287 Matching Annotations
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    Mutability and hypermutation antagonize immunoglobulin codon optimality
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    sciencedirect.com/science/article/pii/S1097276524009882
  3. Dec 2024
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A temporal cortex cell atlas highlights gene expression dynamics during human brain maturation
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      DOI: 10.1038/s41588-024-01990-6

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    Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus
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    1. scibot 10 Dec 2024
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    Single chromatin fiber profiling and nucleosome position mapping in the human brain
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    1. scibot 06 Dec 2024
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    Age-Related ECM Stiffness Mediates TRAIL Activation in Muscle Stem Cell Differentiation
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    1. scibot 06 Dec 2024
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      DOI: 10.1002/adbi.202400334

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  8. Nov 2024
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    The immune landscape of murine skeletal muscle regeneration and aging
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    sciencedirect.com/science/article/pii/S2211124724013263
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    Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair
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    1. scibot 16 Nov 2024
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    sciencedirect.com/science/article/pii/S0092867424011589
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    can-24-2248-html.html
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  12. Oct 2024
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    A High-Content Screen Identifies Drugs That Restrict Tumor Cell Extravasation across the Endothelial Barrier
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      DOI: 10.1158/0008-5472.CAN-19-3911

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    aacrjournals.org/cancerres/article/81/3/619/648134/A-High-Content-Screen-Identifies-Drugs-That
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    Transcriptomic cell-type specificity of local cortical circuits
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    sciencedirect.com/science/article/pii/S0896627324006512
  15. Sep 2024
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    Single-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes
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    1. scibot 27 Sep 2024
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    sciencedirect.com/science/article/pii/S0012160624002343
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    A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies
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    sciencedirect.com/science/article/pii/S2666379124004774
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    Discovery and characterization of a pan-betacoronavirus S2-binding antibody
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    1. scibot 27 Sep 2024
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    CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T cells via JAK2/STAT3 pathway
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    1. scibot 26 Sep 2024
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    Single-Cell Profiling Shows Murine Forebrain Neural Stem Cells Reacquire a Developmental State when Activated for Adult Neurogenesis
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    1. scibot 25 Sep 2024
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    Protocol for Dissection and Dissociation of Zebrafish Telencephalon for Single-Cell Sequencing
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      DOI: 10.1016/j.xpro.2020.100042

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    ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer’s disease through BDNF/NGFR signaling
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    Regulatory mechanisms orchestrating cellular diversity of Cd36+ olfactory sensory neurons revealed by scRNA-seq and scATAC-seq analysis
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  24. Aug 2024
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    Genetic association with autoimmune diseases identifies molecular mechanisms of coronary artery disease
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    Single-cell dissection of the human blood-brain barrier and glioma blood-tumor barrier
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    cell.com/neuron/fulltext/S0896-6273(24)00571-3
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    Experimental and Computational Methods for Allelic Imbalance Analysis from Single-Nucleus RNA-seq Data
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    Time- and cell-specific activation of BMP signaling restrains chondrocyte hypertrophy
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    sciencedirect.com/science/article/pii/S2589004224017620
  29. Jul 2024
  30. www.cell.com www.cell.com
    Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system
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    cell.com/immunity/fulltext/S1074-7613(24)00348-0
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    The primitive endoderm supports lineage plasticity to enable regulative development
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    The annotation of GBA1 has been concealed by its protein-coding pseudogene GBAP1
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      DOI: 10.1126/sciadv.adk1296

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    Single-cell spatial multiomics reveals tumor microenvironment vulnerabilities in cancer resistance to immunotherapy
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    cell.com/cell-reports/fulltext/S2211-1247(24)00720-4
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    Single-cell RNA Sequencing Identifies a Novel Subtype of Microglia with High Cd74 Expression that Facilitates White Matter Inflammation During Chronic Cerebral Hypoperfusion
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    Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer
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    Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs
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    Synaptic plasticity in human thalamocortical assembloids
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    ncbi.nlm.nih.gov/pmc/articles/PMC11407288/
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    Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease
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    sciencedirect.com/science/article/pii/S1931312824002312
  39. www.biorxiv.org www.biorxiv.org
    A rewiring of the earliest immune events leading to T-cell mediated disease following intestinal microbial infection in a PINK1KO mouse model of Parkinson’s disease
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      DOI: 10.1101/2024.06.18.598931

