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61 Matching Annotations

Jan 2026
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Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex

1
1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.cell.2025.12.005
  
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sciencedirect.com/science/article/pii/S0092867425014187
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Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly

1
1. scibot 06 Jan 2026
  
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  DOI: 10.1016/j.cell.2025.11.041
  
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sciencedirect.com/science/article/pii/S0092867425013765
Oct 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Molecular dynamics of the matrisome across sea anemone life history

1
1. scibot 25 Oct 2025
  
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  DOI: 10.7554/eLife.105319
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12549020/
Aug 2025
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The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition

1
1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.molcel.2025.07.015
  
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sciencedirect.com/science/article/pii/S1097276525006161
Jun 2025
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Structural insights into the biotechnologically relevant reversible NADPH-oxidizing NiFe-hydrogenase from P. furiosus

1
1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.str.2025.05.017
  
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sciencedirect.com/science/article/pii/S0969212625002151
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Structural basis of GluK2 kainate receptor activation by a partial agonist

1
1. scibot 11 Jun 2025
  
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  DOI: 10.1038/s41594-025-01566-w
  
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nature.com/articles/s41594-025-01566-w
Jan 2025
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Structural and functional analysis of the Nipah virus polymerase complex

1
1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.cell.2024.12.021
  
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sciencedirect.com/science/article/pii/S009286742401434X
Nov 2024
www.biorxiv.org www.biorxiv.org

Inhibition of Parkinson’s Disease-related LRRK2 by type-I and type-II kinase inhibitors: activity and structures

1
1. scibot 26 Nov 2024
  
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  DOI: 10.1101/2023.09.07.556689
  
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biorxiv.org/content/10.1101/2023.09.07.556689v1
Sep 2024
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Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2

1
1. scibot 25 Sep 2024
  
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  DOI: 10.7554/eLife.59991
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7434445/
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Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1

1
1. scibot 25 Sep 2024
  
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  DOI: 10.7554/eLife.59555
  
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elifesciences.org/articles/59555
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Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175

1
1. scibot 25 Sep 2024
  
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  DOI: 10.7554/eLife.53430
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7141809/
Jun 2024
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A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2

1
1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.jbc.2024.107469
  
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sciencedirect.com/science/article/pii/S0021925824019707
www.cell.com www.cell.com

POT1 recruits and regulates CST-Polα/primase at human telomeres

1
1. scibot 05 Jun 2024
  
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  RRID:SCR_016732
  
  DOI: 10.1016/j.cell.2024.05.002
  
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cell.com/cell/fulltext/S0092-8674(24)00493-8
Apr 2024
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Structural basis of ligand specificity and channel activation in an insect gustatory receptor

1
1. scibot 04 Apr 2024
  
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  RRID:SCR_016732
  
  DOI: 10.1016/j.celrep.2024.114035
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00363-2
Nov 2023
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Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa

1
1. scibot 03 Nov 2023
  
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  RRID:SCR_016732
  
  DOI: 10.1016/j.cell.2023.10.002
  
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sciencedirect.com/science/article/pii/S009286742301084X
Aug 2023
52.53.155.43 52.53.155.43

EMBO Reports - 2023 - Jiang-html.html

1
1. scibot 16 Aug 2023
  
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  RRID:SCR_016732
  
  DOI: 10.15252/embr.202356864
  
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52.53.155.43/72eed5338814ac6922d23d3395f365b4e68799b2/EMBO Reports - 2023 - Jiang-html.html
Jul 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor

1
1. scibot 14 Jul 2023
  
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  RRID:SCR_016732
  
  DOI: 10.7554/eLife.86029
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10338036/
Jun 2023
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Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment

1
1. scibot 21 Jun 2023
  
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  RRID:SCR_016732
  
  DOI: 10.1016/j.molcel.2023.05.036
  
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sciencedirect.com/science/article/pii/S1097276523004203
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster

1
1. scibot 05 Mar 2023
  
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  RRID:SCR_016732
  
  DOI: 10.7554/eLife.84424
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9977279/
Jan 2023
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The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions

1
1. scibot 02 Jan 2023
  
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  RRID:SCR_016732
  
  DOI: 10.1016/j.celrep.2022.111902
  
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sciencedirect.com/science/article/pii/S2211124722018010
Dec 2022
www.nature.com www.nature.com

Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules

1
1. scibot 13 Dec 2022
  
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  RRID:SCR_016732
  
  DOI: 10.1038/s41594-022-00863-y
  
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nature.com/articles/s41594-022-00863-y
Mar 2022
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Structural basis for catalyzed assembly of the Sonic hedgehog–Patched1 signaling complex

