Hypothesis

20 Matching Annotations

Oct 2025
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression

1
1. scibot 08 Oct 2025
  
  in Public
  
  Jackson strain #026554
  
  DOI: 10.1002/advs.202508576
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
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  RRID:IMSR_JAX:026554
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RRID:IMSR_JAX:026554

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scibot

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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202508576
Sep 2025
www.sciencedirect.com www.sciencedirect.com

T cell-intrinsic cGAS-CTCF regulation maintains regulatory T cell development and function

1
1. scibot 17 Sep 2025
  
  in Public
  
  RRID:IMSR_JAX:026554
  
  DOI: 10.1016/j.celrep.2025.116302
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
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  RRID:IMSR_JAX:026554
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RRID:IMSR_JAX:026554

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scibot

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sciencedirect.com/science/article/pii/S2211124725010733
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cardiomyocyte cytosolic nuclear self-DNA contributes to the pathogenesis of desmoplakin cardiomyopathy

1
1. scibot 07 Sep 2025
  
  in Public
  
  RRID:IMSR_JAX:026554
  
  DOI: 10.1172/jci.insight.192283
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
  What is this?
  
  RRID:IMSR_JAX:026554
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RRID:IMSR_JAX:026554

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12406735/
Jun 2025
www.sciencedirect.com www.sciencedirect.com

ILC3s sense gut microbiota through STING to initiate immune tolerance

1
1. scibot 17 Jun 2025
  
  in Public
  
  RRID:IMSR_JAX:026554
  
  DOI: 10.1016/j.immuni.2025.05.016
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
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  RRID:IMSR_JAX:026554
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RRID:IMSR_JAX:026554

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scibot

URL

sciencedirect.com/science/article/pii/S1074761325002377
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

cGAS and STING in Host Myeloid Cells Are Essential for Effective Cyclophosphamide Treatment of Advanced Breast Cancer

1
1. scibot 19 Apr 2025
  
  in Public
  
  RRID:IMSR_JAX:026554
  
  DOI: 10.3390/cancers17071130
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
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  RRID:IMSR_JAX:026554
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RRID:IMSR_JAX:026554

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11987962/
Jun 2024
www.sciencedirect.com www.sciencedirect.com

Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice

1
1. scibot 04 Jun 2024
  
  in Public
  
  026554
  
  DOI: 10.1016/j.celrep.2024.114284
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
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  RRID:IMSR_JAX:026554 DOI:10.1016/j.celrep.2024.114284
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DOI:10.1016/j.celrep.2024.114284

RRID:IMSR_JAX:026554

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scibot

URL

sciencedirect.com/science/article/pii/S2211124724006120
Mar 2024
www.sciencedirect.com www.sciencedirect.com

Type-I-interferon-responsive microglia shape cortical development and behavior

2
1. scibot 15 Mar 2024
  
  in Public
  
  RRID:IMSR_JAX:026554
  
  DOI: 10.1016/j.cell.2024.02.020
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
  What is this?
  
  RRID:IMSR_JAX:026554
2. scibot 15 Mar 2024
  
  in Public
  
  RRID:IMSR_JAX:026554
  
  DOI: 10.1016/j.cell.2024.02.020
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
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  RRID:IMSR_JAX:026554
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RRID:IMSR_JAX:026554

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scibot

URL

sciencedirect.com/science/article/pii/S0092867424001867
Oct 2023
www.sciencedirect.com www.sciencedirect.com

Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells

1
1. scibot 14 Oct 2023
  
  in Public
  
  JAX:026554
  
  DOI: 10.1016/j.celrep.2023.113180
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
  What is this?
  
  RRID:IMSR_JAX:026554
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RRID:IMSR_JAX:026554

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scibot

URL

sciencedirect.com/science/article/pii/S2211124723011920
Mar 2023
europepmc.org europepmc.org

Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity

1
1. scibot 23 Mar 2023
  
  in Public
  
  JAX:026554
  
  DOI: 10.1016/j.celrep.2023.112275
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
  What is this?
  
