296 Matching Annotations
  1. Last 7 days
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    The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex
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    MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons
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  4. Apr 2024
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    Enhanced bovine genome annotation through integration of transcriptomics and epi-transcriptomics datasets facilitates genomic biology
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      DOI: 10.1093/gigascience/giae019

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    Class I HDAC inhibitors enhance antitumor efficacy and persistence of CAR-T cells by activation of the Wnt pathway
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    sciencedirect.com/science/article/pii/S2211124724003930
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    A senescence restriction point acting on chromatin integrates oncogenic signals
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    sciencedirect.com/science/article/pii/S2211124724003723
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    STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10983107/
  9. Mar 2024
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    From degraded to deciphered: ATAC-seq’s application potential in forensic diagnosis
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      DOI: 10.1007/s00414-024-03206-2

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    The transcription factor NF-κB orchestrates nucleosome remodeling during the primary response to Toll-like receptor 4 signaling
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    sciencedirect.com/science/article/pii/S1074761324000803
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    Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation
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    sciencedirect.com/science/article/pii/S1550413123004618
  13. Feb 2024
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    can-23-1129-html.html
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    The EstroGene database reveals diverse temporal, context-dependent, and bidirectional estrogen receptor regulomes in breast cancer
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    SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway
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    A Mutation-driven oncofetal regression fuels phenotypic plasticity in colorectal cancer
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    1. scibot 09 Feb 2024
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      DOI: 10.1101/2023.12.10.570854

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    Parkinson’s Disease Risk Enhancers in Microglia
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    The androgen receptor interacts with GATA3 to transcriptionally regulate a luminal epithelial cell phenotype in breast cancer
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  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide p63-target gene analyses reveal TAp63/NRF2-dependent oxidative stress responses
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    Development of sexual dimorphism of skeletal muscles through the adrenal cortex, caused by androgen-induced global gene suppression
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  22. Jan 2024
  23. www.nature.com www.nature.com
    Cell-type-directed design of synthetic enhancers
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      DOI: 10.1038/s41586-023-06936-2

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  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRDM3/16 Regulate Chromatin Accessibility Required for NKX2-1 Mediated Alveolar Epithelial Differentiation and Function
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    Genomic exploration of the targets of FOXL2 and ESR2 unveils their implication in cell migration, invasion, and adhesion
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      DOI: 10.1096/fj.202002444R

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    Inherited blood cancer predisposition through altered transcription elongation
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    sciencedirect.com/science/article/pii/S009286742301348X
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    An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains
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    Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation
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    Multi-omics integration identifies cell-state-specific repression by PBRM1-PIAS1 cooperation
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    Leveraging tissue-specific enhancer-target gene regulatory networks identifies enhancer somatic mutations that functionally impact lung cancer
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  31. Dec 2023
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    Pluripotency state transition of embryonic stem cells requires the turnover of histone chaperone FACT on chromatin
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    Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma
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    Blimp-1 and c-Maf regulate  Il10 and negatively regulate common and unique proinflammatory gene networks in IL-12 plus IL-27-driven T helper-1 cells
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      DOI: 10.12688/wellcomeopenres.19680.2

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  35. www.science.org www.science.org
    A single-cell multi-omic atlas spanning the adult rhesus macaque brain
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      DOI: 10.1126/sciadv.adh1914

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  36. 52.53.155.43 52.53.155.43
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  37. Nov 2023
  38. www.nature.com www.nature.com
    Selective inhibition of CDK9 in triple negative breast cancer
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      DOI: 10.1038/s41388-023-02892-3

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  39. wellcomeopenresearch.org wellcomeopenresearch.org
    Blimp-1 and c-Maf regulate Il10 and negatively regulate common and unique proinflammatory gene networks in IL-12 plus IL-27-driven T helper-1 cells
    1
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      DOI: 10.12688/wellcomeopenres.19680.1

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    wellcomeopenresearch.org/articles/8-403/v1
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    Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressure
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    Active maintenance of CD8+ T cell naivety through regulation of global genome architecture
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  42. Oct 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Loss of succinyl-CoA synthetase in mouse forebrain results in hypersuccinylation with perturbed neuronal transcription and metabolism
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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A single-cell multi-omic atlas spanning the adult rhesus macaque brain
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      DOI: 10.1126/sciadv.adh1914

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  45. www.nature.com www.nature.com
    TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression
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      DOI: 10.1038/s41467-023-41927-x

