Hypothesis

17 Matching Annotations

Jul 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Tumor-derived complement C3 overexpression in STK11-mutant lung adenocarcinoma drives tumor growth and immune checkpoint inhibitor resistance

1
1. scibot 11 Jul 2026
  
  in Public
  
  RRID:IMSR_JAX:029661
  
  DOI: 10.1158/2326-6066.CIR-25-0534
  
  Resource: (IMSR Cat# JAX_029661,RRID:IMSR_JAX:029661)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
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  RRID:IMSR_JAX:029661
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RRID:IMSR_JAX:029661

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC13348722/
Jun 2026
www.sciencedirect.com www.sciencedirect.com

The complement C3-microglial axis in depression of Parkinson's disease: from mechanism to therapeutic intervention

1
1. scibot 19 Jun 2026
  
  in Public
  
  RRID:IMSR_JAX
  
  DOI: 10.1016/j.ebiom.2026.106325
  
  Resource: RRID:IMSR_JAX:029661
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
  What is this?
  
  RRIDCUR:Unresolved RRID:IMSR_JAX:029661
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RRIDCUR:Unresolved

RRID:IMSR_JAX:029661

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scibot

URL

sciencedirect.com/science/article/pii/S2352396426002070
Mar 2026
www.nature.com www.nature.com

Natural maternal immunity protects neonates from Escherichia coli sepsis

1
1. scibot 19 Mar 2026
  
  in Public
  
  029661
  
  DOI: 10.1038/s41586-026-10225-z
  
  Resource: (IMSR Cat# JAX_029661,RRID:IMSR_JAX:029661)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
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  RRID:IMSR_JAX:029661
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RRID:IMSR_JAX:029661

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scibot

URL

nature.com/articles/s41586-026-10225-z
Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Complement C3 deficiency enhances renal leptospiral load and inflammation while impairing T cell differentiation during chronic Leptospira interrogans infection

1
1. scibot 18 Dec 2025
  
  in Public
  
  JAX:029661
  
  DOI: 10.1128/iai.00398-25
  
  Resource: (IMSR Cat# JAX_029661,RRID:IMSR_JAX:029661)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
  What is this?
  
  RRID:IMSR_JAX:029661
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RRID:IMSR_JAX:029661

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12707143/
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy

1
1. scibot 04 Dec 2025
  
  in Public
  
  Jackson LaboratoryStrain: 029661
  
  DOI: 10.1016/j.celrep.2025.116641
  
  Resource: (IMSR Cat# JAX_029661,RRID:IMSR_JAX:029661)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
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  RRID:IMSR_JAX:029661
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RRID:IMSR_JAX:029661

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scibot

URL

sciencedirect.com:5037/science/article/pii/S2211124725014135
Jul 2025
www.nature.com www.nature.com

Nanobody-based bispecific antibody engagers targeting CTLA-4 or PD-L1 for cancer immunotherapy

1
1. scibot 22 Jul 2025
  
  in Public
  
  RRID:IMSR_JAX:029661
  
  DOI: 10.1038/s41551-025-01447-z
  
  Resource: (IMSR Cat# JAX_029661,RRID:IMSR_JAX:029661)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
  What is this?
  
  RRID:IMSR_JAX:029661
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RRID:IMSR_JAX:029661

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scibot

URL

nature.com/articles/s41551-025-01447-z
Apr 2025
www.biorxiv.org www.biorxiv.org

Complement C3 Deficiency Enhances Renal Leptospiral Load and Inflammation While Impairing T Cell Differentiation During Chronic Leptospira interrogans Infection

1
1. scibot 10 Apr 2025
  
  in Public
  
  JAX:029661
  
  DOI: 10.1101/2025.03.31.646275
  
  Resource: (IMSR Cat# JAX_029661,RRID:IMSR_JAX:029661)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
  What is this?
  
  RRID:IMSR_JAX:029661
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RRID:IMSR_JAX:029661

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scibot

URL

biorxiv.org/content/10.1101/2025.03.31.646275v1
Mar 2024
www.sciencedirect.com www.sciencedirect.com

Neutrophil-inflicted vasculature damage suppresses immune-mediated optic nerve regeneration

1
1. scibot 19 Mar 2024
  
  in Public
  
  The Jackson LaboratoryStock# 029661
  
  DOI: 10.1016/j.celrep.2024.113931
  
  Resource: (IMSR Cat# JAX_029661,RRID:IMSR_JAX:029661)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
  What is this?
  
  RRID:IMSR_JAX:029661
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RRID:IMSR_JAX:029661

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scibot

URL

sciencedirect.com/science/article/pii/S2211124724002596
Feb 2024
www.sciencedirect.com www.sciencedirect.com

DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses

1
1. scibot 16 Feb 2024
  
  in Public
  
  Jackson laboratories029661
  
  DOI: 10.1016/j.celrep.2024.113801
  
  Resource: (IMSR Cat# JAX_029661,RRID:IMSR_JAX:029661)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
  What is this?
  
