182 Matching Annotations
  1. Jun 2026
  2. www.biorxiv.org www.biorxiv.org
    Beta cell reactivity defines disease-relevant pancreatic CD8 T cells in type 1 diabetes
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    biorxiv.org/content/10.64898/2026.06.08.729940v1
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Beta cell microRNAs function as molecular hubs of type 1 diabetes pathogenesis and as biomarkers of diabetes risk
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    pmc.ncbi.nlm.nih.gov/articles/PMC13236762/
  4. May 2026
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13168456/
  6. Apr 2026
  7. www.science.org www.science.org
    Beta cell–targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices
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    science.org/doi/10.1126/sciadv.aec9029
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Beta cell–targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices
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    pmc.ncbi.nlm.nih.gov/articles/PMC13041756/
  9. Mar 2026
  10. www.sciencedirect.com www.sciencedirect.com
    Protocol to study regeneration in human pancreatic slices using viral tracing, extended culture, dissociation, and functional Ca2+ influx techniques
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    sciencedirect.com/science/article/pii/S266616672600095X
  11. www.sciencedirect.com www.sciencedirect.com
    Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes
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    sciencedirect.com/science/article/pii/S2211124726002226
  12. dx.doi.org dx.doi.org
    Islet-derived T cells from both mice and humans recognize conserved insulin A-chain peptides presented by HLA-C*03:04
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    dx.doi.org/10.1093/jimmun/vkaf381
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Characterisation of human pancreatic mesenchymal stromal cells in type 1 diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12957432/
  14. Feb 2026
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Quantitative V-gene-targeted T cell receptor sequencing as a biomarker in type 1 diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12893103/
  16. Dec 2025
  17. watermark02.silverchair.com watermark02.silverchair.com
    DCi250066_proof.pdf
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    watermark02.silverchair.com/dci250066.pdf
  18. journals.sagepub.com journals.sagepub.com
    Cytoplasmic Translocation of the Transcription Factor pCREB and Altered Proteostasis in Human Islet Cells During Type 1 Diabetes Development
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    journals.sagepub.com/doi/full/10.1369/00221554251387770
  19. www.science.org www.science.org
    Small things matter: Lack of extraislet β cells in type 1 diabetes
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    science.org/doi/10.1126/sciadv.adz2251
  20. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Leveraging pre-trained machine learning models for islet quantification in type 1 diabetes
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    sciencedirect.com:5037/science/article/pii/S2153353924000452
  21. Nov 2025
  22. www.biorxiv.org www.biorxiv.org
    Single-Islet Proteomics Maps Pseudo-Temporal Islet Immune Responses and Dysfunction in Stage 1 Type 1 Diabetes
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    biorxiv.org/content/10.1101/2025.11.10.687674v1
  23. Oct 2025
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12549269/
  25. www.biorxiv.org www.biorxiv.org
    Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices
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    biorxiv.org/content/10.1101/2025.10.21.683528v1
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators
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    pmc.ncbi.nlm.nih.gov/articles/PMC11974670/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Hippo terminal effector YAP boosts enterovirus replication in type 1 diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12500894/
  28. Sep 2025
  29. www.biorxiv.org www.biorxiv.org
    Whole tissue spatial cellular analysis reveals increased macrophage infiltration in pancreata of autoantibody positive donors and patients with type 1 diabetes
    1
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    biorxiv.org/content/10.1101/2025.09.13.676053v1
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell multiome and spatial profiling reveals pancreas cell type–specific gene regulatory programs of type 1 diabetes progression
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12422192/
  31. www.science.org www.science.org
    Single-cell multiome and spatial profiling reveals pancreas cell type–specific gene regulatory programs of type 1 diabetes progression
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    science.org/doi/10.1126/sciadv.ady0080
  32. Aug 2025
  33. www.sciencedirect.com www.sciencedirect.com
    A vascular-associated fibroblastic cell controls pancreatic islet immunity
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    sciencedirect.com/science/article/pii/S221112472500960X
  34. www.sciencedirect.com www.sciencedirect.com
    Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis
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    sciencedirect.com/science/article/pii/S2211124725009453
  35. 52.53.155.43 52.53.155.43
    inline-supplementary-material-2-html.html
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    52.53.155.43/100e14b90da09131bf5c9cf9d4efd569ae25716b/inline-supplementary-material-2-html.html
