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Jan 2026
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Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex

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  DOI: 10.1016/j.cell.2025.12.005
  
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sciencedirect.com/science/article/pii/S0092867425014187
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Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly

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sciencedirect.com/science/article/pii/S0092867425013765
Dec 2025
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Cryo-EM structure of cyanopodophage Pan3 reveals a modular tail architecture for host recognition

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sciencedirect.com:5037/science/article/pii/S0969212625004459
Nov 2025
rupress.org rupress.org

Actin arginylation alters myosin engagement and F-actin patterning despite structural conservation

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rupress.org/jcb/article/225/1/e202409067/278468/Actin-arginylation-alters-myosin-engagement-and-F
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Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

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1. scibot 11 Nov 2025
  
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  DOI: 10.7554/eLife.100799
  
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elifesciences.org/articles/100799
Oct 2025
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Lipids modulate the open probability of RyR1 under cryo-EM conditions

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sciencedirect.com/science/article/pii/S0969212625003466
Sep 2025
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Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

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elifesciences.org/reviewed-preprints/100799
Aug 2025
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The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition

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  DOI: 10.1016/j.molcel.2025.07.015
  
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In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment

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  DOI: 10.1073/pnas.2511890122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12337332/
Jul 2025
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LAG3-MHCII interaction induces a tight cell-cell interface at the immunological synapse

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  DOI: 10.1093/jimmun/vkaf120
  
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academic.oup.com/jimmunol/advance-article/doi/10.1093/jimmun/vkaf120/8175755
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Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

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elifesciences.org/articles/104237
Jun 2025
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Structural basis of GluK2 kainate receptor activation by a partial agonist

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  DOI: 10.1038/s41594-025-01566-w
  
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nature.com/articles/s41594-025-01566-w
May 2025
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Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1

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  DOI: 10.7554/eLife.105396
  
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elifesciences.org/articles/105396
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Vaccination of nonhuman primates elicits a broadly neutralizing antibody lineage targeting a quaternary epitope on the HIV-1 Env trimer

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.immuni.2025.04.010
  
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sciencedirect.com/science/article/pii/S1074761325001736
Mar 2025
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Biochemical profiling and structural basis of ADAR1-mediated RNA editing

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  DOI: 10.1016/j.molcel.2025.02.017
  
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sciencedirect.com/science/article/pii/S1097276525001480
Feb 2025
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Structure of the F-tractin–F-actin complex

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  DOI: 10.1083/jcb.202409192
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11809415/
Jan 2025
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Structural and functional analysis of the Nipah virus polymerase complex

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.cell.2024.12.021
  
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sciencedirect.com/science/article/pii/S009286742401434X
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Passage of the HIV capsid cracks the nuclear pore

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.cell.2024.12.008
  
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sciencedirect.com/science/article/pii/S0092867424014211
Dec 2024
elifesciences.org elifesciences.org

Control of 3′ splice site selection by the yeast splicing factor Fyv6

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1. scibot 20 Dec 2024
  
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  DOI: 10.7554/eLife.100449
  
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elifesciences.org/articles/100449
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Dual BACH1 regulation by complementary SCF-type E3 ligases

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1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.cell.2024.11.006
  
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sciencedirect.com/science/article/pii/S0092867424013229
Nov 2024
www.embopress.org www.embopress.org

Structure of a step II catalytically activated spliceosome from Chlamydomonas reinhardtii

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  DOI: 10.1038/s44318-024-00274-3
  
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embopress.org/doi/10.1038/s44318-024-00274-3
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Inhibition of Parkinson’s Disease-related LRRK2 by type-I and type-II kinase inhibitors: activity and structures

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1. scibot 26 Nov 2024
  
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  DOI: 10.1101/2023.09.07.556689
  
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biorxiv.org/content/10.1101/2023.09.07.556689v1
Sep 2024
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Dynamic allostery drives autocrine and paracrine TGF-β signaling

