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Endocardial primary cilia and blood flow regulate EndoMT during endocardial cushion development

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1. scibot 30 Aug 2025
  
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  DOI: 10.1038/s44161-025-00697-z
  
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nature.com/articles/s44161-025-00697-z
Aug 2025
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Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy

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1. scibot 21 Aug 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12363560/
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Evaluating Gene Fusions as Prognostic Biomarkers and Therapeutic Targets in Immune Checkpoint Blockade-Treated Advanced Melanoma: a Retrospective Analysis.

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1. scibot 16 Aug 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12344778/
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Reconstructed cell-type-specific rhythms in human brain link Alzheimer’s pathology, circadian stress, and ribosomal disruption

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1. scibot 07 Aug 2025
  
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  DOI: 10.1016/j.neuron.2025.07.010
  
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sciencedirect.com/science/article/pii/S0896627325005173
Jul 2025
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Cellular crosstalk mediated by TGF-β drives epithelial-mesenchymal transition in patient-derived multi-compartment biliary organoids

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1. scibot 22 Jul 2025
  
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  DOI: 10.1038/s41467-025-61442-5
  
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Complete loss of PAX4 causes transient neonatal diabetes in humans

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1. scibot 22 Jul 2025
  
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  DOI: 10.1016/j.molmet.2025.102201
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12275979/
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Developmental pyrethroid exposure disrupts molecular pathways for MAP kinase and circadian rhythms in mouse brain

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1. scibot 10 Jul 2025
  
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  DOI: 10.1152/physiolgenomics.00033.2024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12232972/
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Parkinson’s disease microglia induce endogenous α-synuclein pathology in patient-specific midbrain organoids

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1. scibot 08 Jul 2025
  
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  DOI: 10.1101/2025.07.01.662685
  
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biorxiv.org/content/10.1101/2025.07.01.662685v1
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The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.001
  
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sciencedirect.com/science/article/pii/S1074761325002481
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Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer

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sciencedirect.com/science/article/pii/S1074761325002742
Jun 2025
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An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier

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PDF-html.html

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52.53.155.43/6f95ee3860ed32eb2fc3447b03e264cd8239544f/PDF-html.html
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Distinct molecular patterns in R6/2 HD mouse brain: Insights from spatiotemporal transcriptomics

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.neuron.2025.05.014
  
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sciencedirect.com/science/article/pii/S0896627325003617
May 2025
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Epigenetic Plasticity Drives Carcinogenesis and Multi-Therapy Resistance in Multiple Myeloma

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1. scibot 21 May 2025
  
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  DOI: 10.21203/rs.3.rs-6306816/v1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12048002/
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Complete Loss of PAX4 causes Transient Neonatal Diabetes in Humans

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1. scibot 20 May 2025
  
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  DOI: 10.1101/2025.04.01.25324926
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11998800/
Apr 2025
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GeneSetCart: assembling, augmenting, combining, visualizing, and analyzing gene sets

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1. scibot 16 Apr 2025
  
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  DOI: 10.1093/gigascience/giaf025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11984350/
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Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB

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1. scibot 08 Apr 2025
  
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  DOI: 10.1016/j.cell.2025.03.006
  
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sciencedirect.com/science/article/pii/S009286742500279X
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Sex differences in DNMT3A-mutant clonal hematopoiesis and the effects of estrogen

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1. scibot 03 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115494
  
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sciencedirect.com/science/article/pii/S2211124725002657
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Augmenting CAR T Cell Functions with LIGHT

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1. scibot 02 Apr 2025
  
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  DOI: 10.1158/2326-6066.CIR-24-0246
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11444887/
Mar 2025
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Characterization of the Temporal Dynamics of the Endothelial–Mesenchymal-like Transition Induced by Soluble Factors from Dengue Virus Infection in Microvascular Endothelial Cells

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1. scibot 14 Mar 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11900998/
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Outer radial glia promotes white matter regeneration after neonatal brain injury

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  DOI: 10.1016/j.xcrm.2025.101986
  
