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Dynamicity of Topoisomerase 1 binding at super-enhancers regulates TLR-responsive gene expression program in macrophages

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1. scibot 29 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117604
  
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sciencedirect.com/science/article/pii/S2211124726006820
May 2026
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Cohesin complex cooperates with PU.1 at super-enhancers to regulate the differentiation and identity of conventional dendritic cells

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1. scibot 07 May 2026
  
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  DOI: 10.1016/j.celrep.2026.117331
  
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sciencedirect.com/science/article/pii/S2211124726004092
May 2025
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Repeat-element RNAs integrate a neuronal growth circuit

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.cell.2025.04.030
  
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cell.com/cell/fulltext/S0092-8674(25)00498-2
May 2024
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T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103+ intestine-resident memory CD8+ T cells

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1. scibot 23 May 2024
  
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sciencedirect.com/science/article/pii/S2211124724005862
Aug 2022
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TOP1 CAD-seq: A protocol to map catalytically engaged topoisomerase 1 in human cells

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1. scibot 04 Aug 2022
  
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  DOI: 10.1016/j.xpro.2022.101581
  
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sciencedirect.com/science/article/pii/S2666166722004610
May 2022
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H3-K27M-mutant nucleosomes interact with MLL1 to shape the glioma epigenetic landscape

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1. scibot 19 May 2022
  
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  DOI: 10.1016/j.celrep.2022.110836
  
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sciencedirect.com/science/article/pii/S221112472200609X
Jan 2022
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MAP3K7 loss drives enhanced androgen signaling and independently confers risk of recurrence in prostate cancer with joint loss of CHD1

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1. scibot 05 Jan 2022
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8254790/
Dec 2021
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MYC assembles and stimulates topoisomerases 1 and 2 in a “topoisome”

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1. scibot 10 Dec 2021
  
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  DOI: 10.1016/j.molcel.2021.11.016
  
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cell.com/molecular-cell/fulltext/S1097-2765(21)00996-5
Nov 2021
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Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1

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1. scibot 12 Nov 2021
  
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  DOI: 10.1016/j.molcel.2021.10.015
  
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sciencedirect.com/science/article/pii/S1097276521009072
Aug 2021
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Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding

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1. scibot 18 Aug 2021
  
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  DOI: 10.1016/j.neuron.2021.07.007
  
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sciencedirect.com/science/article/pii/S0896627321005067
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Untitled document

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1. scibot 11 Aug 2021
  
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  DOI: 10.7554/eLife.17361
  
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elifesciences.org/articles/17361
Jul 2021
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Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

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1. scibot 30 Jul 2021
  
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  DOI: 10.1016/j.cell.2018.09.051
  
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sciencedirect.com/science/article/pii/S0092867418312637
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A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis

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1. scibot 27 Jul 2021
  
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  DOI: 10.1016/j.ccell.2018.10.004
  
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sciencedirect.com/science/article/pii/S1535610818304707
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Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

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1. scibot 09 Jul 2021
  
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  DOI: 10.1016/j.molcel.2021.06.016
  
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sciencedirect.com/science/article/pii/S1097276521004962
Apr 2021
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5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer’s disease

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1. scibot 28 Apr 2021
  
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  DOI: 10.1016/j.celrep.2021.109042
  
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sciencedirect.com/science/article/pii/S2211124721003582
Sep 2020
elifesciences.org elifesciences.org

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency

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1. scibot 17 Sep 2020
  
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  DOI: 10.7554/eLife.54993
  
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elifesciences.org/articles/54993
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Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

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1. scibot 06 Sep 2020
  
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  DOI: 10.1016/j.molcel.2018.11.006
  
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cell.com/molecular-cell/abstract/S1097-2765(18)30948-1
Jan 2020
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Genome-wide analysis of the H3K27me3 epigenome and transcriptome in Brassica rapa

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1. scibot 13 Jan 2020
  
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  DOI: 10.1093/gigascience/giz147
  
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academic.oup.com/gigascience/article/8/12/giz147/5652252
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Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cell.2019.10.044
  
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sciencedirect.com/science/article/pii/S0092867419312218
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Untitled document

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  DOI: 10.1016/j.molcel.2018.11.006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6375729/
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Untitled document

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1. scibot 12 Jan 2020
  
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  DOI: 10.1016/j.molcel.2018.11.006
  
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sciencedirect.com/science/article/pii/S1097276518309481
Nov 2018
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The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1074761318303960
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Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes

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1. scibot 05 Nov 2018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6179960/
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Untitled document

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1934590918304454
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The Epstein-Barr Virus Regulome in Lymphoblastoid Cells

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1931312817303554
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The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1097276518301722
Nov 2017
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Evolutionarily Conserved Principles Predict 3D Chromatin Organization

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1. scibot 08 Nov 2017
  
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sciencedirect.com/science/article/pii/S1097276517305464
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Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity

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1. scibot 08 Nov 2017
  
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elifesciences.org/articles/22194v2
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Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency

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1. scibot 08 Nov 2017
  
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Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency

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1. scibot 08 Nov 2017
  
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sciencedirect.com/science/article/pii/S0092867417301836
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Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia

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1. scibot 08 Nov 2017
  
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sciencedirect.com/science/article/pii/S0092867416316853
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Satb2 determines miRNA expression and long-term memory in the adult central nervous system

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1. scibot 08 Nov 2017
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5207769/