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Structural basis of adenosine 2A receptor-balanced signaling activation relies on allosterically mediated structural dynamics

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  DOI: 10.1016/j.chembiol.2025.08.005
  
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sciencedirect.com/science/article/pii/S2451945625002582
Jun 2025
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An Integrative Analysis of Metagenomic and Metabolomic Profiling Reveals Gut Microbiome Dysbiosis and Metabolic Alterations in ALS: Potential Biomarkers and Therapeutic Insights

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1. scibot 26 Jun 2025
  
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  DOI: 10.1021/acschemneuro.5c00254
  
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  DOI: 10.1021/acschemneuro.5c00254
  
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pubs.acs.org/doi/10.1021/acschemneuro.5c00254
May 2025
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Dynamic interchange of local residue–residue interactions in the largely extended single alpha-helix in Drebrin

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1. scibot 19 May 2025
  
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  DOI: 10.1042/BCJ20253036
  
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sciencedirect.com/org/science/article/pii/S1470872825000256
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PNUTS:PP1 recruitment to Tox4 regulates chromosomal dispersal in Drosophila germline development

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sciencedirect.com/science/article/pii/S2211124725004644
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Metabolic dysregulation in amyotrophic lateral sclerosis: insights from 1H NMR-based metabolomics in a tertiary care center in India

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1. scibot 16 May 2025
  
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link.springer.com/article/10.1007/s11011-025-01616-8
Apr 2025
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Impact of High-Fat Diet-induced Metabolic Dysfunction-associated Steatotic Liver Disease on Heart, Kidney, and Skeletal Muscle Metabolomes in Wild-Type Mice

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1. scibot 17 Apr 2025
  
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  DOI: 10.1021/acs.jproteome.5c00040
  
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pubs.acs.org/doi/full/10.1021/acs.jproteome.5c00040
Feb 2025
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An inducible and reversible system to regulate unsaturated fatty acid biosynthesis in C. elegans

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1. scibot 06 Feb 2025
  
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52.53.155.43/cedea06ef5d4e873337723c4406c4ec8f1bca728/2024.10.01.616130v1.full-html.html
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The structure of a NEMO construct engineered for screening reveals novel determinants of inhibition

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sciencedirect.com/science/article/pii/S0969212625000103
Dec 2024
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Dual BACH1 regulation by complementary SCF-type E3 ligases

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1. scibot 10 Dec 2024
  
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sciencedirect.com/science/article/pii/S0092867424013229
Sep 2024
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DDI2 protease controls embryonic development and inflammation via TCF11/NRF1

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1. scibot 25 Sep 2024
  
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sciencedirect.com/science/article/pii/S2589004224021187
Jun 2024
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Special Prey, Special Glue: NMR Spectroscopy on Aggregate Glue Components of Moth-Specialist Spiders, Cyrtarachninae

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1. scibot 08 Jun 2024
  
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  DOI: 10.3390/biomimetics9050256
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11117802/
Apr 2024
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Disorder in CENP-ACse4 tail-chaperone interaction facilitates binding with Ame1/Okp1 at the kinetochore

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1. scibot 02 Apr 2024
  
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sciencedirect.com/science/article/pii/S0969212624000844
Mar 2024
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Activation of GFRAL+ neurons induces hypothermia and glucoregulatory responses associated with nausea and torpor

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1. scibot 21 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113960
  
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sciencedirect.com/science/article/pii/S2211124724002882
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A Cross-Sectional Quantitative Metabolomics Study Evidencing the Metabolic Signature in Six Organs during a 14-Week High-Fat High-Sucrose and Standard Diet in Mice

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1. scibot 20 Mar 2024
  
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  DOI: 10.3390/nu16060803
  
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mdpi.com/2072-6643/16/6/803
Feb 2024
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Imaging Glioblastoma Response to Radiotherapy Using 2H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism.