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cell.com/cell-reports-medicine/abstract/S2666-3791(25)00059-X
Feb 2025
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NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome

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sciencedirect.com/science/article/pii/S0006497124009662
Jan 2025
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Steatohepatitis-induced vascular niche alterations promote melanoma metastasis

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1. scibot 30 Jan 2025
  
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  DOI: 10.1186/s40170-025-00374-6
  
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link.springer.com/article/10.1186/s40170-025-00374-6
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The Functional Transcriptomic Landscape Informs Therapeutic Strategies in Multiple Myeloma

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1. scibot 25 Jan 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-0886
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11733535/
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Single-Cell RNA Sequencing before and after Light Chain Escape Reveals Intrapatient Multiple Myeloma Subpopulations with Divergent Osteolytic Gene Expression

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1. scibot 18 Jan 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11737298/
Dec 2024
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Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine

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1. scibot 11 Dec 2024
  
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  DOI: 10.1158/2767-9764.CRC-24-0310
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11616010/
Nov 2024
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How the liver transcriptome and lipid composition influence the progression of nonalcoholic fatty liver disease to hepatocellular carcinoma in a murine model

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1. scibot 15 Nov 2024
  
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  DOI: 10.1016/j.bbalip.2024.159574
  
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Drug prioritization identifies panobinostat as a tailored treatment element for patients with metastatic hepatoblastoma

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1. scibot 14 Nov 2024
  
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  DOI: 10.1186/s13046-024-03221-6
  
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crc-24-0310-html.html

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can-24-0886-html.html

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  DOI: 10.1158/0008-5472.can-24-0886
  
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52.53.155.43/656f4a916577efff373ec46750afc04546654778/can-24-0886-html.html
Oct 2024
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Quiescence and aging of melanocyte stem cells and a novel association with PD-L1

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  DOI: 10.1016/j.isci.2024.110908
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11440800/
Sep 2024
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Sex-dependent differences in the ability of nicotine to modulate discrimination learning and cognitive flexibility in mice

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1. scibot 27 Sep 2024
  
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  DOI: 10.1111/jnc.16227
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16227
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Mcam stabilizes a luminal progenitor-like breast cancer cell state via Ck2 control and Src/Akt/Stat3 attenuation

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1. scibot 18 Sep 2024
  
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  DOI: 10.1038/s41523-024-00687-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11401886/
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EWS-FLI1 and Activator Protein-1 (AP-1) Reciprocally Regulate Extracellular-Matrix Proteins in Ewing sarcoma Cells

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1. scibot 13 Sep 2024
  
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  DOI: 10.3390/ijms25168595
  
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  DOI: 10.3390/ijms25168595
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11354993/
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Paneth cell TNF signaling induces gut bacterial translocation and sepsis

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1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.chom.2024.08.007
  
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sciencedirect.com/science/article/pii/S1931312824003147
Aug 2024
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The Lactate Receptor GPR81 is a Mechanism of Leukemia-Associated Macrophage Polarization in the Bone Marrow Microenvironment

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Genetic association with autoimmune diseases identifies molecular mechanisms of coronary artery disease

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ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer

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Islet cell stress induced by insulin-degrading enzyme deficiency promotes regeneration and protection from autoimmune diabetes

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Potential molecular patterns for tuberculosis susceptibility in diabetic patients with poor glycaemic control: a pilot study

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Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects

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Tumor niche network-defined subtypes predict immunotherapy response of esophageal squamous cell cancer

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Metabolic regulator ERRγ governs gastric stem cell differentiation into acid-secreting parietal cells

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A phosphate transporter in VIPergic neurons of the suprachiasmatic nucleus gates locomotor activity during the light/dark transition in mice

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Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration

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Craniofacial Chondrogenesis in Organoids from Human Stem Cell-Derived Neural Crest Cells

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Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells

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Developmental pyrethroid exposure disrupts molecular pathways for MAP kinase and circadian rhythms in mouse brain

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Proteomic analysis shows decreased type I fibers and ectopic fat accumulation in skeletal muscle from women with PCOS

