Hypothesis

29 Matching Annotations

Mar 2026
www.sciencedirect.com www.sciencedirect.com

Stochastic misfolding drives the emergence of distinct α-synuclein strains

1
1. scibot 03 Mar 2026
  
  in Public
  
  RRID:IMSR_JAX:100010
  
  DOI: 10.1016/j.neuron.2026.01.014
  
  Resource: RRID:IMSR_JAX:100010
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

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sciencedirect.com/science/article/pii/S0896627326000401
Aug 2025
www.sciencedirect.com www.sciencedirect.com

Positive Allosteric Modulation of M1 mAChRs with VU0486846 Reverses Cognitive Deficits in Male APPswe/PSEN1ΔE9 Alzheimer’s Mice

1
1. scibot 26 Aug 2025
  
  in Public
  
  RRID:IMSR_JAX:100010
  
  DOI: 10.1016/j.neuropharm.2025.110654
  
  Resource: RRID:IMSR_JAX:100010
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

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sciencedirect.com/science/article/pii/S0028390825003624
www.sciencedirect.com www.sciencedirect.com

Reconstructed cell-type-specific rhythms in human brain link Alzheimer’s pathology, circadian stress, and ribosomal disruption

1
1. scibot 07 Aug 2025
  
  in Public
  
  RRID:IMSR_JAX:100010
  
  DOI: 10.1016/j.neuron.2025.07.010
  
  Resource: RRID:IMSR_JAX:100010
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

URL

sciencedirect.com/science/article/pii/S0896627325005173
www.sciencedirect.com www.sciencedirect.com

PALB2 and 53BP1 govern post-resection homologous recombination DNA repair

1
1. scibot 01 Aug 2025
  
  in Public
  
  Jackson Laboratory Cat_100010
  
  DOI: 10.1016/j.molcel.2025.07.003
  
  Resource: None
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
  What is this?
  
  RRID:IMSR_JAX:100010 RRIDCUR:Unresolved
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RRID:IMSR_JAX:100010

RRIDCUR:Unresolved

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scibot

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sciencedirect.com/science/article/pii/S1097276525006045
Jul 2025
www.sciencedirect.com www.sciencedirect.com

Cerebellar contributions to tau-mediated cognitive and behavioral dysfunction

1
1. scibot 25 Jul 2025
  
  in Public
  
  Jackson Laboratory100010
  
  DOI: 10.1016/j.celrep.2025.116036
  
  Resource: RRID:IMSR_JAX:100010
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

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sciencedirect.com/science/article/pii/S2211124725008071
May 2025
www.sciencedirect.com www.sciencedirect.com

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq

1
1. scibot 18 May 2025
  
  in Public
  
  RRID:IMSR_JAX:100010
  
  DOI: 10.1016/j.neuron.2025.04.017
  
  Resource: RRID:IMSR_JAX:100010
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

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sciencedirect.com/science/article/pii/S0896627325002995
Feb 2025
aacrjournals.org aacrjournals.org

Attenuation of sialylation augments antitumor immunity and improves response to immunotherapy in ovarian cancer

1
1. scibot 13 Feb 2025
  
  in Public
  
  RRID:IMSR_JAX:100010
  
  DOI: 10.1158/0008-5472.CAN-22-3260
  
  Resource: RRID:IMSR_JAX:100010
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

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aacrjournals.org/cancerres/article/83/13/2171/727429/Attenuation-of-Sialylation-Augments-Antitumor
Jan 2025
www.sciencedirect.com www.sciencedirect.com

G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis

1
1. scibot 09 Jan 2025
  
  in Public
  
  The Jackson LaboratoryJax: 100010
  
  DOI: 10.1016/j.celrep.2024.115178
  
  Resource: RRID:IMSR_JAX:100010
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

URL

sciencedirect.com/science/article/pii/S2211124724015298
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice

