158 Matching Annotations
  1. Last 7 days
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RIPK3-mediated inflammation is a conserved β cell response to ER stress
    1
    1. scibot 03 Jul 2024
      RRID:SCR_014393

      DOI: 10.1126/sciadv.abd7272

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    ncbi.nlm.nih.gov/pmc/articles/PMC11206196/
  3. Jun 2024
  4. www.biorxiv.org www.biorxiv.org
    Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
    1
    1. scibot 06 Jun 2024
      RRID:SCR_014393

      DOI: 10.1101/2024.04.23.590798

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    biorxiv.org/content/10.1101/2024.04.23.590798v1
  5. May 2024
  6. www.medrxiv.org www.medrxiv.org
    Elucidating the Epigenetic Landscape of Type 2 Diabetes: A Multi-Omics Analysis Revealing Novel CpG Sites and Their Association with Cardiometabolic Traits
    1
    1. scibot 30 May 2024
      RRID:SCR_014393

      DOI: 10.1101/2024.05.20.24307650

      Resource: Human Islet Research Network (HIRN) (RRID:SCR_014393)

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    medrxiv.org/content/10.1101/2024.05.20.24307650v1
  7. www.biorxiv.org www.biorxiv.org
    Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasis
    1
    1. scibot 29 May 2024
      RRID:SCR_014393

      DOI: 10.1101/2024.03.18.585508

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      DOI:10.1101/2024.03.18.585508 RRID:SCR_014393
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    biorxiv.org/content/10.1101/2024.03.18.585508v1
  8. www.biorxiv.org www.biorxiv.org
    Network approach reveals preferential T-cell and macrophage association with α-linked β-cells in early stage of insulitis in NOD mice
    1
    1. scibot 16 May 2024
      RRID:SCR_014393

      DOI: 10.1101/2024.05.06.592831

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    biorxiv.org/content/10.1101/2024.05.06.592831v1
  9. www.nature.com www.nature.com
    AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics
    1
    1. scibot 08 May 2024
      RRID:SCR_014393

      DOI: 10.1038/s41467-024-47334-0

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    nature.com/articles/s41467-024-47334-0
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NKX2-2 based nuclei sorting on frozen human archival pancreas enables the enrichment of islet endocrine populations for single-nucleus RNA sequencing
    1
    1. scibot 02 May 2024
      RRID:SCR_014393

      DOI: 10.1186/s12864-024-10335-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC11059690/
  11. Mar 2024
  12. dx.doi.org dx.doi.org
    DNA methylation-based assessment of cell composition in human pancreas and islets
    1
    1. scibot 30 Mar 2024
      RRID:SCR_014393

      DOI: 10.2337/db23-0704

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    dx.doi.org/10.2337/db23-0704
  13. www.mdpi.com www.mdpi.com
    Exploring Transcriptional Regulation of Beta Cell SASP by Brd4-Associated Proteins and Cell Cycle Control Protein p21
    1
    1. scibot 21 Mar 2024
      RRID:SCR_014393

      DOI: 10.3390/epigenomes8010010

      Resource: Human Islet Research Network (HIRN) (RRID:SCR_014393)

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    mdpi.com/2075-4655/8/1/10
  14. www.sciencedirect.com www.sciencedirect.com
    Three-dimensional imaging of the enteric nervous system in human pediatric colon reveals new features of Hirschsprung disease
    1
    1. scibot 19 Mar 2024
      RRID:SCR_014393

      DOI: 10.1053/j.gastro.2024.02.045

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    sciencedirect.com/science/article/pii/S0016508524002877
  15. Dec 2023
  16. www.sciencedirect.com www.sciencedirect.com
    Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes
    1
    1. scibot 22 Dec 2023
      RRID:SCR_014393

      DOI: 10.1016/j.cmet.2023.11.011

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    sciencedirect.com/science/article/pii/S1550413123004436
  17. link.springer.com link.springer.com
    Genetic risk converges on regulatory networks mediating early type 2 diabetes
    1
    1. scibot 08 Dec 2023
      RRID:SCR_014393

      DOI: 10.1038/s41586-023-06693-2

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    link.springer.com/article/10.1038/s41586-023-06693-2
  18. Nov 2023
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The beta cell-immune cell interface in type 1 diabetes (T1D)
    1
    1. scibot 09 Nov 2023
      RRID:SCR_014393

      DOI: 10.1016/j.molmet.2023.101809

      Resource: Human Islet Research Network (HIRN) (RRID:SCR_014393)

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    ncbi.nlm.nih.gov/pmc/articles/PMC10622886/
  20. Oct 2023
  21. link.springer.com link.springer.com
    Benchmarking algorithms for joint integration of unpaired and paired single-cell RNA-seq and ATAC-seq data
    1
    1. scibot 26 Oct 2023
      RRID:SCR_014393

      DOI: 10.1186/s13059-023-03073-x

      Resource: Human Islet Research Network (HIRN) (RRID:SCR_014393)