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1. scibot 23 Feb 2024
  
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  DOI: 10.1158/0008-5472.can-22-0101
  
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52.53.155.43/ed46a0337a1a6f27f637ebe609d59495e53f4c47/3622-html.html
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Imaging glioblastoma response to radiotherapy using 2H magnetic resonance spectroscopy measurements of fumarate metabolism

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1. scibot 23 Feb 2024
  
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  DOI: 10.1158/0008-5472.CAN-22-0101
  
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2. scibot 23 Feb 2024
  
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  DOI: 10.1158/0008-5472.CAN-22-0101
  
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aacrjournals.org/cancerres/article/82/19/3622/709416/Imaging-Glioblastoma-Response-to-Radiotherapy
Jan 2024
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The pretreatment and enzymatic hydrolysis behaviors of lignocellulosic biomass (oak and larch) based on structural changes in its lignin-carbohydrate complex

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1. scibot 25 Jan 2024
  
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  DOI: 10.1016/j.indcrop.2024.118110
  
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sciencedirect.com/science/article/pii/S0926669024000906
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Engineering paralog-specific PSD-95 recombinant binders as minimally interfering multimodal probes for advanced imaging techniques

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1. scibot 24 Jan 2024
  
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  DOI: 10.7554/eLife.69620
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10803022/
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Recruitment of trimeric eIF2 by phosphatase non-catalytic subunit PPP1R15B

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  DOI: 10.1016/j.molcel.2023.12.011
  
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sciencedirect.com/science/article/pii/S1097276523010304
Nov 2023
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An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant

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sciencedirect.com/science/article/pii/S2211124723014961
Aug 2023
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A tetracationic porphyrin with dual anti-prion activity

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sciencedirect.com/science/article/pii/S2589004223015572
Jun 2023
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Structural and biochemical characterisation of Co2+-binding sites on serum albumins and their interplay with fatty acids

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1. scibot 17 Jun 2023
  
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  DOI: 10.1039/d3sc01723k
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10266443/
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Structural and biochemical characterisation of Co 2+ -binding sites on serum albumins and their interplay with fatty acids

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pubs.rsc.org/en/content/articlehtml/2023/sc/d3sc01723k
Apr 2023
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AMP-activated protein kinase activators have compound and concentration-specific effects on brain metabolism

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1. scibot 08 Apr 2023
  
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  DOI: 10.1111/jnc.15815
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15815
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Oncogene-mediated nuclear accumulation of lactate promotes epigenetic alterations to induce cancer cell proliferation

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  DOI: 10.1002/jcb.30381
  
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onlinelibrary.wiley.com/doi/10.1002/jcb.30381
Dec 2022
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Multivalency, autoinhibition, and protein disorder in the regulation of interactions of dynein intermediate chain with dynactin and the nuclear distribution protein

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1. scibot 31 Dec 2022
  
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  DOI: 10.7554/eLife.80217
  
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elifesciences.org/articles/80217
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The Cooperative Folding of Annexin A2 Relies on a Transient Non-Native Intermediate

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  DOI: 10.1016/j.bpj.2022.10.043
  
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cell.com/biophysj/abstract/S0006-3495(22)00897-9
Nov 2022
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Duration of dry and humidified incubation of single-step embryo culture medium and oxygen tension during sham culture do not alter medium composition.

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1. scibot 10 Nov 2022
  
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  DOI: 10.12688/f1000research.109895.2
  
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europepmc.org/articles/PMC9214662/
Oct 2022
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Imaging glioblastoma response to radiotherapy using 2H magnetic resonance spectroscopy measurements of fumarate metabolism

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  DOI: 10.1158/0008-5472.CAN-22-0101
  
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aacrjournals.org/cancerres/article/82/19/3622/709416/Imaging-Glioblastoma-Response-to-Radiotherapy
Sep 2022
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Stability Study of Alpinia galanga Constituents and Investigation of Their Membrane Permeability by ChemGPS-NP and the Parallel Artificial Membrane Permeability Assay

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1. scibot 27 Sep 2022
  
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  DOI: 10.3390/pharmaceutics14091967
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9502528/
Mar 2022
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Duration of dry and humidified incubation of single-step embryo culture medium and oxygen tension during sham culture do not alter metabolomics signature

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  DOI: 10.12688/f1000research.109895.1
  
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f1000research.com/articles/11-242
Nov 2021
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An engineered construct of cFLIP provides insight into DED1 structure and interactions

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1. scibot 23 Nov 2021
  
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  DOI: 10.1016/j.str.2021.10.011
  
