308 Matching Annotations
  1. Last 7 days
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drought-induced molecular changes in crown of various barley phytohormone mutants
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    1. scibot 02 Jul 2024
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      DOI: 10.1080/15592324.2024.2371693

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    ncbi.nlm.nih.gov/pmc/articles/PMC11210921/
  3. Jun 2024
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    Islet cell stress induced by insulin-degrading enzyme deficiency promotes regeneration and protection from autoimmune diabetes
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    sciencedirect.com/science/article/pii/S2589004224011519
  5. May 2024
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    CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release
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    sciencedirect.com/science/article/pii/S1097276524004003
  7. aacrjournals.org aacrjournals.org
    CircPDIA4 induces gastric cancer progression by promoting ERK1/2 activation and enhancing biogenesis of oncogenic circRNAs
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      DOI: 10.1158/0008-5472.CAN-22-1923

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    aacrjournals.org/cancerres/article/83/4/538/716437/CircPDIA4-Induces-Gastric-Cancer-Progression-by
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    Quantitative proteomics reveals CLR interactome in primary human cells
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    sciencedirect.com/science/article/pii/S0021925824019008
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    Protocol for affinity purification-mass spectrometry interactome profiling in larvae of Drosophila melanogaster
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      DOI: 10.1016/j.xpro.2024.103064

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    sciencedirect.com/science/article/pii/S2666166724002296
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    Autophagy preferentially degrades non-fibrillar polyQ aggregates
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    sciencedirect.com/science/article/pii/S1097276524003836
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    The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex
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    sciencedirect.com/science/article/pii/S1097276524002855
  12. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    1. scibot 03 May 2024
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      DOI: 10.7554/eLife.90683

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    elifesciences.org/articles/90683
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    Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas
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    1. scibot 03 May 2024
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    sciencedirect.com/science/article/pii/S1535610824001314
  14. Apr 2024
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    Systematic analysis of proteome turnover in an organoid model of pancreatic cancer by dSILO
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    sciencedirect.com/science/article/pii/S2667237524000912
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    Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization
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    sciencedirect.com/science/article/pii/S1535610824001193
  17. aacrjournals.org aacrjournals.org
    Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis
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      DOI: 10.1158/0008-5472.CAN-23-1542

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  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteomic analysis of the serum in dogs with pulmonary hypertension secondary to myxomatous mitral valve disease: the preliminary study
    1
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      DOI: 10.3389/fvets.2024.1327453

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    Dynamic localization of the chromosomal passenger complex in trypanosomes is controlled by the orphan kinesins KIN-A and KIN-B
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      DOI: 10.7554/eLife.93522

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    ncbi.nlm.nih.gov/pmc/articles/PMC10987093/
  20. Mar 2024
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    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
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    sciencedirect.com/science/article/pii/S1097276524001722
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    Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment
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      DOI: 10.1016/j.cmet.2024.02.009

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    sciencedirect.com/science/article/pii/S155041312400055X
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    Structure of the plant plastid-encoded RNA polymerase
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      DOI: 10.1016/j.cell.2024.01.036

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      DOI: 10.1016/j.cell.2024.01.036

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    sciencedirect.com/science/article/pii/S009286742400103X
  24. Feb 2024
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    Origin of eukaryotic-like Vps23 shapes an ancient functional interplay between ESCRT and ubiquitin system in Asgard archaea
    1
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    sciencedirect.com/science/article/pii/S2211124724001098
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parkinson’s VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B
    1
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      DOI: 10.1126/sciadv.adj1205

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    A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1
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      DOI: 10.1038/s41467-024-45067-8

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    nature.com/articles/s41467-024-45067-8
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
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      DOI: 10.1158/2159-8290.CD-22-1401

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  29. Jan 2024
  30. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Comparative Analysis of Various Spider Silks in Regard to Nerve Regeneration: Material Properties and Schwann Cell Response
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      DOI: 10.1002/adhm.202302968