  36. Jul 2025
  37. www.sciencedirect.com www.sciencedirect.com
    The antigen presentation landscape of cytokine-stressed human pancreatic islets
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    sciencedirect.com/science/article/pii/S2211124725006989
  38. www.biorxiv.org www.biorxiv.org
    Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes
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    biorxiv.org/content/10.1101/2025.06.25.661601v1
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pancreatic β-cell regeneration in situ by the ALK3 agonist THR-123
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    pmc.ncbi.nlm.nih.gov/articles/PMC12226732/
  40. Jun 2025
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D): An NIDDK Initiative to Advance Understanding of Mechanisms Underlying Cardiovascular Disease in Type 1 Versus Type 2 Diabetes
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12185973/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Automated analysis of ultrastructure through large-scale hyperspectral electron microscopy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12118689/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry
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    pmc.ncbi.nlm.nih.gov/articles/PMC8609965/
  44. link.springer.com link.springer.com
    T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes
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    link.springer.com/article/10.1007/s00125-025-06458-8
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12132410/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Distribution of glutathione peroxidase-1 immunoreactive cells in pancreatic islets from type 1 diabetic donors and non-diabetic donors with and without islet cell autoantibodies is variable and independent of disease
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12125085/
  47. May 2025
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12086209/
  49. link.springer.com link.springer.com
    Pancreatic exocrine damage induces beta cell stress in zebrafish larvae
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    link.springer.com/article/10.1007/s00125-025-06432-4
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12069483/
  51. Apr 2025
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The extra-islet pancreas supports autoimmunity in human type 1 diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC11999700/
  53. Mar 2025
  54. link.springer.com link.springer.com
    Joint analysis of the nPOD-Virus Group data: the association of enterovirus with type 1 diabetes is supported by multiple markers of infection in pancreas tissue
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    link.springer.com/article/10.1007/s00125-025-06401-x
  55. link.springer.com link.springer.com
    Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes
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    link.springer.com/article/10.1007/s00125-025-06384-9
  56. www.biorxiv.org www.biorxiv.org
    Characterisation of native human pancreatic mesenchymal stromal cells in type 1 diabetes
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    biorxiv.org/content/10.1101/2025.03.05.641596v1
  57. www.biorxiv.org www.biorxiv.org
    Imaging mass cytometry reveals early β-cell dysfunction and changes in immune signatures during type 1 diabetes progression in human pancreata
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    biorxiv.org/content/10.1101/2025.03.05.641526v1
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870426/
  59. link.springer.com link.springer.com
    Beyond the loss of beta cells: a quantitative analysis of islet architecture in adults with and without type 1 diabetes
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    link.springer.com/article/10.1007/s00125-025-06376-9
  60. Feb 2025
  61. dx.doi.org dx.doi.org
    CD4+ T cells from individuals with type 1 diabetes respond to a novel class of deamidated peptides formed in pancreatic islets
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    dx.doi.org/10.2337/db23-0588
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of a vimentin-expressing α-cell phenotype in CF and normal pancreas
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    pmc.ncbi.nlm.nih.gov/articles/PMC11850051/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Developmental beta-cell death orchestrates the islet’s inflammatory milieu by regulating immune system crosstalk
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    pmc.ncbi.nlm.nih.gov/articles/PMC11833124/
  64. Jan 2025
  65. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/0165224f63d612f3695e9281e2b7b41540d1e47d/PDF-html.html
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11748642/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BETA CELL DYSFUNCTION OCCURS INDEPENDENTLY OF INSULITIS IN TYPE 1 DIABETES PATHOGENESIS
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    pmc.ncbi.nlm.nih.gov/articles/PMC11703223/
  68. Oct 2024
  69. www.medrxiv.org www.medrxiv.org
    Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes
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    medrxiv.org/content/10.1101/2024.09.11.24313112v1
  70. www.embopress.org www.embopress.org
    m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation | The EMBO Journal
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    embopress.org/doi/full/10.1038/s44318-024-00213-2
  71. www.embopress.org www.embopress.org
    m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation
