92 Matching Annotations
  1. Last 7 days
  2. 52.53.155.43 52.53.155.43
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    1. scibot 19 Dec 2024
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  3. Dec 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Dual BACH1 regulation by complementary SCF-type E3 ligases
    1
    1. scibot 10 Dec 2024
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      DOI: 10.1016/j.cell.2024.11.006

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    sciencedirect.com/science/article/pii/S0092867424013229
  5. Nov 2024
  6. www.embopress.org www.embopress.org
    Structure of a step II catalytically activated spliceosome from Chlamydomonas reinhardtii
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    1. scibot 28 Nov 2024
      RRID:SCR_016499

      DOI: 10.1038/s44318-024-00274-3

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    embopress.org/doi/10.1038/s44318-024-00274-3
  7. www.biorxiv.org www.biorxiv.org
    Inhibition of Parkinson’s Disease-related LRRK2 by type-I and type-II kinase inhibitors: activity and structures
    1
    1. scibot 26 Nov 2024
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      DOI: 10.1101/2023.09.07.556689

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    biorxiv.org/content/10.1101/2023.09.07.556689v1
  8. Sep 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Dynamic allostery drives autocrine and paracrine TGF-β signaling
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    1. scibot 17 Sep 2024
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      DOI: 10.1016/j.cell.2024.08.036

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    sciencedirect.com/science/article/pii/S0092867424009656
  10. Aug 2024
  11. www.cell.com www.cell.com
    Structural insights into the chloroplast protein import in land plants
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    1. scibot 28 Aug 2024
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      DOI: 10.1016/j.cell.2024.08.003

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    cell.com/cell/fulltext/S0092-8674(24)00894-8
  12. www.sciencedirect.com www.sciencedirect.com
    Conservation and specialization of the Ycf2-FtsHi chloroplast protein import motor in green algae
    1
    1. scibot 28 Aug 2024
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      DOI: 10.1016/j.cell.2024.08.002

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    sciencedirect.com/science/article/pii/S0092867424008936
  13. Jun 2024
  14. www.sciencedirect.com www.sciencedirect.com
    A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2
    1
    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.jbc.2024.107469

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    sciencedirect.com/science/article/pii/S0021925824019707
  15. www.cell.com www.cell.com
    Mechanism of heterochromatin remodeling revealed by the DDM1 bound nucleosome structures
    1
    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.str.2024.05.013

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    cell.com/structure/fulltext/S0969-2126(24)00190-4
  16. www.cell.com www.cell.com
    POT1 recruits and regulates CST-Polα/primase at human telomeres
    1
    1. scibot 05 Jun 2024
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      DOI: 10.1016/j.cell.2024.05.002

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    cell.com/cell/fulltext/S0092-8674(24)00493-8
  17. May 2024
  18. www.sciencedirect.com www.sciencedirect.com
    Autophagy preferentially degrades non-fibrillar polyQ aggregates
    1
    1. scibot 17 May 2024
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      DOI: 10.1016/j.molcel.2024.04.018

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    sciencedirect.com/science/article/pii/S1097276524003836
  19. Apr 2024
  20. www.cell.com www.cell.com
    Structural basis of ligand specificity and channel activation in an insect gustatory receptor
    1
    1. scibot 04 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114035

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    cell.com/cell-reports/fulltext/S2211-1247(24)00363-2
  21. Mar 2024
  22. www.nature.com www.nature.com
    Combinatorial selective ER-phagy remodels the ER during neurogenesis
    1
    1. scibot 07 Mar 2024
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      DOI: 10.1038/s41556-024-01356-4

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    nature.com/articles/s41556-024-01356-4
  23. www.sciencedirect.com www.sciencedirect.com
    Structure of the plant plastid-encoded RNA polymerase
    2
    1. scibot 01 Mar 2024
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      DOI: 10.1016/j.cell.2024.01.036

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    2. scibot 01 Mar 2024
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      DOI: 10.1016/j.cell.2024.01.036

