76 Matching Annotations
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    Pharmacologically targeting CDK12 induces BRCAness and synergizes with merestinib to exacerbate DNA damage in high-risk neuroblastoma
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    sciencedirect.com/science/article/pii/S2211124726010752
  3. Oct 2026
  4. dx.doi.org dx.doi.org
    Berberine and Etoposide Exert Synergistic Anticancer Effects in A431 Epidermoid Carcinoma Cells
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    dx.doi.org/10.1021/acsomega.6c06421
  5. Sep 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting PRMT5 inhibitor-induced adaptation in pancreatic cancer with the RBM39 degrader indisulam
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    pmc.ncbi.nlm.nih.gov/articles/PMC13530115/
  7. Aug 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LIG1 Loss in TP53-mutant Triple Negative Breast Cancer Rewires DNA Repair and Confers Sensitivity to PARP-ATR Inhibitor Combinations
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    pmc.ncbi.nlm.nih.gov/articles/PMC13482947/
  9. Jul 2026
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    A structure-based modeling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2589004226022534
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    TRAPPC4 Promotes GPX4 Stability to Drive Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma
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    aacrjournals.org/cancerres/article/86/14/3436/786573/TRAPPC4-Promotes-GPX4-Stability-to-Drive
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    TNIK overexpression is sufficient for chemoradiation resistance in limited-stage small cell lung cancer
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    Nonsense-Mediated RNA Decay is a Targetable Vulnerability in Splicing Factor Mutant Myeloid Neoplasms by Enhancing R-loop Accumulation and DNA Damage
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  15. Jun 2026
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    MTA-Cooperative PRMT5 Inhibitors are Efficacious in MTAP-Deleted Malignant Peripheral Nerve Sheath Tumor Models
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    aacrjournals.org/clincancerres/article/31/22/4779/767051/MTA-Cooperative-PRMT5-Inhibitors-Are-Efficacious
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    WEE1 kinase inhibition to overcome acquired resistance to targeted therapies in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13269805/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-throughput screening identifies NT-1 that synergizes with MRTX1133 against acquired resistant KRASG12D colorectal cancer
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    Structure-guided optimization of SLC1A1/EAAT3-selective inhibitors targeting renal cancer metabolism
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    pmc.ncbi.nlm.nih.gov/articles/PMC13226657/
  20. May 2026
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    A phase I study of hydroxychloroquine and suba-itraconazole in men with biochemical relapse of prostate cancer (HITMAN-PC): dose escalation results
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    aacrjournals.org/cancerrescommun/article/6/3/687/776538/A-Phase-I-Study-of-Hydroxychloroquine-and-Suba
  22. Apr 2026
  23. aacrjournals.org aacrjournals.org
    Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers
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    aacrjournals.org/cancerdiscovery/article/15/10/2054/765955/Extrachromosomal-DNA-Driven-Oncogene-Dosage
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    Inhibition of Focal Adhesion Restricts Chemoresistance in Pancreatic Cancer by Targeting SLC7A11 Mediated Ferroptosis
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    Synergistic Treatment of Prostate Cancer and Multiple Myeloma using CD46-Targeted Radioimmunotherapy Antibody–Drug Conjugates
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    Camonsertib, an ATRi, in Combination with Low-Dose Gemcitabine in Solid Tumors with DNA Damage Response (DDR) Aberrations: Preclinical and Phase 1b Results
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  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia
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  28. Feb 2026
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma
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  30. www.science.org www.science.org
    Inhibition of focal adhesion kinase impairs tumor formation and preserves hearing in a murine model of NF2-related schwannomatosis
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  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of focal adhesion kinase impairs tumor formation and preserves hearing in a murine model of NF2-related schwannomatosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12857737/
  32. Jan 2026
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide screenings identify BAP1 as a synthetic-lethality target with CDK4/6 inhibitors
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  34. Dec 2025
  35. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  36. www.nature.com www.nature.com
    CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen
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  37. Nov 2025
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting CDK12/13 Drives Mitotic Arrest to Overcome Resistance to KRASG12C Inhibitors
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  39. Oct 2025
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cancer-associated fibroblasts expressing FSTL3 promote vasculogenic mimicry formation and drive colon cancer malignancy
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  41. Sep 2025
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Direct co-targeting of Bcl-xL and Mcl-1 exhibits synergistic effects in AR-V7-expressing CRPC models
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  43. Jul 2025
  44. www.biorxiv.org www.biorxiv.org
    High Throughput Screening Identifies Small Molecules that Synergize with MRTX1133 Against Acquired Resistant KRAS G12D Mutated CRC
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  46. May 2025
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312
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  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SHMT inhibitor synergizes with 5-Fu to suppress gastric cancer via cell cycle arrest and chemoresistance alleviation
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  49. Apr 2025
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors