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    embopress.org/doi/10.1038/s44318-024-00213-2
  72. Sep 2024
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modulation of Leukocytes of the Innate Arm of the Immune System as a Potential Approach to Prevent the Onset and Progression of Type 1 Diabetes
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    ncbi.nlm.nih.gov/pmc/articles/PMC7881863/
  74. www.endocrinepractice.org www.endocrinepractice.org
    EXOCRINE PANCREAS DYSFUNCTION IN TYPE 1 DIABETES
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    endocrinepractice.org/article/S1530-891X(20)48445-9/abstract
  75. www.sciencedirect.com www.sciencedirect.com
    Image-based machine learning algorithms for disease characterization in the human type 1 diabetes pancreas
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    sciencedirect.com/science/article/abs/pii/S0002944020305514
  76. Aug 2024
  77. www.medrxiv.org www.medrxiv.org
    Genetic association and machine learning improves discovery and prediction of type 1 diabetes
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    medrxiv.org/content/10.1101/2024.07.31.24311310v1
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Temporal Analysis of Amylase Expression in Control, Autoantibody Positive, and Type 1 Diabetes Pancreatic Tissues
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    ncbi.nlm.nih.gov/pmc/articles/PMC6925584/
  79. www.science.org www.science.org
    Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses
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    science.org/doi/10.1126/sciadv.adl1122
  80. Jul 2024
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impaired islet function and normal exocrine enzyme secretion occur with low inter-regional variation in type 1 diabetes
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11251461/
  82. Jun 2024
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Germline-like TCR-α chains shared between autoreactive T cells in blood and pancreas
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    ncbi.nlm.nih.gov/pmc/articles/PMC11176301/
  84. diabetesjournals.org diabetesjournals.org
    Exocrine pancreas in type 1 and type 2 diabetes: different patterns of fibrosis, metaplasia, angiopathy, and adiposity
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    diabetesjournals.org/diabetes/article/doi/10.2337/db23-0009/153726/Exocrine-pancreas-in-type-1-and-type-2-diabetes
  85. www.sciencedirect.com www.sciencedirect.com
    Extensive elimination of acinar cells during normal postnatal pancreas growth
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    sciencedirect.com/science/article/pii/S2211124723014699
  86. www.nature.com www.nature.com
    The immunology of type 1 diabetes
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    nature.com/articles/s41577-023-00985-4
  87. www.jove.com www.jove.com
    Advancing Type 1 Diabetes Research Using Innovative Pancreatic Slice Platforms
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    jove.com/v/66468/advancing-type-1-diabetes-research-using-innovative-pancreatic-slice
  88. www.biorxiv.org www.biorxiv.org
    Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
    1
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    biorxiv.org/content/10.1101/2024.04.23.590798v1
  89. link.springer.com link.springer.com
    Capillary contact points determine beta cell polarity, control secretion and are disrupted in the db/db mouse model of diabetes
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    link.springer.com/article/10.1007/s00125-024-06180-x
  90. May 2024
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NKX2-2 based nuclei sorting on frozen human archival pancreas enables the enrichment of islet endocrine populations for single-nucleus RNA sequencing
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11059690/
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness
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    ncbi.nlm.nih.gov/pmc/articles/PMC11194086/
  93. Mar 2024
  94. dx.doi.org dx.doi.org
    DNA methylation-based assessment of cell composition in human pancreas and islets
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    dx.doi.org/10.2337/db23-0704
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses
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    ncbi.nlm.nih.gov/pmc/articles/PMC10917340/
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repositioning the Early Pathology of Type 1 Diabetes to the Extraislet Vasculature
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    ncbi.nlm.nih.gov/pmc/articles/PMC10944819/
  97. Feb 2024
  98. diabetesjournals.org diabetesjournals.org
    Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis
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    diabetesjournals.org/diabetes/article/73/1/11/153749/Bridging-the-Gap-Pancreas-Tissue-Slices-From-Organ
  99. www.biorxiv.org www.biorxiv.org
    Impaired islet function with normal exocrine enzyme secretion is consistent across the head, body, and tail pancreas regions in type 1 diabetes
    1
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    biorxiv.org/content/10.1101/2024.02.08.579175v1
  100. Jan 2024
  101. diabetesjournals.org diabetesjournals.org
    Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis
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    diabetesjournals.org/diabetes/article/73/1/11/153749/Bridging-the-Gap-Pancreas-Tissue-Slices-From-Organ
  102. Nov 2023
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enteroviral infections are not associated with type 2 diabetes
