Hypothesis

23 Matching Annotations

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Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

1
1. scibot 10 Apr 2026
  
  in Public
  
  029213
  
  DOI: 10.1002/advs.202515847
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
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  RRID:IMSR_JAX:029213
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RRID:IMSR_JAX:029213

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scibot

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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202515847
Dec 2025
www.sciencedirect.com www.sciencedirect.com

Renal PIEZO2 is an essential regulator of renin

1
1. scibot 11 Dec 2025
  
  in Public
  
  JAX:029213
  
  DOI: 10.1016/j.cell.2025.11.013
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
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  RRID:IMSR_JAX:029213
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RRID:IMSR_JAX:029213

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scibot

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sciencedirect.com/science/article/pii/S0092867425013091
Aug 2025
www.cell.com www.cell.com

A mechano-resistance mechanism in skin adapts to terrestrial locomotion

1
1. scibot 08 Aug 2025
  
  in Public
  
  Stock No: 029213
  
  DOI: 10.1016/j.cell.2025.07.012
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
  What is this?
  
  RRID:IMSR_JAX:029213
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RRID:IMSR_JAX:029213

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scibot

URL

cell.com/cell/abstract/S0092-8674(25)00801-3
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration

1
1. scibot 15 Jul 2025
  
  in Public
  
  RRID:IMSR_JAX:029213
  
  DOI: 10.1016/j.neuron.2019.01.050
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
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  RRID:IMSR_JAX:029213
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RRID:IMSR_JAX:029213

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC6487666/
Jun 2025
www.sciencedirect.com www.sciencedirect.com

Piezo1 senses hyphae and initiates host defense against pathogenic fungi

1
1. scibot 17 Jun 2025
  
  in Public
  
  Jackson LaboratoryStock No: 029213
  
  DOI: 10.1016/j.celrep.2025.115839
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
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  RRID:IMSR_JAX:029213
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RRID:IMSR_JAX:029213

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scibot

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sciencedirect.com/science/article/pii/S2211124725006102
May 2025
www.sciencedirect.com www.sciencedirect.com

Pyroptosis of periodontal ligament stem cells aggravates periodontitis via Piezo1 channel

1
1. scibot 16 May 2025
  
  in Public
  
  The Jackson Laboratory029213
  
  DOI: 10.1016/j.isci.2025.112395
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
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  RRID:IMSR_JAX:029213
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RRID:IMSR_JAX:029213

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scibot

URL

sciencedirect.com/science/article/pii/S258900422500656X
Apr 2025
www.sciencedirect.com www.sciencedirect.com

Potentiation of macrophage Piezo1 by atherogenic 7-ketocholesterol

1
1. scibot 15 Apr 2025
  
  in Public
  
  The Jackson laboratoryCat#029213
  
  DOI: 10.1016/j.celrep.2025.115542
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
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  RRID:IMSR_JAX:029213
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RRID:IMSR_JAX:029213

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scibot

URL

sciencedirect.com/science/article/pii/S2211124725003134
Mar 2025
www.sciencedirect.com www.sciencedirect.com

Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force

1
1. scibot 29 Mar 2025
  
  in Public
  
  Jackson Laboratory Cat_029213
  
  DOI: 10.1016/j.cell.2025.02.031
  
  Resource: None
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
  What is this?
  
  RRID:IMSR_JAX:029213 RRIDCUR:Unresolved
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RRID:IMSR_JAX:029213

RRIDCUR:Unresolved

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scibot

URL

sciencedirect.com/science/article/pii/S0092867425002582
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

1
1. scibot 10 Nov 2024
  
  in Public
  
  RRID:IMSR_JAX:029213
  
  DOI: 10.7554/eLife.97854
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
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  RRID:IMSR_JAX:029213
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RRID:IMSR_JAX:029213

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11542922/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A vagal reflex evoked by airway closure

1
1. scibot 07 Nov 2024
  
  in Public
  
  029213
  
  DOI: 10.1038/s41586-024-07144-2
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @AleksanderDrozdz
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
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  RRID:IMSR_JAX:029213
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RRID:IMSR_JAX:029213

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC10972749/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity

1
1. scibot 27 Sep 2024
  
  in Public
  
  RRID:IMSR_JAX:029213
  
  DOI: 10.1084/jem.20231835
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
  What is this?
  
  RRID:IMSR_JAX:029213
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RRID:IMSR_JAX:029213

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10965393/
May 2024
www.sciencedirect.com www.sciencedirect.com

Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor

1
1. scibot 14 May 2024
  
  in Public
  
  029213
  
  DOI: 10.1016/j.cell.2024.04.023
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
  What is this?
  
  RRID:IMSR_JAX:029213
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RRID:IMSR_JAX:029213

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scibot

URL

sciencedirect.com/science/article/pii/S0092867424004483
www.sciencedirect.com www.sciencedirect.com

Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact

1
1. scibot 14 May 2024
  
  in Public
  
  RRID:IMSR_JAX:029213
  
  DOI: 10.1016/j.cell.2024.04.010
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
  What is this?
  