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    biorxiv.org/content/10.1101/2024.06.18.598931v1
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    The annotation of GBA1 has been concealed by its protein-coding pseudogene GBAP1
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      DOI: 10.1126/sciadv.adk1296

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  41. Jun 2024
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    Intergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis
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    The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies
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      DOI: 10.1016/j.immuni.2024.05.017

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    sciencedirect.com/science/article/pii/S1074761324002711
  44. May 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrating single‐cell and spatial analysis reveals MUC1‐mediated cellular crosstalk in mucinous colorectal adenocarcinoma
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      DOI: 10.1002/ctm2.1701

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    ncbi.nlm.nih.gov/pmc/articles/PMC11111627/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
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      DOI: 10.7554/eLife.87756

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    ncbi.nlm.nih.gov/pmc/articles/PMC11111218/
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    Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity
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      DOI: 10.1016/j.celrep.2024.114250

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    sciencedirect.com/science/article/pii/S2211124724005783
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    Integrative molecular and spatial analysis reveals evolutionary dynamics and tumor-immune interplay of in situ and invasive acral melanoma
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      DOI: 10.1016/j.ccell.2024.04.012

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    sciencedirect.com/science/article/pii/S1535610824001363
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    Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation
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      DOI: 10.1016/j.stem.2024.04.015

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    sciencedirect.com/science/article/pii/S1934590924001425
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    Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers
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      DOI: 10.1016/j.immuni.2024.04.014

