73 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LIG1 Loss in TP53-mutant Triple Negative Breast Cancer Rewires DNA Repair and Confers Sensitivity to PARP-ATR Inhibitor Combinations
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    pmc.ncbi.nlm.nih.gov/articles/PMC13482947/
  3. Jul 2026
  4. www.sciencedirect.com www.sciencedirect.com
    A structure-based modeling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2589004226022534
  5. aacrjournals.org aacrjournals.org
    TRAPPC4 Promotes GPX4 Stability to Drive Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma
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    aacrjournals.org/cancerres/article/86/14/3436/786573/TRAPPC4-Promotes-GPX4-Stability-to-Drive
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TNIK overexpression is sufficient for chemoradiation resistance in limited-stage small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13339944/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nonsense-Mediated RNA Decay is a Targetable Vulnerability in Splicing Factor Mutant Myeloid Neoplasms by Enhancing R-loop Accumulation and DNA Damage
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  8. 54.241.53.176 54.241.53.176
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  9. Jun 2026
  10. aacrjournals.org aacrjournals.org
    MTA-Cooperative PRMT5 Inhibitors are Efficacious in MTAP-Deleted Malignant Peripheral Nerve Sheath Tumor Models
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    aacrjournals.org/clincancerres/article/31/22/4779/767051/MTA-Cooperative-PRMT5-Inhibitors-Are-Efficacious
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    WEE1 kinase inhibition to overcome acquired resistance to targeted therapies in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13269805/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-throughput screening identifies NT-1 that synergizes with MRTX1133 against acquired resistant KRASG12D colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13249833/
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    Structure-guided optimization of SLC1A1/EAAT3-selective inhibitors targeting renal cancer metabolism
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    pmc.ncbi.nlm.nih.gov/articles/PMC13226657/
  14. May 2026
  15. aacrjournals.org aacrjournals.org
    A phase I study of hydroxychloroquine and suba-itraconazole in men with biochemical relapse of prostate cancer (HITMAN-PC): dose escalation results
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    aacrjournals.org/cancerrescommun/article/6/3/687/776538/A-Phase-I-Study-of-Hydroxychloroquine-and-Suba
  16. Apr 2026
  17. aacrjournals.org aacrjournals.org
    Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers
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    aacrjournals.org/cancerdiscovery/article/15/10/2054/765955/Extrachromosomal-DNA-Driven-Oncogene-Dosage
  18. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Inhibition of Focal Adhesion Restricts Chemoresistance in Pancreatic Cancer by Targeting SLC7A11 Mediated Ferroptosis
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.75216
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Synergistic Treatment of Prostate Cancer and Multiple Myeloma using CD46-Targeted Radioimmunotherapy Antibody–Drug Conjugates
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    pmc.ncbi.nlm.nih.gov/articles/PMC13080322/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Camonsertib, an ATRi, in Combination with Low-Dose Gemcitabine in Solid Tumors with DNA Damage Response (DDR) Aberrations: Preclinical and Phase 1b Results
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  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia
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  22. Feb 2026
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    Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma
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  24. www.science.org www.science.org
    Inhibition of focal adhesion kinase impairs tumor formation and preserves hearing in a murine model of NF2-related schwannomatosis
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    science.org/doi/10.1126/sciadv.ady8382
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of focal adhesion kinase impairs tumor formation and preserves hearing in a murine model of NF2-related schwannomatosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12857737/
  26. Jan 2026
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide screenings identify BAP1 as a synthetic-lethality target with CDK4/6 inhibitors
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  28. Dec 2025
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  30. www.nature.com www.nature.com
    CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen
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    nature.com/articles/s41523-025-00851-7
  31. Nov 2025
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting CDK12/13 Drives Mitotic Arrest to Overcome Resistance to KRASG12C Inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12638015/
  33. Oct 2025
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cancer-associated fibroblasts expressing FSTL3 promote vasculogenic mimicry formation and drive colon cancer malignancy
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  35. Sep 2025
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Direct co-targeting of Bcl-xL and Mcl-1 exhibits synergistic effects in AR-V7-expressing CRPC models
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  37. Jul 2025
  38. www.biorxiv.org www.biorxiv.org
    High Throughput Screening Identifies Small Molecules that Synergize with MRTX1133 Against Acquired Resistant KRAS G12D Mutated CRC
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  40. May 2025
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312
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  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SHMT inhibitor synergizes with 5-Fu to suppress gastric cancer via cell cycle arrest and chemoresistance alleviation
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  43. Apr 2025
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors
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  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BCL-XL Protects ASS1-Deficient Cancers from Arginine Starvation–Induced Apoptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11964295/
  46. Mar 2025
