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Helminth proteins recapitulate key structural motifs of MIF to facilitate immunomodulation of host receptors

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1. scibot 27 Jun 2026
  
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  DOI: 10.1016/j.isci.2026.116513
  
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sciencedirect.com/science/article/pii/S2589004226018882
May 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Two birds with one stone: An antibiotic hit blocking Staphylococcus aureus heme uptake with serendipitous hemoglobin left-shifting activity

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1. scibot 06 May 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13138187/
Apr 2026
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Mechanistic design of cell-penetrating disruptors for phospho-dependent TACC3-CHC interaction

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1. scibot 30 Apr 2026
  
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  DOI: 10.1016/j.str.2026.04.001
  
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sciencedirect.com/science/article/pii/S0969212626001073
Mar 2026
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Structural characterization of the Cu(II)-NTA spin label on α-helices by X-ray crystallography and electron paramagnetic resonance

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1. scibot 10 Mar 2026
  
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sciencedirect.com/science/article/pii/S0969212626000122
Feb 2026
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Structural repertoire of HCV broadly neutralizing antibodies targeting the E2 front layer supersite

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1. scibot 03 Feb 2026
  
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sciencedirect.com/science/article/pii/S0969212626000079
Dec 2025
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Cryo-EM structure of cyanopodophage Pan3 reveals a modular tail architecture for host recognition

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sciencedirect.com:5037/science/article/pii/S0969212625004459
Aug 2025
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Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction

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1. scibot 15 Aug 2025
  
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  DOI: 10.1016/j.str.2025.07.016
  
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sciencedirect.com/science/article/pii/S0969212625002655
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41594_2025_1631_MOESM4_ESM-html.html

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1. scibot 13 Aug 2025
  
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  DOI: 10.5281/zenodo.14243720
  
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52.53.155.43/2894f1585e3ca7aaaea575ab75ca401271c73618/41594_2025_1631_MOESM4_ESM-html.html
Mar 2025
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23ME-01473, an Fc Effector–Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell–Mediated Antitumor Immunity through NKG2D and FcγRIIIa Activation

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1. scibot 27 Mar 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11927390/
Jan 2025
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Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide

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1. scibot 09 Jan 2025
  
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  DOI: 10.1098/rsob.240310
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11706664/
Dec 2024
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Dual BACH1 regulation by complementary SCF-type E3 ligases

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1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.cell.2024.11.006
  
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sciencedirect.com/science/article/pii/S0092867424013229
Aug 2024
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Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes

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1. scibot 02 Aug 2024
  
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  DOI: 10.1016/j.cell.2017.09.008
  
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europepmc.orghttp//europepmc.org/articles/PMC5651216/
Jul 2024
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Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38

1
1. scibot 16 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114502
  
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sciencedirect.com/science/article/pii/S2211124724008313
May 2024
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A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation

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1. scibot 31 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114259
  
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sciencedirect.com/science/article/pii/S2211124724005874
Apr 2024
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Staphylococcus aureus skin colonization is mediated by SasG lectin variation

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1. scibot 04 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114022
  
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sciencedirect.com/science/article/pii/S2211124724003504
Feb 2024
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Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS607-family transposition

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1. scibot 08 Feb 2024
  
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  DOI: 10.7554/eLife.39611
  
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elifesciences.org/articles/39611
Jan 2024
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Structural evidence for protein-protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46

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1. scibot 11 Jan 2024
  
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  DOI: 10.1016/j.str.2023.12.001
  
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sciencedirect.com/science/article/pii/S0969212623004434
Jul 2023
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Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.cell.2023.06.020
  
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sciencedirect.com/science/article/pii/S0092867423006967
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Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity

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1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112827
  
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sciencedirect.com/science/article/pii/S2211124723008380
Mar 2023
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Immunodominant surface epitopes power immune evasion in the African trypanosome

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1. scibot 28 Mar 2023
  
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  DOI: 10.1016/j.celrep.2023.112262
  
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sciencedirect.com/science/article/pii/S2211124723002735
Nov 2022
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IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling

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1. scibot 05 Nov 2022
  
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  DOI: 10.1016/j.celrep.2022.111489
  