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    Changes in the cellular makeup of motor patterning circuits drive courtship song evolution in Drosophila
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    Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses
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    Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti–PD-1 Therapy
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    Villus myofibroblasts are developmental and adult progenitors of mammalian gut lymphatic musculature
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    Single-nucleus RNA sequencing demonstrates an autosomal dominant Alzheimer’s disease profile and possible mechanisms of disease protection
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    Single-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes
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    Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer’s and related dementias
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    A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1
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    Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade
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    HAMSAB diet ameliorates dysfunctional signaling in pancreatic islets in autoimmune diabetes
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    Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms
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    Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection.
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    mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection
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    Multipotent progenitors instruct ontogeny of the superior colliculus
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  93. www.science.org www.science.org
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    A marmoset brain cell census reveals influence of developmental origin and functional class on neuronal identity
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    Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia
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    Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer
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    Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals
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    Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve
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    Germinal centers output clonally diverse plasma cell populations expressing high- and low-affinity antibodies
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  106. Oct 2023
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    Single-cell and spatial analyses reveal a tradeoff between murine mammary proliferation and lineage programs associated with endocrine cues
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    Single-cell transcriptomics illuminates regulatory steps driving anterior-posterior patterning of Drosophila embryonic mesoderm
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    BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer’s disease and related dementias
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  115. Sep 2023
  116. www.sciencedirect.com www.sciencedirect.com
    Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths
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    Spatially Distinct Otic Mesenchyme Cells show Molecular and Functional Heterogeneity Patterns Before Hearing Onset
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    Enrichment of carcinogen-driven “mitochondria-primed” human skin stem cells and their identification using single-cell analyses
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    Molecularly targetable cell types in mouse visual cortex have distinguishable prediction error responses
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    Activin A-mediated polarization of cancer-associated fibroblasts and macrophages confers resistance to checkpoint immunotherapy in skin cancer
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  123. Aug 2023
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    Novel human pluripotent stem cell-derived hypothalamus organoids demonstrate cellular diversity
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    Interaction of an α-synuclein epitope with HLA-DRB1∗15:01 triggers enteric features in mice reminiscent of prodromal Parkinson’s disease
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    Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression
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    Homeostatic PD-1 signaling restrains EOMES-dependent oligoclonal expansion of liver-resident CD8 T cells
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    Distinct mechanisms of mismatch repair deficiency delineate two modes of response to PD-1 immunotherapy in endometrial carcinoma
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    Early clonal extinction in glioblastoma progression revealed by genetic barcoding
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    Sex shapes cell-type-specific transcriptional signatures of stress exposure in the mouse hypothalamus
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  132. Jul 2023
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    FOXC2 promotes vasculogenic mimicry and resistance to anti-angiogenic therapy
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    sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons
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    Cross-organ single-cell transcriptome profiling reveals macrophage and dendritic cell heterogeneity in zebrafish
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    Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks
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    GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies and Synergizes with Anti-PD-L1 in a Murine Model of Colorectal Cancer
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    Low-level repressive histone marks fine-tune gene transcription in neural stem cells
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  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A single-cell atlas of the sexually dimorphic Drosophila foreleg and its sensory organs during development
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  142. Jun 2023
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    Claustral neurons projecting to frontal cortex restrict opioid consumption
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    Transcriptomic landscape of early hair follicle and epidermal development
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    Single-cell RNA-seq uncovers novel metabolic functions of Schwann cells beyond myelination
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    The maturation and aging trajectory of Marchantia polymorpha at single-cell resolution
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    Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
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    MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis
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    Asynchronous transcription and translation of neurotransmitter-related genes characterize the initial stages of neuronal maturation in Drosophila
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    Integrated spatial transcriptome and metabolism study reveals metabolic heterogeneity in human injured brain
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    Efficient self-organization of blastoids solely from mouse ESCs is facilitated by transient reactivation of 2C gene network
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    Modeling human ectopic pregnancies with trophoblast and vascular organoids
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    Immune microenvironment remodeling after radiation of a progressing brain metastasis
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    An in vivo neuroimmune organoid model to study human microglia phenotypes
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    Immune mechanisms shape the clonal landscape during early progression of prostate cancer
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    Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer’s dementia
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  160. www.biorxiv.org www.biorxiv.org
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  161. Apr 2023
  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia
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  163. Mar 2023
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    GSK-3 inhibitor elraglusib enhances tumor-infiltrating immune cell activation in tumor biopsies and synergizes with anti-PD-L1 in a murine model of colorectal cancer
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    Endothelial and Leptin Receptor+ cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow
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    Single-cell transcriptomic profiling redefines the origin and specification of early adrenogonadal progenitors
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  167. Feb 2023
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    IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii
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    Single-cell transcriptome profiles of Drosophila fruitless-expressing neurons from both sexes
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver
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    Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells
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  173. Jan 2023
  174. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance
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    Mapping transcriptional heterogeneity and metabolic networks in fatty livers at single-cell resolution
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    Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy
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    Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits
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  178. Dec 2022
  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies
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    TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development
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    Single-cell RNA sequencing uncovers dynamic roadmap and cell-cell communication during buffalo spermatogenesis
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  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness Versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis
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    Single-cell RNA sequencing reveals distinct T cell populations in immune-related adverse events of checkpoint inhibitors
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    Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity
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    B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing
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  186. Nov 2022
  187. www.nature.com www.nature.com
    Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons
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  188. www.sciencedirect.com www.sciencedirect.com
    Systematic single-cell pathway analysis to characterize early T cell activation
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    Molecular and anatomical characterization of parabrachial neurons and their axonal projections
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    CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation
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    Single-Cell RNA Sequencing Reveals Molecular Features of Heterogeneity in the Murine Retinal Pigment Epithelium
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  204. Aug 2022
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    Multiomics reveal the central role of pentose phosphate pathway in resident thymic macrophages to cope with efferocytosis-associated stress
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    Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator
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  224. Mar 2022
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    Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine
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    Erythropoietin directly remodels the clonal composition of murine hematopoietic multipotent progenitor cells
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  230. Feb 2022
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    Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target
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