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74 Matching Annotations

Oct 2025
www.sciencedirect.com www.sciencedirect.com

Integrated antibody language model accelerates IgG screening and design for broad-spectrum antiviral therapy

1
1. scibot 09 Oct 2025
  
  in Public
  
  The Jackson LaboratoryStrain #:034860
  
  DOI: 10.1016/j.isci.2025.113584
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @areedewitt04
  
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sciencedirect.com/science/article/pii/S2589004225018450
Aug 2025
journals.asm.org journals.asm.org

COVID-19-associated neuroinflammation and astrocyte death in the brain linked to ORF3a-induced activation of Sur1-mediated ion channels

1
1. scibot 20 Aug 2025
  
  in Public
  
  Strain #: 034860
  
  DOI: 10.1128/mbio.02012-25
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @dhovakimyan1
  
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journals.asm.org/doi/10.1128/mbio.02012-25
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Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope

1
1. scibot 13 Aug 2025
  
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  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.celrep.2025.116122
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2211124725008939
Jul 2025
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Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation

1
1. scibot 24 Jul 2025
  
  in Public
  
  Jackson LabsCat# 034860
  
  DOI: 10.1016/j.celrep.2025.116052
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @areedewitt04
  
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sciencedirect.com/science/article/pii/S221112472500823X
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Inhibition of virally induced TFEB proteasomal degradation as a host-centric therapeutic approach for coronaviral infection

1
1. scibot 15 Jun 2025
  
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  JAX:034860
  
  DOI: 10.1126/sciadv.adv4033
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12136031/
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Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling

1
1. scibot 11 Jun 2025
  
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  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.cell.2025.05.012
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S0092867425005628
Apr 2025
www.mdpi.com www.mdpi.com

Severe Acute Respiratory Syndrome Coronavirus 2 Variant Infection Dynamics and Pathogenesis in Transgenic K18-hACE2 and Inbred Immunocompetent C57BL/6J Mice

1
1. scibot 03 Apr 2025
  
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  stock #34860
  
  DOI: 10.3390/v17040500
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @sjvitug
  
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  RRID:IMSR_JAX:034860
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mdpi.com/1999-4915/17/4/500
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A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein

1
1. scibot 03 Apr 2025
  
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  Jackson LabsCat# 034860
  
  DOI: 10.1016/j.celrep.2025.115499
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S2211124725002700
Mar 2025
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 14 Mar 2025
  
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  RRID:IMSR_JAX:034860
  
  DOI: 10.1101/2025.03.04.641465
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
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52.53.155.43/6f9c92d712d7566716569fd5a44dd23a05e30ab6/PDF-html.html
Dec 2024
www.sciencedirect.com www.sciencedirect.com

A single immunization with intranasal Newcastle disease virus (NDV)-based XBB.1.5 variant vaccine reduces disease and transmission in animals against matched-variant challenge

1
1. scibot 14 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.vaccine.2024.126586
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S0264410X24012684
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SARS-CoV-2 3CLpro (main protease) regulates caspase activation of gasdermin-D/E pores leading to secretion and extracellular activity of 3CLpro

1
1. scibot 14 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.celrep.2024.115080
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S2211124724014311
www.nature.com www.nature.com

Adjuvants to the S1-subunit of the SARS-CoV-2 spike protein vaccine improve antibody and T cell responses and surrogate neutralization in mice

1
1. scibot 03 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1038/s41598-024-80636-3
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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nature.com/articles/s41598-024-80636-3
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Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19

1
1. scibot 02 Dec 2024
  
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  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.chom.2024.11.007
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S1931312824004384
Nov 2024
www.sciencedirect.com www.sciencedirect.com

Berbamine prevents SARS-CoV-2 entry and transmission

1
1. scibot 24 Nov 2024
  
  in Public
  
  Strain #:034860
  
  DOI: 10.1016/j.isci.2024.111347
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @vtello
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S2589004224025720
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A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice

1
1. scibot 24 Nov 2024
  
  in Public
  
  Strain #34860
  
  DOI: 10.1016/j.chom.2024.10.016
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @vtello
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S1931312824004037
www.sciencedirect.com www.sciencedirect.com

Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination

1
1. scibot 15 Nov 2024
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.celrep.2024.114922
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S2211124724012737
Sep 2024
www.sciencedirect.com www.sciencedirect.com

Discovery and characterization of a pan-betacoronavirus S2-binding antibody

1
1. scibot 27 Sep 2024
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.str.2024.08.022
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S0969212624003691
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Antibodies and complement are key drivers of thrombosis