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Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons

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Parkinson's disease-related Miro1 mutation induces mitochondrial dysfunction and loss of dopaminergic neurons in vitro and in vivo

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The Immunogenomic Landscape of Neuroendocrine Prostate Cancer

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Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice

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Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals

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Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve

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Integrated Network Analysis of microRNAs, mRNAs, and Proteins Reveals the Regulatory Interaction between hsa-mir-200b and CFL2 Associated with Advanced Stage and Poor Prognosis in Patients with Intestinal Gastric Cancer

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Chromatin accessibility landscape of human triple-negative breast cancer cell lines reveals variation by patient donor ancestry

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TGS1/PIMT knockdown reduces lipid accumulation in adipocytes, limits body weight gain and promotes insulin sensitivity in mice

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CRISPR/Cas9-mediated activation of NR5A1 steers female human embryonic stem cell-derived bipotential gonadal-like cells towards a steroidogenic cell fate

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Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease

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Overcome Prostate Cancer Resistance to Immune Checkpoint Therapy with Ketogenic Diet-Induced Epigenetic Reprogramming

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Original research: Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

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The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina

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Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia

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Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks

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MEF2A suppresses stress responses that trigger DDX41-dependent IFN production

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Obesity during preclinical Alzheimer's disease development exacerbates brain metabolic decline

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hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data

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SAM-Competitive EZH2-Inhibitors Induce Platinum Resistance by EZH2-Independent Induction of ABC-Transporters

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Comprehensive DNA methylation analysis indicates that pancreatic intraepithelial neoplasia lesions are acinar-derived and epigenetically primed for carcinogenesis

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aacrjournals.org/cancerres/article/83/11/1905/726442/Comprehensive-DNA-Methylation-Analysis-Indicates
May 2023
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Mcam stabilizes a luminal progenitor-like breast cancer cell state via Ck2 control and Src/Akt/Stat3 attenuation

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Type I fiber decrease and ectopic fat accumulation in skeletal muscle from women with PCOS

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Apr 2023
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Entrectinib a Plausible Inhibitor for Osteopontin (SPP1) in Cervical Cancer—Integrated Bioinformatic Approach

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Feb 2023
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Spatially resolved transcriptomics reveals pro-inflammatory fibroblast involved in lymphocyte recruitment through CXCL8 and CXCL10

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Jan 2023
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In vitro characterization on the role of APOE polymorphism in human hippocampal neurogenesis

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Integrating methylome and transcriptome signatures expands the molecular classification of the pituitary tumors

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HDAC2 Facilitates Pancreatic Cancer Metastasis

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Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits

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IL-17/CXCL5 signaling within the oligovascular niche mediates human and mouse white matter injury

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Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

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Single-cell RNA sequencing reveals distinct T cell populations in immune-related adverse events of checkpoint inhibitors

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Systematic single-cell pathway analysis to characterize early T cell activation

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Extracellular vesicles from pristane-treated CD38-deficient mice express an anti-inflammatory neutrophil protein signature, which reflects the mild lupus severity elicited in these mice

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A genomic and transcriptomic study toward breast cancer

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Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity

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Aug 2022
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The DCMU Herbicide Shapes T-cell Functions By Modulating Micro-RNA Expression Profiles

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Vision-related convergent gene losses reveal SERPINE3’s unknown role in the eye

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Jun 2022
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mcr-21-1039-html.html

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Activation of Notch and Myc signaling via B cell-restricted depletion of Dnmt3a generates a consistent murine model of chronic lymphocytic leukemia

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Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice

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Global-run on sequencing identifies Gm11967 as an Akt-dependent long noncoding RNA involved in insulin sensitivity

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Apr 2022
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Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches

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PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade

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When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer

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PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP dependent lipid uptake and fatty acid synthesis pathways

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Jan 2022
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Salivary ZG16B expression loss follows exocrine gland dysfunction related to oral Chronic Graft-Versus-Host Disease

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Naive and memory CD4+ T cell subsets can contribute to the generation of human Tfh cells