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sciencedirect.com/science/article/pii/S0969212621003798
Sep 2021
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Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

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1. scibot 18 Sep 2021
  
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  DOI: 10.7554/eLife.68799
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8439657/
Jul 2021
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Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1

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1. scibot 29 Jul 2021
  
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  DOI: 10.1016/j.chembiol.2019.09.002
  
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sciencedirect.com/science/article/pii/S2451945619302764
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Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway

1
1. scibot 29 Jul 2021
  
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  DOI: 10.1016/j.str.2017.10.007
  
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elifesciences.org elifesciences.org

Multivalency regulates activity in an intrinsically disordered transcription factor

1
1. scibot 29 Jul 2021
  
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  RRID:SCR_014227
  
  DOI: 10.7554/eLife.36258
  
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An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death

1
1. scibot 28 Jul 2021
  
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  RRID: SCR_014227
  
  DOI: 10.1016/j.molcel.2019.01.028
  
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sciencedirect.com/science/article/pii/S1097276519300486
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The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules

1
1. scibot 28 Jul 2021
  
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  DOI: 10.1016/j.chembiol.2018.10.018
  
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Conformational Dynamics and Allostery in E2:E3 Interactions Drive Ubiquitination: gp78 and Ube2g2

2
1. scibot 27 Jul 2021
  
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  CPMG relaxation dispersion pulse program for Bruker
  
  DOI: 10.1016/j.str.2017.03.016
  
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2. scibot 27 Jul 2021
  
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  DOI: 10.1016/j.str.2017.03.016
  
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sciencedirect.com/science/article/pii/S096921261730076X
Jun 2021
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A drastic shift in the energetic landscape of toothed whale sperm cells

1
1. scibot 25 Jun 2021
  
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  RRID:SCR_014227
  
  DOI: 10.1016/j.cub.2021.05.062
  
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sciencedirect.com/science/article/pii/S0960982221007600
Feb 2021
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Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family

1
1. scibot 24 Feb 2021
  
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  RRID:SCR_014227
  
  DOI: 10.7554/eLife.61818
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7877911/
Sep 2020
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Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state

1
1. scibot 23 Sep 2020
  
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  RRID:SCR_014227
  
  DOI: 10.7554/eLife.53901
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7069725/
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Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement

1
1. scibot 14 Sep 2020
  
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  RRID:SCR_014227
  
  DOI: 10.7554/eLife.57179
  
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elifesciences.org/articles/57179
Jan 2020
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Altered protein dynamics and increased aggregation in human γS-crystallin due to cataract-associated deamidations

1
1. scibot 13 Jan 2020
  
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  RRID:SCR_014227
  
  DOI: 10.1021/acs.biochem.9b00593
  
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pubs.acs.org/doi/full/10.1021/acs.biochem.9b00593
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The Structural Basis for Low Conductance in the Membrane Protein VDAC upon β-NADH Binding and Voltage Gating

1
1. scibot 13 Jan 2020
  
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  RRID:SCR_014227
  
  DOI: 10.1016/j.str.2019.11.015
  
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sciencedirect.com/science/article/pii/S0969212619304332
Nov 2018
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Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

1
1. scibot 05 Nov 2018
  
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Untitled document

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ncbi.nlm.nih.gov/pmc/articles/PMC6075863/
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Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation

1
1. scibot 05 Nov 2018
  
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  RRID:SCR_014227
  
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sciencedirect.com/science/article/pii/S0092867418302848
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Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor

1
1. scibot 05 Nov 2018
  
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europepmc.org europepmc.org

Untitled document

1
1. scibot 05 Nov 2018
  
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  RRID:SCR_014227
  
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europepmc.org/articles/PMC5601994/
europepmc.org europepmc.org

A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants

1
1. scibot 05 Nov 2018
  
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europepmc.org/articles/PMC5655547/
Nov 2017
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Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

1
1. scibot 08 Nov 2017
  
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  TopSpinTM 3.1
  
  Curator: @Zeljana_Babic
  
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sciencedirect.com/science/article/pii/S0092867417302465
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Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)

1
1. scibot 08 Nov 2017
  
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  Topspin 3.0
  
  Curator: @jcabotaj
  
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ncbi.nlm.nih.gov/pmc/articles/PMC3961105