126 Matching Annotations
  1. Last 7 days
  2. www.science.org www.science.org
    Senataxin promotes recombination fidelity during antigen receptor gene diversification
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    science.org/doi/10.1126/scisignal.adv8801
  3. Oct 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intratumoral B cell and interferon signatures in newly diagnosed glioblastoma are associated with longer survival in patients treated with SurVaxM
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    pmc.ncbi.nlm.nih.gov/articles/PMC12511503/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD27 agonist antibodies mediate clinical responses through intratumoral stimulation in B-cell malignancies: multicenter RiVa trial
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    pmc.ncbi.nlm.nih.gov/articles/PMC7618221/
  6. Sep 2025
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A framework to mine laser microdissection-based omics data and uncover regulators of pancreatic cancer heterogeneity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12412123/
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    Human papillomavirus integration induces oncogenic host gene fusions in oropharyngeal cancers
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    aacrjournals.org/cancerdiscovery/article/15/9/1927/764362/Human-Papillomavirus-Integration-Induces-Oncogenic
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    Differential Chromatin Accessibility, Gene Expression, and mRNA Splicing Between Developing Cochlear Inner and Outer Hair Cells
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    link.springer.com/article/10.1007/s10162-025-01005-z
  10. Aug 2025
  11. www.sciencedirect.com www.sciencedirect.com
    LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
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    sciencedirect.com/science/article/pii/S2666979X25002356
  12. Jul 2025
  13. www.biorxiv.org www.biorxiv.org
    RUNX2 inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and dismantles oncogenic gene programs in fusion-positive rhabdomyosarcoma
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    biorxiv.org/content/10.1101/2025.07.21.665972v1
  14. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225014087-main-html.html
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    TAF1 is required for fetal but not adult hematopoiesis in mice
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    sciencedirect.com/science/article/pii/S1534580725004058
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Uncovering novel lncRNAs linked to melanoma growth and migration with CRISPR-inhibition screening
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    pmc.ncbi.nlm.nih.gov/articles/PMC12238846/
  17. www.cell.com www.cell.com
    TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice
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    cell.com/cell-stem-cell/fulltext/S1934-5909(25)00228-0
  18. Jun 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator
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    pmc.ncbi.nlm.nih.gov/articles/PMC12130801/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11611684/
  21. May 2025
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Improvement in the function of self-activating chimeric antigen receptor by replacing the linker sequence
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    pmc.ncbi.nlm.nih.gov/articles/PMC12040954/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epigenetic Plasticity Drives Carcinogenesis and Multi-Therapy Resistance in Multiple Myeloma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12048002/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Alternative mRNA splicing in anthracycline-induced cardiomyopathy – a COG-ALTE03N1 report
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    pmc.ncbi.nlm.nih.gov/articles/PMC12084991/
  25. 52.53.155.43 52.53.155.43
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  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Treatment Efficacy and Molecular Dynamics of Neoadjuvant Durvalumab and Olaparib in Resectable Urothelial Bladder Cancer: The NEODURVARIB Trial
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    pmc.ncbi.nlm.nih.gov/articles/PMC12010967/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11572484/
  29. Apr 2025
  30. www.nature.com www.nature.com
    α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells
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    nature.com/articles/s41556-025-01658-1
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962407/
  32. Mar 2025
  33. www.sciencedirect.com www.sciencedirect.com
    Lineage contribution of the mesendoderm progenitors in the gastrulating mouse embryo
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  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    23ME-01473, an Fc Effector–Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell–Mediated Antitumor Immunity through NKG2D and FcγRIIIa Activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11927390/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Comparative analysis of AAV serotypes for transduction of olfactory sensory neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC11865030/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acetalax and Bisacodyl for the Treatment of Triple-Negative Breast Cancer: A Combined Molecular and Preclinical Study
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    pmc.ncbi.nlm.nih.gov/articles/PMC11869203/
  37. Feb 2025
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98-rearranged leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838931/
