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Trio analysis in dystonia identifies de novo KLC1 variants in a kinesinopathy with distinct motor and neurodevelopmental features

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1. scibot 30 Jun 2026
  
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  DOI: 10.1016/j.ebiom.2026.106358
  
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sciencedirect.com/science/article/pii/S2352396426002410
May 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Two birds with one stone: An antibiotic hit blocking Staphylococcus aureus heme uptake with serendipitous hemoglobin left-shifting activity

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1. scibot 06 May 2026
  
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  DOI: 10.1016/j.isci.2026.115625
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13138187/
Apr 2026
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Mechanistic design of cell-penetrating disruptors for phospho-dependent TACC3-CHC interaction

1
1. scibot 30 Apr 2026
  
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  DOI: 10.1016/j.str.2026.04.001
  
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sciencedirect.com/science/article/pii/S0969212626001073
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Childhood immunological imprinting of cross-subtype antibodies targeting the hemagglutinin head domain of influenza viruses

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1. scibot 29 Apr 2026
  
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  DOI: 10.1016/j.chom.2026.04.004
  
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www-sciencedirect-com.ezp.lib.cam.ac.uk/science/article/pii/S1931312826001605
Mar 2026
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A BTB extension and ion-binding domain contribute to the pentameric structure and TFAP2A binding of KCTD1

1
1. scibot 27 Mar 2026
  
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  DOI: 10.1016/j.str.2024.07.023
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7618933/
Dec 2025
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Cross-species interactome analysis uncovers a conserved selective autophagy mechanism for protein quality control in plants

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1. scibot 04 Dec 2025
  
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  DOI: 10.1016/j.devcel.2025.11.001
  
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sciencedirect.com:5037/science/article/pii/S1534580725006938
Sep 2025
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Molecular basis of DNA recognition by the HMG-box-C1 module of capicua

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1. scibot 18 Sep 2025
  
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  DOI: 10.1016/j.str.2025.08.018
  
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sciencedirect.com/science/article/pii/S0969212625003223
Aug 2025
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Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction

1
1. scibot 15 Aug 2025
  
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  DOI: 10.1016/j.str.2025.07.016
  
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sciencedirect.com/science/article/pii/S0969212625002655
Jul 2025
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M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer

1
1. scibot 04 Jul 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0699
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12214875/
Mar 2025
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23ME-01473, an Fc Effector–Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell–Mediated Antitumor Immunity through NKG2D and FcγRIIIa Activation

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1. scibot 27 Mar 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0478
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11927390/
Dec 2024
onlinelibrary.wiley.com onlinelibrary.wiley.com

Nanobodies against the myelin enzyme CNPase as tools for structural and functional studies

1
1. scibot 13 Dec 2024
  
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  DOI: 10.1111/jnc.16274
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16274
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Dual BACH1 regulation by complementary SCF-type E3 ligases

1
1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.cell.2024.11.006
  
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sciencedirect.com/science/article/pii/S0092867424013229
Nov 2024
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Structural basis of signaling complex inhibition by IL-6 domain-swapped dimers

1
1. scibot 24 Nov 2024
  
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  DOI: 10.1016/j.str.2024.10.028
  
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sciencedirect.com/science/article/pii/S0969212624004635
Jul 2024
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Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38

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1. scibot 16 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114502
  
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sciencedirect.com/science/article/pii/S2211124724008313
Apr 2024
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Staphylococcus aureus skin colonization is mediated by SasG lectin variation

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1. scibot 04 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114022
  
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sciencedirect.com/science/article/pii/S2211124724003504
Mar 2024
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ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat

2
1. scibot 15 Mar 2024
  
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  DOI: 10.1016/j.cell.2024.02.013
  
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2. scibot 15 Mar 2024
  
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  DOI: 10.1016/j.cell.2024.02.013
  
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sciencedirect.com/science/article/pii/S009286742400179X
Feb 2024
elifesciences.org elifesciences.org

Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS607-family transposition

1
1. scibot 08 Feb 2024
  
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  DOI: 10.7554/eLife.39611
  
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elifesciences.org/articles/39611
Oct 2023
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KANK1 shapes focal adhesions by orchestrating protein binding, mechanical force sensing, and phase separation

1
1. scibot 28 Oct 2023
  
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  DOI: 10.1016/j.celrep.2023.113321
  
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sciencedirect.com/science/article/pii/S2211124723013335
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations

1
1. scibot 08 Sep 2023
  
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  DOI: 10.1158/2159-8290.CD-23-0475
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10481131/
Jul 2023
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Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.cell.2023.06.020
  
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sciencedirect.com/science/article/pii/S0092867423006967
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Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity

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1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112827
  
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sciencedirect.com/science/article/pii/S2211124723008380
52.53.155.43 52.53.155.43

cd-23-0475-html.html

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1. scibot 13 Jul 2023
  
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  DOI: 10.1158/2159-8290.cd-23-0475
  
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52.53.155.43/ab02200bf4457c1e8196af2525f73574a3d0dd99/cd-23-0475-html.html
May 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

High-resolution structures with bound Mn2+ and Cd2+ map the metal import pathway in an Nramp transporter

1
1. scibot 18 May 2023
  
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  DOI: 10.7554/eLife.84006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10185341/
Mar 2023
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Immunodominant surface epitopes power immune evasion in the African trypanosome

