Hypothesis

18 Matching Annotations

Aug 2026
www.sciencedirect.com www.sciencedirect.com

Space radiation promotes clonal hematopoiesis and hematologic disease upon aging in a driver gene and sex-specific manner

1
1. scibot 14 Aug 2026
  
  in Public
  
  RRID:IMSR_JAX:023359
  
  DOI: 10.1016/j.isci.2026.116877
  
  Resource: (IMSR Cat# JAX_023359,RRID:IMSR_JAX:023359)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
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  RRID:IMSR_JAX:023359
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RRID:IMSR_JAX:023359

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scibot

URL

sciencedirect.com/science/article/pii/S2589004226022558
Jun 2026
www.sciencedirect.com www.sciencedirect.com

B cell TET2 recruits OGT for nuclear TET2 and H2B O-GlcNAcylation to drive AID and BLIMP-1 expression and maturation of the antibody response

1
1. scibot 11 Jun 2026
  
  in Public
  
  RRID:IMSR_JAX:023359
  
  DOI: 10.1016/j.celrep.2026.117370
  
  Resource: (IMSR Cat# JAX_023359,RRID:IMSR_JAX:023359)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  What is this?
  
  RRID:IMSR_JAX:023359
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RRID:IMSR_JAX:023359

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scibot

URL

sciencedirect.com/science/article/pii/S2211124726004481
Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

TET2-loss enhances immediate and time-resolved IFNγ signaling responses across myeloid differentiation

1
1. scibot 23 Jan 2026
  
  in Public
  
  RRID:IMSR_JAX:023359
  
  DOI: 10.1016/j.exphem.2025.104727
  
  Resource: (IMSR Cat# JAX_023359,RRID:IMSR_JAX:023359)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  What is this?
  
  RRID:IMSR_JAX:023359
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RRID:IMSR_JAX:023359

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12445325/
Oct 2025
www.sciencedirect.com www.sciencedirect.com

TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors

1
1. scibot 18 Oct 2025
  
  in Public
  
  RRID:IMSR_JAX:023359
  
  DOI: 10.1016/j.ccell.2025.09.011
  
  Resource: (IMSR Cat# JAX_023359,RRID:IMSR_JAX:023359)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  What is this?
  
  RRID:IMSR_JAX:023359
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RRID:IMSR_JAX:023359

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scibot

URL

sciencedirect.com/science/article/pii/S1535610825004039
Jul 2025
www.cell.com www.cell.com

TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice

1
1. scibot 10 Jul 2025
  
  in Public
  
  RRID:IMSR_JAX:023359
  
  DOI: 10.1016/j.stem.2025.06.006
  
  Resource: (IMSR Cat# JAX_023359,RRID:IMSR_JAX:023359)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  What is this?
  
  RRID:IMSR_JAX:023359
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RRID:IMSR_JAX:023359

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scibot

URL

cell.com/cell-stem-cell/fulltext/S1934-5909(25)00228-0
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis

1
1. scibot 11 Jun 2025
  
  in Public
  
  RRID:IMSR_JAX:023359
  
  DOI: 10.1158/2159-8290.CD-24-0093
  
  Resource: (IMSR Cat# JAX_023359,RRID:IMSR_JAX:023359)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  What is this?
  
  RRID:IMSR_JAX:023359
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RRID:IMSR_JAX:023359

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11611684/
Dec 2024
www.nature.com www.nature.com

Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability in mice

1
1. scibot 06 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:023359
  
  DOI: 10.1038/s42003-024-07312-0
  
  Resource: (IMSR Cat# JAX_023359,RRID:IMSR_JAX:023359)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  What is this?
  
  RRID:IMSR_JAX:023359
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RRID:IMSR_JAX:023359

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scibot

URL

nature.com/articles/s42003-024-07312-0
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TET proteins regulate Drosha expression and impact microRNAs in iNKT cells

1
1. scibot 06 Oct 2024
  
  in Public
  
  RRID:IMSR_JAX:023359
  
  DOI: 10.3389/fimmu.2024.1440044
  
  Resource: (IMSR Cat# JAX_023359,RRID:IMSR_JAX:023359)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  What is this?
  
  RRID:IMSR_JAX:023359
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RRID:IMSR_JAX:023359

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC11446755/
www.biorxiv.org www.biorxiv.org

Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy

1
1. scibot 02 Oct 2024
  
  in Public
  
  RRID:IMSR_JAX:023359
  
  DOI: 10.1101/2024.09.09.612140
  
  Resource: (IMSR Cat# JAX_023359,RRID:IMSR_JAX:023359)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  What is this?
  