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    Multiomic QTL mapping reveals phenotypic complexity of GWAS loci and prioritizes putative causal variants
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    sciencedirect.com/science/article/pii/S2666979X2500031X
  40. aacrjournals.org aacrjournals.org
    MR1 gene and protein expression are enhanced by inhibition of the extracellular signal-regulated kinase ERK
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    aacrjournals.org/cancerimmunolres/article/12/10/1452/748716/MR1-Gene-and-Protein-Expression-Are-Enhanced-by
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    Multiomics Profiling Distinguishes Sebaceous Carcinoma from Benign Sebaceous Neoplasms and Provides Insight into the Genetic Evolution of Sebaceous Carcinogenesis
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    aacrjournals.org/clincancerres/article/30/21/4887/749133/Multiomics-Profiling-Distinguishes-Sebaceous
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    A 5-hydroxymethylcytosine-based non-invasive model for early detection of colorectal carcinomas and advanced adenomas: the METHOD-2 study
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    aacrjournals.org/clincancerres/article/30/15/3337/746576/A-5-Hydroxymethylcytosine-Based-Noninvasive-Model
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    A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer
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    aacrjournals.org/clincancerres/article/28/24/5263/711455/A-Phase-II-Randomized-Trial-of-Chemoradiation-with
  45. www.biorxiv.org www.biorxiv.org
    Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma
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    biorxiv.org/content/10.1101/2025.01.28.635193v1
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    Using multiomic integration to improve blood biomarkers of major depressive disorder: a case-control study
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    sciencedirect.com/science/article/pii/S2352396425000131
  47. Jan 2025
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Functional Transcriptomic Landscape Informs Therapeutic Strategies in Multiple Myeloma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11733535/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Increased local DNA methylation disorder in AMLs with DNMT3A-destabilizing variants and its clinical implication
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    pmc.ncbi.nlm.nih.gov/articles/PMC11724044/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    JAK inhibition decreases the autoimmune burden in Down syndrome
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  51. www.nature.com www.nature.com
    Hypoxia drives the formation of lung micropapillary adenocarcinoma-like structure through hypoxia-inducible factor-1α
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    nature.com/articles/s41598-024-80280-x
  52. Dec 2024
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single cell long read whole genome sequencing reveals somatic transposon activity in human brain
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    pmc.ncbi.nlm.nih.gov/articles/PMC11601780/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    H4K20me3-Mediated Repression of Inflammatory Genes is a Characteristic and Targetable Vulnerability of Persister Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617193/
  55. Nov 2024
  56. 52.53.155.43 52.53.155.43
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  57. 52.53.155.43 52.53.155.43
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  58. Oct 2024
  59. aacrjournals.org aacrjournals.org
    RNA sequencing and Immunohistochemistry Reveal ZFN7 as a Stronger Marker of Survival than Molecular Subtypes in G-CIMP–negative Glioblastoma
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    aacrjournals.org/clincancerres/article/27/2/645/83327/RNA-sequencing-and-Immunohistochemistry-Reveal
  60. aacrjournals.org aacrjournals.org
    Glioblastoma TCGA Mesenchymal and IGS 23 Tumors are Identifiable by IHC and have an Immune-phenotype Indicating a Potential Benefit from Immunotherapy
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    aacrjournals.org/clincancerres/article/26/24/6600/82892/Glioblastoma-TCGA-Mesenchymal-and-IGS-23-Tumors
  61. Sep 2024
  62. www.biorxiv.org www.biorxiv.org
    Metastatic tumor cells in bone marrow differ from paired neuroblastoma tumor and contain subsets with therapy-resistant characteristics
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    biorxiv.org/content/10.1101/2024.09.13.612231v1
  63. www.biorxiv.org www.biorxiv.org
    A Comprehensive Proteogenomic and Spatial Analysis of Innate and Acquired Resistance of Metastatic Melanoma to Immune Checkpoint Blockade Therapies
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    biorxiv.org/content/10.1101/2024.09.12.612675v1
  64. Aug 2024
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p53R172H and p53R245W Hotspot Mutations Drive Distinct Transcriptomes in Mouse Mammary Tumors Through a Convergent Transcriptional Mediator
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    ncbi.nlm.nih.gov/pmc/articles/PMC11310746/
  66. Jul 2024
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11285331/
  68. 52.53.155.43 52.53.155.43
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multicellular, IVT-derived, unmodified human transcriptome for nanopore-direct RNA analysis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11221353/
  70. May 2024
  71. www.cell.com www.cell.com
    Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3′ UTR of FAIM2
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    cell.com/cell-genomics/fulltext/S2666-979X(24)00122-8
  72. Mar 2024