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  DOI: 10.1016/j.cell.2024.08.036
  
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sciencedirect.com/science/article/pii/S0092867424009656
Aug 2024
www.cell.com www.cell.com

Structural insights into the chloroplast protein import in land plants

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  DOI: 10.1016/j.cell.2024.08.003
  
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cell.com/cell/fulltext/S0092-8674(24)00894-8
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Conservation and specialization of the Ycf2-FtsHi chloroplast protein import motor in green algae

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Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance

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sciencedirect.com/science/article/pii/S0092867424008420
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Architecture of native kinetochores revealed by structural studies utilizing a thermophilic yeast

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  DOI: 10.1016/j.cub.2024.07.036
  
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sciencedirect.com/science/article/pii/S0960982224009394
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Mechanism of Ca2+ transport by ferroportin - ProQuest

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  DOI: 10.7554/eLife.82947
  
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proquest.com/docview/2771288630
Jul 2024
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Structure of the Hir histone chaperone complex

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  DOI: 10.1016/j.molcel.2024.05.031
  
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sciencedirect.com/science/article/pii/S1097276524004787
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Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

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1. scibot 14 Jul 2024
  
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  DOI: 10.1101/2024.06.18.599606
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11212993/
Jun 2024
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POT1 recruits and regulates CST-Polα/primase at human telomeres

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cell.com/cell/fulltext/S0092-8674(24)00493-8
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Cryo-electron tomography reveals the packaging pattern of RuBisCOs in Synechococcus β-carboxysome

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  DOI: 10.1016/j.str.2024.05.007
  
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sciencedirect.com/science/article/pii/S0969212624001849
Apr 2024
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Structural basis of ligand specificity and channel activation in an insect gustatory receptor

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  DOI: 10.1016/j.celrep.2024.114035
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00363-2
Mar 2024
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Structural mechanisms for VMAT2 inhibition by tetrabenazine

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  DOI: 10.7554/eLife.91973
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10959523/
Nov 2023
www.cell.com www.cell.com

Architecture of the bacteriophage lambda tail

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  DOI: 10.1016/j.str.2023.10.006
  
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cell.com/structure/fulltext/S0969-2126(23)00363-5
Oct 2023
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A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response

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  DOI: 10.1038/s41556-023-01248-z
  
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  DOI: 10.1038/s41556-023-01248-z
  
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nature.com/articles/s41556-023-01248-z
Aug 2023
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Recognition determinants of improved HIV-1 neutralization by a heavy chain matured pediatric antibody

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EMBO Reports - 2023 - Jiang-html.html

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Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels

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  DOI: 10.1016/j.celrep.2023.112926
  
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Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ

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Jul 2023
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Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor

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Jun 2023
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Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment

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Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

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Cryo-EM structure of the endothelin-1-ETB-Gi complex

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Structural and functional properties of a plant NRAMP-related aluminum transporter

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Mar 2023
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Design of a stabilized RBD enables potently neutralizing SARS-CoV-2 single-component nanoparticle vaccines

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Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster

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ncbi.nlm.nih.gov/pmc/articles/PMC9977279/
Feb 2023
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Structural basis of a transcription pre-initiation complex on a divergent promoter

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Mechanism of Ca2+ transport by ferroportin

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Jan 2023
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Nucleosome dyad determines the H1 C-terminus collapse on distinct DNA arms

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The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions

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Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules

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Oct 2022
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A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM

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Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice

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TITLE: Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways

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Conserved structural elements specialize ATAD1 as a membrane protein extraction machine

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Jun 2022
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Rational exploration of fold atlas for human solute carrier proteins

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Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex

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Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine

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RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex

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Assembly of recombinant tau into filaments identical to those of Alzheimer’s disease and chronic traumatic encephalopathy

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Mar 2022
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Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses

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Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB

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Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance

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Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel

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Structural basis for catalyzed assembly of the Sonic hedgehog–Patched1 signaling complex

