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Mar 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A BTB extension and ion-binding domain contribute to the pentameric structure and TFAP2A binding of KCTD1

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  DOI: 10.1016/j.str.2024.07.023
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7618933/
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Structural characterization of the Cu(II)-NTA spin label on α-helices by X-ray crystallography and electron paramagnetic resonance

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sciencedirect.com/science/article/pii/S0969212626000122
Dec 2025
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Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1

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sciencedirect.com:5037/science/article/pii/S0969212625004782
Aug 2025
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41594_2025_1631_MOESM4_ESM-html.html

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52.53.155.43/2894f1585e3ca7aaaea575ab75ca401271c73618/41594_2025_1631_MOESM4_ESM-html.html
Jul 2025
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Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2

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science.org/doi/10.1126/sciadv.adt2050
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M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12214875/
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Zidesamtinib Selective Targeting of Diverse ROS1 Drug-Resistant Mutations

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pmc.ncbi.nlm.nih.gov/articles/PMC12214885/
Jun 2025
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Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2

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science.org/doi/10.1126/sciadv.adt2050
Mar 2025
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23ME-01473, an Fc Effector–Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell–Mediated Antitumor Immunity through NKG2D and FcγRIIIa Activation

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1. scibot 27 Mar 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11927390/
Jan 2025
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Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide

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pmc.ncbi.nlm.nih.gov/articles/PMC11706664/
Dec 2024
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Nanobodies against the myelin enzyme CNPase as tools for structural and functional studies

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  DOI: 10.1111/jnc.16274
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16274
Nov 2024
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Structural basis of signaling complex inhibition by IL-6 domain-swapped dimers

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  DOI: 10.1016/j.str.2024.10.028
  
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sciencedirect.com/science/article/pii/S0969212624004635
Aug 2024
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Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes

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1. scibot 02 Aug 2024
  
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europepmc.orghttp//europepmc.org/articles/PMC5651216/
May 2024
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A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation

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1. scibot 31 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114259
  
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sciencedirect.com/science/article/pii/S2211124724005874
Apr 2024
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Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses

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1. scibot 26 Apr 2024
  
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  DOI: 10.1016/j.immuni.2024.03.022
  
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sciencedirect.com/science/article/pii/S1074761324001432
Mar 2024
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ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat

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1. scibot 15 Mar 2024
  
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  DOI: 10.1016/j.cell.2024.02.013
  
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  DOI: 10.1016/j.cell.2024.02.013
  
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sciencedirect.com/science/article/pii/S009286742400179X
Feb 2024
elifesciences.org elifesciences.org

Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS607-family transposition

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1. scibot 08 Feb 2024
  
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  DOI: 10.7554/eLife.39611
  
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elifesciences.org/articles/39611
Dec 2023
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Titin domains with reduced core hydrophobicity cause dilated cardiomyopathy

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1. scibot 20 Dec 2023
  
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  DOI: 10.1016/j.celrep.2023.113490
  
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sciencedirect.com/science/article/pii/S2211124723015024
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Electron counting with direct electron detectors in MicroED

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  DOI: 10.1016/j.str.2023.10.011
  
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sciencedirect.com/science/article/pii/S0969212623003969
Jul 2023
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Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity

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sciencedirect.com/science/article/pii/S2211124723008380
Jun 2023
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Centromere/kinetochore is assembled through CENP-C oligomerization

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  DOI: 10.1016/j.molcel.2023.05.023
  
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sciencedirect.com/science/article/pii/S1097276523003799
May 2023
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High-resolution structures with bound Mn2+ and Cd2+ map the metal import pathway in an Nramp transporter

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  DOI: 10.7554/eLife.84006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10185341/
Apr 2023
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Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes

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  DOI: 10.1016/j.immuni.2023.03.009
  
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sciencedirect.com/science/article/pii/S1074761323001292
Feb 2023
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Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation

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  DOI: 10.1126/sciadv.adg2997
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9931213/
Dec 2022
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Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding

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1. scibot 13 Dec 2022
  
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  DOI: 10.1016/j.str.2022.11.008
  
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sciencedirect.com/science/article/pii/S0969212622004579
Nov 2022
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Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes

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  DOI: 10.1016/j.immuni.2022.10.019
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9606073/
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IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling

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  DOI: 10.1016/j.celrep.2022.111489
  
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sciencedirect.com/science/article/pii/S2211124722013390
rupress.org rupress.org

Mitoguardin-2–mediated lipid transfer preserves mitochondrial morphology and lipid droplet formation

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  DOI: 10.1083/jcb.202207022
  
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rupress.org/jcb/article/221/12/e202207022/213573/Mitoguardin-2-mediated-lipid-transfer-preserves
Apr 2022
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Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis

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  DOI: 10.1016/j.str.2022.02.012
  
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sciencedirect.com/science/article/pii/S096921262200048X
Mar 2022
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Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel

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  DOI: 10.1016/j.str.2022.02.005
  
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sciencedirect.com/science/article/pii/S0969212622000417
Feb 2022
bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com

Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti

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1. scibot 18 Feb 2022
  
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  DOI: 10.1186/s12915-022-01233-2
  
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bmcbiol.biomedcentral.com/articles/10.1186/s12915-022-01233-2
elifesciences.org elifesciences.org

Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands

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  DOI: 10.7554/eLife.74648
  
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elifesciences.org/articles/74648
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The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria

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1. scibot 16 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110367
  
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sciencedirect.com/science/article/pii/S2211124722000882
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Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats

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1. scibot 08 Feb 2022
  
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  DOI: 10.7554/eLife.72908
  
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elifesciences.org/articles/72908
Jan 2022
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Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1

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1. scibot 20 Jan 2022
  
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  DOI: 10.7554/eLife.72823
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8758145/
Oct 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Structural characterization of NrnC identifies unifying features of dinucleotidases

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Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy

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Structural basis and regulation of the reductive stress response

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Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

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McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation

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Collection of Continuous Rotation MicroED Data from Ion Beam-Milled Crystals of Any Size

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Untitled document

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A Rare Lysozyme Crystal Form Solved Using Highly Redundant Multiple Electron Diffraction Datasets from Micron-Sized Crystals

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Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED

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An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death

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Cross-Reactive Donor-Specific CD8+ Tregs Efficiently Prevent Transplant Rejection

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Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1

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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV

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CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation

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Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form

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SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms

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Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

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A pentameric protein ring with novel architecture is required for herpesviral packaging

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Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site

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Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family

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Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment

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Cannabidiol interactions with voltage-gated sodium channels

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Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling

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Structural model for differential cap maturation at growing microtubule ends

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Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas

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Chemical and structural investigation of the paroxetine-human serotonin transporter complex

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Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

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The architecture of EMC reveals a path for membrane protein insertion

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Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family

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A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl–/H+ transport cycle

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Mechanisms of nucleotide selection by telomerase

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Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation

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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies

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Identification and Characterization of Mutations in Ubiquitin Required for Non-covalent Dimer Formation

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Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins

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Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter

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Structure-based inhibitors of amyloid beta core suggest a common interface with tau

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Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED

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Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies

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Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

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Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway

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In Crystallo Selection to Establish New RNA Crystal Contacts

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Analysis of Global and Site-Specific Radiation Damage in Cryo-EM

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Robo1 Forms a Compact Dimer-of-Dimers Assembly

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Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rβ1

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Structural Basis of Mitochondrial Transcription Initiation

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A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants

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Structural Basis for Apelin Control of the Human Apelin Receptor

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