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10643152/
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Self-reactive germline-like TCR alpha chains shared between blood and pancreas
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    ncbi.nlm.nih.gov/pmc/articles/PMC10602137/
  105. Oct 2023
  106. www.sciencedirect.com www.sciencedirect.com
    Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage
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    sciencedirect.com/science/article/pii/S1550413123003704
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The role of the interferon/JAK-STAT axis in driving islet HLA-I hyperexpression in type 1 diabetes
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10588626/
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Interferon-α promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic β-cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10516036/
  109. Sep 2023
  110. www.sciencedirect.com www.sciencedirect.com
    The pathogenic “symphony” in type 1 diabetes: A disorder of the immune system, β cells, and exocrine pancreas
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    sciencedirect.com/science/article/pii/S1550413123002280
  111. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Nano-Targeted Delivery of Immune Therapeutics in type 1 Diabetes
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    onlinelibrary.wiley.com/doi/10.1002/adma.202300812
  112. Aug 2023
  113. www.biorxiv.org www.biorxiv.org
    Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses
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    biorxiv.org/content/10.1101/2023.08.19.553954v1
  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alpha cell receptor for advanced glycation end products associate with glucagon expression in type 1 diabetes
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10412557/
  115. www.biorxiv.org www.biorxiv.org
    m6A mRNA Methylation Regulates Early Pancreatic β-Cell Differentiation
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  116. Jul 2023
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    β Cell microRNAs Function as Molecular Hubs of Type 1 Diabetes Pathogenesis and as Biomarkers of Diabetes Risk
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    ncbi.nlm.nih.gov/pmc/articles/PMC10312758/
  118. Jun 2023
  119. www.sciencedirect.com www.sciencedirect.com
    Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
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  120. rupress.org rupress.org
    Identification of an anergic BND cell-derived activated B cell population (BND2) in young-onset type 1 diabetes patients
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  121. May 2023
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    A genomic data archive from the Network for Pancreatic Organ donors with Diabetes
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  123. Mar 2023
  124. europepmc.org europepmc.org
    The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes
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  125. link.springer.com link.springer.com
    The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes
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    link.springer.com/article/10.1007/s00125-023-05888-6
  126. link.springer.com link.springer.com
    Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells
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    link.springer.com/article/10.1007/s00125-023-05882-y
  127. Jan 2023
  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of Proinflammatory Cytokines on Alternative Splicing Patterns in Human Islets
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  129. Dec 2022
  130. 52.53.155.43 52.53.155.43
    Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes
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  131. journals.sagepub.com journals.sagepub.com
    Abnormal Expression of an Insulin Synthesizing Enzyme in Islets of Adult Autoantibody Positive Donors
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  132. www.sciencedirect.com www.sciencedirect.com
    A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes
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    sciencedirect.com/science/article/pii/S2352396422005618
  133. Nov 2022
  134. journals.sagepub.com journals.sagepub.com
    Abnormal Expression of an Insulin Synthesizing Enzyme in Islets of Adult Autoantibody Positive Donors
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  135. www.nature.com www.nature.com
    Non-coding variants disrupting a tissue-specific regulatory element in HK1 cause congenital hyperinsulinism
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  136. Oct 2022
  137. link.springer.com link.springer.com
    Milder loss of insulin-containing islets in individuals with type 1 diabetes and type 2 diabetes-associated TCF7L2 genetic variants
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  138. academic.oup.com academic.oup.com
    Exocrine and Endocrine Inflammation Increases Cellular Replication in the Pancreatic Duct Compartment in Type 1 Diabetes
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    academic.oup.com/jes/article/6/11/bvac136/6691224
  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alpha cell dysfunction in type 1 diabetes is independent of a senescence program
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  140. Aug 2022
  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Detection of Antiviral Tissue Responses and Increased Cell Stress in the Pancreatic Islets of Newly Diagnosed Type 1 Diabetes Patients: Results From the DiViD Study