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sciencedirect.com/science/article/pii/S2211124722013390
Aug 2022
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Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC

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1. scibot 22 Aug 2022
  
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  DOI: 10.1016/j.cell.2022.07.010
  
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sciencedirect.com/science/article/pii/S0092867422009138
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Emergence of immune escape at dominant SARS-CoV-2 killer T-cell epitope

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1. scibot 06 Aug 2022
  
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  DOI: 10.1016/j.cell.2022.07.002
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9279490/
Apr 2022
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Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis

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1. scibot 26 Apr 2022
  
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sciencedirect.com/science/article/pii/S096921262200048X
Mar 2022
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Phosphosite-dependent Presentation of Dual Phosphorylated Peptides by MHC Class I Molecules

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1. scibot 23 Mar 2022
  
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  DOI: 10.1016/j.isci.2022.104013
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8931367/
elifesciences.org elifesciences.org

Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis

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1. scibot 17 Mar 2022
  
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  DOI: 10.7554/eLife.75761
  
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elifesciences.org/articles/75761
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Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB

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  DOI: 10.1016/j.str.2022.02.007
  
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sciencedirect.com/science/article/pii/S0969212622000430
Jan 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1

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1. scibot 20 Jan 2022
  
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  DOI: 10.7554/eLife.72823
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8758145/
Nov 2021
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Structure and assembly pattern of a freshwater short-tailed cyanophage Pam1

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  DOI: 10.1016/j.str.2021.10.004
  
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sciencedirect.com/science/article/pii/S0969212621003725
Oct 2021
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Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2

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1. scibot 23 Oct 2021
  
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  DOI: 10.1016/j.isci.2021.103190
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8517388/
Sep 2021
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Structural basis and regulation of the reductive stress response

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  DOI: 10.1016/j.cell.2021.09.002
  
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Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

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  DOI: 10.7554/eLife.68799
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8439657/
Aug 2021
pubs.acs.org pubs.acs.org

Structural, Biochemical, and Evolutionary Characterizations of Glyoxylate/Hydroxypyruvate Reductases Show Their Division into Two Distinct Subfamilies

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1. scibot 14 Aug 2021
  
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  DOI: 10.1021/acs.biochem.7b01137
  
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pubs.acs.org/doi/10.1021/acs.biochem.7b01137
elifesciences.org elifesciences.org

Untitled document

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1. scibot 11 Aug 2021
  
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  DOI: 10.7554/eLife.30189
  
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elifesciences.org/articles/30189
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Untitled document

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  DOI: 10.1016/j.molcel.2018.11.014
  
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sciencedirect.com/science/article/pii/S1097276518309845
Jul 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 31 Jul 2021
  
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  DOI: 10.7554/eLife.21465
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5370187/
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Structural Basis of CD160:HVEM Recognition

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Analysis of Global and Site-Specific Radiation Damage in Cryo-EM

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A Mutation Directs the Structural Switch of DNA Binding Proteins under Starvation to a Ferritin-like Protein Cage

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Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins

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A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family

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Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1

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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV

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Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form

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Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

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Calmodulin binds to Drosophila TRP with an unexpected mode

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Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex

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Mutations in SKI in Shprintzen–Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

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A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

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Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment

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Cannabidiol interactions with voltage-gated sodium channels

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Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

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Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas

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Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family

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Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling

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Crystal structure of the catalytic C‐lobe of the HECT‐type ubiquitin ligase E6AP

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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies

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Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins

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Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

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Structure-based inhibitors of amyloid beta core suggest a common interface with tau

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An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death

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Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)

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Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells

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Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p

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EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics

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Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

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The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix

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Structural basis of host recognition and biofilm formation by Salmonella Saf pili.

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Mapping the ER Interactome: The P Domains of Calnexin and Calreticulin as Plurivalent Adapters for Foldases and Chaperones

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Structure and Cooperativity of the Cytosolic Domain of the CorA Mg2+ Channel from Escherichia coli

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Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases

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Structural Insight into Ubiquitin-Like Protein Recognition and Oligomeric States of JAMM/MPN+ Proteases

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Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination

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Covalent Protein Labeling at Glutamic Acids

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Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense

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A conformational switch regulates the ubiquitin ligase HUWE1

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Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

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