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1. scibot 28 Mar 2023
  
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  DOI: 10.1016/j.celrep.2023.112262
  
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sciencedirect.com/science/article/pii/S2211124723002735
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Structures of NF-κB p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation

1
1. scibot 10 Mar 2023
  
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  DOI: 10.7554/eLife.86258
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9991059/
Jan 2023
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The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions

1
1. scibot 28 Jan 2023
  
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  DOI: 10.1016/j.celrep.2022.111902
  
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sciencedirect.com/science/article/pii/S2211124722018010
Dec 2022
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Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding

1
1. scibot 13 Dec 2022
  
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  DOI: 10.1016/j.str.2022.11.008
  
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sciencedirect.com/science/article/pii/S0969212622004579
Nov 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes

1
1. scibot 16 Nov 2022
  
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  DOI: 10.1016/j.immuni.2022.10.019
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9606073/
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Antibacterial T6SS effectors with a VRR-Nuc domain are structure-specific nucleases

1
1. scibot 09 Nov 2022
  
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  DOI: 10.7554/eLife.82437
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9635880/
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IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling

1
1. scibot 05 Nov 2022
  
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  DOI: 10.1016/j.celrep.2022.111489
  
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sciencedirect.com/science/article/pii/S2211124722013390
rupress.org rupress.org

Mitoguardin-2–mediated lipid transfer preserves mitochondrial morphology and lipid droplet formation

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1. scibot 01 Nov 2022
  
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  DOI: 10.1083/jcb.202207022
  
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rupress.org/jcb/article/221/12/e202207022/213573/Mitoguardin-2-mediated-lipid-transfer-preserves
Aug 2022
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Emergence of immune escape at dominant SARS-CoV-2 killer T-cell epitope

1
1. scibot 06 Aug 2022
  
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  DOI: 10.1016/j.cell.2022.07.002
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9279490/
Mar 2022
elifesciences.org elifesciences.org

Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis

1
1. scibot 17 Mar 2022
  
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  DOI: 10.7554/eLife.75761
  
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elifesciences.org/articles/75761
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Crystals of TELSAM–target protein fusions that exhibit minimal crystal contacts and lack direct inter-TELSAM contacts

1
1. scibot 11 Mar 2022
  
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  DOI: 10.1098/rsob.210271
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8889177/
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Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel

1
1. scibot 04 Mar 2022
  
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  DOI: 10.1016/j.str.2022.02.005
  
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The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria

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Rational engineering enables co-crystallization and structural determination of the HIV-1 matrix-tRNA complex

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Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy

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Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

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Regulation of human mTOR complexes by DEPTOR

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McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation

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HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization

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Protocol for the use of focused ion-beam milling to prepare crystalline lamellae for microcrystal electron diffraction (MicroED)

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Collection of Continuous Rotation MicroED Data from Ion Beam-Milled Crystals of Any Size

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Fcab-HER2 Interaction: a Ménage à Trois. Lessons from X-Ray and Solution Studies

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Regulation of the endosomal SNX27-retromer by OTULIN

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Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway

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Homer Tetramer Promotes Actin Bundling Activity of Drebrin

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Cross-Reactive Donor-Specific CD8+ Tregs Efficiently Prevent Transplant Rejection

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Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

1
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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV

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K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap

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Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form

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SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms

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Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

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A pentameric protein ring with novel architecture is required for herpesviral packaging

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Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site

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Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family

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Mutations in SKI in Shprintzen–Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

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Impact of WIN site inhibitor on the WDR5 interactome

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A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

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Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment

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Cannabidiol interactions with voltage-gated sodium channels

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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies

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Structural model for differential cap maturation at growing microtubule ends

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Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation

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Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling

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Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca2+-dependent Cl- currents in human RPE

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A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling

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Chemical and structural investigation of the paroxetine-human serotonin transporter complex

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A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl–/H+ transport cycle

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Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies

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Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins

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Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter

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Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies

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Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED

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Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies

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Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD

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Preventing an Antigenically Disruptive Mutation in Egg-Based H3N2 Seasonal Influenza Vaccines by Mutational Incompatibility

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Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity

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Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody

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Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation

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Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus

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Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p

1
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Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies

1
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Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase

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A Rare Lysozyme Crystal Form Solved Using Highly Redundant Multiple Electron Diffraction Datasets from Micron-Sized Crystals

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Discrimination against RNA Backbones by a ssDNA Binding Protein

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Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies

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Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC

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Robo1 Forms a Compact Dimer-of-Dimers Assembly

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HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage

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A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription.

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A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants

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A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN

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Mapping the ER Interactome: The P Domains of Calnexin and Calreticulin as Plurivalent Adapters for Foldases and Chaperones

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Structural Basis for Apelin Control of the Human Apelin Receptor

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Autonomous Generation and Loading of DNA Guides by Bacterial Argonaute

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Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesion by MDGA1/Neuroligin-2 Complex

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Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors

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Structural Basis of Egg Coat-Sperm Recognition at Fertilization

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Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly

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A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases

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Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding

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Crystal Structure of the Human Cannabinoid Receptor CB1

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5′ End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding

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Molecular Basis of Substrate Specific Acetylation by N-Terminal Acetyltransferase NatB

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Mechanism of Substrate Translocation in an Alternating Access Transporter

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Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity

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NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres

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S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity

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Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

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NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

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Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

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Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)

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