  RRID:IMSR_JAX:026554
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RRID:IMSR_JAX:026554

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scibot

URL

europepmc.org/article/med/36943864
Nov 2022
www.sciencedirect.com www.sciencedirect.com

Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

1
1. scibot 16 Nov 2022
  
  in Public
  
  RRID:IMSR_JAX:026554
  
  DOI: 10.1016/j.neuron.2022.10.028
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
  What is this?
  
  RRID:IMSR_JAX:026554
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RRID:IMSR_JAX:026554

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scibot

URL

sciencedirect.com/science/article/pii/S0896627322009618
May 2022
www.sciencedirect.com www.sciencedirect.com

The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis

1
1. scibot 11 May 2022
  
  in Public
  
  RRID:IMSR_JAX:026554
  
  DOI: 10.1016/j.immuni.2022.04.006
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
  What is this?
  
  RRID:IMSR_JAX:026554
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RRID:IMSR_JAX:026554

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scibot

URL

sciencedirect.com/science/article/pii/S1074761322001777
Apr 2022
www.sciencedirect.com www.sciencedirect.com

Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS

1
1. scibot 27 Apr 2022
  
  in Public
  
  JAX:026554
  
  DOI: 10.1016/j.molcel.2022.03.034
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
  What is this?
  
  RRID:IMSR_JAX:026554
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RRID:IMSR_JAX:026554

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scibot

URL

sciencedirect.com/science/article/pii/S1097276522002908
Oct 2021
www.sciencedirect.com www.sciencedirect.com

Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair

1
1. scibot 16 Oct 2021
  
  in Public
  
  RRID:IMSR_JAX:026554
  
  DOI: 10.1016/j.neuron.2021.09.040
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
  What is this?
  
  RRID:IMSR_JAX:026554
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RRID:IMSR_JAX:026554

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scibot

URL

sciencedirect.com/science/article/pii/S0896627321007133
Jun 2021
www.cell.com www.cell.com

Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota

1
1. scibot 24 Jun 2021
  
  in Public
  
  Jax 026554
  
  DOI: 10.1016/j.cell.2021.05.020
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
  What is this?
  
  RRID:IMSR_JAX:026554 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:IMSR_JAX:026554

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scibot

URL

cell.com/cell/fulltext/S0092-8674(21)00650-4
May 2021
www.sciencedirect.com www.sciencedirect.com

The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

1
1. scibot 12 May 2021
  
  in Public
  
  RRID:IMSR_JAX:026554
  
  DOI: 10.1016/j.immuni.2021.04.019
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
  What is this?
  
  RRID:IMSR_JAX:026554
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RRID:IMSR_JAX:026554

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scibot

URL

sciencedirect.com/science/article/pii/S1074761321001813
Sep 2020
www.sciencedirect.com www.sciencedirect.com

STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice

1
1. scibot 04 Sep 2020
  
  in Public
  
  Jackson LaboratoryStock# 026554
  
  DOI: 10.1016/j.celrep.2020.107771
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
  What is this?
  
  RRID:IMSR_JAX:026554 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:IMSR_JAX:026554

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124720307518
www.sciencedirect.com www.sciencedirect.com

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

1
1. scibot 03 Sep 2020
  
  in Public
  
  Jackson LaboratoryStock# 026554
  
  DOI: 10.1016/j.immuni.2020.03.016
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
  What is this?
  
  RRID:IMSR_JAX:026554
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RRID:IMSR_JAX:026554

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scibot

URL

sciencedirect.com/science/article/pii/S1074761320301291
www.sciencedirect.com www.sciencedirect.com

TMEM173 Drives Lethal Coagulation in Sepsis

1
1. scibot 03 Sep 2020
  
  in Public
  
  The Jackson Laboratory026554
  
  DOI: 10.1016/j.chom.2020.02.004
  
  Resource: (IMSR Cat# JAX_026554,RRID:IMSR_JAX:026554)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
  What is this?
  
  RRID:IMSR_JAX:026554
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RRID:IMSR_JAX:026554

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scibot

URL

sciencedirect.com/science/article/pii/S1931312820301128
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication

1
1. scibot 05 Nov 2018
  
  in Public
  
  026554
  
  Curator: @Jmenke
  
  Resource used:
  
  RRID:IMSR_JAX:026554
  
  SciCrunch record: RRID:IMSR_JAX:026554
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:026554 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:IMSR_JAX:026554

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1931312818303743