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    sciencedirect.com/science/article/pii/S009286742400103X
  24. www.sciencedirect.com www.sciencedirect.com
    Cryo-EM structures of the plant plastid-encoded RNA polymerase
    1
    1. scibot 01 Mar 2024
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      DOI: 10.1016/j.cell.2024.01.026

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    sciencedirect.com/science/article/pii/S0092867424000631
  25. Feb 2024
  26. www.sciencedirect.com www.sciencedirect.com
    A metabolically controlled contact site between vacuoles and lipid droplets in yeast
    3
    1. scibot 21 Feb 2024
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      DOI: 10.1016/j.devcel.2024.01.016

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    2. scibot 21 Feb 2024
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      DOI: 10.1016/j.devcel.2024.01.016

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      DOI: 10.1016/j.devcel.2024.01.016

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    sciencedirect.com/science/article/pii/S1534580724000364
  27. Nov 2023
  28. www.cell.com www.cell.com
    The evolution and determinants of neutralization of potent head-binding antibodies against Ebola virus
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113366

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    cell.com/cell-reports/fulltext/S2211-1247(23)01378-5
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Membrane remodeling properties of the Parkinson’s disease protein LRRK2
    1
    1. scibot 02 Nov 2023
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      DOI: 10.1073/pnas.2309698120

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    ncbi.nlm.nih.gov/pmc/articles/PMC10614619/
  30. Oct 2023
  31. www.sciencedirect.com www.sciencedirect.com
    Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly
    1
    1. scibot 28 Oct 2023
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      DOI: 10.1016/j.molcel.2023.09.037

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    sciencedirect.com/science/article/pii/S1097276523008031
  32. www.nature.com www.nature.com
    A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response
    2
    1. scibot 20 Oct 2023
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      DOI: 10.1038/s41556-023-01248-z

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    2. scibot 20 Oct 2023
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      DOI: 10.1038/s41556-023-01248-z

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    nature.com/articles/s41556-023-01248-z
  33. Aug 2023
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ
    1
    1. scibot 01 Aug 2023
      RRID:SCR_016499

      DOI: 10.7554/eLife.87672

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    ncbi.nlm.nih.gov/pmc/articles/PMC10382156/
  35. Jul 2023
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor
    1
    1. scibot 14 Jul 2023
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      DOI: 10.7554/eLife.86029

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    ncbi.nlm.nih.gov/pmc/articles/PMC10338036/
  37. Mar 2023
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster
    1
    1. scibot 05 Mar 2023
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      DOI: 10.7554/eLife.84424

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    ncbi.nlm.nih.gov/pmc/articles/PMC9977279/
  39. Feb 2023
  40. www.nature.com www.nature.com
    The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
    1
    1. scibot 04 Feb 2023
      RRID:SCR_016499

      DOI: 10.1038/s41467-023-36058-2

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    nature.com/articles/s41467-023-36058-2
  41. Jan 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Nucleosome dyad determines the H1 C-terminus collapse on distinct DNA arms
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    1. scibot 07 Jan 2023
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      DOI: 10.1016/j.str.2022.12.005

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    sciencedirect.com/science/article/pii/S0969212622004919
  43. www.sciencedirect.com www.sciencedirect.com
    The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions
    1
    1. scibot 02 Jan 2023
      SCR_016499

      DOI: 10.1016/j.celrep.2022.111902

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    sciencedirect.com/science/article/pii/S2211124722018010
  44. Dec 2022
  45. www.nature.com www.nature.com
    Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules
    1
    1. scibot 13 Dec 2022
      RRID:SCR_016499

      DOI: 10.1038/s41594-022-00863-y

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    nature.com/articles/s41594-022-00863-y
  46. Nov 2022
  47. www.sciencedirect.com www.sciencedirect.com
    Structure of a TOC-TIC supercomplex spanning two chloroplast envelope membranes
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    1. scibot 22 Nov 2022
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      DOI: 10.1016/j.cell.2022.10.030

