109 Matching Annotations
  1. Oct 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in multiple sclerosis
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    sciencedirect.com/science/article/pii/S1074761325004182
  3. Sep 2025
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    Gut microbe-derived metabolites drive psoriatic inflammation via modulation of skin Th17 cells
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    sciencedirect.com/science/article/pii/S1074761325003693
  5. www.science.org www.science.org
    Follicular regulatory T cells promote experimental autoimmune encephalomyelitis by supporting B cell egress from germinal centers
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    science.org/doi/10.1126/scitranslmed.ady1268
  6. Aug 2025
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    An age-related decrease in leptin contributes to CD8+ T cell aging in the tumor microenvironment
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    sciencedirect.com/science/article/pii/S2666379125003830
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    The transcription factor BATF pioneers the differentiation program of effector CD8+ T cells through the interaction with IRF4
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    sciencedirect.com/science/article/pii/S2211124725009003
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    Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
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    sciencedirect.com/science/article/pii/S155041312500333X
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    T cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL-1 and TNFα Inflammation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11790381/
  11. www.sciencedirect.com www.sciencedirect.com
    Stress-induced glucocorticoids enhance acute inflammation by promoting the differentiation of Th17 cells
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    sciencedirect.com/science/article/pii/S2211124725008642
  12. Jul 2025
  13. www.biorxiv.org www.biorxiv.org
    Pik3ip1/TrIP Regulation of PI3K Restricts CD8 T Cell Anti-Tumor Immunity
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    biorxiv.org/content/10.1101/2025.07.10.664200v1
  14. Jun 2025
  15. www.science.org www.science.org
    CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity
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    science.org/doi/10.1126/sciimmunol.adq8860
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    ILC3s sense gut microbiota through STING to initiate immune tolerance
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    sciencedirect.com/science/article/pii/S1074761325002377
  17. www.sciencedirect.com www.sciencedirect.com
    Cellular mechanisms underlying beneficial versus detrimental effects of bacterial antitumor immunotherapy
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    sciencedirect.com/science/article/pii/S1074761325001943
  18. Apr 2025
  19. academic.oup.com academic.oup.com
    Mitochondrial fatty acid synthesis and MECR regulate CD4+ T cell function and oxidative metabolism
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    academic.oup.com/jimmunol/advance-article/doi/10.1093/jimmun/vkaf034/8109544
  20. Mar 2025
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness
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    pmc.ncbi.nlm.nih.gov/articles/PMC11880246/
  22. Feb 2025
  23. www.sciencedirect.com www.sciencedirect.com
    Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling
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    sciencedirect.com/science/article/pii/S221112472500052X
  24. www.sciencedirect.com www.sciencedirect.com
    ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation
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    sciencedirect.com/science/article/pii/S0092867425000960
  25. Dec 2024
  26. www.sciencedirect.com www.sciencedirect.com
    EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function
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    sciencedirect.com/science/article/pii/S1535610824004410
  27. Sep 2024
  28. www.pnas.org www.pnas.org
    Disruption of the ZFP574–THAP12 complex suppresses B cell malignancies in mice
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    pnas.org/doi/abs/10.1073/pnas.2409232121
  29. www.sciencedirect.com www.sciencedirect.com
    The transcription regulator ID3 maintains tumor-specific memory CD8+ T cells in draining lymph nodes during tumorigenesis
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    sciencedirect.com/science/article/pii/S2211124724010416
  30. www.sciencedirect.com www.sciencedirect.com
    Smarcd1 subunit of SWI/SNF chromatin-remodeling complexes collaborates with E2a to promote murine lymphoid specification
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    sciencedirect.com/science/article/pii/S1534580724004908
  31. Jul 2024
  32. www.sciencedirect.com www.sciencedirect.com
    MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells
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    sciencedirect.com/science/article/pii/S2211124724008945
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses
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    ncbi.nlm.nih.gov/pmc/articles/PMC11263643/
  34. www.sciencedirect.com www.sciencedirect.com
    A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation
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    sciencedirect.com/science/article/pii/S1550413124002353