1
1. scibot 04 Sep 2024
  
  in Public
  
  Cat#034860
  
  DOI: 10.1016/j.immuni.2024.08.007
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @vtello
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S1074761324004060
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic and enzootic coronaviruses

1
1. scibot 22 Aug 2024
  
  in Public
  
  #034860
  
  DOI: 10.1126/scitranslmed.adj4504
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @vtello
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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ncbi.nlm.nih.gov/pmc/articles/PMC11333937/
www.mdpi.com www.mdpi.com

SARS-CoV-2 Rapidly Infects Peripheral Sensory and Autonomic Neurons, Contributing to Central Nervous System Neuroinvasion before Viremia

1
1. scibot 18 Aug 2024
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.3390/ijms25158245
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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mdpi.com/1422-0067/25/15/8245
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Establishment and characterization of an hACE2/hTMPRSS2 knock-in mouse model to study SARS-CoV-2

1
1. scibot 18 Aug 2024
  
  in Public
  
  JAX:034860
  
  DOI: 10.3389/fimmu.2024.1428711
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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pmc.ncbi.nlm.nih.gov/articles/PMC11266032/
Jul 2024
www.sciencedirect.com www.sciencedirect.com

Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2

1
1. scibot 24 Jul 2024
  
  in Public
  
  The Jackson Laboratory_034860
  
  DOI: 10.1016/j.isci.2024.110354
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @vtello
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRIDCUR:Unresolved RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S2589004224015797
www.science.org www.science.org

PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections

1
1. scibot 16 Jul 2024
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1126/scitranslmed.adi6887
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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science.org/doi/10.1126/scitranslmed.adi6887
Jun 2024
www.sciencedirect.com www.sciencedirect.com

Intranasal SARS-CoV-2 Omicron variant vaccines elicit humoral and cellular mucosal immunity in female mice

1
1. scibot 21 Jun 2024
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.ebiom.2024.105185
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S2352396424002202
May 2024
journals.plos.org journals.plos.org

SARS-CoV-2 infects cells lining the blood-retinal barrier and induces a hyperinflammatory immune response in the retina via systemic exposure

1
1. scibot 21 May 2024
  
  in Public
  
  B6.Cg-Tg(K18-ACE2)2Prlmn/J
  
  DOI: 10.1371/journal.ppat.1012156
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @bandrow
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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journals.plos.org/plospathogens/article
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SARS-CoV-2 infection exacerbates the cellular pathology of Parkinson’s disease in human dopaminergic neurons and a mouse model

1
1. scibot 16 May 2024
  
  in Public
  
  JAX034860
  
  DOI: 10.1016/j.xcrm.2024.101570
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S2666379124002623
Apr 2024
www.sciencedirect.com www.sciencedirect.com

The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection

1
1. scibot 23 Apr 2024
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.bbadis.2024.167193
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S0925443924001820
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Murine alveolar macrophages rapidly accumulate intranasally administered SARS-CoV-2 Spike protein leading to neutrophil recruitment and damage

1
1. scibot 22 Mar 2024
  
  in Public
  
  JAX:034860
  
  DOI: 10.7554/eLife.86764
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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ncbi.nlm.nih.gov/pmc/articles/PMC10954308/
www.sciencedirect.com www.sciencedirect.com

Type-I-interferon-responsive microglia shape cortical development and behavior

2
1. scibot 15 Mar 2024
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.cell.2024.02.020
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
2. scibot 15 Mar 2024
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.cell.2024.02.020
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S0092867424001867
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Bioluminescence Imaging Reveals Enhanced SARS-CoV-2 Clearance in Mice with Combinatorial Regimens

1
1. scibot 18 Feb 2024
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.isci.2024.109049
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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ncbi.nlm.nih.gov/pmc/articles/PMC10867665/
www.sciencedirect.com www.sciencedirect.com

An enhanced broad-spectrum peptide inhibits Omicron variants in vivo

1
1. scibot 14 Feb 2024
  
  in Public
  
  The Jackson LaboratoryStrain#: 034860
  
  DOI: 10.1016/j.xcrm.2024.101418
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S2666379124000417
Jan 2024
www.sciencedirect.com www.sciencedirect.com

Fc-fused IL-7 provides broad antiviral effects against respiratory virus infections through IL-17A-producing pulmonary innate-like T cells

1
1. scibot 21 Jan 2024
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.xcrm.2023.101362
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S2666379123005797
www.sciencedirect.com www.sciencedirect.com