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    sciencedirect.com/science/article/pii/S0092867422013769
  48. Oct 2022
  49. www.sciencedirect.com www.sciencedirect.com
    A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM
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    1. scibot 01 Oct 2022
      RRID:SCR_016499

      DOI: 10.1016/j.xpro.2022.101732

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    sciencedirect.com/science/article/pii/S2666166722006128
  50. Sep 2022
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor
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    1. scibot 21 Sep 2022
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      DOI: 10.7554/eLife.79148

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    ncbi.nlm.nih.gov/pmc/articles/PMC9462852/
  52. Aug 2022
  53. www.sciencedirect.com www.sciencedirect.com
    TITLE: Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways
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      DOI: 10.1016/j.isci.2022.104914

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    sciencedirect.com/science/article/pii/S2589004222011865
  54. Jul 2022
  55. www.pnas.org www.pnas.org
    In situ architecture of the lipid transport protein VPS13C at ER–lysosome membrane contacts
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    1. scibot 27 Jul 2022
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      DOI: 10.1073/pnas.2203769119

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    pnas.org/doi/10.1073/pnas.2203769119
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Conserved structural elements specialize ATAD1 as a membrane protein extraction machine
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      DOI: 10.7554/eLife.73941

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    ncbi.nlm.nih.gov/pmc/articles/PMC9273213/
  57. Mar 2022
  58. www.sciencedirect.com www.sciencedirect.com
    Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB
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      DOI: 10.1016/j.str.2022.02.007

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    sciencedirect.com/science/article/pii/S0969212622000430
  59. Jan 2022
  60. elifesciences.org elifesciences.org
    Nanofluidic chips for cryo-EM structure determination from picoliter sample volumes
    1
    1. scibot 28 Jan 2022
      RRID:SCR_016499v1

      DOI: 10.7554/eLife.72629

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    elifesciences.org/articles/72629
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography
    1
    1. scibot 26 Jan 2022
      RRID:SCR_016499

      DOI: 10.7554/eLife.74512

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    ncbi.nlm.nih.gov/pmc/articles/PMC8776254/
  62. Oct 2021
  63. www.cell.com www.cell.com
    Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells
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    1. scibot 27 Oct 2021
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      DOI: 10.1016/j.celrep.2021.109877

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    cell.com/cell-reports/fulltext/S2211-1247(21)01347-4
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells
    1
    1. scibot 02 Oct 2021
      RRID:SCR_016499

      DOI: 10.7554/eLife.71474

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    ncbi.nlm.nih.gov/pmc/articles/PMC8480983/
  65. Sep 2021
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    Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
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  68. Aug 2021
  69. elifesciences.org elifesciences.org
    Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection
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  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation
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    Structure and analysis of nanobody binding to the human ASIC1a ion channel
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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structures of translationally inactive mammalian ribosomes
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  73. Jul 2021
  74. www.sciencedirect.com www.sciencedirect.com
    Structure of the Mechanosensitive Channel MscS Embedded in the Membrane Bilayer
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    Structures of translationally inactive mammalian ribosomes
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  76. elifesciences.org elifesciences.org
    Structural and functional characterization of an otopetrin family proton channel
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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core
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  78. May 2021
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    The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain
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    Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP
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    Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis
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  82. Apr 2021
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    Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex
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  84. Mar 2021
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A pentameric protein ring with novel architecture is required for herpesviral packaging
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  86. www.sciencedirect.com www.sciencedirect.com
    Structural basis for self-cleavage prevention by tag:anti-tag pairing complementarity in type VI Cas13 CRISPR systems
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  87. Feb 2021
  88. elifesciences.org elifesciences.org
    Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy
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  89. www.cell.com www.cell.com
    Mimicry of Canonical Translation Elongation Underlies Alanine Tail Synthesis in RQC
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  90. Jan 2021
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure of bacterial phospholipid transporter MlaFEDB with substrate bound
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  92. Dec 2020
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation
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  94. www.cell.com www.cell.com
    A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide
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  95. Nov 2020
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    Structural basis of αE-catenin–F-actin catch bond behavior
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  97. Sep 2020
  98. www.sciencedirect.com www.sciencedirect.com
    HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies
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  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2
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  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An ER translocon for multi-pass membrane protein biogenesis
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  101. elifesciences.org elifesciences.org
    Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding
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  102. elifesciences.org elifesciences.org
    Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chemical and structural investigation of the paroxetine-human serotonin transporter complex
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mechanical inhibition of isolated Vo from V/A-ATPase for proton conductance
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  105. elifesciences.org elifesciences.org
    Structure and activation mechanism of the BBSome membrane protein trafficking complex
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  106. elifesciences.org elifesciences.org
    Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism
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    Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β
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  108. elifesciences.org elifesciences.org
    Molecular principles of assembly, activation, and inhibition in epithelial sodium channel
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  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cryo-EM structure of VASH1-SVBP bound to microtubules
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  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The His-Gly motif of acid-sensing ion channels resides in a reentrant ‘loop’ implicated in gating and ion selectivity
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  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175
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  112. elifesciences.org elifesciences.org
    Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction
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  113. Jan 2020
  114. www.sciencedirect.com www.sciencedirect.com
    Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing
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  115. elifesciences.org elifesciences.org
    Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR
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      DOI: 10.7554/eLife.44707

