Hypothesis

17 Matching Annotations

Mar 2026
www.sciencedirect.com www.sciencedirect.com

Mitochondrial transfer to granulocytic myeloid-derived suppressor cells augments immunosuppressive activity

1
1. scibot 17 Mar 2026
  
  in Public
  
  RRID:IMSR_JAX:029340
  
  DOI: 10.1016/j.celrep.2026.117057
  
  Resource: (IMSR Cat# JAX_029340,RRID:IMSR_JAX:029340)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  What is this?
  
  RRID:IMSR_JAX:029340
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RRID:IMSR_JAX:029340

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scibot

URL

sciencedirect.com/science/article/pii/S221112472600135X
Jun 2025
www.sciencedirect.com www.sciencedirect.com

Itaconate promotes inflammatory responses in tissue-resident alveolar macrophages and exacerbates acute lung injury

1
1. scibot 17 Jun 2025
  
  in Public
  
  Jackson Laboratory Stock_029340
  
  DOI: 10.1016/j.cmet.2025.05.012
  
  Resource: None
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  What is this?
  
  RRID:IMSR_JAX:029340 RRIDCUR:Unresolved
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RRID:IMSR_JAX:029340

RRIDCUR:Unresolved

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scibot

URL

sciencedirect.com/science/article/pii/S1550413125002682
Dec 2024
www.sciencedirect.com www.sciencedirect.com

Macrophages are activated toward phagocytic lymphoma cell clearance by pentose phosphate pathway inhibition

1
1. scibot 02 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:02
  
  DOI: 10.1016/j.xcrm.2024.101830
  
  Resource: None
  
  Curator: @vtello
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  What is this?
  
  RRID:IMSR_JAX:029340 RRIDCUR:Unresolved
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RRID:IMSR_JAX:029340

RRIDCUR:Unresolved

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scibot

URL

sciencedirect.com/science/article/pii/S2666379124006013
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Itaconate is a metabolic regulator of bone formation in homeostasis and arthritis

1
1. scibot 07 Nov 2024
  
  in Public
  
  RRID:IMSR_JAX:029340
  
  DOI: 10.1136/ard-2023-224898
  
  Resource: (IMSR Cat# JAX_029340,RRID:IMSR_JAX:029340)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  What is this?
  
  RRID:IMSR_JAX:029340
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RRID:IMSR_JAX:029340

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11503170/
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Aconitate decarboxylase 1 mediates the acute airway inflammatory response to environmental exposures

1
1. scibot 05 Oct 2024
  
  in Public
  
  RRID:IMSR_JAX:029340
  
  DOI: 10.3389/fimmu.2024.1432334
  
  Resource: (IMSR Cat# JAX_029340,RRID:IMSR_JAX:029340)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  What is this?
  
  RRID:IMSR_JAX:029340
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RRID:IMSR_JAX:029340

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC11439662/
Feb 2024
www.sciencedirect.com www.sciencedirect.com

Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation

1
1. scibot 09 Feb 2024
  
  in Public
  
  Jackson Laboratory029340
  
  DOI: 10.1016/j.celrep.2024.113746
  
  Resource: (IMSR Cat# JAX_029340,RRID:IMSR_JAX:029340)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  What is this?
  
  RRID:IMSR_JAX:029340
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RRID:IMSR_JAX:029340

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124724000743
www.sciencedirect.com www.sciencedirect.com

Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells

1
1. scibot 08 Feb 2024
  
  in Public
  
  The Jackson Laboratory029340
  
  DOI: 10.1016/j.cmet.2024.01.008
  
  Resource: (IMSR Cat# JAX_029340,RRID:IMSR_JAX:029340)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  What is this?
  
  RRID:IMSR_JAX:029340
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RRID:IMSR_JAX:029340

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1550413124000081
Oct 2023
www.sciencedirect.com www.sciencedirect.com

Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection

1
1. scibot 13 Oct 2023
  
  in Public
  
  JAX:029340
  
  DOI: 10.1016/j.cmet.2023.09.001
  
  Resource: (IMSR Cat# JAX_029340,RRID:IMSR_JAX:029340)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  What is this?
  
  RRID:IMSR_JAX:029340
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RRID:IMSR_JAX:029340

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scibot

URL

sciencedirect.com/science/article/pii/S1550413123003327
www.sciencedirect.com www.sciencedirect.com

Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1

1
1. scibot 13 Oct 2023
  
  in Public
  
  RRID:IMSR_JAX:029340
  
  DOI: 10.1016/j.cmet.2023.09.004
  
  Resource: (IMSR Cat# JAX_029340,RRID:IMSR_JAX:029340)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  What is this?
  