  RRID:IMSR_JAX:029213
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RRID:IMSR_JAX:029213

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scibot

URL

sciencedirect.com/science/article/pii/S0092867424004057
Dec 2023
www.sciencedirect.com www.sciencedirect.com

trans-Endothelial neutrophil migration activates bactericidal function via Piezo1 mechanosensing

1
1. scibot 17 Dec 2023
  
  in Public
  
  JAX:029213
  
  DOI: 10.1016/j.immuni.2023.11.007
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
  What is this?
  
  RRID:IMSR_JAX:029213
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RRID:IMSR_JAX:029213

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scibot

URL

sciencedirect.com/science/article/pii/S1074761323004892
Feb 2023
www.sciencedirect.com www.sciencedirect.com

The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia

1
1. scibot 09 Feb 2023
  
  in Public
  
  JAX:029
  
  DOI: 10.1016/j.isci.2023.105993
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @sofiakhan13
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
  What is this?
  
  RRID:IMSR_JAX:029213 RRIDCUR:Unresolved
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RRID:IMSR_JAX:029213

RRIDCUR:Unresolved

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scibot

URL

sciencedirect.com/science/article/pii/S2589004223000706
Jan 2023
www.sciencedirect.com www.sciencedirect.com

Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity

1
1. scibot 12 Jan 2023
  
  in Public
  
  RRID:IMSR_JAX:029213
  
  DOI: 10.1016/j.neuron.2022.11.015
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
  What is this?
  
  RRID:IMSR_JAX:029213
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RRID:IMSR_JAX:029213

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scibot

URL

sciencedirect.com/science/article/pii/S0896627322010698
Nov 2022
www.sciencedirect.com www.sciencedirect.com

Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer’s disease

1
1. scibot 11 Nov 2022
  
  in Public
  
  RRID:IMSR_JAX:029213
  
  DOI: 10.1016/j.neuron.2022.10.021
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
  What is this?
  
  RRID:IMSR_JAX:029213
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RRID:IMSR_JAX:029213

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scibot

URL

sciencedirect.com/science/article/pii/S0896627322009540
Dec 2021
www.sciencedirect.com www.sciencedirect.com

Piezo1 and Piezo2 foster mechanical gating of K2P channels

1
1. scibot 01 Dec 2021
  
  in Public
  
  Cat#029213
  
  DOI: 10.1016/j.celrep.2021.110070
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
  What is this?
  
  RRID:IMSR_JAX:029213 RRIDCUR:Missing
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RRID:IMSR_JAX:029213

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S2211124721015564
Oct 2021
www.sciencedirect.com www.sciencedirect.com

Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis

1
1. scibot 08 Oct 2021
  
  in Public
  
  Stock No: 029213
  
  DOI: 10.1016/j.stem.2021.09.009
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
  What is this?
  
  RRID:IMSR_JAX:029213 RRIDCUR:Missing
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RRID:IMSR_JAX:029213

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1934590921003854
Feb 2021
www.sciencedirect.com www.sciencedirect.com

Mechanical Stiffness Controls Dendritic Cell Metabolism and Function

1
1. scibot 28 Feb 2021
  
  in Public
  
  JAX:029213
  
  DOI: 10.1016/j.celrep.2020.108609
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
  What is this?
  
  RRID:IMSR_JAX:029213
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RRID:IMSR_JAX:029213

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720315989
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin

1
1. scibot 24 Feb 2021
  
  in Public
  
  RRID:MSR_JAX:029213
  
  DOI: 10.7554/eLife.52779
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
  Curator comments: STOCK Piezo1tm2.1Apat/J Mus musculus IMSR Cat# JAX:029213
  
  What is this?
  
  RRIDCUR:Unresolved RRID:IMSR_JAX:029213 RRIDCUR:SyntaxError
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RRID:IMSR_JAX:029213

RRIDCUR:SyntaxError

RRIDCUR:Unresolved

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7112954/
Sep 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin

1
1. scibot 17 Sep 2020
  
  in Public
  
  JAX:029213
  
  DOI: 10.7554/eLife.52779
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
  What is this?
  
  RRID:IMSR_JAX:029213 RRIDCUR:Validated
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RRID:IMSR_JAX:029213

RRIDCUR:Validated

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7112954/
Jan 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Stimulation of Piezo1 by mechanical signals promotes bone anabolism

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:IMSR_JAX:029213
  
  DOI: 10.7554/eLife.49631
  
  Resource: (IMSR Cat# JAX_029213,RRID:IMSR_JAX:029213)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:029213
  
  Curator comments: Piezo1tm2.1Apat/J
  
  What is this?
  
  RRID:IMSR_JAX:029213 RRIDCUR:Validated
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RRID:IMSR_JAX:029213

RRIDCUR:Validated

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6779475/