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  116. elifesciences.org elifesciences.org
    Regulation of Eag1 gating by its intracellular domains
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      DOI: 10.7554/eLife.49188

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  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulatory switch at the cytoplasmic interface controls TRPV channel gating
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      DOI: 10.7554/eLife.47746

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    ncbi.nlm.nih.gov/pmc/articles/PMC6538378/
  118. elifesciences.org elifesciences.org
    Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit
    1
    1. scibot 13 Jan 2020
      RRID:SCR_016499

      DOI: 10.7554/eLife.46041

      Resource: MotionCor2 (RRID:SCR_016499)

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      RRID:SCR_016499 RRIDCUR:Validated
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  119. www.sciencedirect.com www.sciencedirect.com
    Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies
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    1. scibot 13 Jan 2020
      SCR_016499

      DOI: 10.1016/j.chom.2019.04.011

      Resource: MotionCor2 (RRID:SCR_016499)

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      RRID:SCR_016499 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1931312819302148
  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases
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    1. scibot 13 Jan 2020
      RRID:SCR_016499

      DOI: 10.7554/eLife.44071

      Resource: MotionCor2 (RRID:SCR_016499)

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      RRID:SCR_016499 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC6602582/
  121. www.sciencedirect.com www.sciencedirect.com
    Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins
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    1. scibot 13 Jan 2020
      RRID:SCR_016499

      DOI: 10.1016/j.chom.2019.05.004

      Resource: MotionCor2 (RRID:SCR_016499)

      Curator: @ethanbadger

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      RRID:SCR_016499 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1931312819302495
  122. www.sciencedirect.com www.sciencedirect.com
    Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD
    1
    1. scibot 13 Jan 2020
      SCR_016499

      DOI: 10.1016/j.celrep.2019.08.052

      Resource: MotionCor2 (RRID:SCR_016499)

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    sciencedirect.com/science/article/pii/S2211124719311003
  123. www.sciencedirect.com www.sciencedirect.com
    Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies
    1
    1. scibot 13 Jan 2020
      SCR_016499

      DOI: 10.1016/j.chom.2019.10.002

      Resource: MotionCor2 (RRID:SCR_016499)

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    sciencedirect.com/science/article/pii/S1931312819305268
  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes
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    1. scibot 13 Jan 2020
      RRID:SCR_016499

      DOI: 10.7554/eLife.45779

      Resource: MotionCor2 (RRID:SCR_016499)

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  125. Nov 2018
  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure of the human epithelial sodium channel by cryo-electron microscopy
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    1. scibot 05 Nov 2018
      SCR_016499

      Curator: @evieth

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      (MotionCor2, RRID:SCR_016499)

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