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  142. Jul 2022
  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  144. www.medrxiv.org www.medrxiv.org
    HLA-DQβ57, anti-insulin T cells and insulin mimicry in autoimmune diabetes
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  145. www.medrxiv.org www.medrxiv.org
    A novel disease mechanism leading to the expression of a disallowed gene in the pancreatic beta-cell identified by non-coding, regulatory mutations controlling HK1
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  146. Jun 2022
  147. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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  148. diabetesjournals.org diabetesjournals.org
    Circulating C-Peptide Levels in Living Children and Young People and Pancreatic Beta Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration
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  149. Apr 2022
  150. www.nature.com www.nature.com
    Generation of human islet cell type-specific identity genesets
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  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices
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  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes
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  153. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MERTK on mononuclear phagocytes regulates T cell antigen recognition at autoimmune and tumor sites
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  154. Jan 2022
  155. diabetesjournals.org diabetesjournals.org
    Syntaxin 4 enrichment in β-cells prevents conversion to autoimmune diabetes in non-obese diabetic (NOD) mice
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    diabetesjournals.org/diabetes/article/70/12/2837/139076/Syntaxin-4-Enrichment-in-Cells-Prevents-Conversion
  156. Dec 2021
  157. diabetesjournals.org diabetesjournals.org
    CD8+ T cells variably recognize native versus citrullinated GRP78 epitopes in type 1 diabetes
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    diabetesjournals.org/diabetes/article/70/12/2879/139067/CD8-T-Cells-Variably-Recognize-Native-Versus
  158. link.springer.com link.springer.com
    Upregulation of HLA class II in pancreatic beta cells from organ donors with type 1 diabetes
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    link.springer.com/article/10.1007/s00125-021-05619-9
  159. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Substance Use Affects Type 1 Diabetes Pancreas Pathology: Implications for Future Studies
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    ncbi.nlm.nih.gov/pmc/articles/PMC8667172/
  160. insight.jci.org insight.jci.org
    Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes
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    insight.jci.org/articles/view/151349
  161. Nov 2021
  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Editorial: Footprints of Immune Cells in the Type 1 Diabetic Pancreas
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  163. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry
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    pmc.ncbi.nlm.nih.gov/articles/PMC8609965/
  164. Oct 2021
  165. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes
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    diabetes.diabetesjournals.org/content/early/2021/10/06/db21-0091
  166. www.pnas.org www.pnas.org
    Human islet T cells are highly reactive to preproinsulin in type 1 diabetes
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    pnas.org/content/118/41/e2107208118
  167. academic.oup.com academic.oup.com
    Human Islet: Mini-organ with Mega-impact
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  168. Aug 2021
  169. www.nature.com www.nature.com
    Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production
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  170. www.sciencedirect.com www.sciencedirect.com
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes
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  172. www.sciencedirect.com www.sciencedirect.com
    IL-17 is expressed on beta and alpha cells of donors with type 1 and type 2 diabetes
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    sciencedirect.com/science/article/pii/S0896841121001165
  173. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8+ T-Cell Numbers
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  175. Jul 2021
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  177. www.sciencedirect.com www.sciencedirect.com
    ACE2 Chromogenic Immunostaining Protocol Optimized for Formalin-fixed Paraffin Embedded Human Tissue Sections
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  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?
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    ncbi.nlm.nih.gov/pmc/articles/PMC8242234/
  179. Jun 2021
  180. papers.ssrn.com papers.ssrn.com
    ACE2 and SARS-CoV-2 Expression in the Normal and COVID-19 Pancreas
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  181. www.frontiersin.org www.frontiersin.org
    Whole-Slide Image Analysis of Human Pancreas Samples to Elucidate the Immunopathogenesis of Type 1 Diabetes Using the QuPath Software
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    frontiersin.org/article/10.3389/fmolb.2021.689799/full
  182. May 2021
  183. onlinelibrary.wiley.com onlinelibrary.wiley.com
    State‐of‐the‐art microscopy to understand Islets of Langerhans: what to expect next?