Olgotrelvir, a dual inhibitor of SARS-CoV-2 Mpro and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19

1
1. scibot 11 Jan 2024
  
  in Public
  
  Jackson laboratoryStrain #:034860
  
  DOI: 10.1016/j.medj.2023.12.004
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S2666634023004026
Nov 2023
www.sciencedirect.com www.sciencedirect.com

Lung transcriptomics of K18-hACE2 mice highlights mechanisms and genes involved in the MVA-S vaccine-mediated immune response and protection against SARS-CoV-2 infection

1
1. scibot 22 Nov 2023
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.antiviral.2023.105760
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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sciencedirect.com/science/article/abs/pii/S0166354223002383
www.sciencedirect.com www.sciencedirect.com

Cross-regulation of antibody responses against the SARS-CoV-2 Spike protein and commensal microbiota via molecular mimicry

1
1. scibot 17 Nov 2023
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.chom.2023.10.007
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S1931312823004110
Oct 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Development of a mutant aerosolized ACE2 that neutralizes SARS-CoV-2 in vivo

1
1. scibot 18 Oct 2023
  
  in Public
  
  Stock # 034860
  
  DOI: 10.1101/2023.09.26.559550
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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ncbi.nlm.nih.gov/pmc/articles/PMC10557691/
Aug 2023
www.sciencedirect.com www.sciencedirect.com

Multimodal, broadly neutralizing antibodies against SARS-CoV-2 identified by high-throughput native pairing of BCRs from bulk B cells

1
1. scibot 16 Aug 2023
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.chembiol.2023.07.011
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S2451945623002398
Jul 2023
52.53.155.43 52.53.155.43

Combinatorial Regimens Augment Drug Monotherapy for SARS-CoV-2 Clearance in Mice

1
1. scibot 18 Jul 2023
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1101/2023.05.31.543159
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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52.53.155.43/3122d005cdf8bbe9c1e1f743a4779437bd44eed7/2023.05.31.543159v1.full-html.html
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants

1
1. scibot 08 Jul 2023
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.isci.2023.107085
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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ncbi.nlm.nih.gov/pmc/articles/PMC10251734/
May 2023
www.sciencedirect.com www.sciencedirect.com

Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2

1
1. scibot 05 May 2023
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.celrep.2022.111088
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S2211124722008907
Mar 2023
www.embopress.org www.embopress.org

Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice

1
1. scibot 18 Mar 2023
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.15252/embr.202256660
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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embopress.org/doi/10.15252/embr.202256660
Feb 2023
www.sciencedirect.com www.sciencedirect.com

Preclinical evaluation of a COVID-19 vaccine candidate based on a recombinant RBD fusion heterodimer of SARS-CoV-2

1
1. scibot 17 Feb 2023
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.isci.2023.106126
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S2589004223002031
Jan 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SARS-CoV-2 variants induce distinct disease and impact in the bone marrow and thymus of mice

1
1. scibot 27 Jan 2023
  
  in Public
  
  JAX:034860
  
  DOI: 10.1016/j.isci.2023.105972
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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ncbi.nlm.nih.gov/pmc/articles/PMC9838028/
www.mdpi.com www.mdpi.com

Pharmacokinetic and Pharmacodynamic Effects of Polyclonal Antibodies against SARS-CoV2 in Mice

1
1. scibot 19 Jan 2023
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.3390/v15010123
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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mdpi.com/1999-4915/15/1/123
www.nature.com www.nature.com

Full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice conferred by MVA-CoV2-S vaccine candidate

1
1. scibot 12 Jan 2023
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1038/s41593-022-01242-y
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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nature.com/articles/s41593-022-01242-y
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice

1
1. scibot 06 Jan 2023
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.xcrm.2022.100893
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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ncbi.nlm.nih.gov/pmc/articles/PMC9799175/
Nov 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Enhanced virulence and waning vaccine-elicited antibodies account for breakthrough infections caused by SARS-CoV-2 delta and beyond

1
1. scibot 19 Nov 2022
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.isci.2022.105507
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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ncbi.nlm.nih.gov/pmc/articles/PMC9635945/
Sep 2022
www.sciencedirect.com www.sciencedirect.com

Mucosal plasma cells are required to protect the upper airway and brain from infection

1
1. scibot 23 Sep 2022
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.immuni.2022.08.017
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S1074761322004113
www.sciencedirect.com www.sciencedirect.com

Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariants

1
1. scibot 01 Sep 2022
  
  in Public
  
  Jackson laboratoryStrain #:034860
  
  DOI: 10.1016/j.medj.2022.08.002
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S266663402200321X
Jun 2022
www.sciencedirect.com www.sciencedirect.com

Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism

1
1. scibot 30 Jun 2022
  
  in Public
  
  The Jackson LaboratoryStrain code: 034860
  
  DOI: 10.1016/j.immuni.2022.06.002
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S1074761322002400
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

VE607 Stabilizes SARS-CoV-2 Spike In the “RBD-up” Conformation and Inhibits Viral Entry

1
1. scibot 24 Jun 2022
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.isci.2022.104528
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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ncbi.nlm.nih.gov/pmc/articles/PMC9164512/
May 2022
www.sciencedirect.com www.sciencedirect.com

Nasally-delivered interferon-λ protects mice against infection by SARS-CoV-2 variants including Omicron

1
1. scibot 06 May 2022
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.celrep.2022.110799
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S2211124722005666
Mar 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A type I interferon response defines a conserved microglial state required for effective neuronal phagocytosis

1
1. scibot 09 Mar 2022
  
  in Public
  
  JAX#034860
  
  DOI: 10.1101/2021.04.29.441889
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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ncbi.nlm.nih.gov/pmc/articles/PMC8887080/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

1
1. scibot 04 Mar 2022
  
  in Public
  
  RRID:ISMR_JAX:034860
  
  DOI: 10.1016/j.cell.2022.02.005
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860 RRIDCUR:Unresolved
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RRIDCUR:Unresolved

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ncbi.nlm.nih.gov/pmc/articles/PMC8825346/
Feb 2022
www.sciencedirect.com www.sciencedirect.com

SARS-CoV-2 variants of concern display enhanced intrinsic pathogenic properties and expanded organ tropism in mouse models

2
1. scibot 11 Feb 2022
  
  in Public
  
  034860
  
  DOI: 10.1016/j.celrep.2022.110387
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
  What is this?
  
  RRID:IMSR_JAX:034860
2. scibot 09 Feb 2022
  
  in Public
  
  034860
  
  DOI: 10.1016/j.celrep.2022.110387
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S2211124722001085
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection

1
1. scibot 08 Feb 2022
  
  in Public
  
  RRID:IMSR_JAX
  
  DOI: 10.1016/j.celrep.2022.110368
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRIDCUR:Unresolved RRID:IMSR_JAX:034860
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RRIDCUR:Unresolved

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ncbi.nlm.nih.gov/pmc/articles/PMC8786652/
Jan 2022
www.sciencedirect.com www.sciencedirect.com

Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses

1
1. scibot 12 Jan 2022
  
  in Public
  
  The Jackson LaboratoryStock no.: 034860
  
  DOI: 10.1016/j.chembiol.2021.11.006
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S2451945621005134
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

1
1. scibot 05 Jan 2022
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.celrep.2021.110210
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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ncbi.nlm.nih.gov/pmc/articles/PMC8673750/
Nov 2021
www.sciencedirect.com www.sciencedirect.com

Beta RBD Boost Broadens Antibody-Mediated Protection Against SARS-CoV-2 Variants in Animal Models

1
1. scibot 18 Nov 2021
  
  in Public
  
  RRID:MSR_JAX:034860
  
  DOI: 10.1016/j.xcrm.2021.100450
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
  Curator comments: B6.Cg-Tg(K18-ACE2)2Prlmn/J Mus musculus IMSR Cat# JAX:034860
  
  What is this?
  
  RRIDCUR:SyntaxError RRIDCUR:Unresolved RRID:IMSR_JAX:034860
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RRIDCUR:Unresolved

RRIDCUR:SyntaxError

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sciencedirect.com/science/article/pii/S2666379121003189
Sep 2021
www.sciencedirect.com www.sciencedirect.com

Live Imaging of SARS-CoV-2 Infection in Mice Reveals that Neutralizing Antibodies Require Fc Function for Optimal Efficacy

1
1. scibot 23 Sep 2021
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.immuni.2021.08.015
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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sciencedirect.com/science/article/pii/S1074761321003472
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals

1
1. scibot 21 Aug 2021
  
  in Public
  
  RRID:IMSR_JAX:03486
  
  DOI: 10.1016/j.celrep.2021.109604
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
  Curator comments: B6.Cg-Tg(K18-ACE2)2Prlmn/J Mus musculus IMSR Cat# JAX:034860
  
  What is this?
  
