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Structural mechanism of MUC5AC mucin net-like polymer formation and its SNP variability that affect risk of the lung diseases COPD and IPF

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1. scibot 11 Apr 2025
  
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A cloaked human stem-cell-derived neural graft capable of functional integration and immune evasion in rodent models

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Transcriptional conservation and evolutionary divergence of cell types across mammalian hypothalamus development

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Protocol for observing tunneling nanotube formation and function in both fixed and live primary mouse neurons and microglia coculture system

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Apr 2025
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Activation of a Src-JNK pathway in unscheduled endocycling cells of the Drosophila wing disc induces a chronic wounding response

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Three-dimensional exploration of the chicken embryo, a comparative study of light sheet and histological visualisation

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A spatiotemporal cell atlas of cardiopulmonary progenitor cell allocation during development

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Reactive Oxygen Species Counteract Wound Contraction and Promote Wound Healing

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Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures

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Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors

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Lineage contribution of the mesendoderm progenitors in the gastrulating mouse embryo

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Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses

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Structure of the MUC5AC VWD3 assembly responsible for the formation of net-like mucin polymers

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1. scibot 27 Mar 2025
  
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  DOI: 10.1038/s44319-025-00395-8
  
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1. scibot 25 Mar 2025
  
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1. scibot 23 Mar 2025
  
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52.53.155.43/bd8b1eb80c0a90d93d052e69613b249b6f3108d9/PDF-html.html
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Comparative Single-Cell Transcriptomics of Human Neuroblastoma and Preclinical Models Reveals Conservation of an Adrenergic Cell State

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The mechanosensitive channel ELKIN1 regulates cellular adaptations to simulated microgravity

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An interleukin-9-ZBTB18 axis promotes germinal center development of memory B cells

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Nonlinear high-activity neuronal excitation enhances odor discrimination

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1-s2.0-S2589004225004626-main-html.html

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Mitochondria are positioned at dendritic branch induction sites, a process requiring rhotekin2 and syndapin I

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Comparative analysis of AAV serotypes for transduction of olfactory sensory neurons

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Astrocyte glypican 5 regulates synapse maturation and stabilization

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Septin 3 regulates memory and L-LTP-dependent extension of endoplasmic reticulum into spines

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cell.com/cell-reports/fulltext/S2211-1247(25)00123-8
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Microglia-Mediated Synaptic Dysfunction Contributes to Chemotherapy-Related Cognitive Impairment

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Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells

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Macrophage-derived CTSS drives the age-dependent disruption of the blood-CSF barrier

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GPNMB and ATP6V1A interact to mediate microglia phagocytosis of multiple types of pathological particles

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A brain organoid/ALL co-culture model reveals the AP-1 pathway as critically associated with CNS-involvement of BCP-ALL

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  DOI: 10.1182/bloodadvances.2023011145
  
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Compositionally unique mitochondria in filopodia support cellular migration

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Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway

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  DOI: 10.7554/eLife.97268
  
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The spatiotemporal distribution of LIN-5/NuMA regulates spindle orientation in the C. elegans germ line

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Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

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  DOI: 10.7554/eLife.92180
  
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A Human Neuron Alzheimer’s Disease Model Reveals Barriers to Senolytic Translatability

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  DOI: 10.1101/2025.01.28.635165
  
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Microglial plasticity governed by state-specific enhancer landscapes

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Rev-erb-α antagonism in alveolar macrophages protects against pneumococcal infection in elderly mice

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A central role for acetylcholine in entorhinal cortex function and dysfunction with age in humans and mice

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Myofibroblasts emerge during alveolar regeneration following influenza-virus-induced lung injury

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Traumatic Brain Injury Promotes Neurogenesis and Oligodendrogenesis in Subcortical Brain Regions of Mice

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jkaf012-html.html

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Patient-derived tumor organoid and fibroblast assembloid models for interrogation of the tumor microenvironment in esophageal adenocarcinoma

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The Lateral Habenula Is Necessary for Maternal Behavior in the Naturally Parturient Primiparous Mouse Dam

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Interleukin-34 and debris clearance by mononuclear phagocytes drive retinal pigment epithelium regeneration in zebrafish

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Endothelial calcium firing mediates the extravasation of metastatic tumor cells

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Functional Regrowth of Norepinephrine Axons in the Adult Mouse Brain Following Injury

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Motor cortical neuronal hyperexcitability associated with α-synuclein aggregation

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Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation

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Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration

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Direct specification of lymphatic endothelium from mesenchymal progenitors

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Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs

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uxae127-html.html

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CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells

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A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit

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Protocol for immunofluorescence staining and large-scale analysis to quantify microglial cell morphology at single-cell resolution in mice

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Early‐life IL‐4 administration induces long‐term changes in microglia in the cerebellum and prefrontal cortex

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Global versus local matrix remodeling drives rotational versus invasive collective migration of epithelial cells

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Clotting Promotes Glioma Growth and Infiltration Through Activation of Focal Adhesion Kinase