  35. www.cell.com www.cell.com
    GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development
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    cell.com/developmental-cell/abstract/S1534-5807(24)00385-X
  36. May 2024
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8+ T cell adoptive therapies in pre-clinical studies
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    ncbi.nlm.nih.gov/pmc/articles/PMC11126743/
  38. www.biorxiv.org www.biorxiv.org
    Dynamic fibroblast-immune interactions shape wound healing after brain injury
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    biorxiv.org/content/10.1101/2024.03.13.584873v1
  39. www.sciencedirect.com www.sciencedirect.com
    Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation
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    sciencedirect.com/science/article/pii/S1074761324002280
  40. www.sciencedirect.com www.sciencedirect.com
    Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy
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    sciencedirect.com/science/article/pii/S0092867424004100
  41. 52.53.155.43 52.53.155.43
    Ablation of Atp5if1 impairs metabolic reprogramming and proliferation of T lymphocytes and compromises mouse survival
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    52.53.155.43/78682a2f6a3221e55b1ab1536c5aacb68d35b4d1/PIIS258900422401085X-html.html
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages
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    ncbi.nlm.nih.gov/pmc/articles/PMC11022165/
  43. Apr 2024
  44. www.sciencedirect.com www.sciencedirect.com
    ER-associated degradation adapter Sel1L is required for CD8+ T cell function and memory formation following acute viral infection
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    sciencedirect.com/science/article/pii/S2211124724004844
  45. Mar 2024
  46. www.sciencedirect.com www.sciencedirect.com
    Tonic TCR and IL-1β signaling mediate phenotypic alterations of naive CD4+ T cells
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    sciencedirect.com/science/article/pii/S2211124724002821
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages
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    ncbi.nlm.nih.gov/pmc/articles/PMC11022165/
  48. Feb 2024
  49. www.sciencedirect.com www.sciencedirect.com
    LAG-3- and CXCR5-expressing CD4 T cells display progenitor-like properties during chronic visceral leishmaniasis
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    sciencedirect.com/science/article/pii/S2211124724002079
  50. www.sciencedirect.com www.sciencedirect.com
    Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells
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    sciencedirect.com/science/article/pii/S1074761324000451
  51. www.sciencedirect.com www.sciencedirect.com
    The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis
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    sciencedirect.com/science/article/pii/S2211124724001529
  52. www.sciencedirect.com www.sciencedirect.com
    Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment
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    sciencedirect.com/science/article/pii/S2211124724001256
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    T cell-specific P2RX7 favors lung parenchymal CD4+ T cell accumulation in response to severe lung infections
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    ncbi.nlm.nih.gov/pmc/articles/PMC10841667/
  54. Jan 2024
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A molecular signature for IL-10–producing Th1 cells in protozoan parasitic diseases
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    ncbi.nlm.nih.gov/pmc/articles/PMC10807716/
  56. 52.53.155.43 52.53.155.43
    Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors
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    52.53.155.43/93ebbe5a83b6a28b0d01edad42fa81f437079176/sciimmunol.abq2424_sm-html.html
  57. Dec 2023
  58. www.sciencedirect.com www.sciencedirect.com
    De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function
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    sciencedirect.com/science/article/pii/S2211124723015309
  59. Oct 2023
  60. www.sciencedirect.com www.sciencedirect.com
    Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses
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    sciencedirect.com/science/article/pii/S1550413123003674
  61. www.cell.com www.cell.com
    The Transcription Factor IRF4 Determines the Anti-Tumor Immunity of CD8+ T cells
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    cell.com/iscience/abstract/S2589-0042(23)02164-8
  62. Aug 2023
  63. 52.53.155.43 52.53.155.43
    Homeostatic PD-1 signaling restrains EOMES-dependent oligoclonal expansion of liver-resident CD8 T cells
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    52.53.155.43/7d9bf3333b9425342ca4204697d643342388db9f/PIIS2211124723008872-html.html
  64. www.sciencedirect.com www.sciencedirect.com
    Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection
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    sciencedirect.com/science/article/pii/S1074761323003278
  65. Jul 2023
  66. www.sciencedirect.com www.sciencedirect.com
    Ketolysis drives CD8+ T cell effector function through effects on histone acetylation
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    sciencedirect.com/science/article/pii/S107476132300314X
  67. Jun 2023
  68. www.sciencedirect.com www.sciencedirect.com