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    D-2-HG Inhibits IDH1mut Glioma Growth via FTO Inhibition and Resultant m6A Hypermethylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10959073/
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-scale requirements for dynein-based transport revealed by a high-content arrayed CRISPR screen
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    ncbi.nlm.nih.gov/pmc/articles/PMC10916854/
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    De novo and histologically transformed small cell lung cancer is sensitive to lurbinectedin treatment through the modulation of EMT and NOTCH signaling pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC10901109/
  76. Feb 2024
  77. aacrjournals.org aacrjournals.org
    p53R245W mutation fuels cancer initiation and metastases in NASH-driven liver tumorigenesis
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    aacrjournals.org/cancerrescommun/article/3/12/2640/732161/p53R245W-Mutation-Fuels-Cancer-Initiation-and
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    A Mutation-driven oncofetal regression fuels phenotypic plasticity in colorectal cancer
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    biorxiv.org/content/10.1101/2023.12.10.570854v1
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    A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1
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    nature.com/articles/s41467-024-45067-8
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide p63-target gene analyses reveal TAp63/NRF2-dependent oxidative stress responses
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    ncbi.nlm.nih.gov/pmc/articles/PMC10832605/
  81. Jan 2024
  82. www.nature.com www.nature.com
    A new genomic framework to categorize pediatric acute myeloid leukemia
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    nature.com/articles/s41588-023-01640-3
  83. www.sciencedirect.com www.sciencedirect.com
    Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy
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    sciencedirect.com/science/article/pii/S1535610823004361
  84. aacrjournals.org aacrjournals.org
    p53R245W mutation fuels cancer initiation and metastases in NASH-driven liver tumorigenesis
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    aacrjournals.org/cancerrescommun/article/3/12/2640/732161/p53R245W-Mutation-Fuels-Cancer-Initiation-and
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence
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    ncbi.nlm.nih.gov/pmc/articles/PMC10762335/
  86. Nov 2023
  87. dx.doi.org dx.doi.org
    Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
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    dx.doi.org/10.1158/2767-9764.CRC-23-0165
  88. www.sciencedirect.com www.sciencedirect.com
    Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressure
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    sciencedirect.com/science/article/pii/S2211124723013633
  89. Oct 2023
  90. www.sciencedirect.com www.sciencedirect.com
    Transcriptomic and proteomic profiling reveals distinct pathogenic features of peripheral non-classical monocytes in systemic lupus erythematosus
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    sciencedirect.com/science/article/pii/S1521661623005284
  91. Sep 2023
  92. www.sciencedirect.com www.sciencedirect.com
    Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths
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    sciencedirect.com/science/article/pii/S1934590923002576
  93. Aug 2023
  94. www.biorxiv.org www.biorxiv.org
    Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3’ UTR of FAIM2
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    biorxiv.org/content/10.1101/2023.08.21.553157v1
  95. Jul 2023
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A network-based approach reveals long non-coding RNAs associated with disease activity in lupus nephritis: key pathways for flare and potential biomarkers to be used as liquid biopsies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10355154/
  97. Jun 2023
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10236151/
  99. May 2023
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning
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    ncbi.nlm.nih.gov/pmc/articles/PMC10209542/
  101. Mar 2023
  102. www.sciencedirect.com www.sciencedirect.com
    Nicotinamide riboside supplementation is not associated with altered methylation homeostasis in Parkinson’s disease
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    sciencedirect.com/science/article/pii/S2589004223003553
  103. Jan 2023
  104. www.sciencedirect.com www.sciencedirect.com
    Enrichment of oral-derived bacteria in inflamed colorectal tumors and distinct associations of Fusobacterium in the mesenchymal subtype
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    sciencedirect.com/science/article/pii/S2666379123000058
  105. Dec 2022
  106. www.mdpi.com www.mdpi.com
    Pancreatic Islet Cells Response to IFNγ Relies on Their Spatial Location within an Islet
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    mdpi.com/2073-4409/12/1/113
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-cancer activity of ST101, a novel antagonist of CCAAT/enhancer binding protein β
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    ncbi.nlm.nih.gov/pmc/articles/PMC9630826/
  108. 52.53.155.43 52.53.155.43
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  109. Oct 2022
  110. 52.53.155.43 52.53.155.43
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  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9584608/
  112. Sep 2022
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
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