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    link.springer.com/article/10.1186/s13059-023-03073-x
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An Integrated Map of Cell Type–Specific Gene Expression in Pancreatic Islets
    2
    1. scibot 25 Oct 2023
      RRID:SCR_014393

      DOI: 10.2337/db23-0130

      Resource: Human Islet Research Network (HIRN) (RRID:SCR_014393)

      Curator: @evieth

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    2. scibot 25 Oct 2023
      RRID:SCR_014393

      DOI: 10.2337/db23-0130

      Resource: Human Islet Research Network (HIRN) (RRID:SCR_014393)

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    ncbi.nlm.nih.gov/pmc/articles/PMC10588282/
  23. dx.doi.org dx.doi.org
    Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings
    1
    1. scibot 06 Oct 2023
      RRID:SCR_014393

      DOI: 10.2337/db22-0942

      Resource: Human Islet Research Network (HIRN) (RRID:SCR_014393)

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    dx.doi.org/10.2337/db22-0942
  24. Sep 2023
  25. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion
    1
    1. scibot 22 Sep 2023
      RRID:SCR_014393

      DOI: 10.1096/fj.202300941R

      Resource: Human Islet Research Network (HIRN) (RRID:SCR_014393)

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202300941R
  26. Aug 2023
  27. 52.53.155.43 52.53.155.43
    Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress
    1
    1. scibot 17 Aug 2023
      RRID:SCR_014393

      DOI: 10.1126/sciadv.abo3932

      Resource: Human Islet Research Network (HIRN) (RRID:SCR_014393)

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    52.53.155.43/3332fca9f9f5417145aee8b440787cc2ea4e4363/sciadv.abo3932-html.html
  28. joe.bioscientifica.com joe.bioscientifica.com
    The human α cell in health and disease
    1
    1. scibot 17 Aug 2023
      RRID:SCR_014393

      DOI: 10.1530/JOE-22-0298

      Resource: Human Islet Research Network (HIRN) (RRID:SCR_014393)

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    joe.bioscientifica.com/view/journals/joe/258/1/JOE-22-0298.xml
  29. www.sciencedirect.com www.sciencedirect.com
    Pericyte dysfunction and impaired vasomotion are hallmarks of islets during the pathogenesis of type 1 diabetes
    1
    1. scibot 03 Aug 2023
      RRID:SCR_014393

      DOI: 10.1016/j.celrep.2023.112913

      Resource: Human Islet Research Network (HIRN) (RRID:SCR_014393)

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    sciencedirect.com/science/article/pii/S2211124723009245
  30. Jul 2023
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings
    1
    1. scibot 12 Jul 2023
      RRID:SCR_014393

      DOI: 10.1097/MPA.0000000000002170

      Resource: Human Islet Research Network (HIRN) (RRID:SCR_014393)

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    ncbi.nlm.nih.gov/pmc/articles/PMC10328394/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inferring regulators of cell identity in the human adult pancreas
    1
    1. scibot 12 Jul 2023
      RRID:SCR_014393

      DOI: 10.1093/nargab/lqad068

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    ncbi.nlm.nih.gov/pmc/articles/PMC10331937/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    When one becomes many - alternative splicing in beta cell function and failure
    1
    1. scibot 06 Jul 2023
      RRID:SCR_014393

      DOI: 10.1111/dom.13388

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    ncbi.nlm.nih.gov/pmc/articles/PMC6148369/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multiplexed in Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes
    1
    1. scibot 06 Jul 2023
      RRID:SCR_014393

      DOI: 10.1016/j.cmet.2019.01.003

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    ncbi.nlm.nih.gov/pmc/articles/PMC6436557/
  35. Jun 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Nutrient-dependent regulation of β-cell proinsulin content
    1
    1. scibot 29 Jun 2023
      RRID:SCR_014393

      DOI: 10.1016/j.jbc.2023.104836

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    sciencedirect.com/science/article/pii/S0021925823018641
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enrichment of stem cell-derived pancreatic beta-like cells and controlled graft size through pharmacological removal of proliferating cells
    1
    1. scibot 21 Jun 2023
      SCR_014393

      DOI: 10.1016/j.stemcr.2023.05.010

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    ncbi.nlm.nih.gov/pmc/articles/PMC10277834/
  38. www.biorxiv.org www.biorxiv.org
    Real Time In vivo Analysis of Pancreatic Beta-cell Autophagic Flux Reveals Impairment Before Onset of Autoimmune Diabetes
    1
    1. scibot 01 Jun 2023
      RRID:SCR_014393

      DOI: 10.1101/2023.05.23.541935

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    biorxiv.org/content/10.1101/2023.05.23.541935v1
  39. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Dissecting the Interrelationship between COVID-19 and Diabetes Mellitus
    1
    1. scibot 01 Jun 2023
      RRID:SCR_014393

      DOI: 10.1002/adbi.202300107

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    onlinelibrary.wiley.com/doi/10.1002/adbi.202300107
  40. May 2023
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits
    1
    1. scibot 12 May 2023
      RRID:SCR_014393