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    onlinelibrary.wiley.com/doi/10.1002/adhm.202302968
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    Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome
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      DOI: 10.1016/j.neuron.2023.12.014

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  32. www.science.org www.science.org
    Temporal landscape of mitochondrial proteostasis governed by the UPRmt
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      DOI: 10.1126/sciadv.adh8228

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  33. www.science.org www.science.org
    Parkinson’s VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B
    1
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      DOI: 10.1126/sciadv.adj1205

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    Response to Bruton’s tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy
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      DOI: 10.1016/j.ccell.2023.12.019

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    sciencedirect.com/science/article/pii/S1535610823004476
  35. Dec 2023
  36. www.sciencedirect.com www.sciencedirect.com
    RAF-like protein kinases mediate a deeply conserved, rapid auxin response
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      DOI: 10.1016/j.cell.2023.11.021

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    sciencedirect.com/science/article/pii/S0092867423012758
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer
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      DOI: 10.1371/journal.pgen.1011043

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    ncbi.nlm.nih.gov/pmc/articles/PMC10715669/
  38. pubs.acs.org pubs.acs.org
    Shotgun Proteomic-Based Approach with a Q-Exactive Hybrid Quadrupole-Orbitrap High-Resolution Mass Spectrometer for Protein Adductomics on a 3D Human Brain Tumor Neurospheroid Culture Model: The Identification of Adduct Formation in Calmodulin-Dependent Protein Kinase-2 and Annexin-A1 Induced by Pesticide Mixture
    1
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      DOI: 10.1021/acs.jproteome.3c00484

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    pubs.acs.org/doi/full/10.1021/acs.jproteome.3c00484
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    A proteomic insight reveals the role of food-associated Lactiplantibacillus plantarum C9O4 in reverting intestinal inflammation
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      DOI: 10.1016/j.isci.2023.108481

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  40. Nov 2023
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    RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks
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      DOI: 10.1016/j.molcel.2023.10.012

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    sciencedirect.com/science/article/pii/S1097276523008493
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Variability analysis of LC-MS experimental factors and their impact on machine learning
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      DOI: 10.1093/gigascience/giad096

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    ncbi.nlm.nih.gov/pmc/articles/PMC10659119/
  43. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Establishing an early indicator for data sharing and reuse
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      DOI: 10.1002/leap.1586

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    onlinelibrary.wiley.com/doi/10.1002/leap.1586
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Differential Proteome Profiling Analysis under Pesticide Stress by the Use of a Nano-UHPLC-MS/MS Untargeted Proteomic-Based Approach on a 3D-Developed Neurospheroid Model: Identification of Protein Interactions, Prognostic Biomarkers, and Potential Therapeutic Targets in Human IDH Mutant High-Grade Gliomas
    1
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      DOI: 10.1021/acs.jproteome.3c00395

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    ncbi.nlm.nih.gov/pmc/articles/PMC10629271/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma
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      DOI: 10.7554/eLife.85654

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      DOI: 10.7554/eLife.85654

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    ncbi.nlm.nih.gov/pmc/articles/PMC10629828/
  46. Sep 2023
  47. www.science.org www.science.org
    Temporal landscape of mitochondrial proteostasis governed by the UPRmt
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      DOI: 10.1126/sciadv.adh8228

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    science.org/doi/10.1126/sciadv.adh8228
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    Direct recruitment of Mis18 to interphase spindle pole bodies promotes CENP-A chromatin assembly
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      DOI: 10.1016/j.cub.2023.08.063