  RRID:IMSR_JAX:029661
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RRID:IMSR_JAX:029661

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scibot

URL

sciencedirect.com/science/article/pii/S2211124724001293
www.sciencedirect.com www.sciencedirect.com

Gut complement induced by the microbiota combats pathogens and spares commensals

1
1. scibot 03 Feb 2024
  
  in Public
  
  Jackson LaboratoryStock #:029661
  
  DOI: 10.1016/j.cell.2023.12.036
  
  Resource: (IMSR Cat# JAX_029661,RRID:IMSR_JAX:029661)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
  What is this?
  
  RRID:IMSR_JAX:029661
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RRID:IMSR_JAX:029661

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scibot

URL

sciencedirect.com/science/article/pii/S0092867424000011
Jan 2024
www.sciencedirect.com www.sciencedirect.com

Complement in breast milk modifies offspring gut microbiota to promote infant health

1
1. scibot 26 Jan 2024
  
  in Public
  
  RRID:IMSR_JAX:029661
  
  DOI: 10.1016/j.cell.2023.12.019
  
  Resource: (IMSR Cat# JAX_029661,RRID:IMSR_JAX:029661)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
  What is this?
  
  RRID:IMSR_JAX:029661
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RRID:IMSR_JAX:029661

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scibot

URL

sciencedirect.com/science/article/pii/S0092867423013843
May 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Macrophages regulate gastrointestinal motility through complement component 1q

1
1. scibot 18 May 2023
  
  in Public
  
  Stock #029661
  
  DOI: 10.7554/eLife.78558
  
  Resource: (IMSR Cat# JAX_029661,RRID:IMSR_JAX:029661)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
  What is this?
  
  RRID:IMSR_JAX:029661
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RRID:IMSR_JAX:029661

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10185340/
Mar 2023
onlinelibrary.wiley.com onlinelibrary.wiley.com

Complement-dependent loss of inhibitory synapses on pyramidal neurons following Toxoplasma gondii infection

1
1. scibot 03 Mar 2023
  
  in Public
  
  RRID:IMSR_JAX:029661
  
  DOI: 10.1111/jnc.15770
  
  Resource: (IMSR Cat# JAX_029661,RRID:IMSR_JAX:029661)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
  What is this?
  
  RRID:IMSR_JAX:029661
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RRID:IMSR_JAX:029661

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scibot

URL

onlinelibrary.wiley.com/doi/10.1111/jnc.15770
Oct 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages

1
1. scibot 26 Oct 2022
  
  in Public
  
  JAX:029661
  
  DOI: 10.1371/journal.ppat.1010237
  
  Resource: (IMSR Cat# JAX_029661,RRID:IMSR_JAX:029661)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
  What is this?
  
  RRID:IMSR_JAX:029661
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RRID:IMSR_JAX:029661

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9578593/
Jul 2022
www.sciencedirect.com www.sciencedirect.com

Bacteria reduce flagellin synthesis to evade microglia-astrocyte-driven immunity in the brain

1
1. scibot 06 Jul 2022
  
  in Public
  
  RRID:IMSR_JAX:029661
  
  DOI: 10.1016/j.celrep.2022.111033
  
  Resource: (IMSR Cat# JAX_029661,RRID:IMSR_JAX:029661)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
  What is this?
  
  RRID:IMSR_JAX:029661
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RRID:IMSR_JAX:029661

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scibot

URL

sciencedirect.com/science/article/pii/S2211124722008270
Jul 2021
www.sciencedirect.com www.sciencedirect.com

The Immunological Organ Environment Dictates the Molecular and Cellular Pathways of Cytotoxic Antibody Activity

1
1. scibot 29 Jul 2021
  
  in Public
  
  The Jackson LaboratoryStock# 029661
  
  DOI: 10.1016/j.celrep.2019.10.111
  
  Resource: (IMSR Cat# JAX_029661,RRID:IMSR_JAX:029661)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
  What is this?
  
  RRID:IMSR_JAX:029661 RRIDCUR:Unrecognized
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RRIDCUR:Unrecognized

RRID:IMSR_JAX:029661

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124719314445
Jan 2020
www.sciencedirect.com www.sciencedirect.com

IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α+ Dendritic Cells Promotes Listeria monocytogenes Infection

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:IMSR_JAX:029661
  
  DOI: 10.1016/j.immuni.2019.05.011
  
  Resource: (IMSR Cat# JAX_029661,RRID:IMSR_JAX:029661)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:029661
  
  What is this?
  
  RRID:IMSR_JAX:029661 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:IMSR_JAX:029661

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1074761319302316