    Mettl3-m6A-Creb1 forms an intrinsic regulatory axis in maintaining iNKT cell pool and functional differentiation
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    sciencedirect.com/science/article/pii/S2211124723005958
  69. www.sciencedirect.com www.sciencedirect.com
    Quantitative control of Ets1 dosage by a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation
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    sciencedirect.com/science/article/pii/S1074761323002212
  70. May 2023
  71. www.sciencedirect.com www.sciencedirect.com
    STAT3 signaling in B cells controls germinal center zone organization and recycling
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    sciencedirect.com/science/article/pii/S2211124723005235
  72. Apr 2023
  73. www.sciencedirect.com www.sciencedirect.com
    NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection
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    sciencedirect.com/science/article/pii/S2211124723004217
  74. Mar 2023
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces
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    pmc.ncbi.nlm.nih.gov/articles/PMC10225046/
  76. www.sciencedirect.com www.sciencedirect.com
    Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions
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    sciencedirect.com/science/article/pii/S221112472300164X
  77. Jan 2023
  78. www.sciencedirect.com www.sciencedirect.com
    Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes
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    sciencedirect.com/science/article/pii/S1074761322006434
  79. www.sciencedirect.com www.sciencedirect.com
    Tissue-specific metabolic profile drives iNKT cell function during obesity and liver injury
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    sciencedirect.com/science/article/pii/S2211124723000463
  80. www.sciencedirect.com www.sciencedirect.com
    Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22
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    sciencedirect.com/science/article/pii/S1074761322006501
  81. Nov 2022
  82. www.sciencedirect.com www.sciencedirect.com
    Chronic type I interferon signaling promotes lipid-peroxidation-driven terminal CD8+ T cell exhaustion and curtails anti-PD-1 efficacy
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    sciencedirect.com/science/article/pii/S2211124722015182
  83. Sep 2022
  84. www.sciencedirect.com www.sciencedirect.com
    Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation
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    sciencedirect.com/science/article/pii/S2211124722011731
  85. Apr 2022
  86. www.sciencedirect.com www.sciencedirect.com
    SENP1-Sirt3 signaling promotes α-ketoglutarate production during M2 macrophage polarization
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    sciencedirect.com/science/article/pii/S2211124722004120
  87. Mar 2022
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intracellular metabolic adaptation of intraepithelial CD4+CD8αα+ T lymphocytes
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    ncbi.nlm.nih.gov/pmc/articles/PMC8933710/
  89. www.sciencedirect.com www.sciencedirect.com
    Setd2 determines distinct properties of intestinal ILC3 subsets to regulate intestinal immunity
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    sciencedirect.com/science/article/pii/S2211124722002716
  90. www.sciencedirect.com www.sciencedirect.com
    A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts
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    sciencedirect.com/science/article/pii/S1074761322000838
  91. www.sciencedirect.com www.sciencedirect.com
    Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
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    sciencedirect.com/science/article/pii/S2211124722001735
  92. Feb 2022
  93. www.sciencedirect.com www.sciencedirect.com
    Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation
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    sciencedirect.com/science/article/pii/S1074761322000401
  94. www.sciencedirect.com www.sciencedirect.com
    Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation
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    sciencedirect.com/science/article/pii/S1074761321005501
  95. Jan 2022
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua
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    ncbi.nlm.nih.gov/pmc/articles/PMC8700290/
  97. Dec 2021
  98. www.sciencedirect.com www.sciencedirect.com
    Coenzyme A fuels T cell anti-tumor immunity
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    sciencedirect.com/science/article/pii/S1550413121005386
  99. Nov 2021
  100. www.sciencedirect.com www.sciencedirect.com
    MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function
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    sciencedirect.com/science/article/pii/S1074761321004489
  101. www.sciencedirect.com www.sciencedirect.com
    MicroRNA-29 specifies age-related differences in the CD8+ T cell immune response
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    sciencedirect.com/science/article/pii/S2211124721014480
  102. Oct 2021
  103. www.sciencedirect.com www.sciencedirect.com
    Costimulation molecules differentially regulate the ERK-Zfp831 axis to shape T follicular helper cell differentiation
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    sciencedirect.com/science/article/pii/S1074761321004039
  104. Sep 2021
  105. www.sciencedirect.com www.sciencedirect.com
    Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma