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    MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy
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    Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease
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  52. Jul 2023
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    Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition
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    Mechanism of orphan subunit recognition during assembly quality control
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    Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA
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    Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses
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    Parkinson’s VP535[D620N] mutation induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B
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  58. Jun 2023
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    ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation
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    ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
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    The Rab5 effector FERRY links early endosomes with mRNA localization
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  62. May 2023
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    Proteomics of immune cells from liver tumors reveals immunotherapy targets
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    Unconventional initiation of PINK1/Parkin mitophagy by Optineurin
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    BAP1 loss is associated with higher ASS1 expression in epithelioid mesothelioma: implications for therapeutic stratification.
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  66. Apr 2023
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    Vascular cells improve functionality of human cardiac organoids
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    Spatial and temporal dynamics of ATP synthase from mitochondria toward the cell surface
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    Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair
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    TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment
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    N-Terminomic Changes of Neurons During Excitotoxicity Reveal Proteolytic Events Associated with Synaptic Dysfunctions and Potential Targets for Neuroprotection
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    Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes
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  73. Mar 2023
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    Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets
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    Lysosomal trafficking of the glucose transporter GLUT1 requires sequential regulation by TXNIP and ubiquitin
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    Proteomics profiling of vitreous humor reveals complement and coagulation components, adhesion factors, and neurodegeneration markers as discriminatory biomarkers of vitreoretinal eye diseases
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    Ricca’s factors as mobile proteinaceous effectors of electrical signaling
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    Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2
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  79. Feb 2023
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    The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
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    RNA-DNA hybrids prevent resection at dysfunctional telomeres
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  82. Jan 2023
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    A mitochondrion-free eukaryote contains proteins capable of import into an exogenous mitochondrion-related organelle
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    Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
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    EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal
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    Antitumor Activity of the Novel BTK Inhibitor TG-1701 Is Associated with Disruption of Ikaros Signaling in Patients with B-cell Non–Hodgkin Lymphoma
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    Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance
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    Neuronal and astrocytic contributions to Huntington’s disease dissected with zinc finger protein transcriptional repressors
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    Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma
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    SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
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    Epidermal stratification requires retromer-mediated desmoglein-1 recycling
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    Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning
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  95. Nov 2022
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    Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2
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    The freezability of Mediterranean buffalo sperm is associated with lysine succinylation and lipid metabolism
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    Generation of cell-type-specific proteomes of neurodevelopment from human cerebral organoids
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  99. Sep 2022
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    The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
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    Comparative maternal protein profiling of mouse biparental and uniparental embryos
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    Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior
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    Convergent cerebrospinal fluid proteomes and metabolic ontologies in humans and animal models of Rett syndrome
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  104. Aug 2022
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    Comparative phosphoproteomic profiling in the prefrontal cortex of prenatally stressed male offspring rats
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    Substrate spectrum of PPM1D in the cellular response to DNA double-strand breaks
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  107. Jul 2022
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    Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition
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  111. Jun 2022
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    Phosphorylation of SHP2 at Tyr62 enables acquired resistance to SHP2 allosteric inhibitors in FLT3-ITD-driven AML
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    MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels
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    The focal adhesion protein β-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load
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  116. May 2022
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    Regionally defined proteomic profiles of human cerebral tissue and organoids reveal conserved molecular modules of neurodevelopment
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    Increased microtubule growth triggered by microvesicle-mediated paracrine signaling is required for melanoma cancer cell invasion
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    Proteomic-Based Machine Learning Analysis Reveals PYGB as a Novel Immunohistochemical Biomarker to Distinguish Inverted Urothelial Papilloma From Low-Grade Papillary Urothelial Carcinoma With Inverted Growth
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  124. Mar 2022
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    Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria
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    Reducing Nitrogen Rate and Increasing Plant Density Accomplished High Yields with Satisfied Grain Quality of Soft Wheat via Modifying the Free Amino Acid Supply and Storage Protein Gene Expression
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    The proteomic profile of the human myotendinous junction
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  129. Feb 2022
  130. elifesciences.org elifesciences.org
    Dual roles for ATP in the regulation of phase separated protein aggregates in Xenopus oocyte nucleoli
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  131. Dec 2021
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    Extracellular Vesicles Induce an Aggressive Phenotype in Luminal Breast Cancer Cells Via PKM2 Phosphorylation
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    Quantifying phosphorylation dynamics in primary neuronal cultures using LC-MS/MS
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    Lysine Acetylation in the Proteome of Renal Tubular Epithelial Cells in Diabetic Nephropathy
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  136. Nov 2021
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    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
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    A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer
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    Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription
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  140. Oct 2021
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    Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling
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    PGFinder, a novel analysis pipeline for the consistent, reproducible, and high-resolution structural analysis of bacterial peptidoglycans
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  143. Sep 2021
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    Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes
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  145. Aug 2021
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    Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes
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    Dynamic bi-directional phosphorylation events associated with the reciprocal regulation of synapses during homeostatic up- and down-scaling
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    Skin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior
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    SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer
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    Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE
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  195. elifesciences.org elifesciences.org
    Quantitative mapping of human hair greying and reversal in relation to life stress
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      DOI: 10.7554/eLife.67437