1
1. scibot 23 Nov 2024
  
  in Public
  
  100010
  
  DOI: 10.1016/j.pbb.2009.11.009
  
  Resource: RRID:IMSR_JAX:100010
  
  Curator: @AleksanderDrozdz
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC2828687/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Strain Background Influences Neurotoxicity and Behavioral Abnormalities in Mice Expressing the Tetracycline Transactivator

1
1. scibot 22 Nov 2024
  
  in Public
  
  100010
  
  DOI: 10.1523/JNEUROSCI.0893-12.2012
  
  Resource: RRID:IMSR_JAX:100010
  
  Curator: @AleksanderDrozdz
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC3431916/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PET neuroimaging studies of [18F]CABS13 in a double transgenic mouse model of Alzheimer’s disease and non-human primates

1
1. scibot 22 Nov 2024
  
  in Public
  
  B6C3F1/J
  
  DOI: 10.1021/acschemneuro.5b00055
  
  Resource: RRID:IMSR_JAX:100010
  
  Curator: @AleksanderDrozdz
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC4879824/
Aug 2024
www.sciencedirect.com www.sciencedirect.com

Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer’s disease

1
1. scibot 14 Aug 2024
  
  in Public
  
  Jax: Strain #:100010
  
  DOI: 10.1016/j.xcrm.2024.101669
  
  Resource: RRID:IMSR_JAX:100010
  
  Curator: @vtello
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
  What is this?
  
  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

URL

sciencedirect.com/science/article/pii/S2666379124003835
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mitigation of TDP-43 toxic phenotype by an RGNEF fragment in amyotrophic lateral sclerosis models

1
1. scibot 07 Jul 2024
  
  in Public
  
  JAX:100010
  
  DOI: 10.1093/brain/awae078
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC11146434/
May 2024
52.53.155.43 52.53.155.43

Mark4 ablation attenuates pathological phenotypes in a mouse model of tauopathy

1
1. scibot 03 May 2024
  
  in Public
  
  RRID:IMSR_JAX:100010
  
  DOI: 10.1093/braincomms/fcae136
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

URL

52.53.155.43/88fa296b3636c5d5cfc19001d0db77c2230ebd0a/fcae136-html.html
Jun 2023
52.53.155.43 52.53.155.43

can-22-3260-html.html

1
1. scibot 30 Jun 2023
  
  in Public
  
  JAX:100010
  
  DOI: 10.1158/0008-5472.can-22-3260
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

URL

52.53.155.43/a7530054ba237cfe383053dc9303e44d675e972e/can-22-3260-html.html
May 2023
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Sex-dependent effects of acute stress on amyloid-β in male and female mice

1
1. scibot 04 May 2023
  
  in Public
  
  JAX:100010
  
  DOI: 10.1093/brain/awad052
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC10232275/
Oct 2022
www.jneurosci.org www.jneurosci.org

Somatotopy of mouse spinothalamic innervation and the localisation of a noxious stimulus requires DCC expression by Phox2a neurons

1
1. scibot 20 Oct 2022
  
  in Public
  
  RRID:IMSR_JAX:100010
  
  DOI: 10.1523/JNEUROSCI.1164-22.2022
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
  What is this?
  
  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

URL

jneurosci.org/content/42/42/7885
Sep 2022
link.springer.com link.springer.com

Mercury chloride alters heterochromatin domain organization and nucleolar activity in mouse liver

1
1. scibot 24 Sep 2022
  
  in Public
  
  RRID:IMSR_JAX:100
  
  DOI: 10.1007/s00418-022-02151-8
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
  What is this?
  