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    onlinelibrary.wiley.com/doi/10.1111/imcb.12450
  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pancreas Optical Clearing and 3-D Microscopy in Health and Diabetes
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  185. journals.sagepub.com journals.sagepub.com
    Human Islets Contain a Beta Cell Type That Expresses Proinsulin But Not the Enzyme That Converts the Precursor to Insulin - Gladys Teitelman, 2020
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    journals.sagepub.com/doi/10.1369/0022155420961361
  186. link.springer.com link.springer.com
    Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes
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    link.springer.com/article/10.1007/s00125-021-05453-z
  187. Apr 2021
  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors
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    ncbi.nlm.nih.gov/pmc/articles/PMC8027116/
  189. Mar 2021
  190. www.nature.com www.nature.com
    Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes
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    nature.com/articles/s41598-021-85659-8
  191. www.sciencedirect.com www.sciencedirect.com
    TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes
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    sciencedirect.com/science/article/pii/S009286742031607X
  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Islet expression of type I interferon response sensors is associated with immune infiltration and viral infection in type 1 diabetes
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    ncbi.nlm.nih.gov/pmc/articles/PMC7904254/
  193. Feb 2021
  194. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    Intracrine Testosterone Activation in Human Pancreatic β Cells Stimulates Insulin Secretion.
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    diabetes.diabetesjournals.org/content/69/11/2392
  195. insight.jci.org insight.jci.org
    Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis
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    insight.jci.org/articles/view/134525
  196. link.springer.com link.springer.com
    Pancreatic beta cell autophagy is impaired in type 1 diabetes
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    link.springer.com/article/10.1007/s00125-021-05387-6
  197. Jan 2021
  198. link.springer.com link.springer.com
    Expression of immunoreactive inducible nitric oxide synthase in pancreatic islet cells from newly diagnosed and long-term type 1 diabetic donors is heterogeneous and not disease-associated
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    link.springer.com/article/10.1007/s00441-020-03340-4
  199. www.frontiersin.org www.frontiersin.org
    Gene Expression Analysis of the Pre-Diabetic Pancreas to Identify Pathogenic Mechanisms and Biomarkers of Type 1 Diabetes
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    frontiersin.org/article/10.3389/fendo.2020.609271/full
  200. link.springer.com link.springer.com
    Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes
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    link.springer.com/article/10.1007/s00125-020-05345-8
  201. Dec 2020
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    Removing Formaldehyde‐Induced Peptidyl Crosslinks Enables Mass Spectrometry Imaging of Peptide Hormone Distributions from Formalin‐Fixed Paraffin‐Embedded Tissues
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    onlinelibrary.wiley.com/doi/10.1002/anie.202008847
  203. Nov 2020
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    Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19
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    ncbi.nlm.nih.gov/pmc/articles/PMC7664515/
  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IL-4R is expressed on alpha and beta cells of human pancreata
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  206. Oct 2020
  207. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?
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    pubmed.ncbi.nlm.nih.gov/33084970/
  208. Sep 2020
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    Erratum. GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner. Diabetes 2019;68:34–44
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  210. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes
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  211. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long-term culture of human pancreatic slices as a model to study real-time islet regeneration
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  212. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Organisation of the human pancreas in health and in diabetes
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  213. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Large-scale electron microscopy database for human type 1 diabetes
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  214. www.pnas.org www.pnas.org
    Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche
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    pnas.org/content/early/2020/04/29/1918314117
  215. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes
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    onlinelibrary.wiley.com/doi/10.1111/dme.14361
  216. Jan 2020
  217. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell
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    pubmed.ncbi.nlm.nih.gov/32432213/
  218. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes
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    diabetes.diabetesjournals.org/content/68/5/988
  219. link.springer.com link.springer.com
    Phenotypic alterations in pancreatic lymph node stromal cells from human donors with type 1 diabetes and NOD mice
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    link.springer.com/article/10.1007/s00125-019-04984-w
  220. academic.oup.com academic.oup.com
    Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns
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    academic.oup.com/hmg/article/28/16/2763/5487670
  221. www.sciencedirect.com www.sciencedirect.com
    IL-6 is present in beta and alpha cells in human pancreatic islets: Expression is reduced in subjects with type 1 diabetes
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  222. link.springer.com link.springer.com
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  224. Nov 2018
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    link.springer.com/article/10.1007/s00125-018-4731-y
  226. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes
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  227. www.sciencedirect.com www.sciencedirect.com
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  229. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes
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