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Development of a First-in-Class Click Chemistry–Based Cancer Therapeutic, from Preclinical Evaluation to a First-in-Human Dose Escalation Clinical Trial

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1. scibot 07 Sep 2025
  
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  RRID:SCR_014311
  
  DOI: 10.1158/1078-0432.CCR-24-2539
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12402790/
Jul 2025
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Genomic profiling of a collection of patient-derived xenografts and cell lines identified ixabepilone as an active drug against chemo-resistant osteosarcoma

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1. scibot 10 Jul 2025
  
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  DOI: 10.1186/s13046-025-03440-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12235892/
Apr 2025
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Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway

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1. scibot 09 Apr 2025
  
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  DOI: 10.1016/j.immuni.2025.03.005
  
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sciencedirect.com/science/article/pii/S1074761325001244
Feb 2025
aacrjournals.org aacrjournals.org

Inflammation mediated by gut microbiome alterations promotes lung cancer development and an immunosuppressed tumor microenvironment

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1. scibot 20 Feb 2025
  
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  DOI: 10.1158/2326-6066.CIR-24-0469
  
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aacrjournals.org/cancerimmunolres/article/12/12/1736/750301/Inflammation-Mediated-by-Gut-Microbiome
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Targeting GPC2 on intraocular and CNS metastatic retinoblastomas with local and systemic delivery of CAR T-cells

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/1078-0432.CCR-24-0221
  
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aacrjournals.org/clincancerres/article/30/16/3578/746772/Targeting-GPC2-on-Intraocular-and-CNS-Metastatic
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Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-23-3419
  
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aacrjournals.org/cancerres/article/84/18/2968/747793/Scribble-Deficiency-Promotes-Pancreatic-Ductal
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SMAD4 and KRAS Status Shape Cancer Cell-Stromal Crosstalk and Therapeutic Response in Pancreatic Cancer

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1. scibot 11 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2330
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617379/
Dec 2024
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Pathogenic mitochondrial DNA variants are associated with response to anti-VEGF therapy in ovarian cancer PDX models

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1. scibot 21 Dec 2024
  
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  DOI: 10.1186/s13046-024-03239-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11657443/
Sep 2024
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Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.ccell.2024.08.018
  
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sciencedirect.com/science/article/pii/S1535610824003179
Jul 2024
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RNF185 control of COL3A1 expression limits prostate cancer migration and metastatic potential

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1. scibot 07 Jul 2024
  
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  DOI: 10.1158/1541-7786.MCR-23-0512
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10841372/
May 2024
onlinelibrary.wiley.com onlinelibrary.wiley.com

Manganese drives ferroptosis of cancer cells via YAP/TAZ phase separation activated ACSL4 in OSCC

1
1. scibot 24 May 2024
  
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  DOI: 10.1111/odi.14925
  
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  RRID:SCR_014311 DOI:10.1111/odi.14925
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onlinelibrary.wiley.com/doi/10.1111/odi.14925
www.biorxiv.org www.biorxiv.org

SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer

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1. scibot 23 May 2024
  
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  DOI: 10.1101/2024.04.28.591518
  
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biorxiv.org/content/10.1101/2024.04.28.591518v1
Apr 2024
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NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo

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1. scibot 05 Apr 2024
  
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  DOI: 10.1016/j.stem.2024.03.003
  
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sciencedirect.com/science/article/pii/S1934590924000845
Feb 2024
aacrjournals.org aacrjournals.org

Engagement of CD99 activates distinct programs in Ewing sarcoma and macrophages

3
1. scibot 27 Feb 2024
  
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  DOI: 10.1158/2326-6066.CIR-23-0440
  
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2. scibot 27 Feb 2024
  
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  DOI: 10.1158/2326-6066.CIR-23-0440
  
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3. scibot 06 Feb 2024
  
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  RRID:SCR_014311
  
  DOI: 10.1158/2326-6066.CIR-23-0440
  
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aacrjournals.org/cancerimmunolres/article/12/2/247/733768/Engagement-of-CD99-Activates-Distinct-Programs-in
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer

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1. scibot 11 Feb 2024
  
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  DOI: 10.1158/2767-9764.CRC-23-0321
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10851855/
Aug 2023
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CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis

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1. scibot 10 Aug 2023
  
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  RRID:SCR_014311
  
  DOI: 10.1016/j.celrep.2023.112936
  
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sciencedirect.com/science/article/pii/S2211124723009476
Apr 2023
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PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation