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Hormone-responsive progenitors have a unique identity and exhibit high motility during mammary morphogenesis

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Agarose hydrogel-mediated electroporation method for retinal tissue cultured at the air-liquid interface

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PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress

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Endoplasmic reticulum stress triggers unfolded protein response as an antiviral strategy of teleost erythrocytes

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The L27 domain of MPP7 enhances TAZ-YY1 cooperation to renew muscle stem cells

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1-s2.0-S2589004224027755-main-html.html

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Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus

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Glucose-6-phosphatase is required for sperm energy metabolism, motility and fertility in Drosophila

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KPNA3 regulates histone locus body formation by modulating condensation and nuclear import of NPAT

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The vertebrate segmentation clock drives segmentation by stabilizing Dusp phosphatases in zebrafish

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Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain

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Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency

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Molecular diversity and migration of GABAergic neurons in the developing ventral midbrain

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  DOI: 10.1016/j.isci.2024.111239
  
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Impairment of the glial phagolysosomal system drives prion-like propagation in a Drosophila model of Huntington's disease

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Autophagosome development and chloroplast segmentation occur synchronously for piecemeal degradation of chloroplasts

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Astrocyte allocation during brain development is controlled by Tcf4-mediated fate restriction

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Somatostatin interneuron fate-mapping and structure in a Pten knockout model of epilepsy

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Negative cell cycle regulation by calcineurin is necessary for proper beta cell regeneration in zebrafish

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Nanoscale Optical Imaging, Reconstruction, and Spatial Analysis of Whole Mouse Glomeruli

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ProDiVis: a method to normalize fluorescence signal localization in 3D specimens

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The epitranscriptomic m6A RNA modification modulates synaptic function in ageing and in a mouse model of synucleinopathy

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A High-Content Screen Identifies Drugs That Restrict Tumor Cell Extravasation across the Endothelial Barrier

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Modulating DNA Polα Enhances Cell Reprogramming Across Species

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A closed 3D printed microfluidic device for automated growth and differentiation of cerebral organoids from single-cell suspension

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Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation

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Early hippocampal hyperexcitability and synaptic reorganization in mouse models of amyloidosis

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Disruption of perinatal myeloid niches impacts the aging clock of pancreatic β cells

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Signal flow in the NMDA receptor–dependent phosphoproteome regulates postsynaptic plasticity for aversive learning

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Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps

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Overexpression of the schizophrenia risk gene C4 in PV cells drives sex-dependent behavioral deficits and circuit dysfunction

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NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation

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Global and single-cell proteomics view of the co-evolution between neural progenitors and breast cancer cells in a co-culture model

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Long-term mesoscale imaging of 3D intercellular dynamics across a mammalian organ

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Activated tissue-resident macrophages contribute to hair cell insults in noise-induced hearing loss in mice

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Gamma-protocadherins regulate dendrite self-recognition and dynamics to drive self-avoidance

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Lipids from a snail host regulate the multicellular behavior of a predator of parasitic schistosomes

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Functional Regrowth of Norepinephrine Axons in the Adult Mouse Brain Following Injury

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Non-canonical function of ADAM10 in presynaptic plasticity

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BDNF-dependent nano-organization of Neogenin and the WAVE Regulatory Complex promotes actin remodelling in dendritic spines

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Protocol for machine-learning-based 3D image analysis of nuclear envelope tubules in cultured cells

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VAP-mediated membrane-tethering mechanisms implicate ER-PM contact function in pH homeostasis

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Calcineurin is an adaptor required for assembly of the TCR signaling complex

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Somatic and neuritic spines on tyrosine hydroxylase–immunopositive cells of rat retina

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Imaging and manipulating pituitary function in the awake mouse

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Untitled document

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A beginner’s guide to rigor and reproducibility in fluorescence imaging experiments | Molecular Biology of the Cell

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Melanopsin expressing human retinal ganglion cells: Subtypes, distribution, and intraretinal connectivity

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Cryptic laminar and columnar organization in the dorsolateral pallium of a weakly electric fish

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Mapping chromatic pathways in the Drosophila visual system

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Role of primary afferents in the developmental regulation of motor axon synapse numbers on Renshaw cells

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Morphology and connectivity of the small bistratified A8 amacrine cell in the mouse retina

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Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer

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Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis

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Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation

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Local DNA compaction creates TF-DNA clusters that enable transcription

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Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes

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Actin-dependent astrocytic infiltration is a key step for axon defasciculation during remodeling

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Dynamic landscapes and protective immunity coordinated by influenza-specific lung-resident memory CD8+ T cells revealed by intravital imaging

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The primitive endoderm supports lineage plasticity to enable regulative development

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The Drosophila melanogaster Y-linked gene, WDY, is required for sperm to swim in the female reproductive tract

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Mitochondrial transfer between BMSCs and Müller promotes mitochondrial fusion and suppresses gliosis in degenerative retina

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The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells

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Acetylcholine Neurons Become Cholinergic during Three Time Windows in the Developing Mouse Brain

