66 Matching Annotations
  1. Last 7 days
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    RAS/MEK/PI3K pathway inhibition augments response to CD40 agonism by targeting CD11b+ Bregs thereby overcoming melanoma PD1-resistance
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    nature.com/articles/s41467-025-67315-1
  3. Dec 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Extracellular matrix-myCAF signatures correlate with resistance to neoadjuvant aPD-L1 immune checkpoint inhibition with durvalumab + metformin in HPV+ HNSCC
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    pmc.ncbi.nlm.nih.gov/articles/PMC12703361/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intratumoral three-cell-type clusters are a conserved feature of endogenous antitumor immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12707859/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cancer Genomic Alterations and Microenvironmental Features Encode Synergistic Interactions with Disease Outcomes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12670080/
  7. Oct 2025
  8. www.nature.com www.nature.com
    Pan-cancer analysis of RNA expression signatures associated with cancer tissue architecture
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    nature.com/articles/s41416-025-03233-9
  9. www.sciencedirect.com www.sciencedirect.com
    Updated efficacy and predictive biomarkers of QL1706, a bifunctional PD-1/CTLA-4 dual blocker in advanced solid tumors—A phase 1/1b study
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    sciencedirect.com/science/article/pii/S2666379125004690
  10. Sep 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial colocalization and molecular crosstalk of myofibroblastic CAFs and tumor cells shape lymph node metastasis in oral squamous cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12410789/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Potential role of immune-related LncRNAs in prognosis of hepatocellular carcinoma: an integrative study
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    pmc.ncbi.nlm.nih.gov/articles/PMC12399479/
  13. Aug 2025
  14. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225016992-main-html.html
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  15. Jun 2025
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12130809/
  17. May 2025
  18. link.springer.com link.springer.com
    Tumour-associated macrophage infiltration differs in meningioma genotypes, and is important in tumour dynamics
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    link.springer.com/article/10.1186/s13046-025-03419-2
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046329/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Treatment Efficacy and Molecular Dynamics of Neoadjuvant Durvalumab and Olaparib in Resectable Urothelial Bladder Cancer: The NEODURVARIB Trial
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    pmc.ncbi.nlm.nih.gov/articles/PMC12010967/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11572484/
  22. Apr 2025
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EFTUD2 is a promising diagnostic and prognostic indicator involved in the tumor immune microenvironment and glycolysis of lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11996642/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962405/
  25. Feb 2025
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98-rearranged leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838931/
  27. www.sciencedirect.com www.sciencedirect.com
    Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma
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    sciencedirect.com/science/article/pii/S2666379125000503
  28. aacrjournals.org aacrjournals.org
    Predictive and dynamic signature for anti-angiogenics in combination with PD-1 inhibitor in soft-tissue sarcoma: correlative studies linked to the IMMUNOSARC trial
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    aacrjournals.org/clincancerres/article/30/22/5192/749561/Predictive-and-Dynamic-Signature-for
  29. link.springer.com link.springer.com
    Machine learning-based integration reveals immunological heterogeneity and the clinical potential of T cell receptor (TCR) gene pattern in hepatocellular carcinoma
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    link.springer.com/article/10.1007/s10495-025-02080-6
  30. Jan 2025
  31. www.tandfonline.com www.tandfonline.com
    Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content
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    tandfonline.com/doi/full/10.1080/19490976.2024.2447821
  32. Oct 2024
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biomarker analyses investigating disease biology and associations with outcomes in the JAVELIN Merkel 200 trial of avelumab in metastatic Merkel cell carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443199/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypoxia-Induced Long Noncoding RNA HIF1A-AS2 Regulates Stability of MHC Class I Protein in Head and Neck Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443317/
  35. Aug 2024