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  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BCL-XL Protects ASS1-Deficient Cancers from Arginine Starvation–Induced Apoptosis
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  52. Mar 2025
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Impact of Co-mutations and Transcriptional Signatures in Non–Small Cell Lung Cancer Patients Treated with Adagrasib in the KRYSTAL-1 Trial
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  54. Feb 2025
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling
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    Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma
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  58. Oct 2024
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
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  60. Sep 2024
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A benzarone derivative inhibits EYA to suppress tumor growth in SHH medulloblastoma
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  62. aacrjournals.org aacrjournals.org
    Drosophila Screening Identifies Dual Inhibition of MEK and AURKB as an Effective Therapy for Pancreatic Ductal Adenocarcinoma
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    aacrjournals.org/cancerres/article/83/16/2704/728339/Drosophila-Screening-Identifies-Dual-Inhibition-of
  63. May 2024
  64. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    elifesciences.org/articles/90683
  65. Apr 2024
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription
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  67. Mar 2024
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDK4/6-MEK inhibition in MPNSTs causes plasma cell infiltration, sensitization to PD-L1 blockade, and tumor regression
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  69. Oct 2023
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inducing Mitotic Catastrophe as a Therapeutic Approach to Improve Outcomes in Ewing Sarcoma
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    Synergistic antitumor efficacy of rMV-Hu191 and Olaparib in pancreatic cancer by generating oxidative DNA damage and ROS-dependent apoptosis
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  72. dx.doi.org dx.doi.org
    Hyper-Dependence on NHEJ Enables Synergy Between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma
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    dx.doi.org/10.1158/1078-0432.CCR-23-0998
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYCN driven oncogenesis involves cooperation with WDR5 to activate canonical MYC targets and G9a to repress differentiation genes
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    Piperacetazine directly binds to the PAX3::FOXO1 fusion protein and inhibits its transcriptional activity.
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  76. Sep 2023
  77. academic.oup.com academic.oup.com
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  78. Aug 2023
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia
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    Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway
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  81. Jul 2023
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Caffeine supplementation and FOXM1 inhibition enhance the antitumor effect of statins in neuroblastoma
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  84. Jun 2023
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    An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets
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    SAM-Competitive EZH2-Inhibitors Induce Platinum Resistance by EZH2-Independent Induction of ABC-Transporters
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    mdpi.com/2072-6694/15/11/3043
  88. aacrjournals.org aacrjournals.org
    HAND2 assists MYCN enhancer invasion to regulate a noradrenergic neuroblastoma phenotype
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    aacrjournals.org/cancerres/article/83/5/686/716682/HAND2-Assists-MYCN-Enhancer-Invasion-to-Regulate-a
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  90. May 2023
  91. www.nature.com www.nature.com
    Targeting metabolism by B-raf inhibitors and diclofenac restrains the viability of BRAF-mutated thyroid carcinomas with Hif-1α-mediated glycolytic phenotype
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    nature.com/articles/s41416-023-02282-2
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9633392/
  93. Apr 2023
  94. aacrjournals.org aacrjournals.org
    Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
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    aacrjournals.org/cancerimmunolres/article/11/3/381/716712/Cancer-Cell-Resistance-to-IFN-Can-Occur-via
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10102849/
  96. www.sciencedirect.com www.sciencedirect.com
    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
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    sciencedirect.com/science/article/pii/S2666379123001179
  97. Feb 2023
  98. link.springer.com link.springer.com
    The BRD4 inhibitor JQ1 augments the antitumor efficacy of abemaciclib in preclinical models of gastric carcinoma
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    link.springer.com/article/10.1186/s13046-023-02615-2
  99. Nov 2022
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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    ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC promotes tyrosine kinase inhibitor resistance in ROS1 fusion-positive lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9081178/
  102. Jul 2022
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NPC1 Confers Metabolic Flexibility in Triple Negative Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9319388/
  104. Jun 2022
  105. aacrjournals.org aacrjournals.org
    Phosphorylation of SHP2 at Tyr62 enables acquired resistance to SHP2 allosteric inhibitors in FLT3-ITD-driven AML
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    aacrjournals.org/cancerres/article/82/11/2141/699099/Phosphorylation-of-SHP2-at-Tyr62-Enables-Acquired
  106. aacrjournals.org aacrjournals.org
    Porcupine inhibition disrupts mitochondrial function and homeostasis in WNT ligand-addicted pancreatic cancer
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    aacrjournals.org/mct/article/21/6/936/699192/Porcupine-Inhibition-Disrupts-Mitochondrial
  107. Jan 2022
  108. www.sciencedirect.com www.sciencedirect.com
    AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2211124721017010
  109. Jul 2021
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS‐CoV‐2 infection in vitro
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