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1. scibot 05 Apr 2023
  
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  DOI: 10.1016/j.isci.2023.106314
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10064239/
Jan 2023
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S-adenosylmethionine blocks tumorigenesis and with immune checkpoint inhibitor enhances anti-cancer efficacy against BRAF mutant and wildtype melanomas

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1. scibot 25 Jan 2023
  
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  DOI: 10.1016/j.neo.2022.100874
  
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sciencedirect.com/science/article/pii/S1476558622000999
link.springer.com link.springer.com

Hysteroscopic injections of autologous endometrial cells and platelet-rich plasma in patients with thin endometrium: a pilot randomized study

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1. scibot 19 Jan 2023
  
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  RRID:SCR_014311
  
  DOI: 10.1038/s41598-023-27982-w
  
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link.springer.com/article/10.1038/s41598-023-27982-w
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Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients

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1. scibot 11 Jan 2023
  
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  DOI: 10.1158/2326-6066.CIR-21-0171
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9381099/
Dec 2022
www.mdpi.com www.mdpi.com

Co-Targeting Luminal B Breast Cancer with S-Adenosylmethionine and Immune Checkpoint Inhibitor Reduces Primary Tumor Growth and Progression, and Metastasis to Lungs and Bone

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1. scibot 27 Dec 2022
  
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  DOI: 10.3390/cancers15010048
  
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mdpi.com/2072-6694/15/1/48
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Quantitative Spatial Profiling of Immune Populations in Pancreatic Ductal Adenocarcinoma Reveals Tumor Microenvironment Heterogeneity and Prognostic Biomarkers

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1. scibot 13 Dec 2022
  
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  RRID:SCR_014311
  
  DOI: 10.1158/0008-5472.CAN-22-1190
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9716253/
Oct 2022
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Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier

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1. scibot 27 Oct 2022
  
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  RRID:SCR_014311
  
  DOI: 10.7554/eLife.80690
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9596162/
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STAG2 expression is associated with adverse survival outcomes and regulates cell phenotype in muscle-invasive bladder cancer

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1. scibot 26 Oct 2022
  
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  RRID:SCR_014311
  
  DOI: 10.1158/2767-9764.crc-22-0155
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9583756/
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Distinct biomarker profiles and TCR sequence diversity characterize the response to PD-L1 blockade in a mouse melanoma model

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1. scibot 08 Oct 2022
  
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  DOI: 10.1158/1541-7786.MCR-20-0881
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9533714/
Jun 2022
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Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas

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1. scibot 18 Jun 2022
  
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  DOI: 10.1016/j.molcel.2022.05.023
  
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sciencedirect.com/science/article/pii/S1097276522004907
Apr 2022
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HER2 isoforms uniquely program intratumor heterogeneity and predetermine breast cancer trajectories during the occult tumorigenic phase

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1. scibot 02 Apr 2022
  
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  RRID:SCR_014311
  
  DOI: 10.1158/1541-7786.MCR-21-0215
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8507429/
Feb 2022
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Steroid hormone receptor and infiltrating immune cell status reveals therapeutic vulnerabilities of ESR1 mutant breast cancer.

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1. scibot 02 Feb 2022
  
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  DOI: 10.1158/0008-5472.CAN-20-1200
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7854521/
Jan 2022
clincancerres.aacrjournals.org clincancerres.aacrjournals.org

Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy

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1. scibot 29 Jan 2022
  
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  RRID:SCR_014311
  
  DOI: 10.1158/1078-0432.CCR-21-2495
  
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clincancerres.aacrjournals.org/content/28/1/150
Nov 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Circulating Immunosuppressive Regulatory T Cells Predict Risk of Incident Cutaneous Squamous Cell Carcinoma

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1. scibot 19 Nov 2021
  
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  DOI: 10.3389/fmed.2021.735585
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8593034/
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Deep learning and pathomics analyses reveal cell nuclei as important features for mutation prediction of BRAF-mutated melanomas

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1. scibot 02 Nov 2021
  
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  DOI: 10.1016/j.jid.2021.09.034
  
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sciencedirect.com/science/article/pii/S0022202X21024052
Sep 2021
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High fat / high cholesterol diet does not provoke atherosclerosis in the ω3-and ω6-polyunsaturated fatty acid synthesis inactivated Δ6-fatty acid desaturase deficient mouse

1
1. scibot 23 Sep 2021
  
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  DOI: 10.1016/j.molmet.2021.101335
  
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sciencedirect.com/science/article/pii/S2212877821001824
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 04 Aug 2021
  
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  RRID:SCR_014311
  
  DOI: 10.7554/eLife.30054
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5736353/
Jul 2021
onlinelibrary.wiley.com onlinelibrary.wiley.com

Extracellular pH mapping of liver cancer on a clinical 3T MRI scanner

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1. scibot 31 Jul 2021
  
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FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

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Transferrin and H‐ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype

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  DOI: 10.1111/jnc.14834
  
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onlinelibrary.wiley.com/doi/abs/10.1111/jnc.14834
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Inhibitory neuronal changes following a mixed diffuse‐focal model of traumatic brain injury

1
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Inducible and reversible phenotypes in a novel mouse model of Friedreich's Ataxia.