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mast Cell Infiltration and Subtype Promote Malignant Transformation of Oral Precancer and Progression of Oral Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11339667/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A New Genetic Signature of Lactate Metabolism-Associated Genes Predicting Clinically Distinctive Features and Tumor Microenvironment in Colorectal Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11316264/
  38. Jul 2024
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Timing of whole genome duplication is associated with tumor-specific MHC-II depletion in serous ovarian cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11258338/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrating Multisector Molecular Characterization into Personalized Peptide Vaccine Design for Patients with Newly Diagnosed Glioblastoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11215407/
  41. May 2024
  42. aacrjournals.org aacrjournals.org
    Targeting ferroptosis-elicited inflammation suppresses hepatocellular carcinoma metastasis and enhances sorafenib efficacy
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    aacrjournals.org/cancerres/article/84/6/841/735013/Targeting-Ferroptosis-Elicited-Inflammation
  43. www.sciencedirect.com www.sciencedirect.com
    Integrative molecular and spatial analysis reveals evolutionary dynamics and tumor-immune interplay of in situ and invasive acral melanoma
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    sciencedirect.com/science/article/pii/S1535610824001363
  44. Mar 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10529249/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDK4/6-MEK inhibition in MPNSTs causes plasma cell infiltration, sensitization to PD-L1 blockade, and tumor regression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10528807/
  47. Jan 2024
  48. www.nature.com www.nature.com
    A new genomic framework to categorize pediatric acute myeloid leukemia
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    nature.com/articles/s41588-023-01640-3
  49. Nov 2023
  50. dx.doi.org dx.doi.org
    Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
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    dx.doi.org/10.1158/2767-9764.CRC-23-0165
  51. Oct 2023
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Analysis of Tumor Microenvironment Reveals Prognostic ceRNA Network Related to Immune Infiltration in Sarcoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10543973/
  53. Jul 2023
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Immunological modifications following chemotherapy are associated with delayed recurrence of ovarian cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10331425/
  55. Jun 2023
  56. www.biorxiv.org www.biorxiv.org
    Human plasma-like medium facilitates metabolic tracing and enables upregulation of immune signaling pathways in glioblastoma explants
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    biorxiv.org/content/10.1101/2023.05.29.542774v1
  57. May 2023
  58. www.sciencedirect.com www.sciencedirect.com
    Tumor biology and immune infiltration define primary liver cancer subsets linked to overall survival after immunotherapy
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    sciencedirect.com/science/article/pii/S2666379123001660
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comparative Tumor Microenvironment Analysis of Primary and Recurrent Ovarian Granulosa Cell Tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10150241/
  60. Apr 2023
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modeling cross‐talk of RNA modification enzymes reveals tumor microenvironment‐associated clinical significance and immunotherapy prediction in hepatobiliary malignancy
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    ncbi.nlm.nih.gov/pmc/articles/PMC10113697/
  62. aacrjournals.org aacrjournals.org
    Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
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    aacrjournals.org/cancerimmunolres/article/11/3/381/716712/Cancer-Cell-Resistance-to-IFN-Can-Occur-via
  63. Mar 2023
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inactivation of interleukin-30 in colon cancer stem cells via CRISPR/Cas9 genome editing inhibits their oncogenicity and improves host survival
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    ncbi.nlm.nih.gov/pmc/articles/PMC10030651/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZL-1211 Exhibits Robust Antitumor Activity by Enhancing ADCC and Activating NK Cell–mediated Inflammation in CLDN18.2-High and -Low Expressing Gastric Cancer Models
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    ncbi.nlm.nih.gov/pmc/articles/PMC10010325/
  66. Jan 2023
  67. www.nature.com www.nature.com
    Germline rare deleterious variant load alters cancer risk, age of onset and tumor characteristics
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    nature.com/articles/s41698-023-00354-3
  68. aacrjournals.org aacrjournals.org
    Spatial transcriptomic analysis of a diverse patient cohort reveals a conserved architecture in triple-negative breast cancer
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    aacrjournals.org/cancerres/article/83/1/34/711842/Spatial-Transcriptomic-Analysis-of-a-Diverse
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9397609/
  70. Nov 2022
  71. www.mdpi.com www.mdpi.com