  RRID:IMSR_JAX:023359
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RRID:IMSR_JAX:023359

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scibot

URL

biorxiv.org/content/10.1101/2024.09.09.612140v1
Aug 2024
www.biorxiv.org www.biorxiv.org

TET proteins regulate Drosha expression and impact microRNAs in iNKT cells

1
1. scibot 18 Aug 2024
  
  in Public
  
  RRID:IMSR_JAX:023359
  
  DOI: 10.1101/2024.07.31.605991
  
  Resource: (IMSR Cat# JAX_023359,RRID:IMSR_JAX:023359)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  What is this?
  
  RRID:IMSR_JAX:023359
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RRID:IMSR_JAX:023359

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scibot

URL

biorxiv.org/content/10.1101/2024.07.31.605991v1
www.biorxiv.org www.biorxiv.org

Tet2 loss suppress α-synuclein pathology by stimulating ciliogenesis

1
1. scibot 14 Aug 2024
  
  in Public
  
  023359
  
  DOI: 10.1101/2024.08.02.606408
  
  Resource: (IMSR Cat# JAX_023359,RRID:IMSR_JAX:023359)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  What is this?
  
  RRID:IMSR_JAX:023359
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RRID:IMSR_JAX:023359

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scibot

URL

biorxiv.org/content/10.1101/2024.08.02.606408v1
Sep 2023
www.sciencedirect.com www.sciencedirect.com

TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal

1
1. scibot 29 Sep 2023
  
  in Public
  
  RRID:IMSR_JAX:023359
  
  DOI: 10.1016/j.stem.2023.07.001
  
  Resource: (IMSR Cat# JAX_023359,RRID:IMSR_JAX:023359)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  What is this?
  
  RRID:IMSR_JAX:023359
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RRID:IMSR_JAX:023359

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scibot

URL

sciencedirect.com/science/article/pii/S1934590923002461
Jan 2022
www.sciencedirect.com www.sciencedirect.com

Opioid receptor signaling suppresses leukemia through both catalytic and non-catalytic functions of TET2

1
1. scibot 26 Jan 2022
  
  in Public
  
  The Jackson LaboratoryStock No: 023359
  
  DOI: 10.1016/j.celrep.2021.110253
  
  Resource: (IMSR Cat# JAX_023359,RRID:IMSR_JAX:023359)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  What is this?
  
  RRID:IMSR_JAX:023359
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RRID:IMSR_JAX:023359

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scibot

URL

sciencedirect.com/science/article/pii/S2211124721017654
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis

1
1. scibot 27 Apr 2021
  
  in Public
  
  Cat# 023359
  
  DOI: 10.1016/j.cell.2021.01.049
  
  Resource: (IMSR Cat# JAX_023359,RRID:IMSR_JAX:023359)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  What is this?
  
  RRIDCUR:Missing RRID:IMSR_JAX:023359
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RRID:IMSR_JAX:023359

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0092867421000921
www.sciencedirect.com www.sciencedirect.com

MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism

1
1. scibot 22 Apr 2021
  
  in Public
  
  023359
  
  DOI: 10.1016/j.ccell.2021.02.006
  
  Resource: (IMSR Cat# JAX_023359,RRID:IMSR_JAX:023359)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  What is this?
  
  RRIDCUR:Missing RRID:IMSR_JAX:023359
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RRID:IMSR_JAX:023359

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1535610821001082
Oct 2020
www.sciencedirect.com www.sciencedirect.com

TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity

1
1. scibot 31 Oct 2020
  
  in Public
  
  TET2-KO (B6(Cg)-Tet2tm1.2Rao/J) mice
  
  DOI: 10.1016/j.celrep.2020.108326
  
  Resource: (IMSR Cat# JAX_023359,RRID:IMSR_JAX:023359)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  Curator comments: B6(Cg)-Tet2tm1.2Rao/J Mus musculus IMSR Cat# JAX:023359
  
  What is this?
  
  RRIDCUR:Missing RRID:IMSR_JAX:023359
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RRID:IMSR_JAX:023359

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124720313152
Nov 2018
www.sciencedirect.com www.sciencedirect.com

SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function

1
1. scibot 05 Nov 2018
  
  in Public
  
  023359
  
  Curator: @Jmenke
  
  Resource used:
  
  RRID:IMSR_JAX:023359
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:023359 RRIDCUR:Missing
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RRID:IMSR_JAX:023359

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1934590918303850
Nov 2017
www.sciencedirect.com www.sciencedirect.com

The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression

1
1. scibot 08 Nov 2017
  
  in Public
  
  RRID:IMSR_JAX:023359
  
  Curator: @Jmenke
  
  Resource used:
  
  RRID:IMSR_JAX:023359
  
  SciCrunch record: RRID:IMSR_JAX:023359
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:023359 RRIDCUR:Validated
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RRID:IMSR_JAX:023359

RRIDCUR:Validated

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1074761317303278