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    sciencedirect.com/science/article/pii/S2666379121002573
  106. Aug 2021
  107. www.sciencedirect.com www.sciencedirect.com
    Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes
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    sciencedirect.com/science/article/pii/S2211124721010469
  108. www.sciencedirect.com www.sciencedirect.com
    ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis
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    sciencedirect.com/science/article/pii/S2211124721010408
  109. www.sciencedirect.com www.sciencedirect.com
    Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
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    sciencedirect.com/science/article/pii/S1074761317304806
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection
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    ncbi.nlm.nih.gov/pmc/articles/PMC8315795/
  111. Jul 2021
  112. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1074761318303959
  113. www.sciencedirect.com www.sciencedirect.com
    The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility
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    sciencedirect.com/science/article/pii/S1074761319304509
  114. www.sciencedirect.com www.sciencedirect.com
    Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf
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    sciencedirect.com/science/article/pii/S2211124719312616
  115. www.sciencedirect.com www.sciencedirect.com
    TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision
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    sciencedirect.com/science/article/pii/S1074761319304091
  116. www.sciencedirect.com www.sciencedirect.com
    Oncolytic Viruses Engineered to Enforce Leptin Expression, Reprogram Tumor-Infiltrating T Cell Metabolism, and Promote Tumor Clearance
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    sciencedirect.com/science/article/pii/S107476131930319X
  117. www.sciencedirect.com www.sciencedirect.com
    The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis
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    sciencedirect.com/science/article/pii/S1074761319302420
  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC5759774/
  119. Jun 2021
  120. www.sciencedirect.com www.sciencedirect.com
    Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function
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    sciencedirect.com/science/article/pii/S2211124721005593
  121. May 2021
  122. www.sciencedirect.com www.sciencedirect.com
    Bach2 attenuates IL-2R signaling to control Treg homeostasis and Tfr development
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    sciencedirect.com/science/article/pii/S2211124721004307
  123. www.sciencedirect.com www.sciencedirect.com
    Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis
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    sciencedirect.com/science/article/pii/S1074761320304556
  124. www.sciencedirect.com www.sciencedirect.com
    The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation
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  125. Apr 2021
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    Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy
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  127. Mar 2021
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    Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function
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  129. Feb 2021
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    The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation
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    The kinase PDK1 is critical for promoting T follicular helper cell differentiation
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  132. www.sciencedirect.com www.sciencedirect.com
    Plasma cell dynamics in the bone marrow niche
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  133. Sep 2020
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    mTORC1 Signaling Controls TLR2-Mediated T-Cell Activation by Inducing TIRAP Expression
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  135. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
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    Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
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  137. Aug 2020
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    The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development
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    Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells
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  140. Jan 2020
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    Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells
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  143. Nov 2018
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    Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production
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    Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4
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  146. Nov 2017
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    The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells
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    Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen
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