      DOI: 10.1093/sleep/zsac109

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    ncbi.nlm.nih.gov/pmc/articles/PMC9366645/
  42. Apr 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Generation of functional thymic organoids from human pluripotent stem cells.
    1
    1. scibot 27 Apr 2023
      RRID:SCR_014393

      DOI: 10.1016/j.stemcr.2023.02.013

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    sciencedirect.com/science/article/pii/S2213671123000607
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Peeling the onion: another layer in the regulation of insulin secretion
    1
    1. scibot 20 Apr 2023
      RRID:SCR_014393

      DOI: 10.1172/JCI169718

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    ncbi.nlm.nih.gov/pmc/articles/PMC10104890/
  45. Mar 2023
  46. www.nature.com www.nature.com
    Multivariate indicators of disease severity in COVID-19
    1
    1. scibot 31 Mar 2023
      RRID:SCR_014393

      DOI: 10.1038/s41598-023-31683-9

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    nature.com/articles/s41598-023-31683-9
  47. www.biorxiv.org www.biorxiv.org
    Pericyte dysfunction and impaired vasomotion are hallmarks of islets during the pathogenesis of type 1 diabetes
    1
    1. scibot 09 Mar 2023
      RRID:SCR_014393

      DOI: 10.1101/2023.03.02.530808

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    biorxiv.org/content/10.1101/2023.03.02.530808v1
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex differences in islet stress responses support female β cell resilience
    1
    1. scibot 05 Mar 2023
      RRID:SCR_014393

      DOI: 10.1016/j.molmet.2023.101678

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    ncbi.nlm.nih.gov/pmc/articles/PMC9971554/
  49. www.biorxiv.org www.biorxiv.org
    An integrated map of cell type-specific gene expression in pancreatic islets
    1
    1. scibot 03 Mar 2023
      RRID:SCR_014393

      DOI: 10.1101/2023.02.03.526994

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    biorxiv.org/content/10.1101/2023.02.03.526994v1
  50. www.mdpi.com www.mdpi.com
    Cell Replacement Therapy for Type 1 Diabetes Patients: Potential Mechanisms Leading to Stem-Cell-Derived Pancreatic β-Cell Loss upon Transplant
    1
    1. scibot 02 Mar 2023
      RRID:SCR_014393

      DOI: 10.3390/cells12050698

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    mdpi.com/2073-4409/12/5/698
  51. Feb 2023
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics
    1
    1. scibot 15 Feb 2023
      RRID:SCR_014393

      DOI: 10.1101/2023.01.15.524135

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    ncbi.nlm.nih.gov/pmc/articles/PMC9882100/
  53. journals.physiology.org journals.physiology.org
    ajpendo.00246.2022.pdf
    1
    1. scibot 06 Feb 2023
      RRID: SCR_014393

      DOI: 10.1152/ajpendo.00246.2022

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      Curator: @bandrow

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    journals.physiology.org/doi/pdfdirect/10.1152/ajpendo.00246.2022
  54. journals.physiology.org journals.physiology.org
    Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss
    2
    1. scibot 06 Feb 2023
      RRID:SCR_014393

      DOI: 10.1152/ajpendo.00246.2022

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    2. scibot 01 Feb 2023
      RRID:SCR_014393

      DOI: 10.1152/ajpendo.00246.2022

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    journals.physiology.org/doi/epdf/10.1152/ajpendo.00246.2022
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of functional human thymic cells from induced pluripotent stem cells
    1
    1. scibot 02 Feb 2023
      RRID:SCR_014393

      DOI: 10.1016/j.jaci.2021.07.021

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    ncbi.nlm.nih.gov/pmc/articles/PMC8815270/
  56. Jan 2023
  57. diabetesjournals.org diabetesjournals.org
    A Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for in vivo β-Cell Imaging and Islet-Specific Therapies
    1
    1. scibot 21 Jan 2023
      RRID:SCR_014393

      DOI: 10.2337/db22-0477

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    diabetesjournals.org/diabetes/article/72/2/184/147931/Cell-Surface-Autoantibody-Targets-Zinc-Transporter
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ARID1A loss in pancreas leads to islet developmental defect and metabolic disturbance
    1
    1. scibot 18 Jan 2023
      RRID:SCR_014393

      DOI: 10.1016/j.isci.2022.105881

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    ncbi.nlm.nih.gov/pmc/articles/PMC9840936/
  59. Dec 2022
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human stem cell derived beta-like cells engineered to present PD-L1 improve transplant survival in NOD mice carrying human HLA class I
    1
    1. scibot 13 Dec 2022
      SCR_014393

      DOI: 10.3389/fendo.2022.989815

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    ncbi.nlm.nih.gov/pmc/articles/PMC9732725/
  61. diabetesjournals.org diabetesjournals.org
    Dynamic Ins2 Gene Activity Defines β-cell Maturity States
    1
    1. scibot 09 Dec 2022
      RRID:SCR_014393