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Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats

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Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family

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Jan 2022
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Structural basis of bacteriophage lambda capsid maturation

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Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II

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Dec 2021
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Conserved and divergent features of neuronal CaMKII holoenzyme structure, function, and high-order assembly

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Nov 2021
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Structure and assembly pattern of a freshwater short-tailed cyanophage Pam1

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Oct 2021
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Pan-ebolavirus protective therapy by two multifunctional human antibodies

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Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells

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Structural characterization of NrnC identifies unifying features of dinucleotidases

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Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

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Regulation of human mTOR complexes by DEPTOR

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Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

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Negative charge in the RACK1 loop broadens the translational capacity of the human ribosome

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Structural snapshots of TRPV1 reveal mechanism of polymodal functionality

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High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor

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Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection

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Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy

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Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

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Untitled document

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Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling

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Structure and analysis of nanobody binding to the human ASIC1a ion channel

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Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

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Structures of translationally inactive mammalian ribosomes

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High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms

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Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

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Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii

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Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

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Self-capping of nucleoprotein filaments protects Newcastle Disease Virus genome

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Structure of the Mechanosensitive Channel MscS Embedded in the Membrane Bilayer

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Structures of translationally inactive mammalian ribosomes

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Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor

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Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition

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Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody

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Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis

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Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

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CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation

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Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP

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Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis

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Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization

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Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex

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Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor

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Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

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A pentameric protein ring with novel architecture is required for herpesviral packaging

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Structural basis for self-cleavage prevention by tag:anti-tag pairing complementarity in type VI Cas13 CRISPR systems

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Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

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Mimicry of Canonical Translation Elongation Underlies Alanine Tail Synthesis in RQC

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Atomic structures of respiratory complex III 2, complex IV, and supercomplex III 2-IV from vascular plants

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Structure of bacterial phospholipid transporter MlaFEDB with substrate bound

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Structure of the human core transcription-export complex reveals a hub for multivalent interactions

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The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism

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Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation

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The structures of secretory and dimeric immunoglobulin A

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A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide

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Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters

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Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

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Structural basis of αE-catenin–F-actin catch bond behavior

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Molecular mechanism for direct actin force-sensing by α-catenin

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A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch

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Antibody escape by polyomavirus capsid mutation facilitates neurovirulence

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An ER translocon for multi-pass membrane protein biogenesis

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EDF1 coordinates cellular responses to ribosome collisions

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Structural basis of substrate recognition by a polypeptide processing and secretion transporter

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Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding

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Mechanical inhibition of isolated Vo from V/A-ATPase for proton conductance

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Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5

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Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β

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Chemical and structural investigation of the paroxetine-human serotonin transporter complex

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Atomic structure of a mitochondrial complex I intermediate from vascular plants

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Structure and activation mechanism of the BBSome membrane protein trafficking complex

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Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction

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Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175

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Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2

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Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens

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Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

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Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

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Cryo-EM structure of VASH1-SVBP bound to microtubules

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Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1

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Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

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Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction

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Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR

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Regulation of Eag1 gating by its intracellular domains

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Capsid Structure of a Freshwater Cyanophage Siphoviridae Mic1

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Regulatory switch at the cytoplasmic interface controls TRPV channel gating

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  DOI: 10.7554/eLife.47746
  
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Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies

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Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases

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Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins

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Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability

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Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State

1
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Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

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Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes

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High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms

1
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  DOI: 10.1016/j.molcel.2018.10.014
  
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Structure of the human epithelial sodium channel by cryo-electron microscopy

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Human SEIPIN Binds Anionic Phospholipids

1
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Human β-Tubulin Isotypes Can Regulate Microtubule Protofilament Number and Stability

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TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells

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1. scibot 05 Nov 2018
  
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Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION

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elifesciences.org/articles/36861
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Multivalency regulates activity in an intrinsically disordered transcription factor

1
1. scibot 05 Nov 2018
  
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