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  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acquisition of Neural Fate by Combination of BMP Blockade and Chromatin Modification
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  47. Sep 2023
  48. www.sciencedirect.com www.sciencedirect.com
    Perturbations in 3D genome organization can promote acquired drug resistance
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  49. Aug 2023
  50. 52.53.155.43 52.53.155.43
    Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function
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  51. 52.53.155.43 52.53.155.43
    Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression
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  52. Jul 2023
  53. www.sciencedirect.com www.sciencedirect.com
    The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pharmacological HDAC inhibition impairs pancreatic β-cell function through an epigenome-wide reprogramming
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    Prenatal Δ9-tetrahydrocannabinol exposure in males leads to motivational disturbances related to striatal epigenetic dysregulation
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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Low-level repressive histone marks fine-tune gene transcription in neural stem cells
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  57. Jun 2023
  58. www.embopress.org www.embopress.org
    DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres
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    5-Azacytidine- and retinoic-acid-induced reprogramming of DCCs into dormancy suppresses metastasis via restored TGF-β-SMAD4 signaling
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  60. May 2023
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Developmental dynamics of chromatin accessibility during post-implantation development of monkey embryos
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  62. 52.53.155.43 52.53.155.43
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  63. Apr 2023
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    Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis
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    Novel enhancers conferring compensatory transcriptional regulation of Nkx2-5 in heart development
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    Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload
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    Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia
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  68. 52.53.155.43 52.53.155.43
    Active maintenance of CD8+ T cell naïvety through regulation of global genome architecture
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia
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    Asparagine starvation suppresses histone demethylation through iron depletion
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  71. Mar 2023
  72. www.sciencedirect.com www.sciencedirect.com
    Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion
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    Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1
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  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function
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  75. Feb 2023
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    Genome-wide epigenetic and mRNA-expression profiling followed by CRISPR/Cas9-mediated gene-disruptions corroborate the MIR141/MIR200C-ZEB1/ZEB2-FGFR1 axis in acquired EMT-associated EGFR TKI-resistance in NSCLC cells
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    Loss of PBRM1 alters promoter histone modifications and activates ALDH1A1 to drive renal cell carcinoma
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  78. Jan 2023
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    SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis
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  80. Dec 2022
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    Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters
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    BAF complex maintains glioma stem cells in pediatric H3K27M-glioma
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  83. Nov 2022
  84. www.sciencedirect.com www.sciencedirect.com
    Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation
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    Essential role of MESP1-RING1A complex in cardiac differentiation
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    Transcription factor antagonism regulates heterogeneity in embryonic stem cell states
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  87. Oct 2022
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    CircIPO7 Promotes Nasopharyngeal Carcinoma Metastasis and Cisplatin Chemoresistance by Facilitating YBX1 Nuclear Localization
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    A cis-regulatory lexicon of DNA motif combinations mediating cell-type-specific gene regulation
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  90. Sep 2022
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    In Vivo Genome-Wide CRISPR Activation Screening Identifies Functionally Important Long Noncoding RNAs in Hepatocellular Carcinoma
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    STAG2 promotes the myelination transcriptional program in oligodendrocytes
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    Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
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  94. Aug 2022
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    Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors
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    SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression
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  97. Jun 2022
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    Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction
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    Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine
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    JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation
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    Mediator recruits the cohesin loader Scc2 to RNA Pol II-transcribed genes and promotes sister chromatid cohesion
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    Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells
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  104. Apr 2022
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    Presence of H3K4me3 on Paternally Expressed Genes of the Paternal Genome From Sperm to Implantation
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  108. Mar 2022
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    Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit
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    EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma
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    A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair
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  114. Feb 2022
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    HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization
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    Dynamic chromatin state profiling reveals regulatory roles of auxin and cytokinin in shoot regeneration
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    Multimodal regulatory elements within a hormone-specific super enhancer control a heterogeneous transcriptional response
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    PRC1 sustains the integrity of neural fate in the absence of PRC2 function
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    Enhancer RNA Expression in Response to Glucocorticoid Treatment in Murine Macrophages
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    Heat shock factor 1 (HSF1) cooperates with estrogen receptor α (ERα) in the regulation of estrogen action in breast cancer cells
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    MAP3K7 loss drives enhanced androgen signaling and independently confers risk of recurrence in prostate cancer with joint loss of CHD1
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  127. Dec 2021
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    MYC assembles and stimulates topoisomerases 1 and 2 in a “topoisome”
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    Parity-induced changes to mammary epithelial cells control NKT cell expansion and mammary oncogenesis
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    Altered H3 histone acetylation impairs high-fidelity DNA repair to promote cerebellar degeneration in spinocerebellar ataxia type 7
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    Identification of a novel FUS/ETV4 fusion and comparative analysis with other Ewing sarcoma fusion proteins
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    Kr-h1 maintains distinct caste-specific neurotranscriptomes in response to socially regulated hormones
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    Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription
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  136. Oct 2021
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    DREAM represses distinct targets by cooperating with different THAP domain proteins
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    A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex
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    PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation
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    Spt4 facilitates the movement of RNA polymerase II through the +2 nucleosomal barrier
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    H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity
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    SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling
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    SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape
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    Multiplatform discovery and regulatory function analysis of structural variations in non-small cell lung carcinoma
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  148. Aug 2021
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    Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia
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  150. www.nature.com www.nature.com
    Genome-wide and sister chromatid-resolved profiling of protein occupancy in replicated chromatin with ChOR-seq and SCAR-seq
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    Novel cell adhesion/migration pathways are predictive markers of HDAC inhibitor resistance in cutaneous T cell lymphoma
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    Chromatin Environment and Cellular Context Specify Compensatory Activity of Paralogous MEF2 Transcription Factors
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    Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors
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    MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis
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    Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets
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    Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification
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    A Prion-like Domain in Transcription Factor EBF1 Promotes Phase Separation and Enables B Cell Programming of Progenitor Chromatin
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    Self-Reporting Transposons Enable Simultaneous Readout of Gene Expression and Transcription Factor Binding in Single Cells
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    The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages
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    The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers
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  216. Dec 2020
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    Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance
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    NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency
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