      DOI: 10.2337/db21-1065

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    diabetesjournals.org/diabetes/article/71/12/2612/147687/Dynamic-Ins2-Gene-Activity-Defines-Cell-Maturity
  62. www.mdpi.com www.mdpi.com
    Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity
    1
    1. scibot 05 Dec 2022
      RRID:SCR_014393

      DOI: 10.3390/cells11233845

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    mdpi.com/2073-4409/11/23/3845
  63. Oct 2022
  64. 52.53.155.43 52.53.155.43
    Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress
    1
    1. scibot 27 Oct 2022
      RRID:SCR_014393

      DOI: 10.1126/sciadv.abo3932

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    52.53.155.43/3332fca9f9f5417145aee8b440787cc2ea4e4363/sciadv.abo3932-html.html
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mouse models and human islet transplantation sites for intravital imaging
    1
    1. scibot 26 Oct 2022
      SCR_014393

      DOI: 10.3389/fendo.2022.992540

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    ncbi.nlm.nih.gov/pmc/articles/PMC9579277/
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stem cell-based multi-tissue platforms to model human autoimmune diabetes
    1
    1. scibot 25 Oct 2022
      RRID:SCR_014393

      DOI: 10.1016/j.molmet.2022.101610

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    ncbi.nlm.nih.gov/pmc/articles/PMC9587366/
  67. academic.oup.com academic.oup.com
    Sex differences in the molecular programs of pancreatic cells contribute to the differential risks of type 2 diabetes
    1
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      RRID:SCR_014393

      DOI: 10.1210/endocr/bqac156

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    academic.oup.com/endo/article/163/11/bqac156/6708266
  68. www.science.org www.science.org
    Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress
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    1. scibot 22 Oct 2022
      RRID:SCR_014393

      DOI: 10.1126/sciadv.abo3932

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    science.org/doi/10.1126/sciadv.abo3932
  69. www.sciencedirect.com www.sciencedirect.com
    Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program
    1
    1. scibot 07 Oct 2022
      RRID:SCR_014393

      DOI: 10.1016/j.cmet.2022.09.013

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    sciencedirect.com/science/article/pii/S155041312200403X
  70. Sep 2022
  71. journals.plos.org journals.plos.org
    Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response
    1
    1. scibot 17 Sep 2022
      RRID:SCR_014393

      DOI: 10.1371/journal.pbio.3001761

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    journals.plos.org/plosbiology/article
  72. www.sciencedirect.com www.sciencedirect.com
    Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways
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      RRID:SCR_014393

      DOI: 10.1016/j.isci.2022.105056

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    sciencedirect.com/science/article/pii/S2589004222013281
  73. Aug 2022
  74. www.nature.com www.nature.com
    Every islet matters: improving the impact of human islet research
    1
    1. scibot 13 Aug 2022
      RRID:SCR_014393

      DOI: 10.1038/s42255-022-00607-8

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    nature.com/articles/s42255-022-00607-8
  75. www.nature.com www.nature.com
    Adaptation to chronic ER stress enforces pancreatic β-cell plasticity
    1
    1. scibot 10 Aug 2022
      RRID:SCR_014393

      DOI: 10.1038/s41467-022-32425-7

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    nature.com/articles/s41467-022-32425-7
  76. Jul 2022
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion
    1
    1. scibot 12 Jul 2022
      RRID:SCR_014393

      DOI: 10.2337/db21-0800

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    ncbi.nlm.nih.gov/pmc/articles/PMC9233298/
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gene Expression Signatures Reveal Common Virus Infection Pathways in Target Tissues of Type 1 Diabetes, Hashimoto’s Thyroiditis, and Celiac Disease
    1
    1. scibot 06 Jul 2022
      RRID:SCR_014393

      DOI: 10.3389/fimmu.2022.891698

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    ncbi.nlm.nih.gov/pmc/articles/PMC9251511/
  79. 52.53.155.43 52.53.155.43
    Pericyte Control of Blood Flow in Intraocular Islet Grafts Impacts Glucose Homeostasis in Mice
    1
    1. scibot 06 Jul 2022
      RRID:SCR_014393

      DOI: 10.2337/db21-1104

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    52.53.155.43/40e4d41191b65cd0a4449c8082df7a1008f68009/db211104 (1)-html.html
  80. Jun 2022
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Small molecules released from islets of Langerhans determined by liquid chromatography – mass spectrometry
    1
    1. scibot 24 Jun 2022
      RRID:SCR_014393

      DOI: 10.1039/d2ay00402j

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    ncbi.nlm.nih.gov/pmc/articles/PMC9159447/
  82. May 2022
  83. pubs.rsc.org pubs.rsc.org
    Small molecules released from islets of Langerhans determined by liquid chromatography – mass spectrometry
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    1. scibot 24 May 2022
      RRID:SCR_014393