1
1. scibot 02 Mar 2022
  
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  RRID:SCR_016732
  
  DOI: 10.1016/j.devcel.2022.02.008
  
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sciencedirect.com/science/article/pii/S1534580722000740
Nov 2021
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Structure and assembly pattern of a freshwater short-tailed cyanophage Pam1

1
1. scibot 02 Nov 2021
  
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  RRID:SCR_016732
  
  DOI: 10.1016/j.str.2021.10.004
  
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sciencedirect.com/science/article/pii/S0969212621003725
Oct 2021
www.cell.com www.cell.com

Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells

1
1. scibot 27 Oct 2021
  
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  RRID:SCR_016732
  
  DOI: 10.1016/j.celrep.2021.109877
  
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cell.com/cell-reports/fulltext/S2211-1247(21)01347-4
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

1
1. scibot 02 Oct 2021
  
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  RRID:SCR_016732
  
  DOI: 10.7554/eLife.71474
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8480983/
Sep 2021
elifesciences.org elifesciences.org

Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

1
1. scibot 30 Sep 2021
  
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  RRID:SCR_016732
  
  DOI: 10.7554/eLife.71420
  
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elifesciences.org/articles/71420
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Regulation of human mTOR complexes by DEPTOR

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1. scibot 18 Sep 2021
  
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  DOI: 10.7554/eLife.70871
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8439649/
Aug 2021
elifesciences.org elifesciences.org

Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection

1
1. scibot 25 Aug 2021
  
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  RRID:SCR_016732
  
  DOI: 10.7554/eLife.68110
  
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elifesciences.org/articles/68110
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Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

1
1. scibot 17 Aug 2021
  
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  DOI: 10.7554/eLife.68710
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8357420/
Jul 2021
elifesciences.org elifesciences.org

Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

1
1. scibot 29 Jul 2021
  
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  DOI: 10.7554/eLife.46417
  
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elifesciences.org/articles/46417
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Structure of the Mechanosensitive Channel MscS Embedded in the Membrane Bilayer

1
1. scibot 29 Jul 2021
  
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  CTFFind4
  
  DOI: 10.1016/j.jmb.2019.07.006
  
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sciencedirect.com/science/article/pii/S0022283619304279
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Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

1
1. scibot 27 Jul 2021
  
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  CTFFIND4
  
  DOI: 10.7554/eLife.37688
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6237438/
May 2021
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The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain

1
1. scibot 09 May 2021
  
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  RRID:SCR_016732
  
  DOI: 10.1016/j.str.2020.06.008
  
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sciencedirect.com/science/article/pii/S0969212620302112
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Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis

1
1. scibot 07 May 2021
  
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  RRID:SCR_016732
  
  DOI: 10.1016/j.molcel.2020.08.010
  
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sciencedirect.com/science/article/pii/S1097276520305530
Apr 2021
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Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex

1
1. scibot 28 Apr 2021
  
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  RRID:SCR_016732
  
  DOI: 10.1016/j.str.2021.04.003
  
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sciencedirect.com/science/article/pii/S0969212621001192
elifesciences.org elifesciences.org

Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor

1
1. scibot 06 Apr 2021
  
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  RRID:SCR_016732
  
  DOI: 10.7554/eLife.66097
  
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A pentameric protein ring with novel architecture is required for herpesviral packaging

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Structural basis for self-cleavage prevention by tag:anti-tag pairing complementarity in type VI Cas13 CRISPR systems

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Atomic structure of a mitochondrial complex I intermediate from vascular plants

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Atomic structures of respiratory complex III 2, complex IV, and supercomplex III 2-IV from vascular plants

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Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters

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Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

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Structural basis of αE-catenin–F-actin catch bond behavior

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Molecular mechanism for direct actin force-sensing by α-catenin

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Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding

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Molecular principles of assembly, activation, and inhibition in epithelial sodium channel

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Chemical and structural investigation of the paroxetine-human serotonin transporter complex

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Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β

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Structure and activation mechanism of the BBSome membrane protein trafficking complex

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Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction

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Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies

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Structural basis of substrate recognition by a polypeptide processing and secretion transporter

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Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

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Atomic structure of a mitochondrial complex I intermediate from vascular plants

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Regulation of Eag1 gating by its intracellular domains

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Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing

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Capsid Structure of a Freshwater Cyanophage Siphoviridae Mic1

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Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State

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Untitled document

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