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  196. www.sciencedirect.com www.sciencedirect.com
    Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin
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  197. www.cell.com www.cell.com
    TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis
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  198. May 2021
  199. www.mdpi.com www.mdpi.com
    Proteomic Exploration of Plasma Exosomes and Other Small Extracellular Vesicles in Pediatric Hodgkin Lymphoma: A Potential Source of Biomarkers for Relapse Occurrence
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  200. www.sciencedirect.com www.sciencedirect.com
    Mass-spectrometry-based proteomics reveals mitochondrial supercomplexome plasticity
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  201. mcr.aacrjournals.org mcr.aacrjournals.org
    Crosstalk between YAP and RAR-RXR drives expression of stemness genes to promote 5-FU resistance and self-renewal in colorectal cancer cells
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  202. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Diagnostic Biomarkers from Proteomic Characterization of Cerebrospinal Fluid in Patients with Brain Malignancies
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  203. www.sciencedirect.com www.sciencedirect.com
    ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system
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    Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP
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  205. Apr 2021
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    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
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    Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin
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    Erosion of human X chromosome inactivation causes major remodeling of the iPSC proteome
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  209. www.sciencedirect.com www.sciencedirect.com
    Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190
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    Triplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome
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  211. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila
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  212. www.sciencedirect.com www.sciencedirect.com
    Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics
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    Integrated Omics of Metastatic Colorectal Cancer
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    A membrane arm of mitochondrial complex I sufficient to promote respirasome formation
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    Insight into the human pathodegradome of the V8 protease from Staphylococcus aureus
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  216. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BET Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection
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  217. Mar 2021
  218. www.sciencedirect.com www.sciencedirect.com
    Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling
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    Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma
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  220. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SUMO is a pervasive regulator of meiosis
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    Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine
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    Proteogenomics of glioblastoma associates molecular patterns with survival
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    Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function
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  224. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia
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  225. Feb 2021
  226. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of host proteins differentially associated with HIV-1 RNA splice variants
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  227. www.cell.com www.cell.com
    Fatal Perinatal Mitochondrial Cardiac Failure Caused by Recurrent De Novo Duplications in the ATAD3 Locus
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    cell.com/med/fulltext/S2666-6340(20)30009-X
  228. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Population-scale proteome variation in human induced pluripotent stem cells
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  229. www.cell.com www.cell.com
    Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation
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    cell.com/cell-reports/abstract/S2211-1247(20)30020-6
  230. www.frontiersin.org www.frontiersin.org
    Factor H Is Bound by Outer Membrane-Displayed Carbohydrate Metabolism Enzymes of Extraintestinal Pathogenic Escherichia coli and Contributes to Opsonophagocytosis Resistance in Bacteria
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    The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers
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  232. Jan 2021
  233. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Homogentisic acid induces cytoskeleton and extracellular matrix alteration in alkaptonuric cartilage
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    Impact of WIN site inhibitor on the WDR5 interactome
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  235. Dec 2020
  236. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    B-Cell-Specific Myd88 L252P Expression Causes a Premalignant Gammopathy Resembling IgM MGUS
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