      DOI: 10.1039/D2AY00402J

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    pubs.rsc.org/en/content/articlehtml/2022/ay/d2ay00402j
  84. www.sciencedirect.com www.sciencedirect.com
    Increasing insulin measurement throughput by fluorescence anisotropy imaging immunoassays
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    1. scibot 19 May 2022
      RRID:SCR_014393

      DOI: 10.1016/j.aca.2022.339942

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    sciencedirect.com/science/article/pii/S000326702200513X
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Expanded LUXendin Color Palette for GLP1R Detection and Visualization In Vitro and In Vivo
    1
    1. scibot 18 May 2022
      RRID:SCR_014393

      DOI: 10.1021/jacsau.2c00130

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    ncbi.nlm.nih.gov/pmc/articles/PMC9088800/
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pancreatic islet reserve in type 1 diabetes
    1
    1. scibot 04 May 2022
      RRID:SCR_014393

      DOI: 10.1111/nyas.14572

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    ncbi.nlm.nih.gov/pmc/articles/PMC9059955/
  87. Apr 2022
  88. www.nature.com www.nature.com
    RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells
    1
    1. scibot 09 Apr 2022
      RRID:SCR_014393

      DOI: 10.1038/s41467-022-29377-3

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    nature.com/articles/s41467-022-29377-3
  89. Mar 2022
  90. www.sciencedirect.com www.sciencedirect.com
    Emerging Diabetes Therapies: Bringing back the β-cells
    1
    1. scibot 31 Mar 2022
      RRID:SCR_014393

      DOI: 10.1016/j.molmet.2022.101477

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    sciencedirect.com/science/article/pii/S2212877822000461
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Improving the Prediction of Type 1 Diabetes Across Ancestries
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    1. scibot 23 Mar 2022
      RRID:SCR_014393

      DOI: 10.2337/dc21-1254

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    ncbi.nlm.nih.gov/pmc/articles/PMC8918258/
  92. Feb 2022
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Islet Lymphocytes Maintain a Stable Regulatory Phenotype Under Homeostatic Conditions and Metabolic Stress
    2
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      SCR_014393

      DOI: 10.3389/fimmu.2022.814203

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      SCR_014393

      DOI: 10.3389/fimmu.2022.814203

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    ncbi.nlm.nih.gov/pmc/articles/PMC8821107/
  94. www.sciencedirect.com www.sciencedirect.com
    From the dish to humans: A stem cell recipe for success
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      RRID:SCR_014393

      DOI: 10.1016/j.cmet.2022.01.002

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      DOI: 10.1016/j.cmet.2022.01.002

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    sciencedirect.com/science/article/pii/S155041312200002X
  95. www.sciencedirect.com www.sciencedirect.com
    Generation of thymic cells from pluripotent stem cells for basic research and cell therapy
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      RRID:SCR_014393

      DOI: 10.1016/B978-0-12-824390-9.00010-4

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    sciencedirect.com/science/article/pii/B9780128243909000104
  96. www.sciencedirect.com www.sciencedirect.com
    Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state
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    1. scibot 02 Feb 2022
      RRID:SCR_014393

      DOI: 10.1016/j.cmet.2021.12.021

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    sciencedirect.com/science/article/pii/S1550413121006859
  97. Jan 2022
  98. www.sciencedirect.com www.sciencedirect.com
    Modeling human T1D-associated autoimmune processes
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    1. scibot 12 Jan 2022
      RRID:SCR_014393

      DOI: 10.1016/j.molmet.2021.101417

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    sciencedirect.com/science/article/pii/S2212877821002751
  99. Dec 2021
  100. diabetesjournals.org diabetesjournals.org
    ENTPD3 Marks Mature Stem Cell Derived Beta Cells Formed by Self-Aggregation in Vitro
    1
    1. scibot 23 Dec 2021
      RRID:SCR_014393

      DOI: 10.2337/db20-0873

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    diabetesjournals.org/diabetes/article/70/11/2554/123865/ENTPD3-Marks-Mature-Stem-Cell-Derived-Cells-Formed
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated analysis of the pancreas and islets reveals unexpected findings in human male with type 1 diabetes
    1
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      RRID:SCR_014393

      DOI: 10.1210/jendso/bvab162

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    ncbi.nlm.nih.gov/pmc/articles/PMC8633619/
  102. Nov 2021
  103. www.sciencedirect.com www.sciencedirect.com
    Microvessels enhance vascularization and function of transplanted insulin-producing cells
    1
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      RRID:SCR_014393

      DOI: 10.1016/j.cmet.2021.10.013

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    sciencedirect.com/science/article/pii/S1550413121004915
  104. Oct 2021
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combinatorial transcription factor profiles predict mature and functional human islet α and β cells
    1
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      RRID:SCR_014393

      DOI: 10.1172/jci.insight.151621

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    ncbi.nlm.nih.gov/pmc/articles/PMC8492318/
  106. academic.oup.com academic.oup.com
    Human Islet: Mini-organ with Mega-impact
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      RRID:SCR_014393