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Tridimensional mapping of Phox2b expressing neurons in the brainstem of adult Macaca fascicularis and identification of the retrotrapezoid nucleus

1
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Serelaxin enhances the therapeutic effects of human amnion epithelial cell‐derived exosomes in experimental models of lung disease

1
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14666
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Intermittent hypoxia impairs uterine artery function in pregnant mice

1
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Differential responses to increasing numbers of mild traumatic brain injury in a rodent closed‐head injury model

1
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  DOI: 10.1111/jnc.14673
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.14673
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NLRP3 Regulates IL-4 Expression in TOX+ CD4+ T Cells of Cutaneous T Cell Lymphoma to Potentially Promote Disease Progression

1
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ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation

1
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MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer

1
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  DOI: 10.1038/s41523-021-00273-1
  
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nature.com/articles/s41523-021-00273-1
May 2021
clincancerres.aacrjournals.org clincancerres.aacrjournals.org

G9a Inhibition Enhances Checkpoint Inhibitor Blockade Response in Melanoma

1
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clincancerres.aacrjournals.org/content/27/9/2624
Apr 2021
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Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis

1
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Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

1
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BPS Publications

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  DOI: 10.1111/bph.15428
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15428
Nov 2020
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FEBS Press

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  DOI: 10.1002/1878-0261.12820
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.12820
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Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation

1
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  DOI: 10.1016/j.celrep.2020.108331
  
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Lonidamine potentiates the oncolytic efficiency of M1 virus independent of hexokinase 2 but via inhibition of antiviral immunity

1
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  DOI: 10.1186/s12935-020-01598-w
  
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cancerci.biomedcentral.com/article/10.1186/s12935-020-01598-w
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Zinc-finger antiviral protein acts as a tumor suppressor in colorectal cancer

2
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  DOI: 10.1038/s41388-020-01416-7
  
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nature.com/articles/s41388-020-01416-7
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Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression

1
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sciencedirect.com/science/article/pii/S1534580720300575
Jan 2020
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Novel CB1-ligands maintain homeostasis of the endocannabinoid-system in ω3- and ω6-long chain-PUFA deficiency

1
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Neutral Sphingomyelinase 2 (SMPD3)-Deficiency in Mice Causes Chondrodysplasia with Unimpaired Skeletal Mineralization

1
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Persistent vs Transient Alteration of Folliculogenesis and Estrous Cycle After Neonatal vs Adult Exposure to Bisphenol A

1
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academic.oup.com/endo/article/160/11/2558/5565236
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AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration

1
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sciencedirect.com/science/article/pii/S1934590919304321
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Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model

1
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ncbi.nlm.nih.gov/pmc/articles/PMC6890461/
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Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver

1
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  DOI: 10.1016/j.cell.2019.07.017
  
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sciencedirect.com/science/article/pii/S0092867419307822
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Untitled document

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  DOI: 10.1016/j.stem.2019.04.005
  
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sciencedirect.com/science/article/pii/S1934590919301547
Nov 2018
cancerres.aacrjournals.org cancerres.aacrjournals.org

Long chain n-3 fatty acids attenuate oncogenic KRas-driven proliferation by altering plasma membrane nanoscale proteolipid composition

1
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cancerres.aacrjournals.org/content/78/14/3899
Nov 2017
onlinelibrary.wiley.com onlinelibrary.wiley.com

Patterns of cell death in the perinatal mouse forebrain

1
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onlinelibrary.wiley.com/doi/10.1002/cne.24041/full
onlinelibrary.wiley.com onlinelibrary.wiley.com

Differential susceptibility of cortical and subcortical inhibitory neurons and astrocytes in the long term following diffuse traumatic brain injury

1
1. scibot 08 Nov 2017
  
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onlinelibrary.wiley.com/doi/10.1002/cne.24014/full
onlinelibrary.wiley.com onlinelibrary.wiley.com

Feedback in the brainstem: An excitatory disynaptic pathway for control of whisking

1
1. scibot 08 Nov 2017
  
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onlinelibrary.wiley.com/doi/10.1002/cne.23724/full