  RRID:IMSR_JAX:029340
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RRID:IMSR_JAX:029340

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scibot

URL

sciencedirect.com/science/article/pii/S1550413123003364
Jul 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Succinate mediates inflammation-induced adrenocortical dysfunction

1
1. scibot 29 Jul 2023
  
  in Public
  
  RRID:IMSR_JAX:029340
  
  DOI: 10.7554/eLife.83064
  
  Resource: (IMSR Cat# JAX_029340,RRID:IMSR_JAX:029340)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  What is this?
  
  RRID:IMSR_JAX:029340
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RRID:IMSR_JAX:029340

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10374281/
Apr 2022
www.sciencedirect.com www.sciencedirect.com

Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection

1
1. scibot 13 Apr 2022
  
  in Public
  
  JAX:029340
  
  DOI: 10.1016/j.cmet.2022.03.009
  
  Resource: (IMSR Cat# JAX_029340,RRID:IMSR_JAX:029340)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  What is this?
  
  RRID:IMSR_JAX:029340
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RRID:IMSR_JAX:029340

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1550413122000973
Jul 2021
www.sciencedirect.com www.sciencedirect.com

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons

1
1. scibot 28 Jul 2021
  
  in Public
  
  029340
  
  DOI: 10.1016/j.immuni.2018.11.017
  
  Resource: (IMSR Cat# JAX_029340,RRID:IMSR_JAX:029340)
  
  Curator: @Jmenke
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  What is this?
  
  RRID:IMSR_JAX:029340 RRIDCUR:Missing
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RRID:IMSR_JAX:029340

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1074761318305259
May 2021
www.sciencedirect.com www.sciencedirect.com

Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection

1
1. scibot 19 May 2021
  
  in Public
  
  https://www.jax.org/strain/029340
  
  DOI: 10.1016/j.xcrm.2021.100277
  
  Resource: (IMSR Cat# JAX_029340,RRID:IMSR_JAX:029340)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  What is this?
  
  RRIDCUR:Missing RRID:IMSR_JAX:029340
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Tags

RRID:IMSR_JAX:029340

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2666379121001051
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome

1
1. scibot 29 Apr 2021
  
  in Public
  
  RRID:IMSR_JAX:029340
  
  DOI: 10.1016/j.cmet.2020.05.003
  
  Resource: (IMSR Cat# JAX_029340,RRID:IMSR_JAX:029340)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  What is this?
  
  RRID:IMSR_JAX:029340
Visit annotations in context

Tags

RRID:IMSR_JAX:029340

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1550413120302424
www.sciencedirect.com www.sciencedirect.com

Pseudomonas aeruginosa Utilizes Host-Derived Itaconate to Redirect Its Metabolism to Promote Biofilm Formation

1
1. scibot 29 Apr 2021
  
  in Public
  
  JAX:029340
  
  DOI: 10.1016/j.cmet.2020.04.017
  
  Resource: (IMSR Cat# JAX_029340,RRID:IMSR_JAX:029340)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  What is this?
  
  RRID:IMSR_JAX:029340
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Tags

RRID:IMSR_JAX:029340

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1550413120301996
Sep 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response

1
1. scibot 17 Sep 2020
  
  in Public
  
  RRID:IMSR_JAX:029340
  
  DOI: 10.7554/eLife.54877
  
  Resource: (IMSR Cat# JAX_029340,RRID:IMSR_JAX:029340)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  What is this?
  
  RRID:IMSR_JAX:029340 RRIDCUR:Validated
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RRID:IMSR_JAX:029340

RRIDCUR:Validated

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7185992/
www.sciencedirect.com www.sciencedirect.com

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

1
1. scibot 03 Sep 2020
  
  in Public
  
  C57BL/6N-Acod1em1(IMPC)J/J
  
  DOI: 10.1016/j.cmet.2020.07.016
  
  Resource: (IMSR Cat# JAX_029340,RRID:IMSR_JAX:029340)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:029340
  
  Curator comments: C57BL/6NJ-Acod1em1(IMPC)J/J Mus musculus IMSR Cat# JAX:029340
  
  What is this?
  
  RRID:IMSR_JAX:029340 RRIDCUR:Missing
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Tags

RRID:IMSR_JAX:029340

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1550413120304113