      DOI: 10.1210/endrev/bnab010

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    academic.oup.com/edrv/article/42/5/605/6223906
  107. Sep 2021
  108. www.sciencedirect.com www.sciencedirect.com
    What is a β cell? – Chapter I in the Human Islet Research Network (HIRN) Review Series
    1
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      RRID:SCR_014393

      DOI: 10.1016/j.molmet.2021.101323

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  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A microfluidic system for monitoring glucagon secretion from human pancreatic islets of Langerhans
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      DOI: 10.1039/d1ay00703c

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  110. Aug 2021
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Debates in Pancreatic Beta Cell Biology: Proliferation Versus Progenitor Differentiation and Transdifferentiation in Restoring β Cell Mass
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      DOI: 10.3389/fendo.2021.722250

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  112. www.sciencedirect.com www.sciencedirect.com
    From Type 1 Diabetes Biology to Therapy: The Human Islet Research Network
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      DOI: 10.1016/j.molmet.2021.101283

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  113. pubs.acs.org pubs.acs.org
    Targeted Quantification of Phosphorylation Dynamics in the Context of EGFR-MAPK Pathway
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      DOI: 10.1021/acs.analchem.8b00071

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  114. link.springer.com link.springer.com
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  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1038/s41467-018-07466-6

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  116. www.sciencedirect.com www.sciencedirect.com
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  117. pubs.rsc.org pubs.rsc.org
    A microfluidic system for monitoring glucagon secretion from human pancreatic islets of Langerhans
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      DOI: 10.1039/D1AY00703C

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  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition
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      DOI: 10.3389/fendo.2021.707881

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  119. www.jci.org www.jci.org
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  120. www.nature.com www.nature.com
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      DOI: 10.1038/s41586-019-1168-5

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  121. Jul 2021
  122. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      DOI: 10.1111/dom.13388

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  123. pubs.acs.org pubs.acs.org
    Targeted Quantification of Phosphorylation Dynamics in the Context of EGFR-MAPK Pathway
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      DOI: 10.1021/acs.analchem.8b00071

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  124. www.nature.com www.nature.com
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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deconstructing the origins of sexual dimorphism in sensory modulation of pancreatic β cells
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      DOI: 10.1016/j.molmet.2021.101260

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  126. May 2021
  127. www.jci.org www.jci.org
    Type 1 diabetes mellitus: much progress, many opportunities
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      DOI: 10.1172/JCI142242

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  128. www.sciencedirect.com www.sciencedirect.com
    Role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice
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      DOI: 10.1016/j.jaut.2021.102612

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    sciencedirect.com/science/article/pii/S0896841121000202
  129. Apr 2021
  130. www.sciencedirect.com www.sciencedirect.com
    Rapid Liquid Chromatography-Mass Spectrometry Quantitation of Glucose-Regulating Hormones from Human Islets of Langerhans
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      DOI: 10.1016/j.chroma.2020.461805

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    sciencedirect.com/science/article/pii/S0021967320310797
  131. www.sciencedirect.com www.sciencedirect.com
    In vitro assembly of peri-islet basement membrane-like structures
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      DOI: 10.1016/j.biomaterials.2021.120808

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    sciencedirect.com/science/article/pii/S0142961221001642
  132. www.pnas.org www.pnas.org
    Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets
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      DOI: 10.1073/pnas.2022142118

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  133. Mar 2021
  134. www.pnas.org www.pnas.org
    Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets
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      DOI: 10.1073/pnas.2022142118

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  135. Feb 2021
  136. pubs.acs.org pubs.acs.org
    Profiling Glucose-Stimulated and M3 Receptor-Activated Insulin Secretion Dynamics from Islets of Langerhans Using an Extended-Lifetime Fluorescence Dye
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    1. scibot 25 Feb 2021
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      DOI: 10.1021/acs.analchem.0c01226

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    pubs.acs.org/doi/full/10.1021/acs.analchem.0c01226
  137. link.springer.com link.springer.com
    Pancreatic beta cell autophagy is impaired in type 1 diabetes
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    1. scibot 24 Feb 2021
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      DOI: 10.1007/s00125-021-05387-6

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  138. www.sciencedirect.com www.sciencedirect.com
    Image-based machine learning algorithms for disease characterization in the human type 1 diabetes pancreas
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      DOI: 10.1016/j.ajpath.2020.11.010

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    sciencedirect.com/science/article/abs/pii/S0002944020305514
  139. www.frontiersin.org www.frontiersin.org
    Functional Characterization of the Human Islet Microvasculature Using Living Pancreas Slices
    2
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      DOI: 10.3389/fendo.2020.602519

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      DOI: 10.3389/fendo.2020.602519

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    frontiersin.org/article/10.3389/fendo.2020.602519/full
  140. Dec 2020
  141. www.frontiersin.org www.frontiersin.org
    Modular Microphysiological System for Modeling of Biologic Barrier Function
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      DOI: 10.3389/fbioe.2020.581163