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Impact of Co-mutations and Transcriptional Signatures in Non–Small Cell Lung Cancer Patients Treated with Adagrasib in the KRYSTAL-1 Trial
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  48. Feb 2025
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling
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    Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma
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    biorxiv.org/content/10.1101/2025.01.28.635193v1
  52. Oct 2024
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443213/
  54. Sep 2024
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A benzarone derivative inhibits EYA to suppress tumor growth in SHH medulloblastoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10948029/
  56. aacrjournals.org aacrjournals.org
    Drosophila Screening Identifies Dual Inhibition of MEK and AURKB as an Effective Therapy for Pancreatic Ductal Adenocarcinoma
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    aacrjournals.org/cancerres/article/83/16/2704/728339/Drosophila-Screening-Identifies-Dual-Inhibition-of
  57. May 2024
  58. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    elifesciences.org/articles/90683
  59. Apr 2024
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription
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    ncbi.nlm.nih.gov/pmc/articles/PMC11003700/
  61. Mar 2024
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDK4/6-MEK inhibition in MPNSTs causes plasma cell infiltration, sensitization to PD-L1 blockade, and tumor regression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10528807/
  63. Oct 2023
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inducing Mitotic Catastrophe as a Therapeutic Approach to Improve Outcomes in Ewing Sarcoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10605681/
  65. www.sciencedirect.com www.sciencedirect.com
    Synergistic antitumor efficacy of rMV-Hu191 and Olaparib in pancreatic cancer by generating oxidative DNA damage and ROS-dependent apoptosis
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    sciencedirect.com/science/article/pii/S1936523323001985
  66. dx.doi.org dx.doi.org
    Hyper-Dependence on NHEJ Enables Synergy Between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma
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    dx.doi.org/10.1158/1078-0432.CCR-23-0998
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYCN driven oncogenesis involves cooperation with WDR5 to activate canonical MYC targets and G9a to repress differentiation genes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10541123/
  68. aacrjournals.org aacrjournals.org
    Piperacetazine directly binds to the PAX3::FOXO1 fusion protein and inhibits its transcriptional activity.
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  70. Sep 2023
  71. academic.oup.com academic.oup.com
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  72. Aug 2023
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10425730/
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10391328/
  75. Jul 2023
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Caffeine supplementation and FOXM1 inhibition enhance the antitumor effect of statins in neuroblastoma
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  78. Jun 2023
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    An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets
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    SAM-Competitive EZH2-Inhibitors Induce Platinum Resistance by EZH2-Independent Induction of ABC-Transporters
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    mdpi.com/2072-6694/15/11/3043
  82. aacrjournals.org aacrjournals.org
    HAND2 assists MYCN enhancer invasion to regulate a noradrenergic neuroblastoma phenotype
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    aacrjournals.org/cancerres/article/83/5/686/716682/HAND2-Assists-MYCN-Enhancer-Invasion-to-Regulate-a
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  84. May 2023
  85. www.nature.com www.nature.com
    Targeting metabolism by B-raf inhibitors and diclofenac restrains the viability of BRAF-mutated thyroid carcinomas with Hif-1α-mediated glycolytic phenotype
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    nature.com/articles/s41416-023-02282-2
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9633392/
  87. Apr 2023
  88. aacrjournals.org aacrjournals.org
    Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
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    aacrjournals.org/cancerimmunolres/article/11/3/381/716712/Cancer-Cell-Resistance-to-IFN-Can-Occur-via
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10102849/
  90. www.sciencedirect.com www.sciencedirect.com
    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
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    sciencedirect.com/science/article/pii/S2666379123001179
  91. Feb 2023
  92. link.springer.com link.springer.com
    The BRD4 inhibitor JQ1 augments the antitumor efficacy of abemaciclib in preclinical models of gastric carcinoma
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    link.springer.com/article/10.1186/s13046-023-02615-2
  93. Nov 2022
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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    ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC promotes tyrosine kinase inhibitor resistance in ROS1 fusion-positive lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9081178/
  96. Jul 2022
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NPC1 Confers Metabolic Flexibility in Triple Negative Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9319388/
  98. Jun 2022
  99. aacrjournals.org aacrjournals.org
    Phosphorylation of SHP2 at Tyr62 enables acquired resistance to SHP2 allosteric inhibitors in FLT3-ITD-driven AML
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    aacrjournals.org/cancerres/article/82/11/2141/699099/Phosphorylation-of-SHP2-at-Tyr62-Enables-Acquired
  100. aacrjournals.org aacrjournals.org
    Porcupine inhibition disrupts mitochondrial function and homeostasis in WNT ligand-addicted pancreatic cancer
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    aacrjournals.org/mct/article/21/6/936/699192/Porcupine-Inhibition-Disrupts-Mitochondrial
  101. Jan 2022
  102. www.sciencedirect.com www.sciencedirect.com
    AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2211124721017010
  103. Jul 2021
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS‐CoV‐2 infection in vitro
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