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Kv2 channels do not function as canonical delayed rectifiers in spinal motoneurons

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Respiratory infection with influenza A virus delays remyelination and alters oligodendrocyte metabolism

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Importin α inhibitors act against the differentiated stages of apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii

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Accelerating the continuous community sharing of digital neuromorphology data

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Disruption of EGF Feedback by Intestinal Tumors and Neighboring Cells in Drosophila

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Egg multivesicular bodies elicit an LC3-associated phagocytosis-like pathway to degrade paternal mitochondria after fertilization

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The sex of organ geometry

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Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC

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RESPAN: an accurate, unbiased and automated pipeline for analysis of dendritic morphology and dendritic spine mapping

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The Mohawk homeobox gene represents a marker and osteo-inhibitory factor in calvarial suture osteoprogenitor cells

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The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies

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A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma

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Rewarding Capacity of Optogenetically Activating a Giant GABAergic Central-Brain Interneuron in Larval Drosophila

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The sex of organ geometry

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Delilah, prospero, and D-Pax2 constitute a gene regulatory network essential for the development of functional proprioceptors

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An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination

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Heterochromatic 3D genome organization is directed by HP1a- and H3K9-dependent and independent mechanisms

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Quantitative effects of co-culture on T cell motility and cancer-T cell interactions

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Non-apoptotic caspase events and Atf3 expression underlie direct neuronal differentiation of adult neural stem cells

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Prenatal tuning of thalamic spontaneous activity patterns regulates somatosensory map resolution

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RSU-1 Regulates the Integrity of Dense Bodies in Muscle Cells of Aging Caenorhabditis elegans

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Impaired Cortico-Amygdala Functional Connectivity Can Drive Social Behavior Deficits in Synucleinopathies

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A 3D atlas of sexually dimorphic lumbosacral motor neurons that control and integrate pelvic visceral and somatic functions in rats

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Paclitaxel and Carboplatin in Combination with Low-Intensity Pulsed Ultrasound for Glioblastoma

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Cooperation of Various Cytoskeletal Components Orchestrates Intercellular Spread of Mitochondria between B Cells through Tunnelling Nanotubes

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Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation

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Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact

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The first two blastomeres contribute unequally to the human embryo

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Loss of Midbrain Dopamine Neurons Does Not Alter GABAergic Inhibition Mediated by Parvalbumin-Expressing Interneurons in Mouse Primary Motor Cortex

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Rho-associated kinase regulates Langerhans cell morphology and responsiveness to tissue damage

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Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation

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Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation

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Morphological deficits of glial cells in a transgenic mouse model for developmental stuttering

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Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma

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ER-associated degradation adapter Sel1L is required for CD8+ T cell function and memory formation following acute viral infection

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Sex-specific expression of distinct serotonin receptors mediates stress vulnerability of adult hippocampal neural stem cells in mice

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JNEUROSCI.1256-23.2024.full-html.html

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Growth hormone promotes myelin repair after chronic hypoxia via triggering pericyte-dependent angiogenesis

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Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization

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Adipose triglyceride lipase is a therapeutic target in advanced prostate cancer that promotes metabolic plasticity

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EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth

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Selective vulnerability of the ventral hippocampus-prelimbic cortex axis parvalbumin interneuron network underlies learning deficits of fragile X mice

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Cooperation of Various Cytoskeletal Components Orchestrates Intercellular Spread of Mitochondria between B-Lymphoma Cells through Tunnelling Nanotubes

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Early deficits in an in vitro striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation

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Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons

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Mechanical forces in plant tissue matrix orient cell divisions via microtubule stabilization

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Early-wave macrophages control late hematopoiesis

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Telomere dysfunction alters intestinal stem cell dynamics to promote cancer

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Parvalbumin and somatostatin: biomarkers for two parallel tectothalamic pathways in the auditory midbrain

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Spatial patterning controls neuron numbers in the Drosophila visual system

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Villus myofibroblasts are developmental and adult progenitors of mammalian gut lymphatic musculature

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Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli

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Exploration biases forelimb reaching strategies

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Mesenchyme instructs growth while epithelium directs branching in the mouse mammary gland

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Interleukin-4 downregulates transcription factor BCL6 to promote memory B cell selection in germinal centers

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Ankrd26 is a retinoic acid-responsive plasma membrane-binding and -shaping protein critical for proper cell differentiation

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N-cadherin dynamically regulates pediatric glioma cell migration in complex environments

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Kdm1a safeguards the topological boundaries of PRC2-repressed genes and prevents aging-related euchromatinization in neurons

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Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia

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Multimodal sensory control of motor performance by glycinergic interneurons of the mouse spinal cord deep dorsal horn

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Ly6C+ monocytes in the skin promote systemic alphavirus dissemination

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Neuromuscular organoids model spinal neuromuscular pathologies in C9orf72 amyotrophic lateral sclerosis

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Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients

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A Versatile Pipeline for High-fidelity Imaging and Analysis of Vascular Networks Across the Body

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can-23-0555-html.html

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