-based adjuvanted R21 vaccine formulations mediate protection against malaria through distinct immune mechanisms

1
1. scibot 02 Dec 2023
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.1016/j.xcrm.2023.101245
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

sciencedirect.com/science/article/pii/S2666379123004226
Oct 2023
www.sciencedirect.com www.sciencedirect.com

Inflammasome-mediated glucose limitation induces antibiotic tolerance in Staphylococcus aureus

1
1. scibot 01 Oct 2023
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.1016/j.isci.2023.107942
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

sciencedirect.com/science/article/pii/S2589004223020199
Apr 2023
aacrjournals.org aacrjournals.org

IL-18 receptor signaling regulates tumor-reactive CD8+ T-cell exhaustion via activation of the IL-2/STAT5/mTOR pathway in a pancreatic cancer model

1
1. scibot 21 Apr 2023
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.1158/2326-6066.CIR-22-0398
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

aacrjournals.org/cancerimmunolres/article/11/4/421/718978/IL18-Receptor-Signaling-Regulates-Tumor-Reactive
Oct 2022
www.sciencedirect.com www.sciencedirect.com

Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice

1
1. scibot 26 Oct 2022
  
  in Public
  
  021302
  
  DOI: 10.1016/j.celrep.2022.111532
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

sciencedirect.com/science/article/pii/S2211124722013882
Sep 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MLKL protects against Clostridium perfringens infection by enhancing NLRP3 inflammasome-extracellular traps axis

1
1. scibot 30 Sep 2022
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.1016/j.isci.2022.105121
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9515590/
Jun 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Age and Chronodisruption in Mouse Heart: Effect of the NLRP3 Inflammasome and Melatonin Therapy

1
1. scibot 25 Jun 2022
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.3390/ijms23126846
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9224376/
www.sciencedirect.com www.sciencedirect.com

Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease

1
1. scibot 02 Jun 2022
  
  in Public
  
  Jackson LaboratoryStock No: 021302
  
  DOI: 10.1016/j.neuron.2022.05.009
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

sciencedirect.com/science/article/pii/S0896627322004500
Nov 2021
www.sciencedirect.com www.sciencedirect.com

APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis

1
1. scibot 09 Nov 2021
  
  in Public
  
  Stock#21302
  
  DOI: 10.1016/j.immuni.2021.10.004
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
  What is this?
  
  RRID:IMSR_JAX:021302 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:IMSR_JAX:021302

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scibot

URL

sciencedirect.com/science/article/pii/S1074761321004106
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Hemozoin-mediated inflammasome activation limits long-lived anti-malarial immunity

1
1. scibot 25 Aug 2021
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.1016/j.celrep.2021.109586
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

sciencedirect.com/science/article/pii/S2211124721010202
Jun 2021
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

1
1. scibot 25 Jun 2021
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.1111/bph.15532
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15532
Apr 2021
www.sciencedirect.com www.sciencedirect.com

The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis

1
1. scibot 23 Apr 2021
  
  in Public
  
  JAX 021302
  
  DOI: 10.1016/j.cell.2020.05.048
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
  What is this?
  
  RRIDCUR:Missing RRID:IMSR_JAX:021302
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RRIDCUR:Missing

RRID:IMSR_JAX:021302

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scibot

URL

sciencedirect.com/science/article/pii/S0092867420306814
Jan 2021
www.sciencedirect.com www.sciencedirect.com

Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen

1
1. scibot 22 Jan 2021
  
  in Public
  
  JAX 021302
  
  DOI: 10.1016/j.celrep.2020.108613
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
  What is this?
  
  RRIDCUR:Missing RRID:IMSR_JAX:021302
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RRIDCUR:Missing

RRID:IMSR_JAX:021302

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720316028
Nov 2020
www.sciencedirect.com www.sciencedirect.com

Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity

1
1. scibot 24 Nov 2020
  
  in Public
  
  B6.129S6-Nlrp3tm1Bhk/J (NLRP3 −/−)
  
  DOI: 10.1016/j.celrep.2020.108381
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
  Curator comments: B6.129S6-Nlrp3tm1Bhk/J Mus musculus IMSR Cat# JAX:021302
  
  What is this?
  
  RRIDCUR:Missing RRID:IMSR_JAX:021302
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RRIDCUR:Missing

RRID:IMSR_JAX:021302

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scibot

URL

sciencedirect.com/science/article/pii/S221112472031370X
Sep 2020
www.sciencedirect.com www.sciencedirect.com

A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling

1
1. scibot 03 Sep 2020
  
  in Public
  
  JAX stock #021302
  
  DOI: 10.1016/j.celrep.2020.03.030
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
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  RRID:IMSR_JAX:021302
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RRID:IMSR_JAX:021302

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720303442
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:IMSR_JAX:021302
  
  DOI: 10.1016/j.ccell.2019.04.003
  
  Resource: (IMSR Cat# JAX_021302,RRID:IMSR_JAX:021302)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
  What is this?
  
  RRID:IMSR_JAX:021302 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:IMSR_JAX:021302

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scibot

URL

sciencedirect.com/science/article/pii/S1535610819301989
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages

1
1. scibot 05 Nov 2018
  
  in Public
  
  JAX:021302
  
  Curator: @Jmenke
  
  Resource used:
  
  RRID:IMSR_JAX:021302
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:021302 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:IMSR_JAX:021302

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scibot

URL

sciencedirect.com/science/article/pii/S1074761318303844
www.sciencedirect.com www.sciencedirect.com

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

1
1. scibot 05 Nov 2018
  
  in Public
  
  021302
  
  Curator: @Jmenke
  
  Resource used:
  
  RRID:IMSR_JAX:021302
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:021302 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:IMSR_JAX:021302

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scibot

URL

sciencedirect.com/science/article/pii/S1931312818302634
Nov 2017
www.sciencedirect.com www.sciencedirect.com

Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity

1
1. scibot 08 Nov 2017
  
  in Public
  
  JAX 021302
  
  Curator: @Jmenke
  
  Resource used:
  
  RRID:IMSR_JAX:021302
  
  SciCrunch record: RRID:IMSR_JAX:021302
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:021302 RRIDCUR:Missing
Visit annotations in context

Tags

RRIDCUR:Missing

RRID:IMSR_JAX:021302

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1550413117302103