  RRIDCUR:Unresolved RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

RRIDCUR:Unresolved

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scibot

URL

link.springer.com/article/10.1007/s00418-022-02151-8
Feb 2022
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

A M1 muscarinic acetylcholine receptor positive allosteric modulator improves pathology and cognitive deficits in female APPswe/PSEN1ΔE9 mice

1
1. scibot 04 Feb 2022
  
  in Public
  
  RRID:IMSR_JAX:100010
  
  DOI: 10.1111/bph.15750
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

URL

bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15750
Jan 2022
www.sciencedirect.com www.sciencedirect.com

Stride-level analysis of mouse open field behavior using deep-learning-based pose estimation

1
1. scibot 16 Jan 2022
  
  in Public
  
  JAX:100010
  
  DOI: 10.1016/j.celrep.2021.110231
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

URL

sciencedirect.com/science/article/pii/S221112472101740X
Dec 2021
academic.oup.com academic.oup.com

A novel CARM1-HuR axis involved in muscle differentiation and plasticity misregulated in spinal muscular atrophy

1
1. scibot 21 Dec 2021
  
  in Public
  
  RRID:IMSR_JAX:100010
  
  DOI: 10.1093/hmg/ddab333
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
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  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

URL

academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddab333/6428333
Nov 2021
www.sciencedirect.com www.sciencedirect.com

Inhibition of neutral sphingomyelinase 2 reduces extracellular vesicle release from neurons, oligodendrocytes, and activated microglial cells following acute brain injury

1
1. scibot 09 Nov 2021
  
  in Public
  
  100010
  
  DOI: 10.1016/j.bcp.2021.114796
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
  What is this?
  
  RRIDCUR:Missing RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S0006295221004123
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Metabolic plasticity drives development during mammalian embryogenesis

1
1. scibot 24 Aug 2021
  
  in Public
  
  Stock No: 100010
  
  DOI: 10.1016/j.devcel.2021.07.020
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
  What is this?
  
  RRIDCUR:Missing RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1534580721006031
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D

1
1. scibot 29 Jul 2021
  
  in Public
  
  Mouse: B6C3F1/J: female donors
  
  DOI: 10.1016/j.celrep.2019.07.026
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
  What is this?
  
  RRID:IMSR_JAX:100010 RRIDCUR:Missing
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RRID:IMSR_JAX:100010

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S2211124719309234
Feb 2021
www.sciencedirect.com www.sciencedirect.com

Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans

1
1. scibot 24 Feb 2021
  
  in Public
  
  RRID:IMSR_JAX
  
  DOI: 10.1016/j.celrep.2020.108425
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
  Curator comments: B6C3F1/J Mus musculus IMSR Cat# JAX:100010
  
  What is this?
  
  RRIDCUR:Unresolved RRIDCUR:SyntaxError RRID:IMSR_JAX:100010
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RRIDCUR:SyntaxError

RRID:IMSR_JAX:100010

RRIDCUR:Unresolved

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720314145
Dec 2020
www.sciencedirect.com www.sciencedirect.com

Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans

1
1. scibot 07 Dec 2020
  
  in Public
  
  JAX:100010
  
  DOI: 10.1016/j.celrep.2020.108425
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
  What is this?
  
  RRID:IMSR_JAX:100010 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:IMSR_JAX:100010

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720314145
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis

1
1. scibot 03 Sep 2020
  
  in Public
  
  Jackson LaboratoryStock No: 100010
  
  DOI: 10.1016/j.devcel.2020.02.015
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
  What is this?
  
  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

URL

sciencedirect.com/science/article/pii/S1534580720301428
www.sciencedirect.com www.sciencedirect.com

Metabolic Control over mTOR-Dependent Diapause-like State

1
1. scibot 03 Sep 2020
  
  in Public
  
  Jackson LaboratoriesCat#100010
  
  DOI: 10.1016/j.devcel.2019.12.018
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
  What is this?
  
  RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

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scibot

URL

sciencedirect.com/science/article/pii/S1534580719310676
www.sciencedirect.com www.sciencedirect.com

BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance

1
1. scibot 03 Sep 2020
  
  in Public
  
  B6C3F1/J
  
  DOI: 10.1016/j.celrep.2018.08.086
  
  Resource: (IMSR Cat# JAX_100010,RRID:IMSR_JAX:100010)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:100010
  
  Curator comments: B6C3F1/J Mus musculus IMSR Cat# JAX:100010
  
  What is this?
  
  RRIDCUR:Missing RRID:IMSR_JAX:100010
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RRID:IMSR_JAX:100010

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S2211124718314050