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Oct 2021
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An atlas of gene regulatory elements in adult mouse cerebrum

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Sep 2021
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SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling

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Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

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Aug 2021
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Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding

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Untitled document

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Untitled document

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Untitled document

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A kinase-independent role for CDK8 in BCR-ABL1 + leukemia

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Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia

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BPS Publications

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  DOI: 10.1111/bph.14708
  
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BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses

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  DOI: 10.15252/embj.2018100293
  
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emboj.embopress.org/content/early/2019/03/06/embj.2018100293
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MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis

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  DOI: 10.1016/j.molcel.2018.09.031
  
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sciencedirect.com/science/article/pii/S1097276518308025
May 2021
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Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis

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Loss of Ambra1 promotes melanoma growth and invasion

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clincancerres.aacrjournals.org clincancerres.aacrjournals.org

Clinical responsiveness to All-trans Retinoic Acid is potentiated by LSD1 inhibition and associated with a quiescent transcriptome in myeloid malignancies

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Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation

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Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis

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Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition

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Aberrant expression of BAX, MEG3, and miR-214-3P genes in recurrent pregnancy loss

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Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

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Molecular pathways behind acquired obesity: adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI

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Mar 2021
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Transcriptional profiling of the response to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine revealed activation of the eIF2α/ATF4 integrated stress response in two in vitro placental models

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Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma

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Aberrant expression of BAX, MEG3, and miR-214-3P genes in recurrent pregnancy loss

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Feb 2021
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Def6 regulates endogenous type-I interferon responses in osteoblasts and suppresses osteogenesis

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An Atlas of Gene Regulatory Elements in Adult Mouse Cerebrum

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biorxiv.org/content/10.1101/2020.05.10.087585v2
Jan 2021
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Defining human mesenchymal and epithelial heterogeneity in response to oral inflammatory disease

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Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division

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QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis

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sciencedirect.com/science/article/pii/S2211124720315497
Dec 2020
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Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis

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cell.com/current-biology/abstract/S0960-9822(20)31685-7
Nov 2020
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Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution

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ncbi.nlm.nih.gov/pmc/articles/PMC7609066/
Oct 2020
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Hsa‐miR‐27a‐3p and epidermal growth factor receptor expression analysis in glioblastoma FFPE samples

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onlinelibrary.wiley.com/doi/10.1111/ajco.13399
Sep 2020
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Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

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Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids

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Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity

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Noncoding microdeletion in mouse Hgf disrupts neural crest migration into the stria vascularis, reduces the endocochlear potential and suggests the neuropathology for human nonsyndromic deafness DFNB39

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Transcriptional and Spatial Resolution of Cell Types in the Mammalian Habenula

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Regionally specified human pluripotent stem cell-derived astrocytes exhibit different molecular signatures and functional properties

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PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells

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ncbi.nlm.nih.gov/pmc/articles/PMC7064337/
Jan 2020
cancerpreventionresearch.aacrjournals.org cancerpreventionresearch.aacrjournals.org

Proteomic analysis of plasma reveals fat mass influences cancer-related pathways in healthy humans fed controlled diets differing in glycemic load

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cancerpreventionresearch.aacrjournals.org/content/12/9/567
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A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

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RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer

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  DOI: 10.1016/j.chembiol.2019.12.005
  
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The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4

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  DOI: 10.1016/j.neuron.2019.08.007
  
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The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity

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  DOI: 10.1016/j.celrep.2019.08.028
  
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sciencedirect.com/science/article/pii/S2211124719310629
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  DOI: 10.1002/jcb.28206
  
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  DOI: 10.1016/j.celrep.2018.12.087
  
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Nov 2018
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The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism

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Mitohormesis in Mice via Sustained Basal Activation of Mitochondrial and Antioxidant Signaling

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Peripheral blood gene expression reveals an inflammatory transcriptomic signature in Friedreich’s ataxia patients

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academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddy198/5001460
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White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection

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Nov 2017
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iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

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Mutations in Human Accelerated Regions Disrupt Cognition and Social Behavior

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Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration

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