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    frontiersin.org/article/10.3389/fbioe.2020.581163/full
  142. www.sciencedirect.com www.sciencedirect.com
    Pancreatlas: Applying an Adaptable Framework to Map the Human Pancreas in Health and Disease
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    1. scibot 09 Dec 2020
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      DOI: 10.1016/j.patter.2020.100120

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  143. Nov 2020
  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells
    1
    1. scibot 24 Nov 2020
      RRID:SCR_014393

      DOI: 10.1016/j.cmet.2020.11.006

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    ncbi.nlm.nih.gov/pmc/articles/PMC7664344/
  145. Sep 2020
  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    High throughput pMHC-I tetramer library production using chaperone-mediated peptide exchange
    1
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      RRID:SCR_014393

      DOI: 10.1038/s41467-020-15710-1

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  147. link.springer.com link.springer.com
    Islet pericytes convert into profibrotic myofibroblasts in a mouse model of islet vascular fibrosis
    1
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      DOI: 10.1007/s00125-020-05168-7

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  148. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Rapid thymectomy of NSG mice to analyze the role of native and grafted thymi in humanized mice
    1
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      DOI: 10.1002/eji.201948205

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  149. insight.jci.org insight.jci.org
    Tacrolimus- and sirolimus-induced human <b>β</b> cell dysfunction is reversible and preventable
    1
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      DOI: 10.1172/jci.insight.130770

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  150. diabetesjournals.org diabetesjournals.org
    Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation
    1
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      DOI: 10.2337/db19-0546

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    diabetesjournals.org/diabetes/article/69/2/205/16218/Serotonin-Regulates-Adult-Cell-Mass-by-Stimulating
  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    3-D Physiomimetic Extracellular Matrix Hydrogels Provide a Supportive Microenvironment for Rodent and Human Islet Culture
    1
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      RRID:SCR_014393

      DOI: 10.1016/j.biomaterials.2018.08.057

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  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally
    1
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      DOI: 10.2337/db18-0903

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  153. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    Lipid Droplet Accumulation in Human Pancreatic Islets is Dependent Upon Both Donor Age and Health
    1
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      DOI: 10.2337/db19-0281

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  154. www.jci.org www.jci.org
    Sel1L-Hrd1 ER-associated degradation maintains β-cell identity via TGFβ signaling
    1
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      DOI: 10.1172/JCI134874

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  155. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D
    1
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      DOI: 10.1016/j.molmet.2020.101057

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  156. insight.jci.org insight.jci.org
    Integrated human pseudoislet system and microfluidic platform demonstrates differences in G-protein-coupled-receptor signaling in islet cells
    1
    1. scibot 11 Sep 2020
      RRID:SCR_014393

      DOI: 10.1172/jci.insight.137017

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  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Organisation of the human pancreas in health and in diabetes
    1
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      DOI: 10.1007/s00125-020-05203-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC7565096/
  158. academic.oup.com academic.oup.com
    Circulating unmethylated insulin DNA as a biomarker of human beta cell death: a multi-laboratory assay comparison
    1
    1. scibot 09 Sep 2020
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      DOI: 10.1210/clinem/dgaa008

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    academic.oup.com/jcem/article/105/3/dgaa008/5698251
  159. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis
    1
    1. scibot 07 Sep 2020
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      DOI: 10.2337/db19-0942

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    diabetes.diabetesjournals.org/content/69/3/413
  160. link.springer.com link.springer.com
    Decreased pancreatic acinar cell number in type 1 diabetes
    1
    1. scibot 06 Sep 2020
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      DOI: 10.1007/s00125-020-05155-y

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  161. academic.oup.com academic.oup.com
    Dapagliflozin does not directly affect human α or β cells
    1
    1. scibot 06 Sep 2020
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      DOI: 10.1210/endocr/bqaa080

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    academic.oup.com/endo/article/161/8/bqaa080/5840747
  162. www.sciencedirect.com www.sciencedirect.com
    Robust, 3-Dimensional Visualization of Human Colon Enteric Nervous System Without Tissue Sectioning
    1
    1. scibot 05 Sep 2020
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      DOI: 10.1053/j.gastro.2020.02.035

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    sciencedirect.com/science/article/pii/S0016508520302626
  163. www.nature.com www.nature.com
    Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics
    1
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      DOI: 10.1038/s41467-020-14309-w

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  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Use of human islets to understand islet biology and diabetes: progress, challenges and suggestions
    1
    1. scibot 04 Sep 2020
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      DOI: 10.1007/s00125-018-4772-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC6325002/
  165. www.mdpi.com www.mdpi.com
    Microelectrode Array based Functional Testing of Pancreatic Islet Cells
    1
    1. scibot 04 Sep 2020
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      DOI: 10.3390/mi11050507

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    mdpi.com/2072-666X/11/5/507
  166. Jan 2020
  167. pubs.rsc.org pubs.rsc.org
    A microfluidic platform integrating pressure-driven and electroosmotic-driven flow with inline filters for affinity separations
    2
    1. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.1039/C9AY01758E