  RRIDCUR:Incorrect RRIDCUR:Unresolved RRID:IMSR_JAX:034860
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RRIDCUR:Incorrect

RRID:IMSR_JAX:034860

RRIDCUR:Unresolved

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sciencedirect.com/science/article/pii/S2211124721010421
Jul 2021
52.53.155.43 52.53.155.43

An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

1
1. scibot 23 Jul 2021
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.celrep.2021.109452
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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52.53.155.43/505882aeea4f51f2790a07d89e9823edcfae5813/pdf-html.html
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects

1
1. scibot 17 Jul 2021
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.celrep.2021.109353
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
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  RRID:IMSR_JAX:034860
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ncbi.nlm.nih.gov/pmc/articles/PMC8216847/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Ultrapotent miniproteins targeting the SARS-CoV-2 receptor-binding domain protect against infection and disease

1
1. scibot 01 Jul 2021
  
  in Public
  
  JAX:034860
  
  DOI: 10.1016/j.chom.2021.06.008
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
  What is this?
  
  RRID:IMSR_JAX:034860
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RRID:IMSR_JAX:034860

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8221914/
May 2021
www.sciencedirect.com www.sciencedirect.com

Therapeutic antibodies, targeting the SARS-CoV-2 spike N-terminal domain, protect lethally infected K18-hACE2 mice

1
1. scibot 14 May 2021
  
  in Public
  
  JAX:034860
  
  DOI: 10.1016/j.isci.2021.102479
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
  What is this?
  
  RRID:IMSR_JAX:034860
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Tags

RRID:IMSR_JAX:034860

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2589004221004478
Apr 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The antigenic anatomy of SARS-CoV-2 receptor binding domain

1
1. scibot 29 Apr 2021
  
  in Public
  
  JAX:034860
  
  DOI: 10.1016/j.cell.2021.02.032
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
  What is this?
  
  RRID:IMSR_JAX:034860
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RRID:IMSR_JAX:034860

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7891125/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation

1
1. scibot 14 Apr 2021
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.cell.2021.03.051
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
  What is this?
  
  RRIDCUR:Validated RRID:IMSR_JAX:034860
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Tags

RRIDCUR:Validated

RRID:IMSR_JAX:034860

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8008343/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

BET Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection

1
1. scibot 06 Apr 2021
  
  in Public
  
  RRID:IMSR_JAX:034860
  
  DOI: 10.1016/j.cell.2021.03.026
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
  What is this?
  
  RRID:IMSR_JAX:034860
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RRID:IMSR_JAX:034860

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7962543/
Mar 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

1
1. scibot 28 Mar 2021
  
  in Public
  
  RRID:IMSR_JAX:03486
  
  DOI: 10.1016/j.cell.2021.03.029
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
  What is this?
  
  RRIDCUR:Incorrect RRIDCUR:Unresolved RRID:IMSR_JAX:034860
Visit annotations in context

Tags

RRIDCUR:Incorrect

RRID:IMSR_JAX:034860

RRIDCUR:Unresolved

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7962591/
Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Regen med therapeutic opportunities for fighting COVID‐19

1
1. scibot 27 Feb 2021
  
  in Public
  
  JAX:034860
  
  DOI: 10.1002/sctm.20-0245
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
  What is this?
  
  RRID:IMSR_JAX:034860
Visit annotations in context

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RRID:IMSR_JAX:034860

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7461298/
www.sciencedirect.com www.sciencedirect.com

Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice

1
1. scibot 24 Feb 2021
  
  in Public
  
  JAX:034860
  
  DOI: 10.1016/j.chom.2020.07.018
  
  Resource: (IMSR Cat# JAX_034860,RRID:IMSR_JAX:034860)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
  What is this?
  
  RRIDCUR:Unresolved RRIDCUR:SyntaxError RRID:IMSR_JAX:034860
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Tags

RRID:IMSR_JAX:034860

RRIDCUR:Unresolved

RRIDCUR:SyntaxError

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1931312820304212
Sep 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

1
1. scibot 16 Sep 2020
  
  in Public
  
  RRID:IMSR_JAX:03486
  
  DOI: 10.1016/j.cell.2020.08.026
  
  Resource: IMSR_JAX:034860
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:034860
  
  What is this?
  
  RRID:IMSR_JAX:034860 RRIDCUR:Unresolved RRIDCUR:Incorrect
Visit annotations in context

Tags

RRIDCUR:Incorrect

RRID:IMSR_JAX:034860

RRIDCUR:Unresolved

Annotators

scibot

URL

pubmed.ncbi.nlm.nih.gov/32931734/

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