    Identification and Application of a Novel Immune-Related lncRNA Signature on the Prognosis and Immunotherapy for Lung Adenocarcinoma
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    mdpi.com/2075-4418/12/11/2891
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Using machine learning to find genes associated with sudden death
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    ncbi.nlm.nih.gov/pmc/articles/PMC9641215/
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exploration of immune infiltration and feature genes in viral hepatitis-associated liver fibrosis using transcriptome data
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    ncbi.nlm.nih.gov/pmc/articles/PMC9622482/
  74. Sep 2022
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined – whole blood and skin fibroblasts- transcriptomic analysis in Psoriatic Arthritis reveals molecular signatures of activity, resistance and early response to treatment
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    ncbi.nlm.nih.gov/pmc/articles/PMC9493103/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lactate: A regulator of immune microenvironment and a clinical prognosis indicator in colorectal cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9458902/
  77. Aug 2022
  78. link.springer.com link.springer.com
    Identification of stromal microenvironment characteristics and key molecular mining in pancreatic cancer
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    link.springer.com/article/10.1007/s12672-022-00532-y
  79. May 2022
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC8568653/
  81. Mar 2022
  82. link.springer.com link.springer.com
    Comprehensive transcriptomic analysis shows disturbed calcium homeostasis and deregulation of T lymphocyte apoptosis in inclusion body myositis
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    link.springer.com/article/10.1007/s00415-022-11029-7
  83. Jan 2022
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bacterial-driven inflammation and mutant BRAF expression combine to promote murine colon tumorigenesis that is sensitive to immune checkpoint therapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC8295175/
  85. Dec 2021
  86. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Transcriptome analysis reveals the contribution of oligodendrocyte and radial glia-derived cues for maintenance of microglia identity
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    onlinelibrary.wiley.com/doi/10.1002/glia.24136
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deconvolution of Bulk Gene Expression Profiles with Single-Cell Transcriptomics to Develop a Cell Type Composition-Based Prognostic Model for Acute Myeloid Leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC8633313/
  88. Aug 2021
  89. www.sciencedirect.com www.sciencedirect.com
    Exploring the longitudinal glioma microenvironment landscape uncovers reprogrammed pro-tumorigenic neutrophils in the bone marrow
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    sciencedirect.com/science/article/pii/S2211124721009074
  90. Jul 2021
  91. www.sciencedirect.com www.sciencedirect.com
    Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes
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    sciencedirect.com/science/article/pii/S2211124718320588
  92. May 2021
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Morphological and genomic shifts in mole-rat ‘queens’ increase fecundity but reduce skeletal integrity
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    ncbi.nlm.nih.gov/pmc/articles/PMC8104968/
  94. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    The Oxford Classic Links Epithelial-to-Mesenchymal Transition to Immunosuppression in Poor Prognosis Ovarian Cancers
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    clincancerres.aacrjournals.org/content/27/5/1570
  95. Sep 2020
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Analysis of Tumor-Infiltrating Immune Cells and Relevant Therapeutic Strategy in Esophageal Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC7238334/
  97. journals.sagepub.com journals.sagepub.com
    Paclitaxel Promotes Tumor-Infiltrating Macrophages in Breast Cancer - Jun Shen, Cong Chen, Zhaoqing Li, Shufang Hu, 2020
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    journals.sagepub.com/doi/full/10.1177/1533033820945821
  98. www.hindawi.com www.hindawi.com
    Comprehensive Analysis of Tumor-Infiltrating Immune Cells and Relevant Therapeutic Strategy in Esophageal Cancer
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    hindawi.com/journals/dm/2020/8974793/
  99. www.sciencedirect.com www.sciencedirect.com
    The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells
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    sciencedirect.com/science/article/pii/S1535610820300428
  100. Jan 2020
  101. www.sciencedirect.com www.sciencedirect.com
    TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes
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    sciencedirect.com/science/article/pii/S2352396419304402
  102. www.sciencedirect.com www.sciencedirect.com
    Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration
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    sciencedirect.com/science/article/pii/S2211124719313130