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      RRID:SCR_014393

      DOI: 10.1039/C9AY01758E

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    pubs.rsc.org/en/content/articlelanding/2019/ay/c9ay01758e
  168. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)
    1
    1. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.2337/db19-0058

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    diabetes.diabetesjournals.org/content/68/7/1394
  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Microfluidic-enabled quantitative measurements of insulin release dynamics from single islets of Langerhans in response to 5-palmitic acid hydroxy stearic acid
    1
    1. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.1039/c8lc00624e

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    ncbi.nlm.nih.gov/pmc/articles/PMC6133761/
  170. academic.oup.com academic.oup.com
    Evaluating Vascularization of Heterotopic Islet Constructs for Type 1 Diabetes Using an In Vitro Platform
    1
    1. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.1093/intbio/zyz027

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    academic.oup.com/ib/advance-article/doi/10.1093/intbio/zyz027/5625269
  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRPV1 neurons regulate β-cell function in a sex-dependent manner
    1
    1. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.1016/j.molmet.2018.10.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC6308974/
  172. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell
    1
    1. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.1038/s42255-019-0135-7

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    pubmed.ncbi.nlm.nih.gov/32432213/
  173. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeted demethylation at the CDKN1C/p57 locus induces human β cell replication
    1
    1. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.1172/JCI99170

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    ncbi.nlm.nih.gov/pmc/articles/PMC6307972/
  174. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evaluation of Different Decellularization Protocols on the Generation of Pancreas-Derived Hydrogels
    1
    1. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.1089/ten.tec.2018.0180

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    ncbi.nlm.nih.gov/pmc/articles/PMC6306687/
  175. www.nature.com www.nature.com
    A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo
    1
    1. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.1038/s41598-019-44777-0

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    nature.com/articles/s41598-019-44777-0
  176. www.jci.org www.jci.org
    Cross-reactive public TCR sequences undergo positive selection in the human thymic repertoire
    1
    1. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.1172/JCI124358

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    jci.org/articles/view/124358
  177. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes
    1
    1. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.2337/db18-0686

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    diabetes.diabetesjournals.org/content/68/5/988
  178. www.sciencedirect.com www.sciencedirect.com
    A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets
    2
    1. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.1016/j.cell.2018.12.003

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    2. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.1016/j.cell.2018.12.003

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    sciencedirect.com/science/article/pii/S0092867418315861
  179. www.sciencedirect.com www.sciencedirect.com
    Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A
    1
    1. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.1016/j.stem.2019.07.007

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    sciencedirect.com/science/article/pii/S1934590919303054
  180. www.sciencedirect.com www.sciencedirect.com
    Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice
    1
    1. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.1016/j.cmet.2019.08.009

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    sciencedirect.com/science/article/pii/S1550413119304383
  181. www.sciencedirect.com www.sciencedirect.com
    Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development
    1
    1. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.1016/j.celrep.2019.04.083

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    sciencedirect.com/science/article/pii/S2211124719305637
  182. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:SCR_014393

      DOI: 10.1016/j.cmet.2019.01.003

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    sciencedirect.com/science/article/pii/S1550413119300038
  183. link.springer.com link.springer.com
    Untitled document
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    1. scibot 12 Jan 2020
      RRID:SCR_014393

      DOI: 10.1007/s00125-019-4855-8

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  184. Nov 2018
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cystic fibrosis–related diabetes is caused by islet loss and inflammation
    2
    1. scibot 05 Nov 2018
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    ncbi.nlm.nih.gov/pmc/articles/PMC5931120/
  186. www.sciencedirect.com www.sciencedirect.com
    GABA and Artesunate Do Not Induce Pancreatic α-to-β Cell Transdifferentiation In Vivo
    1
    1. scibot 05 Nov 2018
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    sciencedirect.com/science/article/pii/S1550413118304455
  187. www.cell.com www.cell.com
    &alpha; Cell Function and Gene Expression Are Compromised in Type 1 Diabetes
    1
    1. scibot 05 Nov 2018
      RID:SCR_014393

      Curator: @bandrow

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    cell.com/cell-reports/pdfExtended/S2211-1247(18)30213-4
  188. insight.jci.org insight.jci.org
    Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA
    1
    1. scibot 05 Nov 2018
      RRID:SCR_014393

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    insight.jci.org/articles/view/120687
  189. www.sciencedirect.com www.sciencedirect.com
    Postnatal Exocrine Pancreas Growth by Cellular Hypertrophy Correlates with a Shorter Lifespan in Mammals
    1
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  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA
    1
    1. scibot 05 Nov 2018
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  191. www.nature.com www.nature.com
    Untitled document
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    nature.com/articles/s41467-018-03961-y
  192. www.sciencedirect.com www.sciencedirect.com
    α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes
    1
    1. scibot 05 Nov 2018
      RRID:SCR_014393

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    sciencedirect.com/science/article/pii/S2211124718302134